Just Like Cooking
Chemistry-Related Hijinks, Hoopla, and Skullduggery - Since 2011
Just Like Cooking's Latest Posts
Let's say you have a late-stage drug candidate, with an alcohol, an olefin, and a pyridine. Now you toss in one equivalent of a chlorinating reagent.Which functional group gets halogenated first?Babak Borhan and colleagues from Michigan State and Dow may have your answer. In a recent JACS full article, they disclose the HalA (halenium affinity) scale, a DFT-calculated delta to describe the relative reactivity of various groups to an incoming halogen source. They back up their calculations […]
From the Sept 2014 issue of Wired magazine:I understand that magazines require flashy, highly-posed photographs to move copy.That said, did no one in the Editor's office notice all the warnings on that hood sash?They read:"Wear proper PPE (Goggles, Gloves, Protective Clothing)""Always properly label your chemicals, including your initials. Any unknowns will be disposed of as Hazardous Waste""NO STORAGE"As far as I can tell, the researcher pictured is in violation of all three signs.
From the August 2014 issue of Scientific American:This illustration hurts on a few levels. "Methyl" and "Acetyl" are functional groups - common clusters of atoms that appear in larger molecules - not themselves chemicals, per se. If the methyl were actually represented by this red ball, it wouldn't be quite so large (it's only four atoms), nor would it be attached at the outside of the sugar backbone (it's on the nucleobases themselves).Did no one see last year's Discover infographic? At least […]
*Update - I see CJ beat me to it!Buried deep within a recent NY Times Magazine article, a humbling reminder that not all knowledge comes easily to billionaire tech scions:source: Microsoft"Without prompting, [Bill Gates] recounted getting a bad grade in an eighth-grade geography course (“They paired me up with a moron, and I realized these people thought I was stupid, and it really pissed me off!”) and the only C-plus he ever received, in organic chemistry, at Harvard […]
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