Posts

March 06, 2015

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2:15 PM | Alternative cancer therapies: The quest for certainty
“I don’t want knowledge. I want certainty!” –David Bowie, from Law (Earthlings on Fire) I know I’ve already said this once, but I have to say it again, but it’s been a rather stressful week on the old blog, but I hadn’t planned on writing about this particular topic again (although I will say that…
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2:15 PM | Alternative cancer therapies: The quest for certainty
“I don’t want knowledge. I want certainty!” –David Bowie, from Law (Earthlings on Fire) I know I’ve already said this once, but I have to say it again, but it’s been a rather stressful week on the old blog, but I hadn’t planned on writing about this particular topic again (although I will say that…
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1:35 PM | The data junkie and the lamp post: Cancer, genomics and technological solutionism
The Cancer Genome AtlasThe other day I was having a nice discussion with a very knowledgable colleague about advances in genomic sequencing and how they are poised to transform the way we acquire and process genetic information in biology, biochemistry and medicine. The specific topic under consideration was the bevy of sequencing companies who are showcasing their wares at the Advances in Genome Biology and Technology 2015 conference. Many companies like Solexa and Oxford Nanopore are in an […]

March 05, 2015

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9:00 AM | Biobank Ireland Trust: Getting Started and Continuing On
The Biobank Ireland Trust (BIT) was first established in 2004 and eventually started running four years later, with two hospital biobanks under its administration.1 The trust got its first funding not from government sources, but from a commercial grant; the Vodafone Ireland Foundation’s “World of Difference” award enabled implementation of the first BIT biobank. Authors Mee et Read the rest of this article The post Biobank Ireland Trust: Getting Started and […]
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6:00 AM | Florida tells Brian Clement to stop practicing medicine
  The State of Florida has finally taken action against Brian Clement. David Gorski, Orac and the Canadian media, especially the Canadian Broadcasting Corporation (CBC), have done an excellent job of chronicling “Dr.” Clements. All have reported on Florida’s taking action against Clement. I’ll give a brief background here, most of which comes from Dr. […]

March 04, 2015

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5:01 PM | Why media coverage of alternative cancer cures is dangerous
A Mirror Online report on a breast cancer patient who refused medical treatment for so-called natural alternatives ignores the health risksLast week the Mirror Online reported on the story of Kelly Logan – a 34-year old breast cancer patient who has refused the surgery and chemotherapy her doctors advised, electing instead to try and treat her condition with an intense regime of raw food and supplements.While nobody would dispute Logan’s right to make her own choices about her body, […]
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2:44 PM | Early diagnosis of cancer: advances and new evidence
CCHSR researchers have been busy with a number of new analyses on the early diagnosis of cancer, including the potential impact of delayed diagnosis on survival. Gary Abel summarises our collection of five new papers here
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1:30 PM | Alternative oncology versus oncology
I hadn’t planned on discussing the death of Jess Ainscough again, figuring two posts in a row were enough for now, barring new information. Besides, I was getting a little tired of the seemingly unending stream of her fans castigating me for being “insensitive” and saying it was “too soon” to discuss her death and…
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1:30 PM | Alternative oncology versus oncology
I hadn’t planned on discussing the death of Jess Ainscough again, figuring two posts in a row were enough for now, barring new information. Besides, I was getting a little tired of the seemingly unending stream of her fans castigating me for being “insensitive” and saying it was “too soon” to discuss her death and…

March 02, 2015

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5:18 PM | Eliminating colorectal cancer as a major public health problem
The University of Chicago Medicine Comprehensive Cancer Center is working closely with the surrounding community to increase colorectal cancer screening rates to 80% by 2018.
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2:52 PM | Extinction Edge: a new thriller on how epigenetic changes induced by viruses could kill us all
Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are […]

Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U & Scott RS (2014). Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes., Journal of virology, 88 (19) 11442-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25056883

Tian Y, Yang W, Song J, Wu Y & Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis., Molecular and cellular biology, 33 (15) 2810-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23716588

Rongrui L, Na H, Zongfang L, Fanpu J & Shiwen J (2014). Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis., Current pharmaceutical design, 20 (11) 1715-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23888939

Mbonye U & Karn J (2011). Control of HIV latency by epigenetic and non-epigenetic mechanisms., Current HIV research, 9 (8) 554-67. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22211660

Citation
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2:52 PM | Extinction Edge: a new thriller on how epigenetic changes induced by viruses could kill us all
Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are […]

Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U & Scott RS (2014). Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes., Journal of virology, 88 (19) 11442-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25056883

Tian Y, Yang W, Song J, Wu Y & Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis., Molecular and cellular biology, 33 (15) 2810-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23716588

Rongrui L, Na H, Zongfang L, Fanpu J & Shiwen J (2014). Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis., Current pharmaceutical design, 20 (11) 1715-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23888939

Mbonye U & Karn J (2011). Control of HIV latency by epigenetic and non-epigenetic mechanisms., Current HIV research, 9 (8) 554-67. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22211660

Citation
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2:52 PM | Extinction Edge: a new thriller on how epigenetic changes induced by viruses could kill us all
Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are […]

Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U & Scott RS (2014). Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes., Journal of virology, 88 (19) 11442-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25056883

Tian Y, Yang W, Song J, Wu Y & Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis., Molecular and cellular biology, 33 (15) 2810-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23716588

Rongrui L, Na H, Zongfang L, Fanpu J & Shiwen J (2014). Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis., Current pharmaceutical design, 20 (11) 1715-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23888939

Mbonye U & Karn J (2011). Control of HIV latency by epigenetic and non-epigenetic mechanisms., Current HIV research, 9 (8) 554-67. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22211660

Citation
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2:52 PM | Extinction Edge: a new thriller on how epigenetic changes induced by viruses could kill us all
Today my friend Nicholas Sansbury Smith releases Extinction Edge, the sequel to Extinction Horizon, a sci-fi thriller where humanity is driven to extinction by a lethal virus. I posted an interview with Nick for the release of his first book, but today I wanted to talk about the science behind his premise: can a virus induce epigenetic changes?In a way, Nick's premise is similar to the premise I used in Chimeras: a large part of our DNA is made of pseudogenes, which are ancient genes that are […]

Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U & Scott RS (2014). Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes., Journal of virology, 88 (19) 11442-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25056883

Tian Y, Yang W, Song J, Wu Y & Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis., Molecular and cellular biology, 33 (15) 2810-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23716588

Rongrui L, Na H, Zongfang L, Fanpu J & Shiwen J (2014). Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis., Current pharmaceutical design, 20 (11) 1715-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23888939

Mbonye U & Karn J (2011). Control of HIV latency by epigenetic and non-epigenetic mechanisms., Current HIV research, 9 (8) 554-67. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22211660

Citation
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11:00 AM | Aftermath: Will the “alternative health movement” learn anything from Jess Ainscough’s death?
It’s been a rather…interesting…weekend. Friday, I noted the death of Jess Ainscough, a.k.a. “The Wellness Warrior,” a young Australian woman who was unfortunate enough to develop epithelioid sarcoma, a rare cancer, at the age of 22. I’ve been blogging about her because after her doctors tried isolated limb perfusion with chemotherapy in an attempt to…
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11:00 AM | Aftermath: Will the “alternative health movement” learn anything from Jess Ainscough’s death?
It’s been a rather…interesting…weekend. Friday, I noted the death of Jess Ainscough, a.k.a. “The Wellness Warrior,” a young Australian woman who was unfortunate enough to develop epithelioid sarcoma, a rare cancer, at the age of 22. I’ve been blogging about her because after her doctors tried isolated limb perfusion with chemotherapy in an attempt to…
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5:01 AM | The Gerson protocol, cancer, and the death of Jess Ainscough, a.k.a. “The Wellness Warrior”
Less than four days ago, a young Australian woman died of a very rare type of cancer. Most of my American and probably many of my European readers have never heard of her, but in Australia she had become quite famous over the last seven years as a major proponent of “natural health.” Her name […]

February 28, 2015

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11:08 PM | Heady suggestions
Assertions by the Italian neuroscientist, Sergio Canavero of the Turin Advanced Neuromodulation Group, have caught the media’s attention this past week. In fact, head transplants were first proposed by him in 2013, as a means to “extend the lives of people whose muscles and nerves have degenerated or whose organs are riddled with cancer”. Canavero […]

February 27, 2015

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12:23 PM | DNews: A New Reason Why Soda Could Mess with Your Health
Everybody knows soda isn't exactly at the tip-top of a healthy diet, and now a new study finds a particular ingredient in the fizzy drinks has generated evidence of tumors in mice! Is it safe to have our pop?
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11:35 AM | The Wellness Warrior, Jess Ainscough, has passed away
Two months ago, I took note of a somewhat cryptic blog post by a young woman named Jess Ainscough. In Australia and much of the world, Ainscough was known as the Wellness Warrior. She was a young woman who developed an epithelioid sarcoma in 2008 and ended up choosing “natural healing” to treat her cancer.…
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11:35 AM | The Wellness Warrior, Jess Ainscough, has passed away
Two months ago, I took note of a somewhat cryptic blog post by a young woman named Jess Ainscough. In Australia and much of the world, Ainscough was known as the Wellness Warrior. She was a young woman who developed an epithelioid sarcoma in 2008 and ended up choosing “natural healing” to treat her cancer.…

February 26, 2015

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10:00 AM | Digesting yeast's message
A new paper in Nature by Levy et al. reports on the genomic consequences of large-scale selection experiments in yeast.  Yeast reproduce asexually and clones can be labeled with DNA 'barcode' tags and followed in terms of their relative frequency in a colony over time.  This study was able to deal with very large numbers of yeast cells and because they used barcodes the investigators could practicably follow individual clones without needing to do large-scale genome sequencing. […]
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4:45 AM | Operationalizing replicator dynamics and partitioning fitness functions
As you know, dear regular reader, I have a rather uneasy relationship with reductionism, especially when doing mathematical modeling in biology. In mathematical oncology, for example, it seems that there is a hope that through our models we can bring a more rigorous mechanistic understanding of cancer, but at the same time there is the […]

Archetti, M., Ferraro, D.A. & Christofori, G. (2015). Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer., Proceedings of the National Academy of Sciences of the United States of America, 112 (6) 1833-8. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25624490

Citation
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4:45 AM | Operationalizing replicator dynamics and partitioning fitness functions
As you know, dear regular reader, I have a rather uneasy relationship with reductionism, especially when doing mathematical modeling in biology. In mathematical oncology, for example, it seems that there is a hope that through our models we can bring a more rigorous mechanistic understanding of cancer, but at the same time there is the […]

Archetti, M., Ferraro, D.A. & Christofori, G. (2015). Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer., Proceedings of the National Academy of Sciences of the United States of America, 112 (6) 1833-8. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25624490

Citation

February 25, 2015

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12:12 PM | Graphene Oxide Neutralizes Cancer Stem Cells
ByThe Toombst A “super” material might be useful in other areas than engineering or electronics. New research finds that graphene oxide neutralizes cancer stem cells. Cancer stem cells, CSCs, are the horrifying equivalent to “normal” stem cells. These cancer cells have the ability to form many different types of cancers. The CSCs can survive anti-cancer treatments causing a relapse of cancer or form metastases that spreads malignant cells to other parts of the body. […]
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11:00 AM | Finally, the State of Florida acts against Brian Clement and the Hippocrates Health Institute
Every so often, it’s good to post some heartening news regarding quackery. After all, after a decade of blogging about this, preceded by five years in the trenches of Usenet battling quackery and Holocaust denial, sometimes it’s hard for me not to become depressed. After all, there are times when it really does feel as…
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11:00 AM | Finally, the State of Florida acts against Brian Clement and the Hippocrates Health Institute
Every so often, it’s good to post some heartening news regarding quackery. After all, after a decade of blogging about this, preceded by five years in the trenches of Usenet battling quackery and Holocaust denial, sometimes it’s hard for me not to become depressed. After all, there are times when it really does feel as…

February 24, 2015

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8:45 PM | Designing a better clinical trial to sort out complex tumors
Oncologist Daniel Catenacci designed a "supercontinent" of clinical trials to find the best treatments for patients with esophageal and gastric cancers.
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11:58 AM | Dr. Agnes A. Day...
Image Source: History Makers [link below]Topics: Biology, Breast Cancer, Microbiology, Research, STEMMicrobiologist Agnes A. Day was born on July 20, 1952 in Plains, Georgia to Annie Lee Laster and David Laster. The youngest of thirteen children, Day was raised by her third-grade teacher, Reverend Mrs. Rose Marie Bryon. Day’s interest in science began when she and her older brother would walk through the woods catching insects and animals. After graduating from Mainland Sr. High School, […]

February 23, 2015

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7:50 PM | New treatments are reducing the risk of second cancers for Hodgkin’s survivors
Hodgkin’s lymphoma has become one of the success stories of cancer treatment, and a new study shows signs that new treatments are limiting the risk of survivors developing second cancers down the road.
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