Posts

January 26, 2015

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3:02 PM | Obesity, Inflammation and Cognitive Decline
The rate of cognitive decline with aging is quite variable. Identifying important components of this process is needed for developing interventions to reduce the burden of Alzheimer's and other dementias.Excess inflammation has been linked to obesity as well as aging-related cognitive decline.Archana Singh-Manoux and colleagues recently published a study of the association between blood markers of inflammation and cognitive decline.This study used data from the U.K. Whitehall II cohort, a […]

January 21, 2015

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12:01 PM | Is there an abnormal regulation of the immune response in autism?
One month ago the online journal Nature Communication published a study claiming that inflammation is a hallmark of autism. The study, a conjoint effort between Johns Hopkins and the University […]

January 20, 2015

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12:25 PM | Sleep the flu away
Flu season is upon us. With all that coughing and spluttering it may seem that there is little to ease the pain. But, some of the clever scientists at Washington State University have found a brain protein that boosts the healing power of sleep and speeds an animal’s recovery from the flu. Research led byRead More

January 19, 2015

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3:09 PM | Mediterranean Diet and Aging
There is a growing research body of evidence to support beneficial effects of a Mediterranean diet on brain health.In previous posts I have reviewed research on the Mediterranean diet and:Cognitive DeclineAlzheimer's Disease PreventionA recent study adds an important element in potential mechanisms for the beneficial effects of the Mediterranean diet.Marta Crous-Bou and colleauges from Harvard University and the University of Washington published a study of the Mediterranean diet and chromosome […]

January 15, 2015

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2:00 PM | Fixing ‘Leaky’ Blood Vessels in Severe Respiratory Ailments and Ebola
When you get an infection, your immune system responds with an influx of inflammatory cells that target the underlying bacteria or viruses. These immune cells migrate from your blood into the infected tissue in order to release a cocktail of pro-inflammatory proteins and help eliminate the infectious threat. During this inflammatory response, the blood vessel barrier becomes “leaky.” This allows for an even more rapid influx of additional immune cells. Once the infection resolves, […]

Gong, H., Rehman, J., Tang, H., Wary, K., Mittal, M., Chatturvedi, P., Zhao, Y., Komorova, Y., Vogel, S. & Malik, A. & (2015). HIF2α signaling inhibits adherens junctional disruption in acute lung injury, Journal of Clinical Investigation, DOI: 10.1172/JCI77701

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2:00 PM | Fixing ‘Leaky’ Blood Vessels in Severe Respiratory Ailments and Ebola
When you get an infection, your immune system responds with an influx of inflammatory cells that target the underlying bacteria or viruses. These immune cells migrate from your blood into the infected tissue in order to release a cocktail of pro-inflammatory proteins and help eliminate the infectious threat. During this inflammatory response, the blood vessel barrier becomes “leaky.” This allows for an even more rapid influx of additional immune cells. Once the infection resolves, […]

January 14, 2015

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3:51 PM | Obesity, Inflammation and the Brain
Brain inflammation produces a variety of emotional, behavior and cognitive symptoms.I remember clearly a patient I cared for with central nervous system lupus erythrematosis (SLE). With SLE flairs she developed flagrant psychotic symptoms including hallucinations requiring inpatient psychiatric care.Between flares she had no significant psychiatric symptoms.Nicole Castanon and two colleagues from France have published a review of the role of obesity-associated inflammation and brain […]

January 12, 2015

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1:02 PM | Personalised medicine is changing our view of disease
If three patients present with rheumatoid arthritis symptoms to their doctor each may be prescribed methotrexate, an antifolate. Statistically, this medication will work for only one of the three. The other two will return to the doctor to be switched to a more expensive biologic therapy. In the meantime the hope is that irreversible damage toRead More

January 10, 2015

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11:30 AM | Psychology Around the Net: January 10, 2015
Happy Saturday, readers! As cliche as it might sound, we can’t help but think of new beginnings when we think of a new year, and what better way to welcome new beginnings than by keeping up with all the new mental health news, research, and even opinions as we launch into 2015? After all, we […]

January 08, 2015

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3:13 PM | Diet, Weight Loss and the Brain Links: Weekend Reading
Here are links to a series of abstracts that I am reviewing for this month.I will do a full post on some of the most interesting and important research on this topic over the next month. Clicking on the title will link you to the PubMed abstract. Most articles highlighted in this post have free full-text access.Mediterranean Diet and Chromosome Telomere LengthThis recent study from the Harvard Nurse cohort examined telomere length in reference to a score of adherence to a Mediterranean […]

January 07, 2015

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9:55 AM | Inflaming inflammation and autism: linking microglial activation and neuronal activity
It has been quite a few weeks since the publication of the paper by Simone Gupta and colleagues [1] (open-access) talking about "observations [that] provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism."I'm a wrecker. I wreck things, professionally. I mean.At the time of publication in early December (2014), there was quite a bit of media interest in the findings as per reports such as this one and […]

Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J, West AB & Arking DE (2014). Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism., Nature communications, 5 5748. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25494366

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