Posts

October 21, 2014

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9:39 PM | PPE for Ebola: This is how Emory does it
Remember how I said my lab wanted to do a PPE response video to Sanjay Guptas terrifying attempt? But we couldnt for liability reasons? Now there is an even better option! We can all take a peek into how Ebola patients are treated at Emory University, and get to see their protocols for putting on/taking off PPE:…
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8:05 PM | You Should Get a Flu Shot One of the arguments you hear most...
You Should Get a Flu Shot One of the arguments you hear most often by people who don’t want to get immunized against influenza is that the flu just isn’t a big deal; it’s just a bad cold. It’s not. There are lots of other things people often get wrong about flu shots, too. For those of you who want references or more information, go here: http://theincidentaleconomist.com/wordpress/?p=58721 By: Healthcare Triage.
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6:27 PM | Walrus Flash Mob & 20 Years of Pot Research scishow: 35,000...
Walrus Flash Mob & 20 Years of Pot Research scishow: 35,000 walruses all hanging out at the same beach in Alaska? Why? Does global warming have anything to do with it? And what have we learned after 20 years of studying the effects of marijuana? SciShow News explains. Support on Subbable: https://subbable.com/scishow
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5:57 PM | Paralyzed patient regains partial movement due to olfactory nerve cells
Polish team has stabbing victim upright with walker and braces.
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4:59 PM | Stem cell treatment of spinal cord injuries
I have to admit that my first response to these reports out of Britain that stem cells had been successfully used to repair a complete spinal cord transection was skepticism — incredulity even. They’re reporting that a man with a completely severed spinal cord at level T10-T11 is able to walk again! The Guardian gushes!…
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2:20 PM | Explainer: Where Is It Legal to End Your Own Life?
In some parts of the world, it is legal for people to voluntarily end their lives with help of their doctors. It is so common in one country, in fact, they even have a booming business in suicide tourism.
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8:53 AM | Antibiotics and childhood obesity: a weighty correlation
It's been a few weeks since the publication of the paper by L. Charles Bailey and colleagues [1] correlating early multiple exposure to broad spectrum antibiotics with obesity in infancy. On purpose I've left it a while before talking about this research so as to let the scientific dust settle a little and get a flavour for some of the discussions about this research (see here and see here).You're a true vulgarian, aren't you?A few details about the Bailey study first:Looking at the […]

Bailey LC, Forrest CB, Zhang P, Richards TM, Livshits A & DeRusso PA (2014). Association of Antibiotics in Infancy With Early Childhood Obesity., JAMA pediatrics, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25265089

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October 20, 2014

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4:08 PM | Through the Eyes of the Locals
Lost in the middle of a storm, Sadia and Andrew trek up the mountains to find a remote village in authentic Laos.
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2:56 PM | Persistent Insomnia and Alcoholism
Sleep problems complicate the treatment and recovery in alcoholism. Heavy alcohol consumption modifies the nature of sleep architecture.A high blood alcohol concentration at bedtime may promote sleep early in the sleep cycle.However, as alcohol levels decline, sleep is often interrupted with limiting rapid eye movement (REM) sleep duration.Shortened total sleep time with alcohol can produce a lack of feeling well rested on awakening.For those with alcoholism or alcohol dependence, […]

Brower KJ, Krentzman A & Robinson EA (2011). Persistent insomnia, abstinence, and moderate drinking in alcohol-dependent individuals., The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions, 20 (5) 435-40. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21838842

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9:00 AM | 'Obstetric dilemma' skeptic has c-section and remains skeptical ... & ... Why my c-section was natural childbirth
This is a new kind of Tale for me. The rock'n'roll's turned way up, and every couple sentences I have to stop typing to twirl a blue hound dog, a bear holding an umbrella, a Flying Spaghetti Monster, and other oddities that I strung up to hypnotize this little guy into letting me type one thought at a time:The thing that needs to be hypnotized.Or the three wise monkeys say: The thing that makes it impossible to create or to dwell on the negative. (e.g. his birth by c-section)That young […]
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8:36 AM | Reasons for visiting ER by those with autism
ER - Emergency Room - or as we call it here in Blighty Accident & Emergency (A & E), is never a particularly desirable place to visit given the emphasis on illness or injury of yourself or loved one. That being said, staff there do a sterling job sometimes under very stressful circumstances, responding to all-manner of complaints, some of which are life-threatening.The paper by Dorothea Iannuzzi and colleagues [1] sought to identify some of the medical reasons why ER […]

Iannuzzi DA, Cheng ER, Broder-Fingert S & Bauman ML (2014). Brief Report: Emergency Department Utilization by Individuals with Autism., Journal of autism and developmental disorders, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25261249

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7:05 AM | An old “friend” thinks Ayurvedic “auto-urine therapy” can cure Ebola
I’m beginning to feel that I’m flogging a topic a bit too hard again. Usually, this happens primarily when I’m on a roll over some particularly tasty ridiculous tidbit of antivaccine nonsense. This time around, it’s not so much antivaccine nonsense (although some did manage to slip its way into the discussion) but rather Ebola…

October 19, 2014

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5:43 PM | DNA Nanotech: The First Large DNA Crystals
DNA is the stuff of life as we know it, but it is the potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, […]

Ke, Y., Ong, L., Sun, W., Song, J., Dong, M., Shih, W. & Yin, P. (2014). DNA brick crystals with prescribed depths, Nature Chemistry, DOI: 10.1038/nchem.2083

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5:43 PM | DNA Nanotech: The First Large DNA Crystals
DNA is the stuff of life as we know it, but it is the potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, […]

Ke, Y., Ong, L., Sun, W., Song, J., Dong, M., Shih, W. & Yin, P. (2014). DNA brick crystals with prescribed depths, Nature Chemistry, DOI: 10.1038/nchem.2083

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5:43 PM | DNA Nanotech: The First Large DNA Crystals
DNA is the stuff of life as we know it, but it is the potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, […]

Ke, Y., Ong, L., Sun, W., Song, J., Dong, M., Shih, W. & Yin, P. (2014). DNA brick crystals with prescribed depths, Nature Chemistry, DOI: 10.1038/nchem.2083

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5:43 PM | DNA Nanotech: The First Large DNA Crystals
DNA is the stuff of life as we know it, but it is the potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, […]

Ke, Y., Ong, L., Sun, W., Song, J., Dong, M., Shih, W. & Yin, P. (2014). DNA brick crystals with prescribed depths, Nature Chemistry, DOI: 10.1038/nchem.2083

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3:00 PM | Ten years into the making, the HIV-1 mosaic vaccine finally goes into human trial
© Bette Korber et al. I hope you will all forgive me if this week I'm gushing over my amazing mentor Bette Korber, as last week she shared some awesome news on Facebook:"A landmark in my life happened yesterday, a major step in a long story. A decade ago I had an idea for making an HIV vaccine that had the potential to work globally. After a struggle (in my first 2 failed proposals, reviewers declared what I proposed was impossible), I got an internal grant from Los Alamos to develop the […]

Fischer W, Perkins S, Theiler J, Bhattacharya T, Yusim K, Funkhouser R, Kuiken C, Haynes B, Letvin NL, Walker BD & Hahn BH (2007). Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants., Nature medicine, 13 (1) 100-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17187074

Nkolola JP, Bricault CA, Cheung A, Shields J, Perry J, Kovacs JM, Giorgi E, van Winsen M, Apetri A, Brinkman-van der Linden EC & Chen B (2014). Characterization and immunogenicity of a novel mosaic M HIV-1 gp140 trimer., Journal of virology, 88 (17) 9538-52. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24965452

Barouch DH, Stephenson KE, Borducchi EN, Smith K, Stanley K, McNally AG, Liu J, Abbink P, Maxfield LF, Seaman MS & Dugast AS (2013). Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys., Cell, 155 (3) 531-9. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24243013

Santra S, Muldoon M, Watson S, Buzby A, Balachandran H, Carlson KR, Mach L, Kong WP, McKee K, Yang ZY & Rao SS (2012). Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens., Virology, 428 (2) 121-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22521913

Barouch DH, O'Brien KL, Simmons NL, King SL, Abbink P, Maxfield LF, Sun YH, La Porte A, Riggs AM, Lynch DM & Clark SL (2010). Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys., Nature medicine, 16 (3) 319-23. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20173752

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11:18 AM | This Week in Chemistry: Improving Autism Symptoms, & Making Batteries Safer
It’s been another bumper week in the world of chemistry research, with a range of stories to choose from for this week’s graphic. Highlights include the discovery that a compound found in broccoli could help improve behaviour in autism, and a new detection method for metal contamination in water using DNA. As always, links to studies […]

October 18, 2014

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7:39 PM | Morsels For The Mind – 17/10/2014
Every day we provide you with Six Incredible Things Before Breakfast to nibble away at. Here you can fill your brain with the most intellectually stimulating “amuse bouches” from the past week – a veritable smorgasbord for the cranium. They’re all here for you to load up your plate – this week’s “Morsels for the mind”. Enjoy! If you do nothing else, make sure to check out the “Reads / views / listens of the week”. **** Feather, fur […]
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7:39 PM | Morsels For The Mind – 17/10/2014
Every day we provide you with Six Incredible Things Before Breakfast to nibble away at. Here you can fill your brain with the most intellectually stimulating “amuse bouches” from the past week – a veritable smorgasbord for the cranium. They’re all here for you to load up your plate – this week’s “Morsels for the mind”. Enjoy! If you do nothing else, make sure to check out the “Reads / views / listens of the week”. **** Feather, fur […]
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6:55 PM | New Genetic Test to help Solve Rare Disease Diagnosis
My sister suffers from a rare disease which causes small fiber polyneuropathy, or the killing of nerves in her hands and feet. As it progresses she has trouble standing or […]

Lee, H., Deignan, J., Dorrani, N., Strom, S., Kantarci, S., Quintero-Rivera, F., Das, K., Toy, T., Harry, B., Yourshaw, M. & Fox, M. (2014). Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders, JAMA, DOI: 10.1001/jama.2014.14604

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6:55 PM | New Genetic Test to help Solve Rare Disease Diagnosis
My sister suffers from a rare disease which causes small fiber polyneuropathy, or the killing of nerves in her hands and feet. As it progresses she has trouble standing or […]

Lee, H., Deignan, J., Dorrani, N., Strom, S., Kantarci, S., Quintero-Rivera, F., Das, K., Toy, T., Harry, B., Yourshaw, M. & Fox, M. (2014). Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders, JAMA, DOI: 10.1001/jama.2014.14604

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6:55 PM | New Genetic Test to help Solve Rare Disease Diagnosis
My sister suffers from a rare disease which causes small fiber polyneuropathy, or the killing of nerves in her hands and feet. As it progresses she has trouble standing or […]

Lee, H., Deignan, J., Dorrani, N., Strom, S., Kantarci, S., Quintero-Rivera, F., Das, K., Toy, T., Harry, B., Yourshaw, M. & Fox, M. (2014). Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders, JAMA, DOI: 10.1001/jama.2014.14604

Citation
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6:55 PM | New Genetic Test to help Solve Rare Disease Diagnosis
My sister suffers from a rare disease which causes small fiber polyneuropathy, or the killing of nerves in her hands and feet. As it progresses she has trouble standing or […]

Lee, H., Deignan, J., Dorrani, N., Strom, S., Kantarci, S., Quintero-Rivera, F., Das, K., Toy, T., Harry, B., Yourshaw, M. & Fox, M. (2014). Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders, JAMA, DOI: 10.1001/jama.2014.14604

Citation
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6:55 PM | New Genetic Test to help Solve Rare Disease Diagnosis
My sister suffers from a rare disease which causes small fiber polyneuropathy, or the killing of nerves in her hands and feet. As it progresses she has trouble standing or […]

Lee, H., Deignan, J., Dorrani, N., Strom, S., Kantarci, S., Quintero-Rivera, F., Das, K., Toy, T., Harry, B., Yourshaw, M. & Fox, M. (2014). Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders, JAMA, DOI: 10.1001/jama.2014.14604

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6:55 PM | Scientists Just Built A Robot That Performs Brain Surgery Through Your Cheek
3-D printing, robotics and other technological advances have been revolutionizing the field of medicine in the past few years. From 3-D printed prosthetics for amputee victims to the bionic pancreas, there is no denying that modern medicine owes many of its recent advances to technology. Now, researchers from Vanderbilt University have designed a robot that can perform brain surgery on people suffering from conditions that affect the hippocampus, a region of the […]
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5:38 PM | PCOS by tumblingdoe: PCOS is the most requested topic for...
PCOS by tumblingdoe: PCOS is the most requested topic for Sexplanations to cover. This episode doesn’t cover everything there is to know about the disorder but it gives the curios a great start. At the end of the video I suggest dressing as a vulva for Halloween. All it takes it a hoodie. You can find the original outfit I wore in the the Vulva video on eBay if you’d like to bid on it and simultaneously raise awareness and support for PCOS research. Here’s a link: […]
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9:30 AM | More epigenetics, EN-2 and autism... the plot thickens
I don't mind admitting that I was to some extent 'winging it' with my previous post on epigenetics and Engrailed-2 (EN-2) as a consequence of the findings reported by Jill James and colleagues [1] with autism in mind. Although an avid follower of the science of epigenetics when (cautiously) applied to autism, I am by no means any authority on the subject matter particularly when it comes to the nitty-gritty details. You can probably therefore expect similar things in my latest […]

James SJ, Shpyleva S, Melnyk S, Pavliv O & Pogribny IP (2014). Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum., Translational psychiatry, 4 PMID: http://www.ncbi.nlm.nih.gov/pubmed/25290267

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October 17, 2014

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11:30 PM | Your Weight Doesn't Just Depend on What You Eat, But When You Eat It
We all know that diet can dramatically affect our health, both mentally and physically. But a new study shows that an off-kilter eating schedule could also affect well-being, too. Here's why.Read more...
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9:51 PM | Life, um, finds a way—except when it doesn’t
This week the LA Review of Books has my review of Unnatural Selection, a nifty new book in which ecological toxicologist Emily Monosson describes how living things evolve their way around the things we humans do to try and contain them. … the introduction of the insecticide DDT rapidly led to the evolution of resistant […]
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