Posts

October 31, 2014

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8:34 PM | Ancedotal Evidence provides insight into the “Dry Drunk”
Alcoholics Anonymous refers to the alcoholic who has stopped drinking, but who still demonstrates alcoholic attitudes and behaviors, as a “dry drunk.” Such individuals are said to have sobriety but not recovery. We will explore the dry drunk syndrome in more … Continue reading →
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8:22 PM | “Staying in Action” – A Gambling Addict’s Dry Drunk.
In this first of two blogs we look more closely at an article (1) which proposes the symptoms of the gambling addict’s equivalent to a sober alcoholic’s “dry drunk”.  When reading this I, as someone in recovery from alcoholism and substance and behavioural addiction thought a lot of the “symptoms” were relevant to me and […]
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8:05 PM | New Genetic Editing Technique Offers Novel Treatment of Defects
The promises of genetic modifications are endless, longer life, better health, cures for genetic based diseases that would otherwise cause an unimaginable amount of suffering all wiped out. We’ve come a […]

Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY & Liu DR & (2014). Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo., Nature biotechnology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25357182

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6:14 PM | Halloween Post: Parasites That “Zombify” Their Hosts
Zombies may still be a thing of fiction, but some parasites more or less turn their hosts into the walking dead. These masters of mind control manipulate their hosts from within, causing them to act in self-destructive ways that ultimately benefit the parasite. Read my latest National Geographic Weird & Wild post: Meet 5 “Zombie” Parasites That Mind-Control Their Hosts .
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4:33 PM | Halloween Post: Paging Dr. Frankenstein to Cardiothoracic Surgery... Dr. Frankenstein to Cardiothoracic Surgery.
“With how many things are we on the brink of becoming acquainted, if cowardice or carelessness did not restrain our inquiries.” ― Mary Shelley, FrankensteinWhen Mary Shelley published the novel Frankenstein; or The Modern Prometheus in 1818, it received mixed critical reviews at best, but became wildly successful with the public and remains one of the most widely recognized and influential horror figures to this day (along with Dracula, the Werewolf, and the […]
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4:05 PM | I Need How Many Calories? Caloric Needs in Bulimia Nervosa Patients
In the 1980s, a few studies came out suggesting that patients with bulimia nervosa (BN) require fewer calories for weight maintenance than anorexia nervosa patients (e.g., Newman, Halmi, & Marchi, 1987) and healthy female controls (e.g., Gwirtsman et al., 1989). Gwirtsman et al. (1989), after finding that patients with bulimia nervosa required few calories for weight maintenance than healthy volunteers, had these suggestions for clinicians: When bulimic patients are […]

de Zwaan, M., Aslam, Z. & Mitchell, J.E. (2002). Research on energy expenditure in individuals with eating disorders: a review., International Journal of Eating Disorders, 31 (4) 361-9. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11948641

Gwirtsman, H.E., Kaye, W.H., Obarzanek, E., George, D.T., Jimerson, D.C. & Ebert, M.H. (1989). Decreased caloric intake in normal-weight patients with bulimia: comparison with female volunteers., American Journal of Clinical Nutrition, 49 (1) 86-92. PMID: http://www.ncbi.nlm.nih.gov/pubmed/2912015

Kotler LA, Devlin MJ, Matthews DE & Walsh BT (2001). Total energy expenditure as measured by doubly-labeled water in outpatients with bulimia nervosa., International Journal of Eating Disorders, 29 (4) 470-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11285585

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3:48 PM | Halloween Special: The Drosophila Halloween Genes
In the movies, spooks and phantoms are often undead humans with unfinished business. But would you be afraid of a ghostly fruit fly? In 1995, fruit fly researchers Christiane Nüsslein-Volhard and Eric Wieschaus were awarded a Nobel Prize for their research on development. They were interested in understanding how a fertilized egg develops into a complex […]

Gilbert L.I. (2008). Drosophila is an inclusive model for human diseases, growth and development, Molecular and Cellular Endocrinology, 293 (1-2) 25-31. DOI: http://dx.doi.org/10.1016/j.mce.2008.02.009

Gilbert L.I. (2004). Halloween genes encode P450 enzymes that mediate steroid hormone biosynthesis in Drosophila melanogaster, Molecular and Cellular Endocrinology, 215 (1-2) 1-10. DOI: http://dx.doi.org/10.1016/j.mce.2003.11.003

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3:19 PM | Rules of thumb for drug discovery
*The* Chris Lipinski is talking at Winship Nov 5 The post Rules of thumb for drug discovery appeared first on Lab Land.
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12:45 PM | Study of psychiatric disorders is difficult in man and mouse
Studying human psychiatric disorders in animals presents a challenge. A new study highlights one of the ways scientists can study human mutations by slipping them into mice.
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12:41 PM | Study of psychiatric disorders is difficult in man and mouse
ScicuriousNeuroscience,Genetics by Bethany Brookshire 8:45am, October 31, 2014 Human gene variants are not limited to one species. By putting a human mutation into a mouse, scientists can study the changes the mutation produces in detail.NHGRIOne of the challenges with treating psychiatric disorders is finding a way to study them outside of the human brain. When there is no fundamental […]
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12:32 PM | Brain Size and Intelligence
I was recently asked about the relationship between brain size and intelligence. This is a question I get every now and then, because the relationship is not an obvious one. In this particular case, the questioner was curious about the fact that Neanderthals had a larger cranial capacity on average than modern Homo sapiens. For [...]
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10:51 AM | Does Max Tegmark Kill A Daughter In A Parallel World ?
The popular description of virtual particles “borrowing” energy and popping in and out of existence all the time is very misleading. There are no such processes “really happening” in the way of a naïve, classically mechanistic physicalism. Instead, all potential partial processes consistent with the observations are together what the observation supervenes on. read more
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7:25 AM | The Science of Fear
Think of Halloween and FEAR comes to mind. From the scary horrors of the darkest of our imagination to just the thought of pestering children knocking on your door! We’ve all been there. Facing our worst nightmares. Heart starts racing. … Continue reading →
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5:36 AM | Sexual Fantasies: Threesomes Are Normal, Golden Showers Not So Much
Fantasizing about sex with two women is common but fantasizing about being urinated on - called a golden shower - is not. That's just one of the findings from a research project on sexual deviation undertaken by scholars at Institut universitaire en santé mentale de Montréal and Institut Philippe-Pinel de Montréal. Deviant sexual fantasies are addressed in numerous speculations and conjectures by psychologists but atypical fantasies (paraphilias) are so subjective they […]
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1:34 AM | Thoughts of Drugs, and Other Things, While in Prison
This post is part of a collaborative narrative series composed of my writing and Chris Arnade’s photos exploring issues of addiction, poverty, prostitution and urban anthropology in Hunts... -- Read more on ScientificAmerican.com
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1:13 AM | Coulrophobia: Are Clowns Scary? Ha Ha Aaaargh
In the realm of pop culture, 'killer clowns' have really proliferated and fostered coulrophobia – the fear of clowns. Mark CrossfieldBy Fiona Gregory, Monash UniversityWhen Australian singer and TV personality Mark Holden appeared as a clown recently on Channel 7’s "Dancing with the Stars", his supposedly “bizarre” behavior sparked furious debate and complaints to the network, demonstrating the problematic nature of the clown figure today. read more
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12:28 AM | Scared Out Of Your Mind: Halloween, Fear And The Brain
Larger than life or small time? Herval, CC BYBy Kira Shaw, University of SheffieldChildren and adults alike are digging out those spooky costumes ready for a celebration. We’ve reached that time of year again: Halloween. October 31 is dedicated to remembering the dead.We’ve all experienced fear, but Halloween is the particular time of year when we look for that rush that usually accompanies feeling scared. Are you in need of a “scare-specialist” for this year’s […]
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12:23 AM | What in the world am I doing.... Going with the flow. #brain #painting in progress. #art
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12:11 AM | Social psychology has lost its balance
The New Yorker has an interesting article about a lack of political diversity in social psychology and how that may be leading to a climate of bias against conservative researchers, ideas and the evidence that might support them. Some of the evidence for a bias against conservative thinking in social psychology goes back some years, […]
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12:02 AM | The School of Psychology’s Health and Clinical Psychology Research Group (H&CPRG) is pleased to present a session of Clinical Program completion presentations
The School of Psychology’s Health and Clinical Psychology Research Group (H&CPRG) is pleased to present a session of Clinical Program completion presentationsOn Wednesday the 5th of November the H&CPRG is holding a special session for students presenting their research conducted as part of their clinical training.When: Wednesday 5th November, starting at 4pm.Where: Keats Reading Room, Psychology (Aviation) Building. Video-conferenced to the Science Offices Meeting Room, […]
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12:01 AM | Mediterranean Diet Linked To Better Kidney Health
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12:01 AM | Spook Me, Please: What Psychology Tells Us About the Appeal of Halloween
By guest blogger Mathias ClasenIt’s the time of year, at least in our part of the world, when darkness encroaches on us—literally and metaphorically. The symbols and agents of darkness dominate Halloween decorations everywhere, and Halloween is growing in popularity across Europe and in the US. According to the National Retail Federation, US Halloween spending now exceeds $7 billion. In the UK, Halloween is worth about £330 million.Why is this Americanized version of the […]

October 30, 2014

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11:48 PM | Ghost Light From Dead Galaxies - A Hubble Halloween
4 billion light-years away, inside a collection of nearly 500 galaxies called Pandora's Cluster, are the faint, ghostly glow of stars gravitationally ripped apart several billion years ago. The scattered stars are no longer bound to any one galaxy and drift freely between galaxies in the cluster. By observing the light from the orphaned stars, Hubble astronomers have assembled forensic evidence that suggests as many as six galaxies were torn to pieces inside the  Abell 2744 cluster over a […]
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11:31 PM | New #brain #painting underway! #art #science
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10:12 PM | PEBS Neuroethics Roundup (JHU)
Last Edition's Most Popular Article(s): New Antidepressant: Rapid Agent Restores Pleasure-Seeking Ahead of Other Antidepressant Action, ScienceDaily Upcoming Event: International Neuroethics Society Annual Meeting Washington, D.C. November 13-14, 2014 In The Popular Press: Your Brain’s Response to Vile Images Says...
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10:06 PM | The Way Architecture Imitates Life, Biology Meets Geometry
Biology can be inspirational.  The spiral ramps in multistory parking garages, the way they are stacked and connecting parallel levels, are replications of helical structures found in a ubiquitous membrane structure in the cells of the body - Terasaki ramps in an organelle called the endoplasmic reticulum (ER), a network of membranes found throughout the cell and connected to and surrounding the cell nucleus. A team of researchers have described endoplasmic reticulum geometry using […]
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9:08 PM | Book Review: Steven Pinker: The Sense of Style: The Thinking Person’s Guide to Writing in the 21st Century (Viking Adult: 2014)
The Mighty Pinker Has Struck OutBy Charles Euchner Charles Euchner is a case writer and editor at Yale School of Management. Author or editor of books on civil rights (Nobody Turn Me Around), writing (The Big Book of Writing), public policy (Urban Policy Reconsidered, Playing the Field, Governing Greater Boston), baseball (The Last Nine Innings), and more, Euchner has contributed to The Boston Globe, The American, CommonWealth, Newsweek, Education Week, The Big Roundtable, The New York […]
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8:19 PM | Neuroscientists Break into the Brain to Expose Its Workings
The brain is a dazzlingly complex web of somewhere around 100 billion neurons, each of which communicates with others through thousands of connections. The idea of manipulating such a complex system... -- Read more on ScientificAmerican.com
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7:45 PM | Zombies: Science Fiction vs. Fact
Well in the spirit of Halloween I thought I would make a nice little zombie post. Zombies, those brain loving little guys, [and girls] are everywhere. From shows like The Walking […]

Lafferty KD (2006). Can the common brain parasite, Toxoplasma gondii, influence human culture?, Proceedings. Biological sciences / The Royal Society, 273 (1602) 2749-55. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17015323

Vyas A, Kim SK, Giacomini N, Boothroyd JC & Sapolsky RM (2007). Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors., Proceedings of the National Academy of Sciences of the United States of America, 104 (15) 6442-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17404235

Passamonti L, Crockett MJ, Apergis-Schoute AM, Clark L, Rowe JB, Calder AJ & Robbins TW (2012). Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression., Biological psychiatry, 71 (1) 36-43. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21920502

Thomas, F., Schmidt-Rhaesa, A., Martin, G., Manu, C., Durand, P. & Renaud, F. (2002). Do hairworms (Nematomorpha) manipulate the water seeking behaviour of their terrestrial hosts?, Journal of Evolutionary Biology, 15 (3) 356-361. DOI: 10.1046/j.1420-9101.2002.00410.x

W. Wesołowska T. Wesołowski (2014). Do Leucochloridium sporocysts manipulate the behaviour of their snail hosts?, Journal of Zoology , 292 (3) 151-155. Other:

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7:22 PM | Game Theory: When Are Groups Social? Or Insufferable?
Humans are primarily social creatures - Thoreau may have pretended he wanted to sit among nature by himself and write a book but he was in a house built by someone else, paid for by someone else, with clothes made by someone else, and writing a book that would be published by someone else. People band together in groups to be stronger - about causes or for actual defense. How to prompt people to become social rather than anti-social is one of the central goals of game theory. read m
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