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Posts

April 18, 2014

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6:04 PM | The Hallmarks of Cancer 8: Tumor-Promoting Inflammation
The Hallmarks of Cancer are ten underlying principles shared by all cancers. You can read the first seven Hallmarks of Cancer articles here. The eighth Hallmark of Cancer is defined as... -- Read more on ScientificAmerican.com
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2:06 PM | New Books Party: books received this week | @GrrlScientist
A veritable smörgåsbord of brilliant science, nature and history writing awaits you! (Well, in this case, a very small smörgåsbord.)Below the jump, I mention the books that I received recently. They are gifts, review copies that arrived in the mail, or that I purchased in London. These are the books that I may review in more depth later, either here or in print somewhere in the world. Continue reading...
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2:19 AM | Malaria Pathogen's Cellular Skeleton Gets A Super-Microscope Look
The tropical disease malaria is caused by the Plasmodium parasite. For its survival and propagation, Plasmodium requires a protein called actin. Scientists of the Helmholtz Centre for Infection Research (HZI) in Germany used high-resolution structural biology methods to investigate the different versions of this protein in the parasite in high detail. Their results may in the future contribute to the development of tailor-made drugs against malaria–a disease that causes more than half a […]

April 17, 2014

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5:39 PM | New MRSA Superbug In Brazil
An international research team has identified a new superbug that caused a bloodstream infection in a Brazilian patient. The new superbug is part of a class of highly-resistant bacteria known as methicillin-resistant Staphylococcus aureus or MRSA, which is a major cause of hospital and community-associated infections. The superbug has also acquired high levels of resistance to vancomycin, the most common and least expensive antibiotic used to treat severe MRSA infections worldwide. read m

April 16, 2014

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12:00 PM | Using Pain To Stop Pain
Biology concepts – desensitization, habituation, counter irritation, cautery, heat sensing, pain, chronic, acute, analgesiaGout usually attacks middle-aged men and the big toe joint is a favorite spot. But it can occur anywhere and in anyone. The accretions or urates build up and clog the joint, causng poor function and intense pain, painful enough that even the weight of a sheet on it at night is too much. Usually the acute attacks are far worse, and become less painful gouty arthritisas […]

Andreev YA, Kozlov SA, Korolkova YV, Dyachenko IA, Bondarenko DA, Skobtsov DI, Murashev AN, Kotova PD, Rogachevskaja OA, Kabanova NV & Kolesnikov SS (2013). Polypeptide modulators of TRPV1 produce analgesia without hyperthermia., Marine drugs, 11 (12) 5100-15. PMID:

Tobaldini G, de Siqueira BA, Lima MM, Tambeli CH & Fischer L (2014). Ascending nociceptive control contributes to the anti-nociceptive effect of acupuncture in a rat model of acute pain., The journal of pain : official journal of the American Pain Society, PMID:

Lee MG, Huh BK, Choi SS, Lee DK, Lim BG & Lee M (2012). The effect of epidural resiniferatoxin in the neuropathic pain rat model., Pain physician, 15 (4) 287-96. PMID:

Kelly S, Chapman RJ, Woodhams S, Sagar DR, Turner J, Burston JJ, Bullock C, Paton K, Huang J, Wong A & McWilliams DF (2013). Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain., Annals of the rheumatic diseases, PMID:

Citation
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12:00 PM | Using Pain To Stop Pain
Biology concepts – desensitization, habituation, counter irritation, cautery, heat sensing, pain, chronic, acute, analgesiaGout usually attacks middle-aged men and the big toe joint is a favorite spot. But it can occur anywhere and in anyone. The accretions or urates build up and clog the joint, causng poor function and intense pain, painful enough that even the weight of a sheet on it at night is too much. Usually the acute attacks are far worse, and become less painful gouty arthritisas […]

Andreev YA, Kozlov SA, Korolkova YV, Dyachenko IA, Bondarenko DA, Skobtsov DI, Murashev AN, Kotova PD, Rogachevskaja OA, Kabanova NV & Kolesnikov SS (2013). Polypeptide modulators of TRPV1 produce analgesia without hyperthermia., Marine drugs, 11 (12) 5100-15. PMID:

Tobaldini G, de Siqueira BA, Lima MM, Tambeli CH & Fischer L (2014). Ascending nociceptive control contributes to the anti-nociceptive effect of acupuncture in a rat model of acute pain., The journal of pain : official journal of the American Pain Society, PMID:

Lee MG, Huh BK, Choi SS, Lee DK, Lim BG & Lee M (2012). The effect of epidural resiniferatoxin in the neuropathic pain rat model., Pain physician, 15 (4) 287-96. PMID:

Kelly S, Chapman RJ, Woodhams S, Sagar DR, Turner J, Burston JJ, Bullock C, Paton K, Huang J, Wong A & McWilliams DF (2013). Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain., Annals of the rheumatic diseases, PMID:

Citation
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12:00 PM | Using Pain To Stop Pain
Biology concepts – desensitization, habituation, counter irritation, cautery, heat sensing, pain, chronic, acute, analgesiaGout usually attacks middle-aged men and the big toe joint is a favorite spot. But it can occur anywhere and in anyone. The accretions or urates build up and clog the joint, causng poor function and intense pain, painful enough that even the weight of a sheet on it at night is too much. Usually the acute attacks are far worse, and become less painful gouty arthritisas […]

Andreev YA, Kozlov SA, Korolkova YV, Dyachenko IA, Bondarenko DA, Skobtsov DI, Murashev AN, Kotova PD, Rogachevskaja OA, Kabanova NV & Kolesnikov SS (2013). Polypeptide modulators of TRPV1 produce analgesia without hyperthermia., Marine drugs, 11 (12) 5100-15. PMID:

Tobaldini G, de Siqueira BA, Lima MM, Tambeli CH & Fischer L (2014). Ascending nociceptive control contributes to the anti-nociceptive effect of acupuncture in a rat model of acute pain., The journal of pain : official journal of the American Pain Society, PMID:

Lee MG, Huh BK, Choi SS, Lee DK, Lim BG & Lee M (2012). The effect of epidural resiniferatoxin in the neuropathic pain rat model., Pain physician, 15 (4) 287-96. PMID:

Kelly S, Chapman RJ, Woodhams S, Sagar DR, Turner J, Burston JJ, Bullock C, Paton K, Huang J, Wong A & McWilliams DF (2013). Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain., Annals of the rheumatic diseases, PMID:

Citation
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2:42 AM | Another Puzzle – about the interaction of host and pathogen
Ok, I realize that some of the past puzzles I’ve made either had errors or were simply too obscure in their clues (again, I’m a crossword novice). I tried to be a little more clear with this puzzle and also did my best to force as many clues into actually ‘crossing’ as possible. Let me […]
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12:30 AM | Antibiotics Improve Health Of Children In Developing Countries
Antibiotics improve growth in children at risk of undernourishment in low and middle income countries, according to a literature review in the British Medical Journal. Malnutrition in early childhood, reflected in poor growth, is the cause of nearly half of all mortality worldwide in children less than five years old. Antibiotics are currently recommended by the World Health Organization (WHO) for severely malnourished children, and those infected or exposed to HIV, to reduce mortality. But […]

April 15, 2014

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11:30 PM | Ménière's Disease: New Insight Into Rare Inner Ear Condition
Ménière's Disease is a rare condition affecting the inner ear.  It can cause tinnitus, hearing loss, vertigo attacks and a feeling of pressure deep within the ear and is a long term but non-fatal illness, making it low profile in scientific community. But 160,000 sufferers in the UK are getting some help from the University of Exeter Medical School, which has been able to suggest what goes wrong in the body when people develop the disease, and provide an insight into factors […]

April 12, 2014

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3:35 PM | Twins’ immune systems look like those of complete strangers
When it comes to our immune response, genetics takes a back seat to pathogens.

April 10, 2014

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1:54 PM | Aluminum adjuvants in vaccines: are they safe?
Multnomah Falls, © EEGDisclaimer: I work on HIV vaccine design and I'm quite proud of it. I know that for three million HIV-positive kids in Africa, a vaccine is the only hope they have to grow into adulthood. So, when people tell me that vaccines are bad I cringe. Infant mortality rates have dropped since vaccinations have been introduced. We live longer, healthier lives thanks to vaccines. Diseases like polio can paralyze and kill, yet they are no longer a concern for children in the […]

Hogenesch H (2012). Mechanism of immunopotentiation and safety of aluminum adjuvants., Frontiers in immunology, 3 406. PMID:

Tomljenovic L & Shaw CA (2011). Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?, Journal of inorganic biochemistry, 105 (11) 1489-99. PMID:

Citation
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1:54 PM | Aluminum adjuvants in vaccines: are they safe?
Multnomah Falls, © EEGDisclaimer: I work on HIV vaccine design and I'm quite proud of it. I know that for three million HIV-positive kids in Africa, a vaccine is the only hope they have to grow into adulthood. So, when people tell me that vaccines are bad I cringe. Infant mortality rates have dropped since vaccinations have been introduced. We live longer, healthier lives thanks to vaccines. Diseases like polio can paralyze and kill, yet they are no longer a concern for children in the […]

Hogenesch H (2012). Mechanism of immunopotentiation and safety of aluminum adjuvants., Frontiers in immunology, 3 406. PMID:

Tomljenovic L & Shaw CA (2011). Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?, Journal of inorganic biochemistry, 105 (11) 1489-99. PMID:

Citation

April 09, 2014

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1:02 AM | Elafin Protein Discovery May Mean Treatment For Celiac Disease
The human protein Elafin plays a key role against the inflammatory reaction typical of Celiac disease and researchers have developed a probiotic bacterium able to deliver Elafin in the gut of mice.Celiac disease is an auto-immune pathology that occurs in individuals genetically predisposed to gluten intolerance. Affected people do not harbor the enzymes required to degrade gluten during digestion and inflammatory reactions are induced by this abnormal digestion which can lead to the destruction […]

April 05, 2014

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3:11 PM | Antibiotics In Manure Implicated In Human Pathogenic Bacteria In Soil
Researchers have have found that the repeated application of manure contaminated with antibiotics changes the composition of bacteria in the soil. The focus of the investigation was on sulfadiazine (SDZ), a widely used antibiotic in animal husbandry which enters the soil via manure. The researchers report that repeated application of the antibiotic leads to a decrease in beneficial soil bacteria and at the same time an increase in bacteria that are harmful to humans.read more

April 04, 2014

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11:00 AM | NSEW: Great White Hope
In an engaging talk during National Science and Engineering Week 2014, Helen Dooley, a lecturer and researcher in the School of Biological Sciences at University of Aberdeen described how she’s spent the last 10 years attempting to understand the evolution of the adaptive immune system. Her hope is that by using a comparative approach, she …

April 03, 2014

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5:31 PM | Study Helps Unravel The Tangled Origin Of Lou Gehrig's Disease
After playing in every game for some 14 years in baseball, Lou Gehrig of the New York Yankees - "The Iron Horse" - took himself out of the lineup because his manager wouldn't. He had been dropping balls, unable to get to routine plays, hitting in the low .100s, shuffling rather than running. A month later he was diagnosed with the disease that would become synonymous with his name - that he had been able to do any sports at all, much less Major League Baseball, with  amyotrophic lateral […]

April 02, 2014

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12:00 PM | It’s Not Just Chili Peppers That Are Hot
Biology concepts – cinnamaldehyde, nasal hyperreactivity, piperine, allyl isothiocyanate, eugenol, gingerol, tinyatoxin, osmotic stress, agonist/antagonistThe last few years have seen the rise and fall of The Cinnamon Challenge. I can’t tell you why it came, but I can explain why it went. And the reason relates to the capsaicin receptors we have been talking about.Don’t think cinnamon candy can be hot. Your unbearably hot cinnamon bears from Jelly Belly and your Atomic […]

Holland C, van Drunen C, Denyer J, Smart K, Segboer C, Terreehorst I, Newlands A, Beerahee M, Fokkens W & Tsitoura DC & (2013). Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist., British journal of clinical pharmacology, PMID:

Chung G, Im ST, Kim YH, Jung SJ, Rhyu MR & Oh SB (2014). Activation of transient receptor potential ankyrin 1 by eugenol., Neuroscience, 261 153-60. PMID:

Alpizar YA, Boonen B, Gees M, Sanchez A, Nilius B, Voets T & Talavera K (2014). Allyl isothiocyanate sensitizes TRPV1 to heat stimulation., Pflugers Archiv : European journal of physiology, 466 (3) 507-15. PMID:

Ciura S, Liedtke W & Bourque CW (2011). Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4., The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 (41) 14669-76. PMID:

Sudbury JR, Ciura S, Sharif-Naeini R & Bourque CW (2010). Osmotic and thermal control of magnocellular neurosecretory neurons--role of an N-terminal variant of trpv1., The European journal of neuroscience, 32 (12) 2022-30. PMID:

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1:50 AM | Unvaccinated Infants Fuel Epidemics
In unvaccinated hotbeds like California and New York, rich elites rely on 'herd immunity' to protect their children - poor families will get the vaccines and protect the rich ones. That's why in those states, easily preventable diseases have come roaring back, with dangerous consequences. Developing nations should be a reminder to anti-science progressives about the risks they are inflicting on kids who can't get vaccines, and their own children as well. Nearly 4 million children […]

April 01, 2014

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8:30 AM | Antibiotics A Potential Mechanism For Autoimmunity
The code for every gene includes a message at the end of it that signals the translation machinery to stop but diseases like cystic fibrosis and Duchenne muscular dystrophy can result from mutations that insert this stop signal into the middle of an essential gene, causing the resulting protein to be truncated. Some antibiotics cause the cell's translation machinery to ignore the stop codons and are therefore being explored as a potential therapy for these diseases. New research in Proceedings […]

March 31, 2014

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8:49 PM | How Immune Cells Tell Healthy And Diseased Cells Apart
A protein named Tim that says "eat me" could help understand how cancerous cells avoid the body's immune system.

March 28, 2014

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1:33 AM | Use Tobacco To Thwart West Nile Virus And Other Infectious Diseases
West Nile virus is spread by infected mosquitoes and targets the central nervous system. It can be fatal disease and there is currently no cure or drug treatment. It has spread across the U.S., Canada, Latin America and the Caribbean.  An international research group has developed a cost-effective therapeutic against West Nile virus and other pathogens. The therapeutics, known as monoclonal antibodies (MAbs) and their derivatives, were shown to neutralize and protect mice against a lethal […]

March 26, 2014

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2:35 PM | MMR: Measles is dangerous, and single jabs aren't good enough
As events in Swansea continue to unfold, people need to remember two things - measles is dangerous, and MMR is a far safer and better option for the nation's children than single jabsOne of the problems of false balance in reporting is that it skews people's perception of where the sensible position lies. When you present two opposite viewpoints as if they're equal, people will tend to be lured to the middle ground, assuming the truth lies in some compromise between the two. In the case of the […]
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12:00 PM | Naked Mole Rats Don’t Feel The Burn
Biology concepts – thermoregulation, heat sensing, TRPV1, evolution, neurotransmitters, birds, ectothermy, diet-induced thermogenesisBBC television has a very nice Sherlock Holmes show running nowadays, but it has ticked off some mental health professionals. Sherlock describes himself as a high functioning sociopath. I have read several angry letters from those in the profession saying that he should stop doing so, he is using a mental disorder as an excuse for just plain rude […]

Smeets AJ, Janssens PL & Westerterp-Plantenga MS (2013). Addition of capsaicin and exchange of carbohydrate with protein counteract energy intake restriction effects on fullness and energy expenditure., The Journal of nutrition, 143 (4) 442-7. PMID:

Clegg ME, Golsorkhi M & Henry CJ (2013). Combined medium-chain triglyceride and chilli feeding increases diet-induced thermogenesis in normal-weight humans., European journal of nutrition, 52 (6) 1579-85. PMID:

Smith ES, Omerbašić D, Lechner SG, Anirudhan G, Lapatsina L & Lewin GR (2011). The molecular basis of acid insensitivity in the African naked mole-rat., Science (New York, N.Y.), 334 (6062) 1557-60. PMID:

Park TJ, Lu Y, Jüttner R, Smith ES, Hu J, Brand A, Wetzel C, Milenkovic N, Erdmann B, Heppenstall PA & Laurito CE (2008). Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber)., PLoS biology, 6 (1) PMID:

Smith ES, Blass GR, Lewin GR & Park TJ (2010). Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P., Molecular pain, 6 29. PMID:

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March 25, 2014

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8:19 AM | Repost: Conversations With My Grandpa
This year marks the 25th anniversary of the Exxon Valdez spill. At the time, it was the biggest oil spill in US history.  As far as the cleanup is concerned, the Exxon spill is far from over. But Exxon isn’t the spill that weighs on American minds. I wrote the following post in June of […]The post Repost: Conversations With My Grandpa appeared first on Science Sushi.

Jonathan L. Ramseur (2010). Oil Spills in U.S. Coastal Waters: Background, Governance, and Issues for Congress, Congressional Research Service , 7-5700 (RL33705) Other: Link

USCG Spill Compendium (2005). Cumulative Data And Graphics For Oil Spills (1973-2004), USCG,

Ralph A. Bianchi, Edward E. Johanson & James H. Farrell (1973). The Application of Skimmers, Piston Films,and Sorbents for Open Water Spills , Offshore Technology Conference,

U.S. Department of Homeland Security & U.S. Coast Guard (2004). California SONS 2004, After Action Report,

Paine, R., Ruesink, J., Sun, A., Soulanille, E., Wonham, M., Harley, C., Brumbaugh, D. & Secord, D. (1996). TROUBLE ON OILED WATERS: Lessons from the Exxon Valdez Oil Spill, Annual Review of Ecology and Systematics, 27 (1) 197-235. DOI:

SWEDMARK, M., GRANMO, A. & KOLLBERG, S. (1973). Effects of oil dispersants and oil emulsions on marine animals, Water Research, 7 (11) 1649-1672. DOI:

CM Tarzwell (1971). Toxicity of oil and oil dispersant mixtures to aquatic life. , Water pollution by oil. London, The Institute of Petroleum. P. Hepple (Ed.) , 263-272.

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March 21, 2014

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1:46 PM | I carry my son's DNA: a look at microchimerism and its effects
To celebrate the upcoming release of my detective thriller CHIMERAS, the next few Research Blogging posts will be dedicated to the different forms of chimerism. I'm sure you are all familiar with dispermic chimeras, which occur when two fertilized eggs fuse together shortly after conception. The result is one individual with two sets of genetically distinct cells. Have you ever heard of microchimerism, though?"Microchimerism refers to a small number of cells (or DNA) harbored by one individual […]

Gammill HS & Nelson JL (2010). Naturally acquired microchimerism., The International journal of developmental biology, 54 (2-3) 531-43. PMID:

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March 20, 2014

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11:40 AM | How we make immune cells that keep the body from attacking itself
Regulatory cells tone down immune attack to block autoimmune disease.
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