September 17, 2014

10:29 AM | Autoimmune disease risk and eating disorders
"We were set up. The cops were waiting for us.""We observed an association between eating disorders and several autoimmune diseases with different genetic backgrounds. Our findings support the link between immune-mediated mechanisms and development of eating disorders".So said the paper by Anu Raevuori and colleagues [1] (open-access) based on an analysis of over 2300 people "treated at the Eating Disorder Unit of Helsinki University Central Hospital between 1995 and 2010" compared with […]

September 11, 2014

8:42 AM | Omega-3 fatty acids rescues Fragile X phenotypes in Fmr1-Ko mice
"These results demonstrate that n-3 PUFAs dietary supplementation, although not a panacea, has a considerable therapeutic value for FXS [Fragile X syndrome] and potentially for ASD [autism spectrum disorder], suggesting a major mediating role of neuroinflammatory mechanisms".A view @ Wikipedia That was the conclusion reached by Susanna Pietropaolo and colleagues [1] who "evaluated the impact of n-3 PUFA dietary supplementation in a mouse model of fragile X syndrome […]

Pietropaolo S, Goubran MG, Joffre C, Aubert A, Lemaire-Mayo V, Crusio WE & Layé S (2014). Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice., Psychoneuroendocrinology, 49C 119-129. PMID:


September 04, 2014

8:51 AM | Epigenetic processes and autism: focusing on immune function?
Although the title of this post talks about the science of epigenetics in autism, I'm actually going to be talking about two papers today, one of which also covers exposure to prenatal immune activation and what effect that might have on epigenetic processes in the mouse brain. This may also be relevant to at least some autism..."Beneath this mask there is an idea, Mr. Creedy. And ideas are bulletproof"First off we have the paper from Nardone and colleagues [1] (open-access) which, following […]

Nardone, S., Sharan Sams, D., Reuveni, E., Getselter, D., Oron, O., Karpuj, M. & Elliott, E. (2014). DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways, Translational Psychiatry, 4 (9) DOI: 10.1038/tp.2014.70

Basil, P., Li, Q., Dempster, E., Mill, J., Sham, P., Wong, C. & McAlonan, G. (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain, Translational Psychiatry, 4 (9) DOI: 10.1038/tp.2014.80


August 28, 2014

8:29 AM | Minocycline for schizophrenia?
"Minocycline may improve the psychopathology of schizophrenia, especially the negative symptoms, and seems to be well tolerated".A Bachelors Drawer (apparently) @ Wikipedia That was the finding from the systematic review and meta-analysis undertaken by Oya and colleagues [1] looking at the collected literature on the use of "minocycline augmentation therapy in patients with schizophrenia receiving antipsychotic agents". Augmentation therapy by the way, refers to the addition of minocycline […]

Oya K, Kishi T & Iwata N (2014). Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta-analysis of randomized controlled trials., Human psychopharmacology, PMID:


August 27, 2014

12:02 PM | The so-called inflammation of autism
This year I have been able to attend a large number of congresses all over the world. One thing that has struck me is how some people within the medical […]
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