Posts

September 17, 2014

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2:15 AM | Colon cancer, mathematical time travel, and questioning the sequential mutation model.
On Saturday, I arrived in Columbus, Ohio for the the MBI Workshop on the Ecology and Evolution of Cancer. Today, our second day started. The meeting is an exciting combination of biology-minded mathematicians and computer scientists, and math-friendly biologist and clinicians. As is typical of workshops, the speakers of the first day had an agenda […]

Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SA, Wright NA & Simons BD (2014). Quantification of crypt and stem cell evolution in the normal and neoplastic human colon., Cell reports, 8 (4) 940-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25127143

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September 16, 2014

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4:15 PM | Divide and conquer vs lung cancer
Biomarkers that can predict whether doctors will see a response with common chemotherapy drugs vs lung cancer The post Divide and conquer vs lung cancer appeared first on Lab Land.
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3:12 PM | From the American Association for Cancer Research—what you should know about cancer in 2014
AACR 2014 Progress Report
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3:12 PM | From the American Association for Cancer Research—what you should know about cancer in 2014
AACR 2014 Progress Report

September 15, 2014

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9:41 PM | September 14, 2014: Wiring an African Wilderness, Starting a Garbage-Fueled Country and More
This week on National Geographic Weekend radio, join host Boyd Matson and his guests as they discover a well-dressed Italian mummy, proclaim a nation devoted to garbage, find the perfect island, find new ways to survive cancer, explore the Okavango Delta for science, relate to a solitary blue whale, celebrate the Wilderness Act, and create a canine soup.
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8:01 PM | Humanized FoxP2 and the timing of habits
Last week, Elizabeth Pennisi asked me to comment on the recent paper from Schreiweis et al. entitled “Humanized FoxP2 accelerates learning by enhancing transitions from declarative to procedural performance”. Since I don’t know how much, if anything, of my answers […] ↓ Read the rest of this entry...

Schreiweis, C., Bornschein, U., Burguiere, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C., Puliyadi, R. & Groszer, M. (2014). Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1414542111

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7:24 AM | Medicine past, present, and future: Star Trek versus Dr. Kildare and The Knick
I’ve been a big Star Trek fan ever since I first discovered reruns of the original Star Trek episodes in the 1970s, having been too young (but not by much!) to have caught the show during its original 1966-1969 run. True, my interest waxed and waned through the years—for instance, I loved Star Trek: The […]

September 11, 2014

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8:00 AM | Sometimes the Stars are Not Aligned
I flew down to Anchorage Wednesday morning, after fasting since noon the day before except for a bit of chicken for supper Tuesday and two hard-boiled eggs for breakfast Wednesday. (Very low-carb diest, which I’m not used to bolusing for.) I had an appointment for a PET scan Wednesday noon, confirmed the day before. While […]
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12:29 AM | Evolution’s Surprise Bag: The African Naked Mole Rat
This beauty wouldn’t win any pageants, but it is a fascinating animal.
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12:29 AM | Evolution’s Surprise Bag: The African Naked Mole Rat
This beauty wouldn’t win any pageants, but it is a fascinating animal. The African naked mole rat (Heterocephalus glaber), whose hairless, tubular, wrinkled body makes it appear a bit like a tiny walrus lives in underground burrows in very dry areas of East Africa (Kenya, Ethiopia and Somalia). Neither Mole nor Rat Eduard Rüppell, a German naturalist of the 19th century, who first documented a naked mole rat, assumed from its unprepossessing appearance that it was a diseased or […]

September 10, 2014

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8:26 PM | The Deafening Silence of Ovarian Cancer
It’s called a “silent killer” because it doesn’t announce its presence. There is no chest pain or difficulty breathing like there is with lung cancer. You won’t have mood swings or nausea like you might with brain cancer. The most noticeable early symptoms of ovarian cancer might be as simple...
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3:29 PM | Training Dogs to Sniff Out Cancer
Scientists hope to isolate cancer chemicals that only dogs can smell, leading to the manufacture of nanotechnology sensors that are capable of detecting cancerous tissue.
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1:15 PM | The unsinkable rubber duck of a myth that bras cause breast cancer
Besides being a researcher and prolific blogger, I still maintain a practice in breast cancer surgery. It’s one of the more satisfying specialties in oncology because, in the vast majority of cases I treat, I can actually remove the cancer and “cure” the patient. (I use the quotes because we generally don’t like to use…
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8:11 AM | Asking the right questions
One of the great things about Twitter is that you get to read other peoples’ takes on things. Matthew Hankins, for example, posts people’s interpretations of p-values (under the hashtag #stillnotsignificant), which are more entertaining than you might think. A few weeks ago he posted the conclusion from a paper which read: “we were quite ...read more

September 08, 2014

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10:40 PM | Free HPV vaccine causes 61% drop in female genital warts in Australia
As I’ve written on many occasions, the HPV quadrivalent vaccine is one of the great achievements of medical science. It protects young men and women against the human papillomavirus (HPV), the most common sexually transmitted infection (STI) in the USA. There are over 170 subtypes of HPV; however, HPV subtypes 16 and 18 not only cause approximately 70% of cervical cancers, but they are […]Continue reading «Free HPV vaccine causes […]
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6:56 PM | Two Diseases Can’t Keep ACC Patient off His Bike
Abramson Cancer Center patient Marc Barag started training for the Ride to Conquer Cancer about two years ago—he just didn’t know it. Diagnosed with non-Hodgkin’s lymphoma and enduring 96-hour sessions of chemotherapy, Barag decided to jump on an exercise bike he spotted on the infusion center floor one day to...
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7:00 AM | One more time: No, wearing a bra does not cause breast cancer
Besides being a researcher and prolific blogger, I still maintain a practice in breast cancer surgery. It’s one of the more satisfying specialties in oncology because, in the vast majority of cases I treat, I can actually remove the cancer “cure” the patient. (I use the quotes because we generally don’t like to use that […]

September 07, 2014

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12:30 PM | Starving Cancer Cells to Death
Cancer is basically the inability of the body to control the division of its own cells. This is caused by mutations in the DNA of a cell that causes it to lose its normal identity in a tissue, ignore signals from surrounding cells, and grow abnormally. Normally, a cell has to undergo a regulated series of events before dividing . When something unnatural in the cell is recognized, such as mutations,  a process called apoptosis  causes the cell to undergo programmed cell death allows […]

Changou C.A., L. Xing, Y. Yen, F. Y. S. Chuang, R. H. Cheng, R. J. Bold, D. K. Ann & H.-J. Kung (2014). Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy, Proceedings of the National Academy of Sciences, DOI: http://dx.doi.org/10.1073/pnas.1404171111

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12:30 PM | Starving Cancer Cells to Death
Cancer is basically the inability of the body to control the division of its own cells. This is caused by mutations in the DNA of a cell that causes it to lose its normal identity in a tissue, ignore signals from surrounding cells, and grow abnormally. Normally, a cell has to undergo a regulated series of events before dividing . When something unnatural in the cell is recognized, such as mutations,  a process called apoptosis  causes the cell to undergo programmed cell death allows […]

Changou C.A., L. Xing, Y. Yen, F. Y. S. Chuang, R. H. Cheng, R. J. Bold, D. K. Ann & H.-J. Kung (2014). Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy, Proceedings of the National Academy of Sciences, DOI: http://dx.doi.org/10.1073/pnas.1404171111

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10:00 AM | DNews: New Light Shed on Efficacy of Double Mastectomies
A new study has some surprising findings about the efficacy of a double mastectomy compared to other forms of breast cancer treatment. Tara breaks down the study's results.

September 06, 2014

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8:00 PM | Morsels For The Mind – 05/09/2014
Every day we provide you with Six Incredible Things Before Breakfast to nibble away at. Here you can fill your brain with the most intellectually stimulating “amuse bouches” from the past week – a veritable smorgasbord for the cranium. They’re all here for you to load up your plate – this week’s “Morsels for the mind”. Enjoy! If you do nothing else, make sure to check out the “Reads / views / listens of the week”. **** Feather, fur […]
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8:00 PM | Morsels For The Mind – 05/09/2014
Every day we provide you with Six Incredible Things Before Breakfast to nibble away at. Here you can fill your brain with the most intellectually stimulating “amuse bouches” from the past week – a veritable smorgasbord for the cranium. They’re all here for you to load up your plate – this week’s “Morsels for the mind”. Enjoy! If you do nothing else, make sure to check out the “Reads / views / listens of the week”. **** Feather, fur […]
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12:53 PM | A Suggestion that Wearing a Bra Does Not Cause Cancer
No summary available for this post.

September 05, 2014

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10:07 AM | Why we shouldn't sneer at Ashya King's parents
Andrew Holding: Its easy to dismiss the parents of Ashya King as scientific illiterates in need of a good education, but science engagement that assumes and mocks ignorance is offensive and rarely effective. (Guest Post)The narrative for many skeptics and rationalists is simple. For example; in 2002 two parents in Australia chose to ignore medical recommendations, and continue to treat their daughters eczema with homeopathy. Their decision resulted in her death. It is these kinds of events that […]

September 04, 2014

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11:03 PM | GMO foods cause cancer–pseudoscience says it’s so
Let’s make something clear right here, at the beginning of the article–there is a vast amount of legitimate scientific literature that describes evidence that GMO crops are safe to both human health and the environment. In the world of scientific research, the absolute highest quality evidence are meta reviews, which are methods to contrast and combine results from a […]Continue reading «GMO foods cause cancer–pseudoscience says it's so»
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2:00 PM | Understanding Our Desire to Explore and Invent
Recently we’ve been chatting (via blog posts at least) about a number of, well, less “naturally desirable” character traits and where they might have come from. And why. And how. And what (if anything) we can do to get them to go away. The other morning I was snoozing as usual. The night before I had […]

September 03, 2014

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12:32 PM | US Patent Office approved a cure for cancer
Our tipster received a copy of this U.S. patent and assumed it was a hoax. It’s real, issued last December. What does this say about the competency and purpose of the US Patent Office? Why not just buy a rubber stamp and not bother reading the applications? This kind of stuff is abuse of the system.… Source: Doubtful News

September 02, 2014

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4:52 PM | Epigenetics: Taking Control of the Music
When I try to explain epigenetics to someone, I like to use the musician metaphor. Your genes are the sheet music and how your body reads those genes, that is your […]

Müller-Ott K, Erdel F, Matveeva A, Mallm JP, Rademacher A, Hahn M, Bauer C, Zhang Q, Kaltofen S, Schotta G & Höfer T (2014). Specificity, propagation, and memory of pericentric heterochromatin., Molecular systems biology, 10 (8) 746. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25134515

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2:06 PM | Russians Love Their Varmints, Too
By Jason Bittel The first morning after a long weekend is never easy, but things could be worse: you could be stuck in a hole in the middle of the road like this prairie dog in Russia. Perhaps the rodent ate one too many pirozhkis this summer, or maybe a passing car collapsed the burrow, trapping the little p-dog. Either way, two tourists came to the rescue! On this side of the world, prairie dogs could use some help, too. Thanks to habitat destruction and […]

September 01, 2014

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6:12 PM | Assemblages: 50 Years Later, We Know Nothing About Them
You would think we learn about every part of a cell in biology, but we really don’t. Case in point, about 50 years ago, electron microscopy revealed the presence of […]

Toretsky, J. & Wright, P. (2014). Assemblages: Functional units formed by cellular phase separation, The Journal of Cell Biology, 206 (5) 579-588. DOI: 10.1083/jcb.201404124

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