Posts

September 02, 2014

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2:06 PM | What is going on at the James Randi Educational Foundation?
And now for something completely different… Due to the holiday and suddenly being informed that my revised manuscript for a certain journal (more on that later) is needed NOW, I don’t have time for much of a post. However, a certain bit of bombshell landed over the weekend that should keep those of you interested…
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8:33 AM | The epigenetics of Chronic Fatigue Syndrome?
"These data are consistent with evidence of multisystem dysregulation in CFS [Chronic Fatigue Syndrome] and implicate the involvement of DNA modifications in CFS pathology". So said the paper by Wilfred de Vega and colleagues [1] (open-access here) which, I think, represents a bit of a first for CFS with their examination of the possible role of epigenetic modifications in relation to the condition(s) [2].Ladies first @ Wikipedia I have to say that I was really quite excited […]

de Vega WC, Vernon SD & McGowan PO (2014). DNA Methylation Modifications Associated with Chronic Fatigue Syndrome., PloS one, 9 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25111603

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3:46 AM | Unpacking Recovery Part 4: Are We All on the Same Page?
Another issue in defining and understanding recovery is that patients and clinicians may have different opinions about what recovery looks like and how to get there. Certainly, there is a body of literature from the critical feminist tradition in particular that explores how at times, patients can “follow the rules” of treatment systems to achieve a semblance of “recovery,” from a weight restoration and nutrition stabilization perspective, but feels nothing like a full […]

Noordenbos, G. & Seubring, A. (2006). Criteria for Recovery from Eating Disorders According to Patients and Therapists, Eating Disorders, 14 (1) 41-54. DOI: 10.1080/10640260500296756

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September 01, 2014

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6:12 PM | Assemblages: 50 Years Later, We Know Nothing About Them
You would think we learn about every part of a cell in biology, but we really don’t. Case in point, about 50 years ago, electron microscopy revealed the presence of […]

Toretsky, J. & Wright, P. (2014). Assemblages: Functional units formed by cellular phase separation, The Journal of Cell Biology, 206 (5) 579-588. DOI: 10.1083/jcb.201404124

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6:12 PM | Assemblages: 50 Years Later, We Know Nothing About Them
You would think we learn about every part of a cell in biology, but we really don’t. Case in point, about 50 years ago, electron microscopy revealed the presence of […]

Toretsky, J. & Wright, P. (2014). Assemblages: Functional units formed by cellular phase separation, The Journal of Cell Biology, 206 (5) 579-588. DOI: 10.1083/jcb.201404124

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2:00 PM | The CDC whistleblower William W. Thompson: One last word
I know that when last I commented, I expressed the desire to move on from the topic of the CDC whistleblower case after having covered it for a week. And so was my intent. However, this being a holiday in the US and my having had an odd experience on Friday led me to think…
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12:28 PM | Tracking the Daily Microbiome
Humans are essentially 90% bacteria. These bacteria pepper our skin and hang out in our digestive tracts, helping to break down complex carbohydrates and keeping bad bugs in check. We know how the human microbiome (our collection of bacteria) gets … Continue reading →

David LA, Materna AC, Friedman J, Campos-Baptista MI, Blackburn MC, Perrotta A, Erdman SE & Alm EJ (2014). Host lifestyle affects human microbiota on daily timescales., Genome biology, 15 (7) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25146375

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12:24 PM | Teen Pharmacist: An Unregulated Distribution of Drugs
After several injuries from a motorcycle accident, Sadia Ali ventures to a remote pharmacy to get medication. Her experience is an outstanding illustration of the pharmaceutical conditions in Laos.
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9:30 AM | Lunch with the Captain
These days I’m having trouble finding time to write, especially to blog.My colleagues and I are busy building a team and a large network of collaborators for a series of related malaria elimination projects.  Our initial goal in this project is to wipe malaria out in very specific populations.  If this works, and from our initial work at a smaller scale it appears as though it can, it will be vastly scaled up – reaching throughout Southeast Asia. The impetus for this work […]
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7:32 AM | Lithium for mood disorder symptoms in autism?
Modern classroom? @ Wikipedia The paper published by Matthew Siegel and colleagues [1] talking about some preliminary observations on the use of lithium where symptoms of mood disorder might be present in cases of autism spectrum disorder (ASD) caught my eye recently. Concluding that: "lithium may be a medication of interest for those who exhibit two or more mood disorder symptoms, particularly mania or euphoria/elevated mood" the sentiments of more research-to-do in this area […]

Siegel M, Beresford CA, Bunker M, Verdi M, Vishnevetsky D, Karlsson C, Teer O, Stedman A & Smith KA (2014). Preliminary Investigation of Lithium for Mood Disorder Symptoms in Children and Adolescents with Autism Spectrum Disorder., Journal of child and adolescent psychopharmacology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25093602

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4:00 AM | Suspicious Minds: How Culture Shapes Madness
By Joel Gold and Ian Gold Synopsis: What if you woke up with the alarming suspicion that you were being watched? One day in 2003, a patient unlike any other that Dr. Joel Gold had seen before was […]

August 31, 2014

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6:38 PM | New Synthetic Amino Acid for a New Class of Drugs
Creating new drug molecules is challenging, developing drugs that are highly effective against a target, but with minimal (or no) toxicity and side-effects to the patient can be an exercise in […]

Chen S. Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C (2014). Di-thiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, Nature Chemistry, Other:

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6:38 PM | New Synthetic Amino Acid for a New Class of Drugs
Creating new drug molecules is challenging, developing drugs that are highly effective against a target, but with minimal (or no) toxicity and side-effects to the patient can be an exercise in […]

Chen S. Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C (2014). Di-thiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, Nature Chemistry, Other:

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6:38 PM | New Synthetic Amino Acid for a New Class of Drugs
Creating new drug molecules is challenging, developing drugs that are highly effective against a target, but with minimal (or no) toxicity and side-effects to the patient can be an exercise in […]

Chen S. Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C (2014). Di-thiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, Nature Chemistry, Other:

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11:20 AM | Genomic sequencing reveals mutations, insights into 2014 Ebola outbreak
In response to an ongoing, unprecedented outbreak of Ebola virus disease in West Africa, a team of researchers has rapidly sequenced and analyzed more than 99 Ebola virus genomes. Their findings could have important implications for rapid field diagnostic tests. For the current study, researchers sequenced 99 Ebola virus genomes collected from 78 patients diagnosed …
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11:04 AM | Marijuana compound may offer treatment for Alzheimer’s disease, study suggests
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease, a recent study from neuroscientists suggests. Researchers from the USF Health Byrd Alzheimer’s Institute showed that extremely low doses of THC reduce the production of amyloid beta, found in a soluble form in …

August 30, 2014

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10:35 PM | Morsels For The Mind – 29/08/2014
Every day we provide you with Six Incredible Things Before Breakfast to nibble away at. Here you can fill your brain with the most intellectually stimulating “amuse bouches” from the past week – a veritable smorgasbord for the cranium. They’re all here for you to load up your plate – this week’s “Morsels for the mind”. Enjoy! If you do nothing else, make sure to check out the “Reads / views / listens of the week”. **** Feather, fur […]
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10:35 PM | Morsels For The Mind – 29/08/2014
Every day we provide you with Six Incredible Things Before Breakfast to nibble away at. Here you can fill your brain with the most intellectually stimulating “amuse bouches” from the past week – a veritable smorgasbord for the cranium. They’re all here for you to load up your plate – this week’s “Morsels for the mind”. Enjoy! If you do nothing else, make sure to check out the “Reads / views / listens of the week”. **** Feather, fur […]
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6:23 PM | Predictor of Sudden Death helps identify ICD candidates
New guidelines for patients with hypertrophic cardiomyopathy (HCM) identifies candidates for implantable cardioverter defibrillators. These devices help protect patients from arrhythmias (an irregular heartbeat) which can limit blood flow to vital organs, like the […]

Perry M. Elliott, (Chairperson) (UK)*, Aris Anastasakis, (Greece), Michael A. Borger, (Germany), Martin Borggrefe, (Germany), Franco Cecchi, (Italy), Philippe Charron, (France), Albert Alain Hagege, (France), Antoine Lafont, (France), Giuseppe Limongelli, (2014). 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC), European Heart Journal , Other:

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6:23 PM | Predictor of Sudden Death helps identify ICD candidates
New guidelines for patients with hypertrophic cardiomyopathy (HCM) identifies candidates for implantable cardioverter defibrillators. These devices help protect patients from arrhythmias (an irregular heartbeat) which can limit blood flow to vital organs, like the […]

Perry M. Elliott, (Chairperson) (UK)*, Aris Anastasakis, (Greece), Michael A. Borger, (Germany), Martin Borggrefe, (Germany), Franco Cecchi, (Italy), Philippe Charron, (France), Albert Alain Hagege, (France), Antoine Lafont, (France), Giuseppe Limongelli, (2014). 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC), European Heart Journal , Other:

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6:23 PM | Predictor of Sudden Death helps identify ICD candidates
New guidelines for patients with hypertrophic cardiomyopathy (HCM) identifies candidates for implantable cardioverter defibrillators. These devices help protect patients from arrhythmias (an irregular heartbeat) which can limit blood flow to vital organs, like the […]

Perry M. Elliott, (Chairperson) (UK)*, Aris Anastasakis, (Greece), Michael A. Borger, (Germany), Martin Borggrefe, (Germany), Franco Cecchi, (Italy), Philippe Charron, (France), Albert Alain Hagege, (France), Antoine Lafont, (France), Giuseppe Limongelli, (2014). 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC), European Heart Journal , Other:

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5:38 PM | Listen: Dr. Brian Goldman’s Soft Take on Alternative Medicine
Dr. Brian Goldman (@nightshiftmd), host of a great CBC radio show called White Coat Black Art that dares to pull back the curtain on the hidden world of medical practice, seems to be the latest victim of integrative medicine (IM). This IM movement has been gaining traction with Western physicians and medical institutions: many North American hospitals … Continue reading →

August 29, 2014

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7:10 PM | The Ever Mutating Ebola Virus
Ebola has a nasty reputation for the way it damages the body. It’s rightfully earned when you look at the death rate. But when you look at the actual details of an […]

Gire, S., Goba, A., Andersen, K., Sealfon, R., Park, D., Kanneh, L., Jalloh, S., Momoh, M., Fullah, M., Dudas, G. & Wohl, S. (2014). Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak, Science, DOI: 10.1126/science.1259657

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7:10 PM | The Ever Mutating Ebola Virus
Ebola has a nasty reputation for the way it damages the body. It’s rightfully earned when you look at the death rate. But when you look at the actual details of an […]

Gire, S., Goba, A., Andersen, K., Sealfon, R., Park, D., Kanneh, L., Jalloh, S., Momoh, M., Fullah, M., Dudas, G. & Wohl, S. (2014). Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak, Science, DOI: 10.1126/science.1259657

Citation
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7:10 PM | The Ever Mutating Ebola Virus
Ebola has a nasty reputation for the way it damages the body. It’s rightfully earned when you look at the death rate. But when you look at the actual details of an […]

Gire, S., Goba, A., Andersen, K., Sealfon, R., Park, D., Kanneh, L., Jalloh, S., Momoh, M., Fullah, M., Dudas, G. & Wohl, S. (2014). Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak, Science, DOI: 10.1126/science.1259657

Citation
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7:10 PM | The Ever Mutating Ebola Virus
Ebola has a nasty reputation for the way it damages the body. It’s rightfully earned when you look at the death rate. But when you look at the actual details of an […]

Gire, S., Goba, A., Andersen, K., Sealfon, R., Park, D., Kanneh, L., Jalloh, S., Momoh, M., Fullah, M., Dudas, G. & Wohl, S. (2014). Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak, Science, DOI: 10.1126/science.1259657

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1:42 PM | Laughter Is OK Medicine, Unless It Kills You
Have a great Labor Day weekend, everybody! But be careful not to enjoy yourself too much. (This post on the dangers of laughter first appeared in December 2013.) Careful with the bedside banter, doctors. Before you put on your best Patch Adams impression, you might want to consider whether your attempts at humor will ease […]The post Laughter Is OK Medicine, Unless It Kills You appeared first on Inkfish.
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1:35 PM | The CDC whistleblower William W. Thompson: Final (for now) roundup and epilogue
It is as I had feared. I must do one more post on a story that I’ve been blogging about for one solid week now. Hopefully after this, I will be able to move on to other topics last week, but after spending this whole week writing just about this, I figured, “What the heck?…
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7:52 AM | Oxytocin and autism: the hype?
Consider some excerpts from two recent papers looking at oxytocin (OXT) - the "love hormone"(!) - and the autism spectrum disorders (ASDs)...“It’s not the years, honey. It’s the mileage”"These findings indicate that dysregulated OXT biology is not uniquely associated with ASD social phenotypes as widely theorized, but instead variation in OXT biology contributes to important individual differences in human social functioning, including the severe social impairments which […]

Parker, K., Garner, J., Libove, R., Hyde, S., Hornbeak, K., Carson, D., Liao, C., Phillips, J., Hallmayer, J. & Hardan, A. & (2014). Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1402236111

Guastella AJ, Gray KM, Rinehart NJ, Alvares GA, Tonge BJ, Hickie IB, Keating CM, Cacciotti-Saija C & Einfeld SL (2014). The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial., Journal of child psychology and psychiatry, and allied disciplines, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25087908

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7:52 AM | Oxytocin and autism: the hype?
Consider some excerpts from two recent papers looking at oxytocin (OXT) - the "love hormone"(!) - and the autism spectrum disorders (ASDs)...“It’s not the years, honey. It’s the mileage”"These findings indicate that dysregulated OXT biology is not uniquely associated with ASD social phenotypes as widely theorized, but instead variation in OXT biology contributes to important individual differences in human social functioning, including the severe social impairments which […]

Parker, K., Garner, J., Libove, R., Hyde, S., Hornbeak, K., Carson, D., Liao, C., Phillips, J., Hallmayer, J. & Hardan, A. & (2014). Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1402236111

Guastella AJ, Gray KM, Rinehart NJ, Alvares GA, Tonge BJ, Hickie IB, Keating CM, Cacciotti-Saija C & Einfeld SL (2014). The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial., Journal of child psychology and psychiatry, and allied disciplines, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25087908

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