Posts

January 16, 2015

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4:57 AM | Q: How has our knowledge of gene regulation in osteoblasts aided...
Q: How has our knowledge of gene regulation in osteoblasts aided our understanding of breast cancer metastasis? Above: mammosphere shown in consecutive confocal sections, immunostained with antibodies against Orai1 (red) and SPCA2 (green), with DAPI stain of nuclei (blue). Video S3, Cross et al. 2013 In a little under a fortnight, breast cancer cells in three-dimensional media form stellate (star-like) structures. The metastatic cells break out of their regimented order, in what’s known […]
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4:06 AM | Q: With reference to experimental data, discuss the role of the...
Q: With reference to experimental data, discuss the role of the transcription factor complex Runx2/CBFβ in the bone and breast. In spreading from the breast to the bone (which ~70% of breast cancers will do), the phenotypic change seen is induced by transcription factors: transcription being the primary mechanism for regulating gene expression. Although perhaps wholly counterintuitive for a breast cell to migrate to compartments of bone, the transcription factor profile ‘switched […]

January 14, 2015

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4:30 PM | DNA methylome profiling beyond promoters: taking an epigenetic snapshot of the breast tumor microenvironment
Aside from tumorigenic cells, which have been the primary research target in the past decades, breast and other tumors contain various other cell populations (immune cells, fibroblasts, adipocytes, endothelial cells), which are referred to as the tumor microenvironment (TME). The TME is an active component of breast cancer disease and ... The post DNA methylome profiling beyond promoters: taking an epigenetic snapshot of the breast tumor microenvironment appeared first on EpiBeat.

January 13, 2015

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6:39 PM | Breast cancer, race and risk
Despite a new study citing biological explanations for racial and ethnic breast cancer disparities, UChicago's Olufunmilayo Olopade says that biology cannot be viewed as the only factor in the survival gap.
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