April 21, 2014

6:56 PM | Easter Chocolate Cravings: The Power of Polyphenols
With the Easter weekend over for another year and the family festivities drawing to a close, we can sit and contemplate one thing…just how much chocolate have I eaten the […]

Katz, D., Doughty, K. & Ali, A. (2011). Cocoa and Chocolate in Human Health and Disease, Antioxidants & Redox Signaling, 15 (10) 2779-2811. DOI:

Franco R, Oñatibia-Astibia A & Martínez-Pinilla E (2013). Health benefits of methylxanthines in cacao and chocolate., Nutrients, 5 (10) 4159-73. PMID:

Selmi C, Cocchi CA, Lanfredini M, Keen CL & Gershwin ME (2008). Chocolate at heart: the anti-inflammatory impact of cocoa flavanols., Molecular nutrition & food research, 52 (11) 1340-8. PMID:

Ellam S & Williamson G (2013). Cocoa and human health., Annual review of nutrition, 33 105-28. PMID:


April 18, 2014

1:42 PM | Chronic inflammation linked to ‘high-grade’ prostate cancer
Men who show signs of chronic inflammation in non-cancerous prostate […]

April 16, 2014

2:42 AM | Another Puzzle – about the interaction of host and pathogen
Ok, I realize that some of the past puzzles I’ve made either had errors or were simply too obscure in their clues (again, I’m a crossword novice). I tried to be a little more clear with this puzzle and also did my best to force as many clues into actually ‘crossing’ as possible. Let me […]

April 03, 2014

8:20 AM | New life for naltrexone and autism?
During the very earliest days of the life of this blog I posted about the opiate antagonist naltrexone (ReVia®) and some research on its history with autism in mind; in particular, the various emerging speculations on low dose naltrexone (LDN) (see here). Today I'm following up that entry based on the results of a systematic review by Ashok Roy and colleagues [1] on the value (or not) of naltrexone for "attenuating the core symptoms of autism spectrum conditions in […]

Roy A, Roy M, Deb S, Unwin G & Roy A (2014). Are opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: a systematic review., Journal of intellectual disability research : JIDR, PMID:


March 29, 2014

12:06 AM | Inflaming inflammation and psychiatry
The systematic review published by Mitchell & Goldstein [1] kinda says it all when it comes to our current view of the topic of inflammation and psychiatry, and in particular inflammation and neuropsychiatric conditions such as autism, schizophrenia and attention deficit hyperactivity disorder (ADHD): "There is preliminary evidence for elevated markers of inflammation in this population".All at sea (JMW Turner) @ Wikipedia I've talked quite a bit on this blog about how, […]

Mitchell RH & Goldstein BI (2014). Inflammation in Children and Adolescents With Neuropsychiatric Disorders: A Systematic Review., Journal of the American Academy of Child and Adolescent Psychiatry, 53 (3) 274-296. PMID:

Onore CE, Schwartzer JJ, Careaga M, Berman RF & Ashwood P (2014). Maternal Immune Activation Leads to Activated Inflammatory Macrophages in Offspring., Brain, behavior, and immunity, PMID:

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