April 16, 2014

2:42 AM | Another Puzzle – about the interaction of host and pathogen
Ok, I realize that some of the past puzzles I’ve made either had errors or were simply too obscure in their clues (again, I’m a crossword novice). I tried to be a little more clear with this puzzle and also did my best to force as many clues into actually ‘crossing’ as possible. Let me […]

April 03, 2014

8:20 AM | New life for naltrexone and autism?
During the very earliest days of the life of this blog I posted about the opiate antagonist naltrexone (ReVia®) and some research on its history with autism in mind; in particular, the various emerging speculations on low dose naltrexone (LDN) (see here). Today I'm following up that entry based on the results of a systematic review by Ashok Roy and colleagues [1] on the value (or not) of naltrexone for "attenuating the core symptoms of autism spectrum conditions in […]

Roy A, Roy M, Deb S, Unwin G & Roy A (2014). Are opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: a systematic review., Journal of intellectual disability research : JIDR, PMID:


March 29, 2014

12:06 AM | Inflaming inflammation and psychiatry
The systematic review published by Mitchell & Goldstein [1] kinda says it all when it comes to our current view of the topic of inflammation and psychiatry, and in particular inflammation and neuropsychiatric conditions such as autism, schizophrenia and attention deficit hyperactivity disorder (ADHD): "There is preliminary evidence for elevated markers of inflammation in this population".All at sea (JMW Turner) @ Wikipedia I've talked quite a bit on this blog about how, […]

Mitchell RH & Goldstein BI (2014). Inflammation in Children and Adolescents With Neuropsychiatric Disorders: A Systematic Review., Journal of the American Academy of Child and Adolescent Psychiatry, 53 (3) 274-296. PMID:

Onore CE, Schwartzer JJ, Careaga M, Berman RF & Ashwood P (2014). Maternal Immune Activation Leads to Activated Inflammatory Macrophages in Offspring., Brain, behavior, and immunity, PMID:


March 18, 2014

10:15 AM | Breaking Bad ‘Meth King’ Real Life
CVS as a company did a big NO-NO selling products with”pseudoephedrine” hand over fist to smurfs. The LAW only allows the sale of a small amount per person but for a while, they did nothing to stop it and as I quoted in part one  “they knowingly under-complied with the law“. I wonder if CVS […]
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