Posts

December 18, 2014

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7:01 AM | Correcting Metabolic Abnormalities May Help Lessen Urinary Problems
Metabolic syndrome is linked with an increased frequency and severity of lower urinary tract symptoms, but weight loss surgery may lessen these symptoms. The findings, which come from two studies published in BJU International, indicate that urinary problems may be added to the list of issues that can improve with efforts that address altered metabolism. […] The post Correcting Metabolic Abnormalities May Help Lessen Urinary Problems appeared first on Wiley Asia Blog.

Pashootan, P., Ploussard, G., Cocaul, A., de Gouvello, A. & Desgrandchamps, F. (2014). Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort, BJU International, DOI: 10.1111/bju.12931

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December 17, 2014

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7:54 PM | Epigenetic changes and autism
Despite what you may think, the supposed “explosion” of children diagnosed with autism can directly attributed to better diagnosing techniques and — more importantly — the change of definition to […]

Gao, Z., Lee, P., Stafford, J., von Schimmelmann, M., Schaefer, A. & Reinberg, D. (2014). An AUTS2–Polycomb complex activates gene expression in the CNS, Nature, 516 (7531) 349-354. DOI: 10.1038/nature13921

Ntziachristos, P., Tsirigos, A., Welstead, G., Trimarchi, T., Bakogianni, S., Xu, L., Loizou, E., Holmfeldt, L., Strikoudis, A., King, B. & Mullenders, J. (2014). Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia, Nature, 514 (7523) 513-517. DOI: 10.1038/nature13605

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7:04 PM | Google Translate not yet ready for medical communications
Image credits: frauczepluch.blogspot.com Communications is key in any relationship, particularly that between patients and doctors.  So what happens when the two parties don’t speak the same...

Patil S & Davies P (2014). Use of Google Translate in medical communication: evaluation of accuracy., BMJ (Clinical research ed.), 349 PMID: http://www.ncbi.nlm.nih.gov/pubmed/25512386

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2:38 PM | Video Tip of the Week: yEd Graph Editor for visualizing pathways and networks
This week’s video tip of the week closes out a series that began last month. I started to explore one gene co-expression tool, which led me to another tool for visualization, and so on. This week’s tool is the final piece that you need to know about if you want to create the kind of […]

Wright D.W., Anton J. Enright & Tom C. Freeman (2014). Visualisation of BioPAX Networks using BioLayout Express3D, F1000Research, DOI: http://dx.doi.org/10.12688/f1000research.5499.1

Smoot M.E., J. Ruscheinski, P.-L. Wang & T. Ideker (2010). Cytoscape 2.8: new features for data integration and network visualization, Bioinformatics, 27 (3) 431-432. DOI: http://dx.doi.org/10.1093/bioinformatics/btq675

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1:30 PM | Picking a New Dog is a Complex Choice
It’s not a case of ‘any puppy will do’ - the whole package counts.Photo: DragoNika / ShutterstockSurprisingly little is known about how people choose a new dog considering how popular they are. While it’s a personal choice, it has wider implications – humane societies would really like to know how to increase adoptions from shelters and decrease purchases from puppy mills. Could relocation programs, where dogs are brought in from out of town, be part of the […]

Garrison, L. & Weiss, E. (2014). What Do People Want? Factors People Consider When Acquiring Dogs, the Complexity of the Choices They Make, and Implications for Nonhuman Animal Relocation Programs, Journal of Applied Animal Welfare Science, 18 (1) 57-73. DOI: 10.1080/10888705.2014.943836

Mornement, K., Coleman, G., Toukhsati, S. & Bennett, P. (2012). What Do Current and Potential Australian Dog Owners Believe about Shelter Practices and Shelter Dogs?, Anthrozoos: A Multidisciplinary Journal of The Interactions of People & Animals, 25 (4) 457-473. DOI: 10.2752/175303712X13479798785850

Siettou, C., Fraser, I. & Fraser, R. (2014). Investigating Some of the Factors That Influence “Consumer” Choice When Adopting a Shelter Dog in the United Kingdom, Journal of Applied Animal Welfare Science, 17 (2) 136-147. DOI: 10.1080/10888705.2014.883924

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1:00 PM | Christmas Greenery - Friend Or Foe?
Biology concepts – toxin, botany, cancer chemotherapies, pregnancy, evergreen Noche de Rábanos (Night of the Radishes) is celebrated in Oaxaca, Mexico on December 23. The townspeople carve radishes into shapes, characters or scenes and then they are judged.  It began as a suggestion by a couple of monks to bring people in to the market to buy the produce that the farmers had raised, so it’s a Christmas plant tradition that really has little to do with […]

Liu, B., Zhou, J., Li, Y., Zou, X., Wu, J., Gu, J., Yuan, J., Zhao, B., Feng, L., Jia, X. & Wang, R. (2014). Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway, BMC Complementary and Alternative Medicine, 14 (1) 412. DOI: 10.1186/1472-6882-14-412

Tröger W, Galun D, Reif M, Schumann A, Stanković N & Milićević M (2014). Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe: a randomized controlled trial., Deutsches Arzteblatt international, 111 (29-30) 493. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25142075

Tsui, K., Wang, J., Wu, L. & Chiu, C. (2012). Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis, Evidence-Based Complementary and Alternative Medicine, 2012 1-12. DOI: 10.1155/2012/190107

Earl, E., Altaf, M., Murikoli, R., Swift, S. & O'Toole, R. (2010). Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis, BMC Complementary and Alternative Medicine, 10 (1) 25. DOI: 10.1186/1472-6882-10-25

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12:11 PM | Humpback Whales Sing Tick-Tock Songs For Supper
Humpback whales (Megaptera novaeangliae) are known to employ group foraging techniques, however details on how individuals coordinate with each other still remain a mystery. A new study by Susan Parks, assistant professor of biology in the College of Arts and Sciences, in collaboration with a consortium of other researchers examined the importance of specific auditory cues that these whales emit

Parks SE, Cusano DA, Stimpert AK, Weinrich MT, Friedlaender AS & Wiley DN (2014). Evidence for acoustic communication among bottom foraging humpback whales., Scientific reports, 4 7508. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25512188

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9:29 AM | Folate receptor autoantibodies and (some) schizophrenia
I am the league's director, Silas Ramsbottom.Upon reading the paper published by Ramaekers and colleagues [1] talking about the use of folinic acid in cases of schizophrenia as a function of the presence of "Auto-antibodies against folate receptor alpha (FRα)", I raised a little smile. Not only because the authors suggested that there may be quite a lot more to see in this area on top of some already interesting discussions about the folate cycle and schizophrenia, but also because […]

Ramaekers VT, Thöny B, Sequeira JM, Ansseau M, Philippe P, Boemer F, Bours V & Quadros EV (2014). Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies., Molecular genetics and metabolism, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25456743

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December 16, 2014

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7:37 PM | Methamphetamine use and the onset of parkinson’s
We’ve all seen the PSA’s trying to show the effects of meth use and in particular, what it does to your teeth. Typically, when it comes to drug use, people […]

Curtin K, Fleckenstein AE, Robison RJ, Crookston MJ, Smith KR & Hanson GR (2014). Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: A population-based assessment., Drug and alcohol dependence, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25479916

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12:14 PM | The scientific community’s Galileo affair (you’re the Pope)
Science is in crisis. Everyone in the scientific community knows about it but few want to talk about it. The crisis is one of honesty. A junior scientist (like me) asks himself a similar question to Galileo in 1633: how much honesty is desirable in science? Science Wonderland According to nearly all empirical scientific publications […]

John, L., Loewenstein, G. & Prelec, D. (2012). Measuring the Prevalence of Questionable Research Practices with Incentives for Truth-Telling, SSRN Electronic Journal, DOI: 10.2139/ssrn.1996631

Simmons, J., Nelson, L. & Simonsohn, U. (2011). False-Positive Psychology: Undisclosed Flexibility in Data Collection and Analysis Allows Presenting Anything as Significant, Psychological Science, 22 (11) 1359-1366. DOI: 10.1177/0956797611417632

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December 15, 2014

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8:07 PM | Finding the neurons that deal with distraction
What’s that over there!? The next time you are around people, count how many people are on their phone? Distractions invade every aspect of our lives. Status updates, text messages, […]

Ahrens, S., Jaramillo, S., Yu, K., Ghosh, S., Hwang, G., Paik, R., Lai, C., He, M., Huang, Z. & Li, B. & (2014). ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection, Nature Neuroscience, DOI: 10.1038/nn.3897

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2:59 PM | Il secondo principio di relatività
Durante i suoi primi passi, la relatività speciale incrociò la strada con l'elettrone e la ricerca della sua massaLa relatività speciale di Albert Einstein proponeva alcuni elementi rivoluzionari, fornendo innanzitutto una serie di strumenti matematici e di discorsi epsitemologici a supporto di una serie di osservazioni apparentemente assurde, prima fra tutte la non conservazione delle equazioni di Maxwell sotto l'azione delle trasformazioni di Galileo.Le trasformazioni di […]

Thomson J.J. (1881). XXXIII. On the electric and magnetic effects produced by the motion of electrified bodies , Philosophical Magazine Series 5, 11 (68) 229-249. DOI: http://dx.doi.org/10.1080/14786448108627008

Searle G.F.C. (1897). XLII. On the steady motion of an electrified ellipsoid , Philosophical Magazine Series 5, 44 (269) 329-341. DOI: http://dx.doi.org/10.1080/14786449708621072

Poincaré M.H. (1906). Sur la dynamique de l’électron, Rendiconti del Circolo matematico di Palermo, 21 (1) 129-175. DOI: http://dx.doi.org/10.1007/bf03013466

Einstein, A. (1905). Zur Elektrodynamik bewegter Körper, Annalen der Physik, 322 (10) 891-921. DOI: 10.1002/andp.19053221004

Kaufmann W. (1906). Über die Konstitution des Elektrons, Annalen der Physik, 324 (3) 487-553. DOI: http://dx.doi.org/10.1002/andp.19063240303

Bestelmeyer A. (1907). Spezifische Ladung und Geschwindigkeit der durch Röntgenstrahlen erzeugten Kathodenstrahlen, Annalen der Physik, 327 (3) 429-447. DOI: http://dx.doi.org/10.1002/andp.19073270303

Bucherer A.H. (1909). Die experimentelle Bestätigung des Relativitätsprinzips, Annalen der Physik, 333 (3) 513-536. DOI: http://dx.doi.org/10.1002/andp.19093330305

Tolman R.C. (1910). The Second Postulate of Relativity, Physical Review (Series I), 31 (1) 26-40. DOI: http://dx.doi.org/10.1103/physrevseriesi.31.26

Neumann G. (1914). Die träge Masse schnell bewegter Elektronen, Annalen der Physik, 350 (20) 529-579. DOI: http://dx.doi.org/10.1002/andp.19143502005

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12:00 PM | The Paradoxical Shrinking Frog
Pseudis paradoxa in a pond Credit: Mauricio Rivera Correa Kingdom: Animalia Phylum: Chordata Class: Amphibia Order: Anura Family: Hylidae Genus: Pseudis Species: Pseudis paradoxa Common Name(s): Paradoxical frog or Shrinking frog Conservation Status: Least Concern (Not Threatened) Looks like a pretty much regular frog, doesn't it? Well.. it's not! Meet P. paradoxa, a frog that grows down

EMERSON, S. (1988). The giant tadpole of Pseudis paradoxa, Biological Journal of the Linnean Society, 34 (2) 93-104. DOI: 10.1111/j.1095-8312.1988.tb01951.x

Abdel-Wahab YH, Power GJ, Ng MT, Flatt PR & Conlon JM (2008). Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue., Biological chemistry, 389 (2) 143-8. PMID: http://www.ncbi.nlm.nih.gov/pubmed/18163889

Arias, M., Peltzer, P. & Lajmanovich, R. (2002). Diet of the giant tadpole Pseudis paradoxa platensis (Anura, Pseudidae) from Argentina, Phyllomedusa: Journal of Herpetology, 1 (2) 97. DOI: 10.11606/issn.2316-9079.v1i2p97-100

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10:46 AM | Want to learn something better? Draw it
When you're trying to learn, do something with your new knowledge, such as summarising it or explaining it to someone else. This deepens your memories and helps integrate what you've learned with what you already knew. A new study has tested the benefits of another beneficial learning activity - drawing.Annett Schmeck and her team asked 48 German school-kids (average age 14) to read a 850-word passage about the biology of influenza, broken down into seven paragraphs. This was an unfamiliar […]

Schmeck, A., Mayer, R., Opfermann, M., Pfeiffer, V. & Leutner, D. (2014). Drawing pictures during learning from scientific text: testing the generative drawing effect and the prognostic drawing effect, Contemporary Educational Psychology, 39 (4) 275-286. DOI: 10.1016/j.cedpsych.2014.07.003

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9:45 AM | Rates of medical illnesses in bipolar disorder
I've mentioned a few times on this blog that a diagnosis of autism or autism spectrum disorder (ASD) is by no means protective against any other diagnosis being received, be it based on a somatic illness or condition, or something more behaviourally defined.Reading through the paper by Liz Forty and colleagues [1] (open-access) it appears that a similar scenario might also pertain to other behaviourally-defined conditions as per the example of bipolar disorder (BD) and their conclusion: […]

Forty L, Ulanova A, Jones L, Jones I, Gordon-Smith K, Fraser C, Farmer A, McGuffin P, Lewis CM, Hosang GM & Rivera M (2014). Comorbid medical illness in bipolar disorder., The British journal of psychiatry : the journal of mental science, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25359927

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6:36 AM | Treatment for Elderly with Breast Cancer May Not Be as Effective
claimtoken-548f952b76556 A new analysis has found that while clinical trial data support omitting radiation treatments in elderly women with early stage breast cancer, nearly two-thirds of these women continue to receive it. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Results published in 2004 from a large, […] The post Treatment for Elderly with Breast Cancer May Not Be as Effective appeared first on Wiley Asia Blog.

Palta, M., Palta, P., Bhavsar, N., Horton, J. & Blitzblau, R. (2014). The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: Changes in practice patterns after publication of Cancer and Leukemia Group B 9343, Cancer, DOI: 10.1002/cncr.28937

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6:36 AM | Treatment for Elderly with Breast Cancer May Not Be as Effective
A new analysis has found that while clinical trial data support omitting radiation treatments in elderly women with early stage breast cancer, nearly two-thirds of these women continue to receive it. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Results published in 2004 from a large, randomized […] The post Treatment for Elderly with Breast Cancer May Not Be as Effective appeared first on Wiley Asia Blog.

Palta, M., Palta, P., Bhavsar, N., Horton, J. & Blitzblau, R. (2014). The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: Changes in practice patterns after publication of Cancer and Leukemia Group B 9343, Cancer, DOI: 10.1002/cncr.28937

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December 14, 2014

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6:28 PM | Scientists find a drug (currently used) to turn white fat to brown
It seems like we’ve been on a weight loss campaign here at the labs, but there just has been so much new and interesting research on the subject to report […]

Anne Loft, Isabel Forss, Majken Storm Siersbæk, Søren Fisker Schmidt, Ann-Sofie Bøgh Larsen, Jesper Grud Skat Madsen, Didier F. Pisani, Ronni Nielsen, Mads Malik Aagaard, Angela Mathison & Matt J. Neville (2014). Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers, Genes & Development, Other:

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5:47 PM | Sulfur hydride blows away previous critical temperature limits for conventional superconductivity
Superconductivity, the phenomenon in which a material conducts electrons without resistance, is the tantalizing theoretical mystery of condensed matter physics attracting some of the greatest minds in the field.  Now, some incredible news has come out of the Max Planck … Continue reading →

A. P. Drozdov, M. I. Eremets & I. A. Troyan (2014). Conventional superconductivity at 190 K at high pressures, arXiv, arXiv: http://arxiv.org/abs/1412.0460v1

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12:57 PM | Increasing Rigor in Huntington’s Disease Research
The CHDI Foundation, a charitable organization who fund a lot of research into Huntington's disease, are interested in reforming the scientific process. The story comes from a paper written by British neuroscientist Marcus Munafo and colleagues (the authors including CHDI staff) published in Nature Biotechnology a couple of months ago: Scientific rigor and the art of motorcycle maintenance. Munafo et al. begin by pointing to the history of car manufacturing as an analogy for the scie

Munafo M, Noble S, Browne WJ, Brunner D, Button K, Ferreira J, Holmans P, Langbehn D, Lewis G, Lindquist M & Tilling K (2014). Scientific rigor and the art of motorcycle maintenance., Nature Biotechnology, 32 (9) 871-3. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25203032

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9:48 AM | Beware the inflated science related press release!
I'm not normally minded to post on a Sunday (day of rest and all that) but I did want to bring your attention to the results presented by Petroc Sumner and colleagues [1] (open-access) concluding that: "Exaggeration in news is strongly associated with exaggeration in press releases" when it comes to the media reporting of [some] health-related science news.The idea behind this particular study - which has been summarised pretty well in some of the accompanying media and in an […]

Sumner, P., Vivian-Griffiths, S., Boivin, J., Williams, A., Venetis, C., Davies, A., Ogden, J., Whelan, L., Hughes, B., Dalton, B. & Boy, F. (2014). The association between exaggeration in health related science news and academic press releases: retrospective observational study, BMJ, 349 (dec09 7) DOI: 10.1136/bmj.g7015

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December 13, 2014

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6:51 PM | High fat diet leads to brain inflammation and obesity
The stomach strikes again, or so it seems. We’ve already covered how your stomach seemingly controls your brain and your blood-brain barrier, but now it seems that what you eat –not […]

Valdearcos, M., Robblee, M., Benjamin, D., Nomura, D., Xu, A. & Koliwad, S. (2014). Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function, Cell Reports, DOI: 10.1016/j.celrep.2014.11.018

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10:19 AM | Social communication disorder (SCD) reviewed
Sometimes I believe in as many as six impossible things before breakfast.A micropost if you will, for today, and a link to a potentially very important paper by Lauren Swineford and colleagues [1] (open-access) talking about the diagnostic concept: social (pragmatic) communication disorder (SCD) and it's various crossings with language impairments and autism spectrum disorder (ASD).SCD, as I've indicated in other posts (see here and see here) is something that the autism community in […]

Swineford, L., Thurm, A., Baird, G., Wetherby, A. & Swedo, S. (2014). Social (pragmatic) communication disorder: a research review of this new DSM-5 diagnostic category, Journal of Neurodevelopmental Disorders, 6 (1) 41. DOI: 10.1186/1866-1955-6-41

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3:56 AM | Animal Research Sheds Light on Harmful Mood Disorders in New Mothers
In the days shortly after giving birth, most mothers experience a period of increased calmness and decreased stress responses, but around 20% of mothers experience anxiety. Some women may become depressed, and around one in a thousand can develop psychosis. The latest evidence indicates that these distressing responses to motherhood are still poorly understood, but […] The post Animal Research Sheds Light on Harmful Mood Disorders in New Mothers appeared first on Wiley Asia Blog.

Perani, C. & Slattery, D. (2014). Using animal models to study post-partum psychiatric disorders, British Journal of Pharmacology, 171 (20) 4539-4555. DOI: 10.1111/bph.12640

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3:56 AM | Animal Research Sheds Light on Harmful Mood Disorders in New Mothers
In the days shortly after giving birth, most mothers experience a period of increased calmness and decreased stress responses, but around 20% of mothers experience anxiety. Some women may become depressed, and around one in a thousand can develop psychosis. The latest evidence indicates that these distressing responses to motherhood are still poorly understood, but […] The post Animal Research Sheds Light on Harmful Mood Disorders in New Mothers appeared first on Wiley Asia Blog.

Perani, C. & Slattery, D. (2014). Using animal models to study post-partum psychiatric disorders, British Journal of Pharmacology, 171 (20) 4539-4555. DOI: 10.1111/bph.12640

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December 12, 2014

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10:30 PM | Diversity working together: cancer, immune system, and microbiome
After a much needed few weeks of recovery, I’ve found some time to post about our annual IMO workshop held this year on the topic of viruses in cancer. Our group had the challenge of learning about all of the complexities of the human microbiome and its interactions with a cancerous lesion. The human microbiome, […]

Human Microbiome Project Consortium (2012). Structure, function and diversity of the healthy human microbiome, Nature, 486 (7402) 207-214. DOI: 10.1038/nature11234

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9:00 PM | Breaking Research: A new technique for studying axon death using fruit fly wings
The axon is the part of a neuron that carries outgoing information. (cb = cell body) In neurodegenerative diseases such as Parkinson’s disease or amyotrophic lateral sclerosis (ALS), a genetic mutation leads to widespread neuron damage. When a neuron is damaged, its axon—the part of the neuron that carries outgoing signals—is actively broken down and […]

Neukomm L.J., M. A. Gonzalez, S. Zuchner & M. R. Freeman (2014). Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila, Proceedings of the National Academy of Sciences, 111 (27) 9965-9970. DOI: http://dx.doi.org/10.1073/pnas.1406230111

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7:13 PM | A new type of memory storage on the horrizon
For those of us old enough to remember the days of the Apple II, you know that storage has exponentially increased. Even just 10 years ago 20+ gigs of data […]

Shimizu, T., Jung, J., Imada, H. & Kim, Y. (2014). Supramolecular Assembly through Interactions between Molecular Dipoles and Alkali Metal Ions, Angewandte Chemie International Edition, 53 (50) 13729-13733. DOI: 10.1002/anie.201407555

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9:00 AM | Why do friendly people usually lead happier lives?
High scorers on the personality trait of agreeableness are eager to please, concerned for others, and compliant to other perspectives. On average, they live happier lives too. A new study suggests a possible reason: when they have the chance, friendly people tend to avoid engaging with negative things.The researchers, Konrad Bresin and Michael Robinson, began by asking participants to view a series of positive and negative images, spending as much time as they wanted on each one. Most people […]

Bresin K & Robinson MD (2014). You Are What You See and Choose: Agreeableness and Situation Selection., Journal of personality, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25109246

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8:32 AM | Party On! (If You're Middle-Class and Young): Age Differences Explain Social Class Differences in University Friendships
In a recent meta-analytic review, I found that working-class students are less integrated at university than their middle-class peers. I offered up nine potential explanations for this working-class exclusion effect. It turns out that one of the simplest explanations in this list is also the most promising. It’s all to do with age.Working-class students tend to be older than middle-class students. Why? Most likely because they don’t tend to go to university immediately after […]

Rubin, M. & Wright, C. (2014). Age differences explain social class differences in students’ friendship at university: Implications for transition and retention, Higher Education, DOI: 10.1007/s10734-014-9844-8

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