Posts

October 02, 2014

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12:03 PM | Coeliac disease risk not affected by early feeding practices
I'd like to bring three papers to your attention, all united by their discussion of coeliac (celiac) disease, that most classic of autoimmune conditions in the most part managed by the use of a lifelong gluten-free diet.First up are the papers by Elena Lionetti and colleagues [1] and Sabine Vriezinga and colleagues [2] which unfortunately pour cold water on the notion that the risk of developing coeliac disease (CD) can be somehow mitigated via the use of either the early or delayed […]

Lionetti E, Castellaneta S, Francavilla R, Pulvirenti A, Tonutti E, Amarri S, Barbato M, Barbera C, Barera G, Bellantoni A & Castellano E (2014). Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children., The New England journal of medicine, 371 (14) 1295-1303. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25271602

Vriezinga SL, Auricchio R, Bravi E, Castillejo G, Chmielewska A, Crespo Escobar P, Kolaček S, Koletzko S, Korponay-Szabo IR, Mummert E & Polanco I (2014). Randomized Feeding Intervention in Infants at High Risk for Celiac Disease., The New England journal of medicine, 371 (14) 1304-1315. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25271603

Elfström P, Sundström J & Ludvigsson JF (2014). Systematic review with meta-analysis: associations between coeliac disease and type 1 diabetes., Alimentary pharmacology & therapeutics, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25270960

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September 30, 2014

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9:06 AM | Autoimmune thyroiditis and depressive disorder
"Our study demonstrates a strong association between anti-TPO levels, which are considered to be of diagnostic value for autoimmune thyroiditis... with uni- or bipolar depression.""Beware the bad cat bearing a grudge"So said the study published by Detlef Degner and colleagues [1]. Anti-TPO antibodies by the way, refers to anti-thyroid peroxidase antibodies which, as the name suggests, are antibodies against thyroid peroxidase, an important step in the production of thyroid […]

Degner D, Haust M, Meller J, Rüther E & Reulbach U (2014). Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients., European archives of psychiatry and clinical neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25193677

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September 25, 2014

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2:37 PM | A New Discovery in the Treatment of Autoimmunity and Chronic Inflammation
Lupus, Type 1 diabetes, and multiple sclerosis are all diseases brought on by autoimmunity — the bodies inability to tell itself apart from foreign invaders. Finding a cure, or even a suitable […]

Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RM & Groll M (2014). Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site., Angewandte Chemie (International ed. in English), PMID: http://www.ncbi.nlm.nih.gov/pubmed/25244435

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