Posts

March 05, 2015

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11:39 AM | Autism, heritability and 'proof of principle' genomic biomarkers
JAMA Psychiatry published a number of interesting articles recently, some of which have grabbed media headlines. "Autism is largely down to genes, twin study suggests" went the BBC headline covering the paper by Emma Colvert and colleagues [1] who, based on an analysis of twin pairs as part of TEDS (Twins Early Development Study), concluded that: "The liability to ASD [autism spectrum disorder] and a more broadly defined high-level autism trait phenotype in this large population-based […]

March 03, 2015

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4:01 PM | DNews: Why Do We Get Headaches?
Most of us know what it's like to suddenly go "eeeyow!!" when a headache decides to pay a visit. A common tension headache is annoying; a stabbing migraine can be debilitating. Find why and how our noggins get achy.

March 02, 2015

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9:49 AM | Systemic low grade inflammation and bowel issues in autism?
The paper from Katarina Babinská and colleagues [1] (open-access here) presents an interesting, if preliminary take on two potentially important issues linked to at least some cases of autism: gastrointestinal (GI) issues and inflammation (see here and see here respectively).Detailing the examination of plasma levels of a compound called high mobility group box 1 protein (HMGB1), a protein which has the apparent ability to 'bend DNA' and has some pretty potent immune effects [2] […]

Babinská K, Bucová M, Ďurmanová V, Lakatošová S, Jánošíková D, Bakoš J, Hlavatá A & Ostatníková D (2015). Increased plasma levels of the high mobility group box 1 protein (HMGB1) are associated with a higher score of gastrointestinal dysfunction in individuals with autism., Physiological research / Academia Scientiarum Bohemoslovaca, 63 Suppl 4 8. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25669692

Citation

February 24, 2015

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4:36 PM | Interleukin-10: the anti-inflammatory cytokine at the heart of the Alzheimer’s disease storm
One of the key pathological characteristics of Alzheimer’s disease is the build-up of extracellular amyloid plaques composed of Aβ peptides. Inflammation triggered by the innate immune system in response to these plaques has long been thought to promote the progression of Alzheimer’s disease, with the development of a ‘cytokine storm’ creating a self-reinforcing, neurotoxic feedbackRead More

February 18, 2015

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10:34 PM | Inflammation, Acupuncture, and HPA axis: Faulty Science Clouds Understanding
In the wake of my recent critique of acupuncture being touted as a remedy for allergic rhinitis, I was pointed (via a Twitter comment) towards a 2013 review in Evidence Based Complementary and Alternative Medicine, which purported to propose a mechanism for the much-claimed anti-inflammatory effects of acupuncture. There are several putative mechanisms, discussing all of which will make this post gargantuan. Therefore, I shall focus on the explanation involving the […]
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10:34 PM | Inflammation, Acupuncture, and HPA axis: Faulty Science Clouds Understanding
In the wake of my recent critique of acupuncture being touted as a remedy for allergic rhinitis, I was pointed (via a Twitter comment) towards a 2013 review in Evidence Based Complementary and Alternative Medicine, which purported to propose a mechanism for the much-claimed anti-inflammatory effects of acupuncture. There are several putative mechanisms, discussing all of which will make this post gargantuan. Therefore, I shall focus on the explanation involving the […]
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10:34 PM | Inflammation, Acupuncture, and HPA axis: Faulty Science Clouds Understanding
In the wake of my recent critique of acupuncture being touted as a remedy for allergic rhinitis, I was pointed (via a Twitter comment) towards a 2013 review in Evidence Based Complementary and Alternative Medicine, which purported to propose a mechanism for the much-claimed anti-inflammatory effects of acupuncture. There are several putative mechanisms, discussing all of which will make this post gargantuan. Therefore, I shall focus on the explanation involving the […]

February 11, 2015

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7:32 PM | Third Annual Contest for Inflammatory Language
Inflammatory Language is a series of primers on inflammation science. Care to contribute? There is a free preview copy of the following for the one winning submission:Preview Copy of The Forgotten PlagueAmerican Experience 2/10/15Photo by CM Doran 2015American Experience: The Forgotten PlagueThe Deadly Story of Tuberculosis in America and the Hunt for a CurePremiered 2/10/15The 2013 winner was Dr. Monica Lalanda of Medicoacuadros. Her illustrations were included […]

February 09, 2015

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3:41 PM | Exercise and the Brain: Research Links
I am posting links to some of the most recent research related to exercise effects on the brain.These come from a process of selecting posts to examine in more detail this month.Clicking on the links will take you to the PubMed abstract. Most of the abstracts also have free full text links.Enhancing brain activity through multidisciplinary interventions in the elderlyThis Chinese study examined the effects of cognitive training, Tai Chi exercise and counseling on a group of 17 elderly […]

February 06, 2015

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5:05 PM | Gut Bacteria Contributes To Non-Alcoholic Fatty Liver Disease
New research shows that the composition of a person's gut bacteria could play an important role in the development of non-alcoholic fatty liver disease. ...
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