Posts

March 05, 2015

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7:18 PM | Not “just” crazy – Some psychoses caused by autoimmunity
Antibodies defend the body against bacterial, viral, and other invaders. But sometimes the body makes antibodies that attack healthy cells. In these cases, autoimmune disorders develop. Immune abnormalities in patients with psychosis have been recognized for over a century, but it has been only relatively recently that scientists have identified specific immune mechanisms that seem to […]
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March 04, 2015

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9:41 AM | Asthma and autism: a spanner in the works?
As happens so many times in autism research, spanners are thrown in works. Take the paper from Ousseny Zerbo and colleagues [1] who concluded that: "children with autism have elevated prevalence of specific immune-related comorbidities". Nothing surprising about that finding based on the volumes of other research which seemed to have reached similar conclusions (see here).Then the spanner: "asthma was diagnosed significantly less often" in autism cases compared with asymptomatic controls. […]

Zerbo O, Leong A, Barcellos L, Bernal P, Fireman B & Croen LA (2015). Immune Mediated Conditions in Autism Spectrum Disorders., Brain, behavior, and immunity, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25681541

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March 01, 2015

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8:52 AM | Vitamin D status affecting autoimmune disease risk?
I want to bring the paper from Tea Skaaby and colleagues [1] to your attention for today's brief blog post and their observation that there may be: "a possible protective role of a higher vitamin D status on autoimmune disease". Autoimmune disease by the way, reflects a breakdown in communication and tolerance of 'self' whereby the body attacks healthy tissue.Their findings, based on an analysis of "a total of 12,555 individuals from three population-based studies with measurements of […]

Skaaby T, Husemoen LL, Thuesen BH & Linneberg A (2015). Prospective population-based study of the association between vitamin D status and incidence of autoimmune disease., Endocrine, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25666936

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February 27, 2015

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10:23 PM | New compounds protect nerves from the damage of MS
Autoimmune diseases are tough to live with, frankly we don’t really understand the reasons they start at all, how to treat them, or even where to start in forming a cure. Well there might be some good news — as far as a treatment goes anyway — a newly characterized group of pharmacological compounds block […]

Haines, J., Herbin, O., de la Hera, B., Vidaurre, O., Moy, G., Sun, Q., Fung, H., Albrecht, S., Alexandropoulos, K., McCauley, D. & Chook, Y. (2015). Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination, Nature Neuroscience, DOI: 10.1038/nn.3953

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February 21, 2015

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10:39 AM | Coeliac disease: genes, autoimmunity, gut bacteria and bafflement?
Some things in life really do baffle me. When it comes to this blog, nothing seems to baffle me more than some of the talk about the triad that is autoimmunity, coeliac disease and gluten (see here for an example).My bafflement continued upon reading the papers by Emilsson and colleagues [1] and by Olivares and colleagues [2]. Respectively suggesting that: "spouses of individuals with celiac disease are at increased risk of non-celiac autoimmune disease" and "a specific disease-biased host […]

Emilsson L, Wijmenga C, Murray JA & Ludvigsson JF (2015). Autoimmune Disease in First-degree Relatives and Spouses of Individuals with Celiac Disease., Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25645875

Olivares M, Neef A, Castillejo G, Palma GD, Varea V, Capilla A, Palau F, Nova E, Marcos A, Polanco I & Ribes-Koninckx C (2014). The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease., Gut, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24939571

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February 13, 2015

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3:28 PM | Immune ‘traffic jam’ from viral infection
Immune complexes formed during an active infection can clog the receptors needed for therapeutic antibodies to work The post Immune ‘traffic jam’ from viral infection appeared first on Lab Land.

February 10, 2015

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6:06 PM | Seafood associated with autoimmune disease
Autoimmunity is one of those great mysteries of the human body. We still aren’t sure what causes it and treating it can be painfully ineffective. Unfortunately my sister knows that one first hand, so here at the labs autoimmunity is a problem close to our heart. While we may not know what causes autoimmunity, a […]

Somers, E., Ganser, M., Warren, J., Basu, N., Wang, L., Zick, S. & Park, S. (2015). Mercury Exposure and Antinuclear Antibodies among Females of Reproductive Age in the United States, Environmental Health Perspectives, DOI: 10.1289/ehp.1408751

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