Posts

March 27, 2015

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10:20 PM | Immune Defense: Inflammatory Language Guest Post
Melanie Stegman, Ph.D., Creative Director of Immune Defense (a novel video game) and Owner of Molecular Jig Games is the winner of this year's Inflammatory Language Contest. In her words...The game is meant to be an introduction, a tool to spark interest and provide basic vocabulary so that players can follow up on Wikipedia or PubMedCentral, or also, so that a teacher could design a lesson based on the game as an introduction. To play the game people can do it two ways: […]

March 26, 2015

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8:00 PM | Antibiotic Use In Livestock Could Increase 67 Percent - What Impact On Effectiveness?
Antibiotic consumption in livestock worldwide could rise by 67 percent from 2010 levels by 2030. What will that mean for the effectiveness of antimicrobials in humans?Five countries - Brazil, Russia, India, China and South Africa - will experience a growth of 99 percent in antibiotic consumption, compared with an expected 13 percent growth in their human populations over the same period. In the United States, antibiotic consumption in animals represents is the overwhelming majority of total […]
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3:57 PM | Winner of 3rd Annual Inflammatory Language Contest!
The Febrile Muse has chosen Immune Defense, a novel molecular game by Melanie Stegman, Ph.D., Creative Director of Immune Defense and Owner of Molecular Jig Games.  Many people were involved in the creation of this game. For more details, go to Immune Defense Game. In addition, congratulations to the creators on their successful IndieGoGo project,  to develop it further!There will soon be a follow-up post by Dr. Stegman that includes game details and screen […]
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3:13 PM | Hepatitis B Virus Exposure Matures Infants’ Immune Systems
A childhood infection of Hepatitis B may actually be beneficial for the immune system in a new study conducted by the Duke-NUS Graduate Medical School. ...

March 25, 2015

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8:10 PM | Raw Milk Is 3 Percent Of The Market But Causes Over 50 Percent Of Milk Foodborne Illnesses
Most people would be horrified if they went to a restaurant bathroom and saw the chef not bother to wash his hands after using the toilet. It's a good thing raw milk fad health buyers do not understand cow milking for the same reason.A new review finds that consumers are nearly 100 times more likely to get foodborne illness from drinking raw milk than they are from drinking pasteurized milk, which is a lower figure than the Centers for Disease Control, which puts that number at 150X. Though a […]

March 24, 2015

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1:55 AM | India Must Address Its TB Epidemic
Effective tuberculosis control in India needs political will and commitment. Unless this happens, TB will continue to be India's silent epidemic and a death sentence for poor people, warns consultant physician and public health specialist, Zarir Udwadia in BMJ.20 years ago it was widely believed that India was successfully on its way to controlling its alarming tuberculosis (TB) epidemic yet India still has 2.2 million new cases and more than 300,000 deaths each year. Economic numbers are a […]

March 19, 2015

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4:29 PM | Potential HIV drugs hit three targets at once
News from the American Chemical Society meeting in Denver The post Potential HIV drugs hit three targets at once appeared first on Lab Land.
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4:07 PM | Medieval Latrine In Jerusalem Provides Window Into Spread Of Infectious Diseases
A medieval cesspit in the old city of Jerusalem has revealed the presence of a number of ancient parasite eggs, which gives researchers a glimpse into the nature and spread of infectious diseases in the Middle East during the 15th century. Scientists found evidence of six species of intestinal parasites in the 500-year-old latrine, which included large quantities of roundworm and whipworm, both spread by fecal contamination of food and probably endemic to the region dating back to human […]

March 05, 2015

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12:53 PM | Silencing the alarms: Innate immune antagonism by rotaviruses
This review discusses the structural and mechanistic basis of innate immune antagonism by two direct effectors, the Rotavirus NSP1 and VP3 proteins. It starts with a nice overview of Rotavirus biology then goes on to describe how the structural and … Continue reading →
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
+
12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation

March 04, 2015

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2:41 AM | Two Of Four Known AIDS Virus Groups Originated In Gorillas
Two of the four known groups of human AIDS viruses (HIV-1 groups O and P) originated in western lowland gorillas, according researchers who conducted a comprehensive survey of simian immunodeficiency virus (SIV) infection in African gorillas. HIV-1, the virus that causes AIDS, has jumped species to infect humans on at least four separate occasions, generating four HIV-1 lineages -- groups M, N, O, and P. Previous research from this team found that groups M and N originated in geographically […]

March 03, 2015

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11:52 PM | You Probably Don't Have The Flu
If you ask doctors what the biggest myth about the flu is, they will tell you that it's people thinking they have the flu. Flu-like illness can be caused by many pathogens, and most people don't go to the doctor for it, making it difficult to assess how often people really have.  Older and young people are more susceptible but adults over the age of 30 only catch flu about twice a decade, according to a new paper.  The immune system responds to flu viruses by producing antibodies […]

March 02, 2015

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2:52 PM | Extinction Edge: a new thriller on how epigenetic changes induced by viruses could kill us all
Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are […]

Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U & Scott RS (2014). Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes., Journal of virology, 88 (19) 11442-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25056883

Tian Y, Yang W, Song J, Wu Y & Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis., Molecular and cellular biology, 33 (15) 2810-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23716588

Rongrui L, Na H, Zongfang L, Fanpu J & Shiwen J (2014). Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis., Current pharmaceutical design, 20 (11) 1715-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23888939

Mbonye U & Karn J (2011). Control of HIV latency by epigenetic and non-epigenetic mechanisms., Current HIV research, 9 (8) 554-67. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22211660

Citation
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2:52 PM | Extinction Edge: a new thriller on how epigenetic changes induced by viruses could kill us all
Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are […]

Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U & Scott RS (2014). Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes., Journal of virology, 88 (19) 11442-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25056883

Tian Y, Yang W, Song J, Wu Y & Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis., Molecular and cellular biology, 33 (15) 2810-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23716588

Rongrui L, Na H, Zongfang L, Fanpu J & Shiwen J (2014). Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis., Current pharmaceutical design, 20 (11) 1715-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23888939

Mbonye U & Karn J (2011). Control of HIV latency by epigenetic and non-epigenetic mechanisms., Current HIV research, 9 (8) 554-67. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22211660

Citation
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2:52 PM | Extinction Edge: a new thriller on how epigenetic changes induced by viruses could kill us all
Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are […]

Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U & Scott RS (2014). Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes., Journal of virology, 88 (19) 11442-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25056883

Tian Y, Yang W, Song J, Wu Y & Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis., Molecular and cellular biology, 33 (15) 2810-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23716588

Rongrui L, Na H, Zongfang L, Fanpu J & Shiwen J (2014). Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis., Current pharmaceutical design, 20 (11) 1715-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23888939

Mbonye U & Karn J (2011). Control of HIV latency by epigenetic and non-epigenetic mechanisms., Current HIV research, 9 (8) 554-67. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22211660

Citation
+
2:52 PM | Extinction Edge: a new thriller on how epigenetic changes induced by viruses could kill us all
Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are […]

Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U & Scott RS (2014). Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes., Journal of virology, 88 (19) 11442-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25056883

Tian Y, Yang W, Song J, Wu Y & Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis., Molecular and cellular biology, 33 (15) 2810-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23716588

Rongrui L, Na H, Zongfang L, Fanpu J & Shiwen J (2014). Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis., Current pharmaceutical design, 20 (11) 1715-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23888939

Mbonye U & Karn J (2011). Control of HIV latency by epigenetic and non-epigenetic mechanisms., Current HIV research, 9 (8) 554-67. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22211660

Citation
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2:25 PM | Pediatricians Under Pressure From Parents To Spread Out Vaccine Schedule
In 2008, President Obama suggested vaccines might be causing autism. In 2009, during the H1N1 swine flu pandemic, there was quickly a vaccine shortage, because the government refused to allow adjuvants, to boost vaccine effectiveness and use less raw material, or multi-dose vials, because they contained a preservative anti-vaccine believers claimed caused autism. 274,000 Americans were hospitalized.read more
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9:03 AM | T cell exhaustion during persistent viral infections
Why does the immune system fail to clear some virus (and other infections) and allow a state of chronic infection to occur? Continue reading →
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