Posts

September 22, 2014

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1:30 PM | Researcher who broke into lab up to nine retractions
Karel Bezouška, a researcher who broke into a lab refrigerator to tamper with an investigation into his work, has nine retractions. Here’s the retraction notice in Biochemistry for 2010’s “Cooperation between Subunits Is Essential for High-Affinity Binding of N-Acetyl-d-hexosamines to Dimeric Soluble and Dimeric Cellular Forms of Human CD69:” We wish to retract this article […]

September 19, 2014

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2:45 PM | Alternative antibody architecture
The complex genomic apparatus for making lampreys' antibody-like receptors The post Alternative antibody architecture appeared first on Lab Land.

September 18, 2014

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6:30 PM | Leukemia's Waterloo: The Battle For Cell Production
To fight leukemia, we have to fight on its terms, and that means understanding the nature of the fight for superiority between mutated genes and normal genes, according to a paper that investigated Acute Myeloid Leukemia to understand why leukemic cells are not able to develop normally into mature blood cells. Stem cells in the bone marrow generate billions of different blood cells each day. The process resembles a production line with genes acting as regulators to control each step of the […]

September 17, 2014

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10:30 PM | Vancomycin Modified To Vanquish Antibiotic-Resistant Bacteria
Scientists have devised a new antibiotic based on vancomycin that is effective against vancomycin-resistant strains of  methicillin-resistant Staphylococcus aureus (MRSA) and other disease-causing bacteria. The new vancomycin analog appears to have not one but two distinct mechanisms of anti-microbial action, against which bacteria probably cannot evolve resistance quickly.read more
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12:00 PM | Should I Stay Or Should I Go
Biology concepts – bacteria, motility, flagella, quorum sensing, bacterial swarming, biofilms, pathogenesisNomads are wanderers. They come in different flavors. Hunter-gatherers follow the animals as they graze in different places. Pastoral nomads have animal herds and move them around to where the grazing is best. But the interesting ones are the peripatetic nomads. These are people that move around within cities and other populated areas, often to sell services or trades. Romanis, or […]

Gloag ES, Turnbull L, Huang A, Vallotton P, Wang H, Nolan LM, Mililli L, Hunt C, Lu J, Osvath SR & Monahan LG (2013). Self-organization of bacterial biofilms is facilitated by extracellular DNA., Proceedings of the National Academy of Sciences of the United States of America, 110 (28) 11541-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23798445

Deng P, de Vargas Roditi L, van Ditmarsch D & Xavier JB (2014). The ecological basis of morphogenesis: branching patterns in swarming colonies of bacteria., New journal of physics, 16 15006-15006. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24587694

McCall J, Hidalgo G, Asadishad B & Tufenkji N (2013). Cranberry impairs selected behaviors essential for virulence in Proteus mirabilis HI4320., Canadian journal of microbiology, 59 (6) 430-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23750959

Alteri CJ, Himpsl SD, Pickens SR, Lindner JR, Zora JS, Miller JE, Arno PD, Straight SW & Mobley HL (2013). Multicellular bacteria deploy the type VI secretion system to preemptively strike neighboring cells., PLoS pathogens, 9 (9) PMID: http://www.ncbi.nlm.nih.gov/pubmed/24039579

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7:02 AM | Ebola Virus And Protein Secrets
The current Ebola virus outbreak in West Africa has claimed more than 2000 lives and has spurred calls for a deeper understanding of the molecular biology of the virus that could be critical in the development of vaccines or antiviral drugs to treat or prevent Ebola hemorrhagic fever. A team at the University of Virginia, under the leadership of Dr. Dan Engel, a virologist, and Dr. Zygmunt Derewenda, a structural biologist, has obtained the crystal structure of a key protein involved in Ebola […]

September 16, 2014

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12:30 PM | Genetically Modified Kamikaze Mosquitoes Take Out Diseases
By Marsha Lewis, Inside Science(Inside Science TV) – One of the deadliest forces on earth is the humble mosquito. Mosquito-borne diseases like malaria, chikungunya, yellow fever and West Nile virus infect more than 350 million people and kill another 1 million people every year.Now, scientists in Florida hope to wipe out some of these deadly diseases by genetically modifying their winged carriers.“Mosquitoes are probably the most dangerous animal in the world. More people are killed […]

September 15, 2014

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3:30 PM | Repair The Muscles In Muscular Dystrophy, Not The Genetic Defect
The saying goes that we shouldn't let the perfect be the enemy of the good, so while there is no cure for muscular dystrophy, rather than solely focusing on the underlying genetic defect might not help people right now as directly targeting muscle repair.  Muscular dystrophies are a group of muscle diseases characterized by skeletal muscle wasting and weakness. Mutations in certain proteins, most commonly the protein dystrophin, cause muscular dystrophy in humans and also in […]

September 14, 2014

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7:40 PM | Audiommunity Episode 9 – Id just like to second everything Abbie said
LOL! Former blag-brother Kevin, along some friends from Harvard, have an independent website set up for educating the public about immunology: Emmunity.org They have a page I will link to many times in the future, describing the basic cellular components of the immune system, as well as another page filled with animations explaining some tricks those…

September 11, 2014

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5:01 PM | New Soldier In The Body's Anti-Virus Army Discovered
When it comes to defense against viruses, the immune system has an arsenal of weapons at its disposal, including killer cells, antibodies and messenger molecules, and when a pathogen attacks the body, the immune system usually activates the appropriate mechanisms. read more

September 07, 2014

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5:37 PM | HPV Vaccine Credited With 61 Percent Decrease In Female Genital Warts
Doctors in Australia are reporting 61 percent fewer cases of genital warts among young women since the introduction of the national human papillomavirus (HPV) vaccination program. The study reviewed more than a million patient encounters between 2000 and 2012 and found a significant year-on-year reduction in the management rate of genital warts in women aged 15-27 years since the vaccination program started.  The HPV vaccination program was introduced in 2007, and the rate of genital wart […]

September 06, 2014

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12:33 AM | Dengue Vaccine May Cause Short-Term Increase
Dengue is a serious illness diminished in importance in much of the developed world. Some efforts evolve around genetic modification while other efforts work on a vaccine.read more

September 05, 2014

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3:18 PM | Double Trouble: How Parasitic Worms Weaken Antiviral Immunity
David Artis, PhD, professor of Microbiology and his team, including first author Lisa Osborne, PhD, demonstrated that mice already infected with parasitic helminths were worse at fighting viral infection.

September 03, 2014

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12:00 PM | Bacteria Are Intelligent Designers
Biology concepts – nature of science, flagella, intelligent design, irreducible complexity, motility, Gram+, Gram -, ion gradient You don’t believe it now, but in the weeks ahead we’re going to discuss how bacterial motility, plant reproduction, intelligence, and the location of your heart are all related to whips and eyelashes. Sounds preposterous, but give me a few posts and a little leeway and you’ll be amazed.Cheetahs can cover about 25 body lengths in a second, but […]

Eisele NA, Ruby T, Jacobson A, Manzanillo PS, Cox JS, Lam L, Mukundan L, Chawla A & Monack DM (2013). Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence., Cell host & microbe, 14 (2) 171-82. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23954156

Lee LK, Ginsburg MA, Crovace C, Donohoe M & Stock D (2010). Structure of the torque ring of the flagellar motor and the molecular basis for rotational switching., Nature, 466 (7309) 996-1000. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20676082

Minamino T, Imada K, Kinoshita M, Nakamura S, Morimoto YV & Namba K (2011). Structural insight into the rotational switching mechanism of the bacterial flagellar motor., PLoS biology, 9 (5) PMID: http://www.ncbi.nlm.nih.gov/pubmed/21572987

Carsiotis M, Weinstein DL, Karch H, Holder IA & O'Brien AD (1984). Flagella of Salmonella typhimurium are a virulence factor in infected C57BL/6J mice., Infection and immunity, 46 (3) 814-8. PMID: http://www.ncbi.nlm.nih.gov/pubmed/6389363

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September 02, 2014

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1:02 PM | Mutating Ebola Viruses Not As Scary As Evolving Ones
Scanning electron micrograph of Ebola virus budding from the surface of a Vero cell (African green monkey kidney epithelial cell line. Credit:NIAIDBy Rob BrooksMy social media accounts today are cluttered with stories about “mutating” Ebola viruses. The usually excellent ScienceAlert, for example, rather breathlessly informs us “The Ebola virus is mutating faster in humans than in animal hosts.” read more

August 30, 2014

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4:30 PM | MERS Has Low Transmissibility But It's Still Dangerous
The MERS coronavirus has caused disease outbreaks across the Arabian Peninsula and spread to Europe several times, claiming the lives of several hundred people since its discovery in 2012. How easily the pathogen spreads from human to human has remained a mystery but recent work shows human transmission is low. Still, a third of infected persons with symptoms die. read more
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9:30 AM | New Antibody Shows Promise Against Sudan Strain Of Ebola
Researchers have developed a potential antibody therapy for Sudan ebolavirus (SUDV), one of the two most lethal strains of Ebola.  Sudan ebolavirus was first identified in 1976 and has caused numerous Ebola outbreaks (most recently in 2012) that have killed more than 400 people in total.   A different strain, the Zaire ebolavirus (EBOV), is now devastating West Africa. read more

August 27, 2014

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5:46 PM | Key to universal flu vaccine: embrace the unfamiliar
Vaccination against H5N1 induced antibodies against the stem region of the viral hemagglutinin protein The post Key to universal flu vaccine: embrace the unfamiliar appeared first on Lab Land.

August 26, 2014

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10:17 PM | Ionic Liquids: Busting Through Biofilm Shatters Defenses Of Serious Skin Infections
Biofilms are the first line of defense for harmful bacteria and make the treatment of skin infections especially difficult because microorganisms protected in a biofilm have antibiotic resistance and recalcitrance to treatment. Biofilm-protected bacteria account for some 80 percent of total bacterial infections in humans and are 50 to 1,000 times more resistant to antibiotics than simpler bacterial infections.  Biofilms often persist in the periphery of an actual wound, beneath an […]
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8:38 PM | Resilience Management: What The Bubonic Plague Can Teach Us About Ebola
In the 14th century, Venice was in many ways still a world power in its own right. The days when it could topple kingdoms using commerce were behind it, but it was still an important trade destination. In that period, trade meant ports and ports meant the Bubonic Plague in 1347. When it hit, some tried prayer, some tried hunting vampires, but then officials quickly began to utilize what we would now call resilience management: rather than trying to target a poorly understood […]
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1:24 AM | Top Secret Ebola serums, how do they work?
One wonderful thing that has come two US citizens being infected Ebola (and successfully treated for the disease) is *education* the general public is getting about this, frankly, ‘scary’ virus. Im not talking about the bizarre nonsense/missed opportunity posted by Sanjay Gupta and his ‘producer’ Danielle Dellorto. Of course science bloggers have capitalized on this opportunity to educate people (its…

August 24, 2014

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1:31 PM | This Month in Blastocystis Research (AUG 2014)
Some August highlights in Blastocystis research:1) The PRE-IOPCA Molecular Parasitology Workshop took place from the 7-10 August at CINVESTAV, Mexico City. Top-motivated students from some 10-15 countries worked hard from 7 am to 7 pm in dry+wet lab sessions, and we all had a really great time, thanks to both participants and fantastic organisers. There was a 4 h session on Blastocystis molecular epidemiology, and I was pleased to learn that some of the participants currently work with (or plan […]

Fayer R, Elsasser T, Gould R, Solano G, Urban J Jr & Santin M (2014). Blastocystis tropism in the pig intestine., Parasitology research, 113 (4) 1465-72. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24535732

Klimeš V, Gentekaki E, Roger AJ & Eliáš M (2014). A large number of nuclear genes in the human parasite blastocystis require mRNA polyadenylation to create functional termination codons., Genome biology and evolution, 6 (8) 1956-61. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25015079

Hanage, W. (2014). Microbiology: Microbiome science needs a healthy dose of scepticism, Nature, 512 (7514) 247-248. DOI: 10.1038/512247a

Scanlan PD, Stensvold CR, Rajilić-Stojanović M, Heilig HG, De Vos WM, O'Toole PW & Cotter PD (2014). The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota., FEMS microbiology ecology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25077936

Venton, D. (2014). Highlight: Not Like a Textbook--Nuclear Genes in Blastocystis Use mRNA Polyadenylation for Stop Codons, Genome Biology and Evolution, 6 (8) 1962-1963. DOI: 10.1093/gbe/evu167

Wang W, Bielefeldt-Ohmann H, Traub RJ, Cuttell L & Owen H (2014). Location and pathogenic potential of blastocystis in the porcine intestine., PloS one, 9 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25093578

Citation
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1:31 PM | This Month in Blastocystis Research (AUG 2014)
Some August highlights in Blastocystis research:1) The PRE-IOPCA Molecular Parasitology Workshop took place from the 7-10 August at CINVESTAV, Mexico City. Top-motivated students from some 10-15 countries worked hard from 7 am to 7 pm in dry+wet lab sessions, and we all had a really great time, thanks to both participants and fantastic organisers. There was a 4 h session on Blastocystis molecular epidemiology, and I was pleased to learn that some of the participants currently work with (or plan […]

Fayer R, Elsasser T, Gould R, Solano G, Urban J Jr & Santin M (2014). Blastocystis tropism in the pig intestine., Parasitology research, 113 (4) 1465-72. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24535732

Klimeš V, Gentekaki E, Roger AJ & Eliáš M (2014). A large number of nuclear genes in the human parasite blastocystis require mRNA polyadenylation to create functional termination codons., Genome biology and evolution, 6 (8) 1956-61. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25015079

Hanage, W. (2014). Microbiology: Microbiome science needs a healthy dose of scepticism, Nature, 512 (7514) 247-248. DOI: 10.1038/512247a

Scanlan PD, Stensvold CR, Rajilić-Stojanović M, Heilig HG, De Vos WM, O'Toole PW & Cotter PD (2014). The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota., FEMS microbiology ecology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25077936

Venton, D. (2014). Highlight: Not Like a Textbook--Nuclear Genes in Blastocystis Use mRNA Polyadenylation for Stop Codons, Genome Biology and Evolution, 6 (8) 1962-1963. DOI: 10.1093/gbe/evu167

Wang W, Bielefeldt-Ohmann H, Traub RJ, Cuttell L & Owen H (2014). Location and pathogenic potential of blastocystis in the porcine intestine., PloS one, 9 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25093578

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