Posts

November 01, 2014

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9:42 AM | Strange, Vampire-like Deer Still Alive in Afghanistan
Musk deers use their distinctive fungs tusks during the rutting season  to compete with other males.Photo shows a Siberian musk deer, a similar and closelyrelated species.Credit: Julie Larsen Maher © WCSIt's been more than 60 years after the last confirmed sighting of the Kashmir musk deer in Afganistan, a strange deer with vampire-like fangs native to Afghanistan, Republic of India, and Pakistan.Now, a new study appearing in the latest edition of the journal Oryx reveals that […]

Ostrowski, S., Rahmani, H., Ali, J., Ali, R. & Zahler, P. (2014). Musk deer Moschus cupreus persist in the eastern forests of Afghanistan, Oryx, 1-6. DOI: 10.1017/S0030605314000611

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October 31, 2014

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8:05 PM | New Genetic Editing Technique Offers Novel Treatment of Defects
The promises of genetic modifications are endless, longer life, better health, cures for genetic based diseases that would otherwise cause an unimaginable amount of suffering all wiped out. We’ve come a […]

Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY & Liu DR & (2014). Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo., Nature biotechnology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25357182

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4:05 PM | I Need How Many Calories? Caloric Needs in Bulimia Nervosa Patients
In the 1980s, a few studies came out suggesting that patients with bulimia nervosa (BN) require fewer calories for weight maintenance than anorexia nervosa patients (e.g., Newman, Halmi, & Marchi, 1987) and healthy female controls (e.g., Gwirtsman et al., 1989). Gwirtsman et al. (1989), after finding that patients with bulimia nervosa required few calories for weight maintenance than healthy volunteers, had these suggestions for clinicians: When bulimic patients are […]

de Zwaan, M., Aslam, Z. & Mitchell, J.E. (2002). Research on energy expenditure in individuals with eating disorders: a review., International Journal of Eating Disorders, 31 (4) 361-9. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11948641

Gwirtsman, H.E., Kaye, W.H., Obarzanek, E., George, D.T., Jimerson, D.C. & Ebert, M.H. (1989). Decreased caloric intake in normal-weight patients with bulimia: comparison with female volunteers., American Journal of Clinical Nutrition, 49 (1) 86-92. PMID: http://www.ncbi.nlm.nih.gov/pubmed/2912015

Kotler LA, Devlin MJ, Matthews DE & Walsh BT (2001). Total energy expenditure as measured by doubly-labeled water in outpatients with bulimia nervosa., International Journal of Eating Disorders, 29 (4) 470-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11285585

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3:48 PM | Halloween Special: The Drosophila Halloween Genes
In the movies, spooks and phantoms are often undead humans with unfinished business. But would you be afraid of a ghostly fruit fly? In 1995, fruit fly researchers Christiane Nüsslein-Volhard and Eric Wieschaus were awarded a Nobel Prize for their research on development. They were interested in understanding how a fertilized egg develops into a complex […]

Gilbert L.I. (2008). Drosophila is an inclusive model for human diseases, growth and development, Molecular and Cellular Endocrinology, 293 (1-2) 25-31. DOI: http://dx.doi.org/10.1016/j.mce.2008.02.009

Gilbert L.I. (2004). Halloween genes encode P450 enzymes that mediate steroid hormone biosynthesis in Drosophila melanogaster, Molecular and Cellular Endocrinology, 215 (1-2) 1-10. DOI: http://dx.doi.org/10.1016/j.mce.2003.11.003

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3:44 PM | Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9
Researchers have always been interested in tissue-specific loss of function to probe the role of specific genes in embryonic development, cell physiology and disease conditions. Migration of lateral plate primordial germ cells in zebrafish, border cell migration during oogenesis in drosophila, interaction of T-cells with their target, and numerous other cases have continued to give […]

Stolfi, A., Gandhi, S., Salek, F. & Christiaen, L. (2014). Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9, Development, 141 (21) 4115-4120. DOI: 10.1242/dev.114488

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3:15 PM | Canonical circuits in neuroscience
Gary Marcus, Adam Marblestone, and Thomas Dean have a nice perspective piece in Science this week on the atoms of neural computation (gated): One hypothesis is that cortical neurons form a single, massively repeated “canonical” circuit, characterized as a kind of a … Continue reading →

Qian, J., Hintze, A. & Adami, C. (2011). Colored Motifs Reveal Computational Building Blocks in the C. elegans Brain, PLoS ONE, 6 (3) DOI: 10.1371/journal.pone.0017013

Borst, A. (2007). Correlation versus gradient type motion detectors: the pros and cons, Philosophical Transactions of the Royal Society B: Biological Sciences, 362 (1479) 369-374. DOI: 10.1098/rstb.2006.1964

Pfeffer, C. (2014). Inhibitory Neurons: Vip Cells Hit the Brake on Inhibition, Current Biology, 24 (1) DOI: 10.1016/j.cub.2013.11.001

Mysore, S. & Knudsen, E. (2012). Reciprocal Inhibition of Inhibition: A Circuit Motif for Flexible Categorization in Stimulus Selection, Neuron, 73 (1) 193-205. DOI: 10.1016/j.neuron.2011.10.037

Marcus, G., Marblestone, A. & Dean, T. (2014). The atoms of neural computation, Science, 346 (6209) 551-552. DOI: 10.1126/science.1261661

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3:14 PM | NS1: It’s all about location, location, location
  Viruses are minimalists when it comes to genomic data. This light packing of genetic information requires that every protein the virus codes for needs to be as versatile as possible. The flavivirus genus is no exception to this; its genome encodes for three structural proteins (capsid, membrane, and envelope) and seven nonstructural proteins (NS1, […]

Muller D.A. (2013). The flavivirus NS1 protein: Molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker, Antiviral Research, 98 (2) 192-208. DOI: http://dx.doi.org/10.1016/j.antiviral.2013.03.008

Crook K.R., Clayton R. Morrison & Frank Scholle (2014). Modulation of innate immune signaling by the secreted form of the West Nile virus NS1 glycoprotein, Virology, 458-459 172-182. DOI: http://dx.doi.org/10.1016/j.virol.2014.04.036

Akey D.L., S. Dutta, J. Konwerski, J. Jose, T. J. Jurkiw, J. DelProposto, C. M. Ogata, G. Skiniotis, R. J. Kuhn & J. L. Smith & (2014). Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System, Science, 343 (6173) 881-885. DOI: http://dx.doi.org/10.1126/science.1247749

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9:06 AM | Caesarean section births and autism risk?
It was a familiar story. Big media headlines such as: Caesarean sections 'may increase risk of autism' appearing all over, but when it came to finding the study behind the headlines, the publishing journal seemed to be trailing a little way behind. We've been in a similar situation before."As the flames rose to her Roman nose"Anyhow, the paper by Eileen Curran and colleagues [1] (open-access) has finally made it to the research table and hence is fodder for today's ramblings with the […]

Curran EA, O'Neill SM, Cryan JF, Kenny LC, Dinan TG, Khashan AS & Kearney PM (2014). Research Review: Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis., Journal of child psychology and psychiatry, and allied disciplines, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25348074

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October 30, 2014

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7:45 PM | Zombies: Science Fiction vs. Fact
Well in the spirit of Halloween I thought I would make a nice little zombie post. Zombies, those brain loving little guys, [and girls] are everywhere. From shows like The Walking […]

Lafferty KD (2006). Can the common brain parasite, Toxoplasma gondii, influence human culture?, Proceedings. Biological sciences / The Royal Society, 273 (1602) 2749-55. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17015323

Vyas A, Kim SK, Giacomini N, Boothroyd JC & Sapolsky RM (2007). Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors., Proceedings of the National Academy of Sciences of the United States of America, 104 (15) 6442-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17404235

Passamonti L, Crockett MJ, Apergis-Schoute AM, Clark L, Rowe JB, Calder AJ & Robbins TW (2012). Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression., Biological psychiatry, 71 (1) 36-43. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21920502

Thomas, F., Schmidt-Rhaesa, A., Martin, G., Manu, C., Durand, P. & Renaud, F. (2002). Do hairworms (Nematomorpha) manipulate the water seeking behaviour of their terrestrial hosts?, Journal of Evolutionary Biology, 15 (3) 356-361. DOI: 10.1046/j.1420-9101.2002.00410.x

W. Wesołowska T. Wesołowski (2014). Do Leucochloridium sporocysts manipulate the behaviour of their snail hosts?, Journal of Zoology , 292 (3) 151-155. Other:

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1:57 PM | Resourceful Crustaceans Turn Invasive Seaweed into Homes
When a new developer comes to town and starts aggressively building up the empty property around your home, you can get mad—or you can move in. That’s what tiny crustaceans in the Georgia mudflats have done. Facing an invasive Japanese seaweed, they’ve discovered that it makes excellent shelter, protecting them from all kinds of threats. […]The post Resourceful Crustaceans Turn Invasive Seaweed into Homes appeared first on Inkfish.

Wright, J., Byers, J., DeVore, J. & Sotka, E. (2014). Engineering or food? mechanisms of facilitation by a habitat-forming invasive seaweed, Ecology, 95 (10) 2699-2706. DOI: 10.1890/14-0127.1

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11:38 AM | Fright Week: The Stranger in the Mirror
In the mirror we see our physical selves as we truly are, even though the image might not live up to what we want, or what we once were. But we recognize the image as “self”. In rare instances, however, this reality breaks down.In Black Swan, Natalie Portman plays Nina Sayers, a ballerina who auditions for the lead in Swan Lake. The role requires her to dance the part of the innocent White Swan (for which she is well-suited), as well as her evil twin the Black Swan — which is […]

Barnier AJ, Cox RE, Connors M, Langdon R & Coltheart M (2011). A stranger in the looking glass: developing and challenging a hypnotic mirrored-self misidentification delusion., The International journal of clinical and experimental hypnosis, 59 (1) 1-26. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21104482

Chandra SR & Issac TG (2014). Mirror image agnosia., Indian journal of psychological medicine, 36 (4) 400-3. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25336773

Connors MH & Coltheart M (2011). On the behaviour of senile dementia patients vis-à-vis the mirror: Ajuriaguerra, Strejilevitch and Tissot (1963)., Neuropsychologia, 49 (7) 1679-92. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21356221

Mendez MF, Martin RJ, Smyth KA & Whitehouse PJ (1992). Disturbances of person identification in Alzheimer's disease. A retrospective study., The Journal of nervous and mental disease, 180 (2) 94-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/1737981

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8:44 AM | Pain and adolescent Chronic Fatigue Syndrome
"We found a higher prevalence of severe pain among adolescents with CFS [Chronic Fatigue Syndrome] and lowered pain thresholds compared with HCs [healthy controls]".That was the headline generated by the study from Anette Winger and colleagues [1] (open-access) looking to describe several parameters tied into experience of pain in the context of CFS. Further: "The total sum of bodily symptoms represented a heavy burden with great functional consequences".Your hokey pokey […]

Winger, A., Kvarstein, G., Wyller, V., Sulheim, D., Fagermoen, E., Smastuen, M. & Helseth, S. (2014). Pain and pressure pain thresholds in adolescents with chronic fatigue syndrome and healthy controls: a cross-sectional study, BMJ Open, 4 (10) DOI: 10.1136/bmjopen-2014-005920

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October 29, 2014

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10:29 PM | Electron Paramagnetic Resonance of hair!
I wanted to switch gears a bit and do a paper on Electron Paramagnetic Resonance (EPR), also know as Electron Spin Resonance (ESR).  The paper for this weeks isElectron spin resonance (ESR/EPR) of free radicals observed in human red hair: a new, simple empirical method of determination of pheomelanin/eumelanin ratio in hair.byChikvaidze EN, Partskhaladze TM and Gogoladze […]

Chikvaidze, E., Partskhaladze, T. & Gogoladze, T. (2014). Electron spin resonance (ESR/EPR) of free radicals observed in human red hair: a new, simple empirical method of determination of pheomelanin/eumelanin ratio in hair, Magnetic Resonance in Chemistry, 52 (7) 377-382. DOI: 10.1002/mrc.4075

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7:19 PM | More Genetic Links Behind Autism
Vaccines do NOT cause autism. One more time, vaccines DO NOT cause autism. So what does cause autism, that problem has been plaguing scientists for awhile now. Thankfully two major […]

Iossifov, I., O’Roak, B., Sanders, S., Ronemus, M., Krumm, N., Levy, D., Stessman, H., Witherspoon, K., Vives, L., Patterson, K. & Smith, J. (2014). The contribution of de novo coding mutations to autism spectrum disorder, Nature, DOI: 10.1038/nature13908

De Rubeis, S., He, X., Goldberg, A., Poultney, C., Samocha, K., Ercument Cicek, A., Kou, Y., Liu, L., Fromer, M., Walker, S. & Singh, T. (2014). Synaptic, transcriptional and chromatin genes disrupted in autism, Nature, DOI: 10.1038/nature13772

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5:10 PM | This Month in Blastocystis Research (OCT 2014) - Trick or Treat Edition
Over the past 30 days I've hardly had any time to focus on Blastocystis. I've been busy preparing for and attending UEGWeek 2014, preparing abstracts for next year's ECCMID conference in Copenhagen, and I've also put a lot of effort into preparing proposals for this round of grant calls from the Danish Council for Independent Research.  Among other things, we are applying for money to develop DNA-probe based diagnostics, including a unique software, for use in the clinical microbiology lab […]

Fletcher S, Caprarelli G, Merif J, Andresen D, Hal SV, Stark D & Ellis J (2014). Epidemiology and geographical distribution of enteric protozoan infections in sydney, australia., Journal of public health research, 3 (2) 298. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25343139

Nagel R, Bielefeldt-Ohmann H & Traub R (2014). Clinical pilot study: efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients., Gut pathogens, 6 34. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25349629

Nowack EC & Melkonian M (2010). Endosymbiotic associations within protists., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 365 (1541) 699-712. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20124339

Prodeus TV, Zelia OP, Khlebnikova TA & Pikul' DA (2014). [Extraenteric infection caused by Blastocystis spp. in a female patient with liver abscess]., Meditsinskaia parazitologiia i parazitarnye bolezni, (2) 6-9. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25296418

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1:46 PM | Video Tip of the Week: PaleoBioDB, for your paleobiology searches
Yeah, I know, it’s not genomics–but it’s the history of life on this planet–right?  The Paleobiology Database has been keeping records of this ancient biology for a while now, and they have some really nice tools to explore the fossil records and resources that have become available. It’s also interesting to me to see the […]

Varela S., González-Hernández J., Sgarbi L., Marshall C., Uhen M., Peters S. & McClennen M. (2014). paleobioDB: an R package for downloading, visualizing and processing data from the Paleobiology Database, Ecography, DOI: 10.1111/ecog.01154

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1:05 PM | Halloween Horrors: Evidence of Torture in the Prehistoric Southwest US
With Halloween coming up right around the corner, there have been an increase in the attention paid to the spookier aspects of archaeology. We are increasingly able to find evidence of […]

Osterholtz, A. (2012). The social role of hobbling and torture: Violence in the prehistoric Southwest, International Journal of Paleopathology, 2 (2-3) 148-155. DOI: 10.1016/j.ijpp.2012.09.011

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12:30 PM | How Does a Dog's Brain Respond to the Smell of a Familiar Human?
And what does it tell us about the importance of people to their dogs?Photo: hitmanphoto / ShutterstockNew fMRI research by Gregory Berns et al (in press) shows that dog’s brains respond differently to the smell of a familiar human compared to an unfamiliar human and other canines – suggesting that certain people are special to their dogs.The research focussed on a part of the brain called the caudate, which has been much investigated in humans, monkeys and rats. The scientists […]

Berns, G., Brooks, A. & Spivak, M. (2014). Scent of the familiar: An fMRI study of canine brain responses to familiar and unfamiliar human and dog odors, Behavioural Processes, DOI: 10.1016/j.beproc.2014.02.011

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12:00 PM | Almost This Or Almost That? Must Be The Other
Biology concepts – Protista, taxonomy, phylum, kingdom, monophyletic, paraphyletic, cladistics, algae, diatom, dinoflagellateEuglena gracilis is an organism in the Kingdom Protista. It has one long flagellar undulipodium, but it can also move by amoeboid movement. It has chloroplasts and can do photosynthesis, but it also can eat other organisms. Is it any wonder that classifying protists is so hard?Classifying living organisms is self-perpetuating job. Imagine if the dentist sold candy […]

Fu G, Nagasato C, Oka S, Cock JM & Motomura T (2014). Proteomics Analysis of Heterogeneous Flagella in Brown Algae (Stramenopiles)., Protist, 165 (5) 662-675. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25150613

Wei Y, Liu Q, Yu J, Feng Q, Zhao L, Song H & Wang W (2014). Antibacterial mode of action of 1,8-dihydroxy-anthraquinone from Porphyra haitanensis against Staphylococcus aureus., Natural product research, 1-4. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25259418

Maggs CA, Fletcher HL, Fewer D, Loade L, Mineur F & Johnson MP (2011). Speciation in red algae: members of the Ceramiales as model organisms., Integrative and comparative biology, 51 (3) 492-504. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21742776

Strauch SM, Richter P, Schuster M & Häder DP (2010). The beating pattern of the flagellum of Euglena gracilis under altered gravity during parabolic flights., Journal of plant physiology, 167 (1) 41-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/19679374

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8:36 AM | The stability of an Asperger syndrome diagnosis
"Asperger Syndrome, when considered as an ASD/PDD [autism spectrum disorder/pervasive developmental disorder] diagnosis, was fairly stable into adulthood, but there was a significant increase over time in cases no longer meeting criteria for an ASD diagnosis according to the DSM-IV, or AS according to the Gillberg criteria".The night is darkest just before the dawn.That was one of the primary conclusions made in the paper by Adam Helles and colleagues [1] who prospectively followed a group […]

Adam Helles, Carina I. Gillberg, Christopher Gillberg & Eva Billstedt (2014). sperger syndrome in males over two decades: stability and predictors of diagnosis, Journal of Child Psychology and Psychiatry, Other:

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2:11 AM | When Should Online Dating Partners Meet Offline?
Will the amount of online communications affect face-to-face (FtF) relational outcomes among online daters? Researchers analysed experience of using various online date sites of 433 online daters recruited by a market research firm. The results of a new study suggest that online daters create mental constructs of their potential partners by using online dating profiles […] The post When Should Online Dating Partners Meet Offline? appeared first on Wiley Asia Blog.

Ramirez, A., Bryant Sumner, E., Fleuriet, C. & Cole, M. (2014). When Online Dating Partners Meet Offline: The Effect of Modality Switching on Relational Communication Between Online Daters, Journal of Computer-Mediated Communication, DOI: 10.1111/jcc4.12101

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October 28, 2014

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8:11 PM | Scientists resurrect 700-year-old viruses, Just in time for Halloween!
You know how some zombie movies start with a discovery of a virus, it gets loose, and things quickly spiral out of control from that? Well in breaking news a […]

Ng, T., Chen, L., Zhou, Y., Shapiro, B., Stiller, M., Heintzman, P., Varsani, A., Kondov, N., Wong, W., Deng, X. & Andrews, T. (2014). Preservation of viral genomes in 700-y-old caribou feces from a subarctic ice patch, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1410429111

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3:38 PM | Turning on proteins with light
Just like for married couples, communication is fundamental for cells. When an embryo is developing, its cells need to tell one another who and where they are, so every tissue and organ grows in the right place and at the right time. Our neurons are constantly talking to each other to control our thoughts, feelings and behaviours. Even single-cell organisms like bacteria can exchange information to decide, for example, how many times they should multiply.But how do cells communicate? Scientists […]

Grusch M., R. Riedler, E. Reichhart, C. Differ, W. Berger, A. Ingles-Prieto & H. Janovjak (2014). Spatio-temporally precise activation of engineered receptor tyrosine kinases by light, The EMBO Journal, 33 (15) 1713-1726. DOI: http://dx.doi.org/10.15252/embj.201387695

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1:51 PM | Tagged Dolphins Adjust by Swimming Slowly
Scientists love the data they get by attaching electronic tags to animals, but these devices can be a literal drag. For animals that fly or swim, tags can mess up their mechanics and force them to spend more energy. That’s what scientists expected to see when they studied dolphins with data loggers suction-cupped to their […]The post Tagged Dolphins Adjust by Swimming Slowly appeared first on Inkfish.

van der Hoop JM, Fahlman A, Hurst T, Rocho-Levine J, Shorter KA, Petrov V & Moore MJ (2014). Bottlenose dolphins modify behavior to reduce metabolic effect of tag attachment., The Journal of experimental biology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25324344

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10:20 AM | What I don’t hear can’t hurt me: insecure managers avoid input from employees
Organisations do better when there are clear communication channels that allow staff to point out ways the company can improve. Similarly, teams who freely share ideas and concerns are more tight-knit and motivated. And their managers get enhanced awareness, and to share in the praise for any improvements that pay off. So encouraging employee voice should be a no-brainer, especially for any manager feeling unsure of their ability to deliver solo. Yet according to new research, these insecure […]

Fast, N., Burris, E. & Bartel, C. (2014). Managing to Stay in the Dark: Managerial Self-Efficacy, Ego Defensiveness, and the Aversion to Employee Voice, Academy of Management Journal, 57 (4) 1013-1034. DOI: 10.5465/amj.2012.0393

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7:42 AM | Zinc and depression
"Low dietary zinc intake is associated with a greater incidence of depression in both men and women, as shown in two prospective cohorts".At the risk of overdoing the whole 'you are what you eat' sentiment, today I'm addressing a portion of the peer-reviewed research literature linking issues with zinc availability to depression. That opening quote by the way, comes from the paper by Khanrin Phungamla Vashum and colleagues [1] who looked at self-reported dietary intake of zinc based on […]

Vashum KP, McEvoy M, Milton AH, McElduff P, Hure A, Byles J & Attia J (2014). Dietary zinc is associated with a lower incidence of depression: findings from two Australian cohorts., Journal of affective disorders, 166 249-57. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25012438

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October 27, 2014

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7:40 PM | Real Zombie-Making Parasites Among Us
The mummified cat and the rat in the crypt of Christ Church in Dublin. Photo by Adrian Grycuk at Wikimedia Commons.The Happening, M. Night Shyamalan’s worst panned movie of all time, is a science fiction thriller about people going into a mysterious trance and committing suicide as a result of other mind-hacking species. One of the leading criticisms raised against this movie is the ridiculousness of the premise. One species can’t cause another to willingly commit suicide! […]

Kaushik, M., Knowles, S. & Webster, J. (2014). What Makes a Feline Fatal in Toxoplasma gondii's Fatal Feline Attraction? Infected Rats Choose Wild Cats, Integrative and Comparative Biology, 54 (2) 118-128. DOI: 10.1093/icb/icu060

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7:37 PM | Research Shows Synapses are Always Ready to Go
The inner workings of the brain are quick, but really they have to be. Neurons need to be able to rapidly propagate information in their interior via electrical signals and […]

Imig, C., Min, S., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T., Rhee, J., Brose, N. & Cooper, B. (2014). The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones, Neuron, 84 (2) 416-431. DOI: 10.1016/j.neuron.2014.10.009

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3:10 PM | Brain Imaging In Alcoholic Brain Thiamine Deficiency
Chronic consumption of large quantities of alcohol can produce severe deficiency of thiamine (vitamin B1).This can precipitate an acute brain failure known as Wernicke's encephalopathy. Wernicke's encephalopathy is characterized by sudden onset of mental status changes, eye muscle impairment and disturbed gait or ataxia.Other illnesses can also produce this level of severe thiamine deficiency. A partial list of these non-alcoholism causes for thiamine deficiency with encephalopathy […]

Manzo G, De Gennaro A, Cozzolino A, Serino A, Fenza G & Manto A (2014). MR imaging findings in alcoholic and nonalcoholic acute Wernicke's encephalopathy: a review., BioMed research international, 2014 503596. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25050351

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8:37 AM | Diagnosing autism late: after psychosis
The case report from Marly Simoncini and colleagues [1] (open-access) is the topic of today's post. Describing the case of Mr. A, a young man who attempted suicide during a psychotic episode, the paper tracks the developmental history and diagnostic evaluation of this person culminating in a diagnosis of autism spectrum disorder (ASD) "that had been completely overlooked".The best thing we can do is go on with our daily routineThe paper is open-access and I would encourage readers to take […]

Simoncini, M., Miniati, M., Vanelli, F., Callari, A., Vannucchi, G., Mauri, M. & Dell’Osso, L. (2014). Lifetime Autism Spectrum Features in a Patient with a Psychotic Mixed Episode Who Attempted Suicide, Case Reports in Psychiatry, 2014 1-4. DOI: 10.1155/2014/459524

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