November 27, 2014

8:42 AM | A Little Poisoning Along the Road to ME/CFS
Anyone else been poisoned along the way? Jody Smith tells part of her horror story … Looking at my symptoms, many of which are far less these days and some are gone, it would be easy to figure that I’d just dealing with some heavy-duty menopausal issues. The sleep abnormalities, the brain fog, digestive issues, astonishing weight gain, I was the right age … I fit the menopause profile. But then I remember some of toxins I’ve been exposed to over the decades, and I […]

November 20, 2014

10:13 PM | Cell death drug discovery: come at the king, you best not miss
Researchers tried to chemically inactivate the king of one form of cell death, only to find their tools triggered another form. The post Cell death drug discovery: come at the king, you best not miss appeared first on Lab Land.
5:23 PM | #SfN14 Day 4: “It’s Not the Stress that Kills Us; It’s Our Reaction to It” –Hans Selye (Theme E)
This post is part of my series on the 2014 Society for Neuroscience annual meeting. You can read other posts in this series here. I’m also live-tweeting some sessions @GainesOnBrains. Join the conversation at #SfN14.Day 4 winding down. You wanna know what a stressful situation is?Being surrounded by 30,500+ people for five days. Whew!For the most part, I like to think I handle stressful situations fairly well. I take a few deep breaths, tell myself the stressor is really not that big […]
10:30 AM | Intestinal permeability: an emerging scientific area (also with autism in mind)
What is the intestinal barrier? What is intestinal permeability? What factors affect the permeability of the intestinal barrier? How do you measure intestinal permeability? How might [altered] intestinal permeability link to health, well-being and various clinical diagnoses?The new triad @ Bischoff SC et al. 2014These are some of the questions tackled by the excellent open-access review by Stephan Bischoff and colleagues [1] which I would like to draw your attention to […]

November 15, 2014

9:40 AM | Milk has gotta lotta bottle?
"High milk intake was associated with higher mortality in one cohort of women and in another cohort of men, and with higher fracture incidence in women". Those were some of the conclusions reached in the study by Karl Michaëlsson and colleagues [1] (open-access) looking at milk consumption and "mortality and fractures in women and men". The BBC among other media have covered the study (see here).Take me out tonightBased on quite a large participant group (two actually) who completed a […]

Michaelsson, K., Wolk, A., Langenskiold, S., Basu, S., Warensjo Lemming, E., Melhus, H. & Byberg, L. (2014). Milk intake and risk of mortality and fractures in women and men: cohort studies, BMJ, 349 (oct27 1) DOI: 10.1136/bmj.g6015


November 12, 2014

9:53 AM | An inflammatory autism subtype?
The paper from Harumi Jyonouchi and colleagues [1] (open-access) continues a theme from this author with their suggestion of "an imbalance in the production of inflammatory (IL-1ß and IL-6) and counterregulatory (IL-10) cytokines by ‘flare’ ASD-IS [autism spectrum disorder - inflammatory subtype] monocytes".Panic on the streets of Birmingham...'Flare' ASD-IS in this case refers to a coding given to a small participant group (n=24) who were: "defined as those […]

November 07, 2014

9:11 AM | Treating depression: exercise or anti-inflammatory meds?
Reiterating my primary caveat on this blog about not giving anything that looks, sounds or smells like medical and/or clinical advice, I'm bringing three papers to the research blogging table today, all published in the JAMA journal family and all talking about depression / depressive symptoms.See my hat... @ Wikipedia First up is the paper by Ole Köhler and colleagues [1] reviewing "the antidepressant and possible adverse effects of anti-inflammatory interventions". Some […]

Ole Köhler, Michael E. Benros, Merete Nordentoft, Michael E. Farkouh, Rupa L. Iyengar, Ole Mors & Jesper Krogh (2014). Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects, JAMA Psychiatry, Other:

Snehal M. Pinto Pereira, Marie-Claude Geoffroy & Christine Power (2014). Depressive Symptoms and Physical Activity During 3 Decades in Adult Life, JAMA Psychiatry, Other:

Toseeb, U., Brage, S., Corder, K., Dunn, V., Jones, P., Owens, M., St Clair, M., van Sluijs, E. & Goodyer, I. (2014). Exercise and Depressive Symptoms in Adolescents, JAMA Pediatrics, DOI: 10.1001/jamapediatrics.2014.1794


November 06, 2014

4:45 PM | Foods to Improve Your Mood
Scientists are beginning to recognize the link between diet, levels of inflammation in the body, and mood. It is a commonly held belief that your gut is in fact your “second brain.” In fact, more serotonin (the “feel-good” neurotransmitter) is produced in the gut than in the brain. Eating anti-inflammatory nutrients on a regular basis […]

October 28, 2014

7:42 AM | Zinc and depression
"Low dietary zinc intake is associated with a greater incidence of depression in both men and women, as shown in two prospective cohorts".At the risk of overdoing the whole 'you are what you eat' sentiment, today I'm addressing a portion of the peer-reviewed research literature linking issues with zinc availability to depression. That opening quote by the way, comes from the paper by Khanrin Phungamla Vashum and colleagues [1] who looked at self-reported dietary intake of zinc based on […]

Vashum KP, McEvoy M, Milton AH, McElduff P, Hure A, Byles J & Attia J (2014). Dietary zinc is associated with a lower incidence of depression: findings from two Australian cohorts., Journal of affective disorders, 166 249-57. PMID:

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