Posts

January 26, 2015

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4:40 AM | Think Mosquitoes Bite You More Than Other People? Here's Why You May Be Right
There are up to 400 chemical compounds on human skin that could play a role in attracting mosquitoes. sookie, CC BY-SABy Cameron Webb, University of SydneyThere’s always one in a crowd, a sort of harbinger of the oncoming mosquito onslaught: a person mosquitoes seem to target more than others. What is it about these unlucky chosen few that makes them mosquito magnets? read more

January 24, 2015

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1:11 PM | Superbugs: How Montezuma's Revenge Impacts Society Long After That Trip
If you are in the United States and travel to Mexico, you are cautioned not to drink the water, just like if you travel to Taiwan or China you are cautioned not to eat chicken bought from a street vendor; people are immune to some nasty stuff you probably are not.Getting diarrhea in Mexico is called Montezuma's revenge - it means the natives are still getting back at the Spanish 500 years later and the rest of the world is thrown in for good measure. But it doesn't just end there. Taking […]

January 23, 2015

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6:53 PM | First Partially Successful Vaccine Developed Against Prion Disease in Deer
The first partially successful vaccine against a prion disease (Chronic Wasting Disease in white tailed deer) is good news, but the journey has just begun.

Goñi, F., Mathiason, C., Yim, L., Wong, K., Hayes-Klug, J., Nalls, A., Peyser, D., Estevez, V., Denkers, N., Xu, J. & Osborn, D. (2015). Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease, Vaccine, 33 (5) 726-733. DOI: 10.1016/j.vaccine.2014.11.035

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January 20, 2015

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9:36 PM | If any of these signs are true, you might not have a gluten issue
Although it may seem like I write only about the lies and ignorance of the antivaccination cult, I truly despise all kinds of pseudoscience. It’s just that refusing vaccines that prevent real diseases, based on antivaccine misinformation (OK, lies), relates directly to the health of real children everywhere. Most (but certainly not all) other pseudosciences are not […]Continue reading «If any of these signs are true, you might not have a gluten issue»
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4:15 PM | General-heavy army disastrous in immune battle
Having more helper T cells around is actually no help The post General-heavy army disastrous in immune battle appeared first on Lab Land.
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1:00 PM | Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?
A recent paper proposes a model which could explain the involvement of CVB as a contributory factor in diabetes. Continue reading →

January 17, 2015

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9:11 PM | Hybrid 'Super Mosquito' Resistant To Insecticide-Treated Bed Nets
Interbreeding of two malaria mosquito species in the West African country of Mali has resulted in a "super mosquito" hybrid that's resistant to insecticide-treated bed nets. Anopheles gambiae, a major malaria vector, is interbreeding with isolated pockets of another malaria mosquito, A. coluzzii. Entomologists initially considered them as the "M and S forms" of Anopheles gambiae. They are now recognized as separate species. Interbreeding of two malaria mosquito species in the West African […]

January 15, 2015

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7:00 PM | If helper T cells have nothing to help, they kill their host
That's some help.
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2:00 PM | Fixing ‘Leaky’ Blood Vessels in Severe Respiratory Ailments and Ebola
When you get an infection, your immune system responds with an influx of inflammatory cells that target the underlying bacteria or viruses. These immune cells migrate from your blood into the infected tissue in order to release a cocktail of pro-inflammatory proteins and help eliminate the infectious threat. During this inflammatory response, the blood vessel barrier becomes “leaky.” This allows for an even more rapid influx of additional immune cells. Once the infection resolves, […]

Gong, H., Rehman, J., Tang, H., Wary, K., Mittal, M., Chatturvedi, P., Zhao, Y., Komorova, Y., Vogel, S. & Malik, A. & (2015). HIF2α signaling inhibits adherens junctional disruption in acute lung injury, Journal of Clinical Investigation, DOI: 10.1172/JCI77701

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January 14, 2015

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2:00 PM | How To Boost The Immune System Of City Dwellers
It's not new that dwellers and cities are a little less hearty than rural cousins. There is even a hygiene hypothesis that says kids in the country get dirtier to their benefit and that wealthy, educated helicopter parenting and all those hand sanitizers and antibacterial soaps are doing more harm than good.Allergies and numerous autoimmune diseases, such as asthma and type 1 diabetes, have become more common in the past 50 years, especially in urban environments. The belief is this is caused […]
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11:01 AM | Targeting HIV vaccines with broader immune responses
If by some marvel of medicine, doctors could instantaneously halt the spread of HIV, about 35 million people would still be infected with the virus. All of them would need expensive antiretroviral treatment for decades. And in that time, millions of children would still be orphaned by AIDS. The sombre fantasy seems even more grimRead More

January 13, 2015

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2:00 PM | Too Little Is Known About Probiotics To Say They Work
We don't actually know whether probiotics have a measurable impact on digestive health - and if it is positive. brownpau/Flickr, CC BY-SABy Paul Bertrand, RMIT University; Andrew Ball, RMIT University, and Kate Polglaze, RMIT University read more

January 12, 2015

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3:21 PM | Carbohydrates not silent to immune system
A systems bio scan of carbohydrate binding by donor antibodies, facilitated by the Emory glycomics team The post Carbohydrates not silent to immune system appeared first on Lab Land.

January 11, 2015

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4:00 PM | The viruses inside us: can endogenous retroviruses elicit antibodies?
January Moonrise © EEGToday I would like to discuss a couple of papers that I used as premise for my new thriller Immunity, which will be part of the Apocalypse Weird series, created by Nick Cole, Michael Bunker and Tim Grahl. Just like all my other thrillers, Immunity too, finds its roots in some fascinating facts about genetics, virology and of course immunity.The premise of the book has to do with something I discussed a long time ago, in one of my very first posts: human […]

Dickerson F, Lillehoj E, Stallings C, Wiley M, Origoni A, Vaughan C, Khushalani S, Sabunciyan S & Yolken R (2012). Antibodies to retroviruses in recent onset psychosis and multi-episode schizophrenia., Schizophrenia research, 138 (2-3) 198-205. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22542615

Yolken R (2004). Viruses and schizophrenia: a focus on herpes simplex virus., Herpes : the journal of the IHMF, 11 Suppl 2 PMID: http://www.ncbi.nlm.nih.gov/pubmed/15319094

Citation
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4:00 PM | The viruses inside us: can endogenous retroviruses elicit antibodies?
January Moonrise © EEGToday I would like to discuss a couple of papers that I used as premise for my new thriller Immunity, which will be part of the Apocalypse Weird series, created by Nick Cole, Michael Bunker and Tim Grahl. Just like all my other thrillers, Immunity too, finds its roots in some fascinating facts about genetics, virology and of course immunity.The premise of the book has to do with something I discussed a long time ago, in one of my very first posts: human […]

Dickerson F, Lillehoj E, Stallings C, Wiley M, Origoni A, Vaughan C, Khushalani S, Sabunciyan S & Yolken R (2012). Antibodies to retroviruses in recent onset psychosis and multi-episode schizophrenia., Schizophrenia research, 138 (2-3) 198-205. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22542615

Yolken R (2004). Viruses and schizophrenia: a focus on herpes simplex virus., Herpes : the journal of the IHMF, 11 Suppl 2 PMID: http://www.ncbi.nlm.nih.gov/pubmed/15319094

Citation

January 10, 2015

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3:00 PM | Fat Cells Under The Skin Help Protect Us From Bacteria
Maybe fat gets a bad rap. Immune responses matter but when it comes to skin infections, those response may depend greatly upon what lies beneath, according to a paper published in Science. Fat cells below the skin help protect us from bacteria, they write.Richard Gallo, MD, PhD, professor and chief of dermatology at UC San Diego School of Medicine, and colleagues have uncovered a previously unknown role for dermal fat cells, known as adipocytes: They produce antimicrobial peptides that help […]

January 09, 2015

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7:00 PM | Teixobactin Antibiotic Kills Pathogens Without Developing Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) infection has gotten a lot of attention. It is caused by a strain of staph bacteria that's become resistant to the antibiotics commonly used to fight it, but antibiotic resistance is not new. For as long as antibiotics have been manufactured (and nature shows evidence of it well before that) resistance evolves.  Science has to stay a step ahead in the interests of public health and a new paper details a newly discovered antibiotic that […]

January 08, 2015

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9:26 PM | Max Cooper celebrated in Nature for 50 yrs of B cells
Studying immune cells in chickens, mice and lampreys The post Max Cooper celebrated in Nature for 50 yrs of B cells appeared first on Lab Land.
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9:26 PM | Max Cooper celebrated in Nature for 50 yrs of B cells
Studying immune cells in chickens, mice and lampreys The post Max Cooper celebrated in Nature for 50 yrs of B cells appeared first on Lab Land.

January 07, 2015

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4:08 PM | The Immunological Role of Fats
A study by scientists from the University of California, San Diego has revealed the immunological properties of fatty tissue. ...
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1:30 PM | Cholera Bacterium Is The Mad Max Of DNA
Cholera is characterized by acute watery diarrhea resulting in severe dehydration and occurs  when the bacterium Vibrio cholerae infects the small intestine. How does it happen? read more

January 06, 2015

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5:08 PM | Two Words Two Definitions: Week One!
This weeks words are from Immunology: Antibacterial Agent, Antibiotic and AntiviralAntibacterial AgentDefinition:1) A synthetic or naturally occurring agent which can kill or inhibit growth of bacterial cells. Antibiotic  Definition: 1) Medicines that are effective against specific types of bacterium2) An antibacterial agent derived from a natural source which can be given in pill, topical and injection form.Types of antibiotics: Streptomycin, Amoxicillin, Penicillin, […]
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4:08 PM | Infections Increase ICU Patient Risk Of Death By 35 Percent
Elderly patients admitted to intensive care units are about 35 percent more likely to die within five years of leaving the hospital if they develop an infection during their stay. The upside to this finding is that preventing two of the most common health care-associated infections - bloodstream infections caused by central lines and pneumonia caused by ventilators - can increase the odds that these patients survive and reduce the cost of their care by more than $150,000, according to a study […]
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12:52 AM | Keep A Cool House, Risk Your Health: Cold Virus Replicates Better In Cool Temps
Folk wisdom has long held that people are more likely to catch a cold in cool-weather or damp conditions but some recent claims have disputed that and found the virus transmits just as often regardless of temperature.  This has been latched onto by people who advocate less energy usage in order to minimize fossil fuel usage. But the rhinovirus, the most frequent cause of the common cold, can reproduce itself more efficiently in the cooler temperatures found inside the […]

January 05, 2015

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11:00 PM | Your Mother Is Right: The Cold Virus Replicates Better In Colder Temperatures
Cold and damp is bad, no matter what you may have heard recently about it making no difference. The common cold virus reproduces itself more efficiently in the cooler temperatures found inside the nose than at core body temperature, confirming the popular-yet-recently-contested notion that people are more likely to catch a cold in cool, damp conditions. Scientifically it is known that the rhinovirus, the  most frequent cause of the common cold, replicates more readily in the slightly […]
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1:11 PM | Noisy networks – The variation in TNF signalling pathway responses
A team of scientists led by systems biologist and biomedical engineer Andre Levchenko from Yale University has developed a novel mechanism for mapping the biochemical variability, or ‘noise’, in how human cells respond to chemical signals. This research could potentially lead to tailored drug delivery to a patient’s individual cell responses and may have implicationsRead More

January 03, 2015

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8:29 PM | SPPL3: This Enzyme Has A Secret Way To Boost The Immune System
The enzyme signal peptide peptidase-like 3 (SPPL3) is known to 'cut' proteins - they cleave the peptide bonds in the polypeptides that make up proteins - but it turns out that it works to activate T-cells, the immune system's foot soldiers - without cutting proteins.  Because its structure is similar to that of presenilin enzymes, which have been implicated in Alzheimer's disease, the researchers believe their findings could shed more light on presenilin functions, in addition to providing […]

January 01, 2015

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7:30 PM | The Ebola Epidemic In West Africa - Maybe It Was Bats
The most recent outbreak of the Ebola virus disease occurring in West Africa may have originated from contact between humans and virus-infected bats, according to a new study in EMBO Molecular Medicine, which identifies insectivorous free-tailed bats as plausible reservoirs and expands the range of possible Ebola virus sources to this type of bats. The virus that spread from Meliandou into other areas of Guinea and Sierra Leone, Liberia, Nigeria and Senegal, represents the largest […]
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2:34 AM | Binge Drinking Disrupts Immune System In Small Study
Binge drinking in young, healthy adults significantly disrupts the immune system, according to a new epidemiology paper.read more

December 31, 2014

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7:00 PM | Remains of long-dead viruses in our genomes aid our immune response
Let B cells respond to pathogens without any help.
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