Posts

July 30, 2014

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3:08 PM | Blood Test Biomarker Could Help Prevent Spina Bifida
Folate is a naturally occurring form of vitamin B found in food, while folic acid is synthetically produced and used in fortified foods and supplements. Taking folic acid before and during early pregnancy is linked to a reduction in the risk of neural tube defects like spina bifida. The current recommended dose is 400 ìg (micrograms) a day though it is unclear how much daily folic acid is needed to prevent neural tube defects.read more
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2:58 PM | Fighting HIV, biomedical and behavioral hand in hand
Emory epidemiologist Kristin Wall gets attention at AIDS 2014 with a presentation on the importance of couples counseling The post Fighting HIV, biomedical and behavioral hand in hand appeared first on Lab Land.

July 25, 2014

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5:06 PM | Anti-inflammatory drug prevents neuron loss in Parkinson’s model
Promising research recently published in Journal of Parkinson's Disease The post Anti-inflammatory drug prevents neuron loss in Parkinson’s model appeared first on Lab Land.
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5:00 PM | Genetic Modification May Lead To Mildew Resistant Barley
In Australia, annual barley production is second only to wheat, with 7-8 million tons grown per year. Powdery mildew is one of the most important diseases of barley and a new project has opened the way for the development of new lines of barley with resistance to powdery mildew. University of Adelaide Senior Research Scientist Dr. Alan Little and colleagues have discovered the composition of special growths on the cell walls of barley plants that block the penetration of the fungus into the […]
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10:00 AM | iLabs: Fall Family Class “Teaser” for the Micro World
It’s that time of year in the Micro World iLab where we’re putting our schedule of upcoming family lab classes together. To give you a “taste” of what’s coming, I’ve included some class information below, for the programs we’ll be doing in September-November. There will be more topics coming for sure, such as: Our 4-part […]

July 23, 2014

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2:53 PM | Valley Fever: The Increased Dangers Of Desert Dust
The rapid rise in valley fever cases in the arid southwest has become a serious health concern, as human habitation has pushed further into desert areas where the soil spores are widespread. Currently, Valley Fever affects an estimated 150,000 people a year, with most cases occurring in Arizona, California, Nevada, New Mexico and Utah. The disease has no cure at present and is tricky to diagnose because it is similar to community-acquired pneumonias.read more

July 22, 2014

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6:48 PM | Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy
[Note: This is a guest post by Tauseef (@CellSpell)] Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases... […]

Cheng, C., Adams, G., Perin, L., Wei, M., Zhou, X., Lam, B., Da Sacco, S., Mirisola, M., Quinn, D., Dorff, T. & Kopchick, J. (2014). Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression, Cell Stem Cell, 14 (6) 810-823. DOI: 10.1016/j.stem.2014.04.014

Citation
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6:48 PM | Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy
[Note: This is a guest post by Tauseef (@CellSpell)] Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases... […]

Cheng, C., Adams, G., Perin, L., Wei, M., Zhou, X., Lam, B., Da Sacco, S., Mirisola, M., Quinn, D., Dorff, T. & Kopchick, J. (2014). Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression, Cell Stem Cell, 14 (6) 810-823. DOI: 10.1016/j.stem.2014.04.014

Citation
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6:48 PM | Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy
[Note: This is a guest post by Tauseef (@CellSpell)] Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases... […]

Cheng, C., Adams, G., Perin, L., Wei, M., Zhou, X., Lam, B., Da Sacco, S., Mirisola, M., Quinn, D., Dorff, T. & Kopchick, J. (2014). Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression, Cell Stem Cell, 14 (6) 810-823. DOI: 10.1016/j.stem.2014.04.014

Citation
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6:48 PM | Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy
[Note: This is a guest post by Tauseef (@CellSpell)] Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases... […]

Cheng, C., Adams, G., Perin, L., Wei, M., Zhou, X., Lam, B., Da Sacco, S., Mirisola, M., Quinn, D., Dorff, T. & Kopchick, J. (2014). Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression, Cell Stem Cell, 14 (6) 810-823. DOI: 10.1016/j.stem.2014.04.014

Citation

July 14, 2014

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6:31 AM | Cachexia: Cancer-Related Wasting Condition Halted By Antibody
Cachexia is a profound wasting of fat and muscle occurring in about half of all cancer patients, raising their risk of death. Many strategies have been tried to reverse the condition, which may cause such frailty that patients can't endure potentially life-saving treatments, but none have had great success. Researchers recently demonstrated that, in mice bearing lung tumors, their symptoms of cachexia improved or were prevented when given an antibody that blocked the effects of a protein, […]

July 12, 2014

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2:30 PM | Hygiene Hypothesis? Growing Up On A Farm Halves The Risk Of Inflammatory Bowel Diseases
If you grew up on a farm, you may have gotten sick lots of times due to exposure to any number of microorgansms. You might not remember getting sick more then, but a new study finds you are less likely to have chronic maladies as an adult. New research conducted at Aarhus University finds that people who have grown up on a farm with livestock are only half as likely as urban counterparts to develop the most common inflammatory bowel diseases: ulcerative colitis and Crohn's disease. […]

July 11, 2014

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1:01 AM | 1960s Redux: Injected Polio Vaccine Could Help Eradicate The Disease
Re-introducing a type of polio vaccine, the injected polio vaccine (IPV), that fell out of favor in the 1960s could hasten eradication of the disease, according to new research. The injected polio vaccine is rarely used today, it lost in competition against the oral polio vaccine (OPV), but it could provide better and longer lasting protection against infection if used in combination with the more commonly used live OPV, write researchers from Imperial College London and the Christian Medical […]

July 10, 2014

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9:01 PM | Disappointment: 'Mississippi Baby' Cured Of HIV Has Recurrence
The child known as the "Mississippi baby", an infant cured of HIV in a case study published in The New England Journal of Medicine last fall, now has detectable levels of HIV after more than two years without taking antiretroviral therapy and without evidence of virus, according to the pediatric HIV specialist and researchers involved in the case.  read more
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2:53 PM | Low Doses Of Antibiotics Linked To Chronic Infections
Researchers have discovered the link between antibiotics and bacterial biofilm formation leading to chronic lung, sinus and ear infections. Bacterial biofilms can actually thrive, rather than decrease, when given low doses of antibiotics.  Biofilms are highly structured communities of microorganisms that attach to one another and to surfaces. The microorganisms group together and form a slimy, polysaccharide cover. This layer is highly protective for the organisms within it, and when new […]
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6:00 AM | Destroying the last samples of smallpox virus could prove short-sighted
The discovery of intact vials of smallpox in a storeroom last week demonstrates the need to maintain samples of the virus in secure facilities for future vaccine researchI confess that, while I'm a middle-aged mother in a fairly typical family, I am not the world's best housekeeper. It is not unusual, in a rare turning of sofa cushions, for me to find several leaky biros and a small fortune in pocket change. I'm pretty sure I've discovered entire mutant food groups while defrosting my […]

July 09, 2014

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3:01 PM | Blocking Immune System Leads To Sepsis Resistance In Study
Molecular microbiologists have discovered that mice lacking a specific component of the immune system are completely resistant to sepsis, a potentially fatal complication of infection. The immune system is the body's first line of defense against infection. The system, however, can also injure the body if it is not turned off after the infection is destroyed, or if it is turned on when there is no infection at all. Scientists do not yet fully understand how the immune response is turned on and […]

July 08, 2014

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2:32 PM | Antibiotic Resistance Threatens A Return To "The Dark Ages Of Medicine"
Ask an older person what it is like to be under the constant threat of infectious disease. They love vaccines and they love antibiotics because everyone once knew someone who was crippled or died due to an inability to prevent or cure serious illnesses.But it won't be wealthy progressive elites who send us back to a "Dark Ages of medicine" with their anti-vaccine fad, warned UK Prime Minister David Cameron last week, it is more likely be the growing threat of resistance to antibiotics.Since […]

July 07, 2014

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2:33 PM | MERS CoV: Can it spread from camels to man?
The Middle Eastern Respiratory Syndrome coronavirus (MERS CoV) is a novel single stranded RNA virus that has been doing the rounds in the Middle East, bits of Europe and North America. Given our experiences the last time we had a new respiratory virus (remember the pandemic?), things have moved rather fast this time once the…

Azhar, E., El-Kafrawy, S., Farraj, S., Hassan, A., Al-Saeed, M., Hashem, A. & Madani, T. (2014). Evidence for Camel-to-Human Transmission of MERS Coronavirus, New England Journal of Medicine, 370 (26) 2499-2505. DOI: 10.1056/NEJMoa1401505

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2:00 PM | Viruses: Deceptive Proteins Unmasked
Some viruses can hide in our bodies for decades. How do they escape notice and destruction? They have 'fake' human proteins that trick our immune cells into thinking they belong. read more

July 02, 2014

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9:30 PM | Exploring the Human Microbiome
Like many people, I have gone through life without paying much attention to my gut –- except, that is, for the times my stomach gave unmistakable indications that it was upset. Most of the time, what was happening inside said stomach remained unknown. On the whole, it was out of...
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7:32 PM | Novel Biosensor to Optimize Bio-Refining Processes
Scientists at the University of British Columbia have developed a new type of biosensor that can help optimize bio-refining processes that produce chemicals, fuels and advanced materials.

Strachan, C., Singh, R., VanInsberghe, D., Ievdokymenko, K., Budwill, K., Mohn, W., Eltis, L. & Hallam, S. (2014). Metagenomic scaffolds enable combinatorial lignin transformation, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1401631111

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12:00 PM | How Do Mosquitoes Find You?
Biology concepts – semiochemicals, hematophagy, proboscis, thermosensing, TRPA1Sure, mosquitoes suck blood and pass along malaria that kill more humans than any other infectious disease. But would it be good to get rid of them. They provide food for birds – one scientist suggests that elimination of Arctic mosquitoes could reduce northern bird populations by 50%. And mosquitoes pollinate flowers too, like blueberries and cranberries. See, they’re not all bad.We can start our […]

Maekawa E, Aonuma H, Nelson B, Yoshimura A, Tokunaga F, Fukumoto S & Kanuka H (2011). The role of proboscis of the malaria vector mosquito Anopheles stephensi in host-seeking behavior., Parasites & vectors, 4 10. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21272298

Albeny-Simões D, Murrell EG, Elliot SL, Andrade MR, Lima E, Juliano SA & Vilela EF (2014). Attracted to the enemy: Aedes aegypti prefers oviposition sites with predator-killed conspecifics., Oecologia, 175 (2) 481-92. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24590205

Olanga EA, Okal MN, Mbadi PA, Kokwaro ED & Mukabana WR (2010). Attraction of Anopheles gambiae to odour baits augmented with heat and moisture., Malaria journal, 9 6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20051143

Liu C & Zwiebel LJ (2013). Molecular characterization of larval peripheral thermosensory responses of the malaria vector mosquito Anopheles gambiae., PloS one, 8 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/23940815

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July 01, 2014

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4:30 PM | 2009 Swine Flu Pandemic Wasn't Due To International Air Travel - Study
The H1N1 2009 pandemic influenza virus, known informally as 'swine flu', has remained a hot topic in science and culture. The science and medical community, including former FDA deputy commissioner Dr. Scott Gottlieb, criticized the Obama admiinistration for not allowing multi-dose vials of vaccines because they contained thimerosal, which had been one of the reasons during the 2008 campaign season that Senator Obama hinted he believed vaccines caused autism. The anti-immigration […]

June 30, 2014

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3:03 PM | Lasers and Drones: June at Penn Medicine, in Photos
The University of Pennsylvania campus largely falls silent in the summer months, but Penn Medicine keeps on truckin'. In fact, the month of June featured two of my favorite photography assignments thus far: lasers and drones. I'll explain. Hang in there, we've got a slideshow at the end of the...
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