Posts

March 02, 2015

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9:49 AM | Systemic low grade inflammation and bowel issues in autism?
The paper from Katarina Babinská and colleagues [1] (open-access here) presents an interesting, if preliminary take on two potentially important issues linked to at least some cases of autism: gastrointestinal (GI) issues and inflammation (see here and see here respectively).Detailing the examination of plasma levels of a compound called high mobility group box 1 protein (HMGB1), a protein which has the apparent ability to 'bend DNA' and has some pretty potent immune effects [2] […]

Babinská K, Bucová M, Ďurmanová V, Lakatošová S, Jánošíková D, Bakoš J, Hlavatá A & Ostatníková D (2015). Increased plasma levels of the high mobility group box 1 protein (HMGB1) are associated with a higher score of gastrointestinal dysfunction in individuals with autism., Physiological research / Academia Scientiarum Bohemoslovaca, 63 Suppl 4 8. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25669692

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February 26, 2015

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7:43 AM | Carnitine and autism continued
The paper from everyone's favourite Saudi - Egyptian autism research tag-team that is Gehan Mostafa and Laila AL-Ayadhi [1] (open-access) on plasma polyunsaturated fatty acids and serum carnitine levels in a cohort of children diagnosed with autism / autism spectrum disorder (ASD) is served up for your reading delight today.Regular readers of this blog might have heard me talk before about the pretty interesting research findings to come from this research partnership (see here and see […]

Mostafa, G. & AL-Ayadhi, L. (2015). Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: relation to gastrointestinal manifestations, Behavioral and Brain Functions, 11 (1) DOI: 10.1186/s12993-014-0048-2

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February 25, 2015

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10:31 AM | Analysing the salivary proteome in autism
The paper from Armand Ngounou Wetie and colleagues [1] (open-access here) reporting pilot results from a mass spectrometry based proteomic analysis of saliva in cases of autism or autism spectrum disorder (ASD) compared with asymptomatic controls is served up for your reading delight today. There has already been some media attention about this paper (see here).It's an interesting paper for quite a few reasons; not least the continuing voyage of the analytical technique known as mass […]

Ngounou Wetie AG, Wormwood KL, Russell S, Ryan JP, Darie CC & Woods AG (2015). A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder., Autism research : official journal of the International Society for Autism Research, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25626423

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February 12, 2015

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9:58 AM | 15q11.2 microdeletion, developmental delay and congenital heart disease
"Our results support the hypothesis that 15q11.2 (BP1-BP2) microdeletion is associated with developmental delay, abnormal behaviour, generalized epilepsy and congenital heart disease."So it was written in the paper from Vanlerberghe and colleagues [1] following their analysis of 52 "unrelated patients" diagnosed with 15q11.2 microdeletion, a 'novel' microdeletion syndrome according to other research [2].Your REAL problem's the monkey.Autism spectrum disorder (ASD) is mentioned in the […]

Vanlerberghe C, Petit F, Malan V, Vincent-Delorme C, Bouquillon S, Boute O, Holder-Espinasse M, Delobel B, Duban B, Vallee L & Cuisset JM (2015). 15q11.2 Microdeletion (BP1-BP2) and Developmental delay, Behaviour issues, Epilepsy and Congenital heart disease: a series of 52 patients., European journal of medical genetics, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25596525

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