Microfluidic Future

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Microfluidic Future serves as a portal to spread the news and developments in the field of microfluidics with the world.

Microfluidic Future's Latest Posts

Continuously Sorting Particles According to Shape

There are numerous filters to separate particles in liquid based on their size, which can be enough to isolate them; however, particle shape can be more important, as it distinguishes healthy red blood cells from those affected by sickle-cell disease or malaria. Shape can also be used to determine what stage a cell is in of the cell cycle, which would benefit researchers looking for dividing cells. Recent research by Dino Di Carlo of UCLA looks to separate particles of differing aspect ratios […]

Masaeli, M., Sollier, E., Amini, H., Mao, W., Camacho, K., Doshi, N., Mitragotri, S., Alexeev, A. & Di Carlo, D. (2012). Continuous Inertial Focusing and Separation of Particles by Shape, Physical Review X, 2 (3) DOI: 10.1103/PhysRevX.2.031017

Di Carlo, D., Irimia, D., Tompkins, R. & Toner, M. (2007). Continuous inertial focusing, ordering, and separation of particles in microchannels, Proceedings of the National Academy of Sciences, 104 (48) 18892-18897. DOI: 10.1073/pnas.0704958104

Sugaya, S., Yamada, M. & Seki, M. (2011). Observation of nonspherical particle behaviors for continuous shape-based separation using hydrodynamic filtration, Biomicrofluidics, 5 (2) 24103. DOI: 10.1063/1.3580757

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Tracking Immune Responses to Food with a Gut on a Chip

Organs on Chips In an effort to model the complex processes occurring in human bodies, Donald Ingber has pioneered the development of ‘organs-on-chips,’ reproducing the lung and the gut on microfluidic devices. These systems allow researchers to replicate and study organs without the use of human test subjects. While this is one of the best options, there are too many variables to control, understand, and more importantly, manipulate. At the other end of the spectrum is an in vitro study […]

Ramadan, Q., Jafarpoorchekab, H., Huang, C., Silacci, P., Carrara, S., Koklü, G., Ghaye, J., Ramsden, J., Ruffert, C., Vergeres, G. & Gijs, M. (2013). NutriChip: nutrition analysis meets microfluidics, Lab on a Chip, 13 (2) 196. DOI: 10.1039/c2lc40845g

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A Microsyringe to Take the Pain out of Shots

Back when I was in sixth grade, I remember reading a little blurb in some science magazine at school that in the future we could receive shots via a method that would feel as soft as a banana peel. Although I’m now a champ at taking shots, it’s still not a bad idea. We’ve had transdermal patches (think nicotine and birth control) for some time now, but those release their medicine over a period of time. A syringe is capable of delivering a dose at once, and can take a biological sample […]

Strambini LM, Longo A, Diligenti A & Barillaro G (2012). A minimally invasive microchip for transdermal injection/sampling applications., Lab on a chip, 12 (18) 3370-9. PMID: 22773092

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Forcing Multi-Daughter Cell Division with Confinement

On Microfluidic Future I like reviewing advancements in therapeutic or diagnostic devices because I’m really drawn to those areas of research. Every once in a while, however, I take interest in research for the sake for knowledge, like the Root Chip. I recently came across an article from Dino Di Carlo of UCLA that describes a microfluidic device used to study cancer cells. The article, “Increased Asymmetric and Multi-Daughter Cell Division in Mechanically Confined Microenvironments” […]

Henry Tat Kwong Tse, Westbrook McConnell Weaver & Dino Di Carlo (2012). Increased Asymmetric and Multi-Daughter Cell Division in Mechanically Confined Microenvironments, PLoS ONE, 7 (6) Other: Link

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Rolling Out Cell Sorting with Microfluidics

Cell Sorting Cells are quite valuable, especially when used for regenerative research, diagnostics or research. But harvested cells do not come presorted and need to be separated from a heterogeneous mixture of cells. There are already numerous methods to sort cells according to biophysical properties such as size, density, morphology, and dielectric or magnetic susceptibility. Cell sorting based on labels can have a higher specificity, but introduces extra steps to add and remove labels, which […]

Choi, S., Karp, J. & Karnik, R. (2012). Cell sorting by deterministic cell rolling, Lab on a Chip, 12 (8) 1427. DOI: 10.1039/c2lc21225k

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