Posts

March 06, 2015

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4:52 PM | Quotable Genius: Martin H. Fischer
Martin H. Fischer was an American doctor and writer known for his pithy comments on the practice of medicine. Continue reading →
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12:43 PM | A Short History of the Discovery of Viruses
A free online book. Continue reading →
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9:00 AM | Ice is the Worst
I am on the record as loving snow and cheerfully tolerating cold. So you’d think I would love winter. And I do, mostly. But as of this week, I am very much ready for winter to pack up its bags and leave the D.C. area. The reason: ice. Ice is the worst. Ok, it’s good […]
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8:24 AM | Women in Science: No more excuses!
Making excellent female researchers more visible. As used to be commonly said and still is heard, far too often, today: “We haven’t been able to find an appropriate female speaker for our panel discussion,” or “There are only men in this discipline.” Even if that is still the case from time to time, thankfully, the […]

March 05, 2015

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7:18 PM | Not “just” crazy – Some psychoses caused by autoimmunity
Antibodies defend the body against bacterial, viral, and other invaders. But sometimes the body makes antibodies that attack healthy cells. In these cases, autoimmune disorders develop. Immune abnormalities in patients with psychosis have been recognized for over a century, but it has been only relatively recently that scientists have identified specific immune mechanisms that seem to […]
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9:49 AM | Persistent hyperlactacidemia in cases of autism
The paper from José Guevara-Campos and colleagues [1] (open-access can be downloaded here) is fodder for today's short post, and a topic that has not been seen on this blog for quite a while: hyperlactacidemia (elevated plasma lactate levels) and autism.Previous mentions of lactate and autism on this blog (see here and see here) were potentially pretty important; specifically, how elevated plasma lactate levels might (a) not be an unfamiliar finding for quite a few people on […]

Guevara-Campos J, González-Guevara L & Cauli O (2015). Autism and Intellectual Disability Associated with Mitochondrial Disease and Hyperlactacidemia., International journal of molecular sciences, 16 (2) 3870-3884. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25679448

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9:00 AM | Losing Control
When you’re carrying a child, you make certain sacrifices. I knew I’d have to give up Tanqueray and the occasional guilty cigarette. I was even prepared to forgo sushi. But I soon learned that the list was far longer than I imagined. No hot tubs, the experts advised. No queso fresco. No Advil. No deli meat. […]
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9:00 AM | Losing Control
When you’re carrying a child, you make certain sacrifices. I knew I’d have to give up Tanqueray and the occasional guilty cigarette. I was even prepared to forgo sushi. But I soon learned that the list was far longer than I imagined. No hot tubs, the experts advised. No queso fresco. No Advil. No deli meat. […]
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

Citation
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12:03 AM | Team accidentally finds key to DNA vaccination and genetic engineering
It might have been an accident, but like some lucky researchers accidents are a good thing. In this particular case, scientists have discovered a new way to manipulate how cells function, a finding that might help advance an experimental approach to improving public health: DNA vaccines, which could be more efficient, less expensive and easier […]

Gou, Y., Byun, H., Zook, A., B. Singh, G., Nash, A., Lozano, M. & Dudley, J. (2015). Retroviral vectors elevate coexpressed protein levels in trans through cap dependent translation through cap-dependent translation , Proceedings of the National Academy of Sciences, 201420477. DOI: 10.1073/pnas.1420477112

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March 04, 2015

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10:00 PM | Video Game Trains Eyes To Work Better Together
Physicians and video game developers have teamed up to help treat a common ocular condition.
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9:02 PM | A study of twins shows that autism is largely genetic
In the fight against misinformation about autism it seems science is starting to come out on top, finally. A new study hopes to add to the recent advancements made in the understanding of autism, which finds that a substantial genetic and moderate environmental influences were associated with risk of autism spectrum disorder (ASD) and broader autism […]

Colvert, E., Tick, B., McEwen, F., Stewart, C., Curran, S., Woodhouse, E., Gillan, N., Hallett, V., Lietz, S., Garnett, T. & Ronald, A. (2015). Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample, JAMA Psychiatry, DOI: 10.1001/jamapsychiatry.2014.3028

Citation
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9:02 PM | A study of twins shows that autism is largely genetic
In the fight against misinformation about autism it seems science is starting to come out on top, finally. A new study hopes to add to the recent advancements made in the understanding of autism, which finds that a substantial genetic and moderate environmental influences were associated with risk of autism spectrum disorder (ASD) and broader autism […]

Colvert, E., Tick, B., McEwen, F., Stewart, C., Curran, S., Woodhouse, E., Gillan, N., Hallett, V., Lietz, S., Garnett, T. & Ronald, A. (2015). Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample, JAMA Psychiatry, DOI: 10.1001/jamapsychiatry.2014.3028

Citation
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9:02 PM | A study of twins shows that autism is largely genetic
In the fight against misinformation about autism it seems science is starting to come out on top, finally. A new study hopes to add to the recent advancements made in the understanding of autism, which finds that a substantial genetic and moderate environmental influences were associated with risk of autism spectrum disorder (ASD) and broader autism […]

Colvert, E., Tick, B., McEwen, F., Stewart, C., Curran, S., Woodhouse, E., Gillan, N., Hallett, V., Lietz, S., Garnett, T. & Ronald, A. (2015). Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample, JAMA Psychiatry, DOI: 10.1001/jamapsychiatry.2014.3028

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8:47 PM | The Ebola Outbreak Has Had Devastating Consequences For Maternal Health
In Liberia, Guinea and Sierra Leone, the Ebola outbreak is having a horrifying impact on pregnant women, regardless of whether they have Ebola.Read more...
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8:00 PM | Smart Necklace Analyzes What Goes Down Your Throat
You’ve said it. I’ve said it. “I’ll just have one more bite.” Then, half a cheesecake later, we were both liars. A new smart necklace aims to rid us of our eating sins by…
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1:30 PM | Alternative oncology versus oncology
I hadn’t planned on discussing the death of Jess Ainscough again, figuring two posts in a row were enough for now, barring new information. Besides, I was getting a little tired of the seemingly unending stream of her fans castigating me for being “insensitive” and saying it was “too soon” to discuss her death and…
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9:41 AM | Asthma and autism: a spanner in the works?
As happens so many times in autism research, spanners are thrown in works. Take the paper from Ousseny Zerbo and colleagues [1] who concluded that: "children with autism have elevated prevalence of specific immune-related comorbidities". Nothing surprising about that finding based on the volumes of other research which seemed to have reached similar conclusions (see here).Then the spanner: "asthma was diagnosed significantly less often" in autism cases compared with asymptomatic controls. […]

Zerbo O, Leong A, Barcellos L, Bernal P, Fireman B & Croen LA (2015). Immune Mediated Conditions in Autism Spectrum Disorders., Brain, behavior, and immunity, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25681541

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March 03, 2015

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10:44 PM | Bad Faith – Book Review
I was shocked and a lot pleased to go to the mail box a […]
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10:44 PM | Bad Faith – Book Review
I was shocked and a lot pleased to go to the mail box a […]
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9:20 PM | A Brain Injury Could Make Your World Look Like This
This is how someone with hemianopsia sees the world. The sight is not due to eye damage. It's due to a brain injury that literally blanks out one half of everything they look at. The complicating factor is that sometimes, the patients don't even realize that they can't see.Read more...
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8:48 PM | Two Lineages of HIV-1 Viruses Originated in Gorillas, New Study Finds
Two of the four lineages of HIV-1 viruses have originated in western lowland gorillas, a new study reported in the Proceedings of the National Academy of Sciences has found. HIV-1, the virus that causes AIDS, has jumped species to infect humans on at least four separate occasions, generating four HIV-1 lineages – groups M, N, [...]
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8:00 PM | Why Adults Are More Likely To Be Hit Hard By The Measles Than Children
The recent measles outbreak has everyone taking another look at "childhood" diseases. Why are these diseases, relatively mild in children over five, so often devastating to adults? An infectious disease expert talks to io9 about possible explanations for why these viruses hit us hard when we should be at our healthiest.Read more...
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7:41 PM | Early life stress may result in a serotonin deficit later
If you have experienced — or are experiencing — mood disorders like anxiety or depression, you know about SSRI’s and chances are they didn’t do much for you. In fact studies indicate that the majority of people with mood and anxiety disorders who receive Selective Serotonin Reuptake Inhibitors (SSRI’s) are not helped by these medications. Sadly, they […]

Coplan, J., Fulton, S., Reiner, W., Jackowski, A., Panthangi, V., Perera, T., Gorman, J., Huang, Y., Tang, C., Hof, P. & Kaffman, A. (2014). Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00440

Coplan, J., Gopinath, S., Abdallah, C. & Berry, B. (2014). A Neurobiological Hypothesis of Treatment-Resistant Depression -- Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00189

Citation
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7:41 PM | Early life stress may result in a serotonin deficit later
If you have experienced — or are experiencing — mood disorders like anxiety or depression, you know about SSRI’s and chances are they didn’t do much for you. In fact studies indicate that the majority of people with mood and anxiety disorders who receive Selective Serotonin Reuptake Inhibitors (SSRI’s) are not helped by these medications. Sadly, they […]

Coplan, J., Fulton, S., Reiner, W., Jackowski, A., Panthangi, V., Perera, T., Gorman, J., Huang, Y., Tang, C., Hof, P. & Kaffman, A. (2014). Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00440

Coplan, J., Gopinath, S., Abdallah, C. & Berry, B. (2014). A Neurobiological Hypothesis of Treatment-Resistant Depression -- Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00189

Citation
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7:41 PM | Early life stress may result in a serotonin deficit later
If you have experienced — or are experiencing — mood disorders like anxiety or depression, you know about SSRI’s and chances are they didn’t do much for you. In fact studies indicate that the majority of people with mood and anxiety disorders who receive Selective Serotonin Reuptake Inhibitors (SSRI’s) are not helped by these medications. Sadly, they […]

Coplan, J., Fulton, S., Reiner, W., Jackowski, A., Panthangi, V., Perera, T., Gorman, J., Huang, Y., Tang, C., Hof, P. & Kaffman, A. (2014). Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00440

Coplan, J., Gopinath, S., Abdallah, C. & Berry, B. (2014). A Neurobiological Hypothesis of Treatment-Resistant Depression -- Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00189

Citation
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7:41 PM | Early life stress may result in a serotonin deficit later
If you have experienced — or are experiencing — mood disorders like anxiety or depression, you know about SSRI’s and chances are they didn’t do much for you. In fact studies indicate that the majority of people with mood and anxiety disorders who receive Selective Serotonin Reuptake Inhibitors (SSRI’s) are not helped by these medications. Sadly, they […]

Coplan, J., Fulton, S., Reiner, W., Jackowski, A., Panthangi, V., Perera, T., Gorman, J., Huang, Y., Tang, C., Hof, P. & Kaffman, A. (2014). Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00440

Coplan, J., Gopinath, S., Abdallah, C. & Berry, B. (2014). A Neurobiological Hypothesis of Treatment-Resistant Depression -- Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00189

Citation
+
7:41 PM | Early life stress may result in a serotonin deficit later
If you have experienced — or are experiencing — mood disorders like anxiety or depression, you know about SSRI’s and chances are they didn’t do much for you. In fact studies indicate that the majority of people with mood and anxiety disorders who receive Selective Serotonin Reuptake Inhibitors (SSRI’s) are not helped by these medications. Sadly, they […]

Coplan, J., Fulton, S., Reiner, W., Jackowski, A., Panthangi, V., Perera, T., Gorman, J., Huang, Y., Tang, C., Hof, P. & Kaffman, A. (2014). Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00440

Coplan, J., Gopinath, S., Abdallah, C. & Berry, B. (2014). A Neurobiological Hypothesis of Treatment-Resistant Depression -- Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00189

Citation
+
7:41 PM | Early life stress may result in a serotonin deficit later
If you have experienced — or are experiencing — mood disorders like anxiety or depression, you know about SSRI’s and chances are they didn’t do much for you. In fact studies indicate that the majority of people with mood and anxiety disorders who receive Selective Serotonin Reuptake Inhibitors (SSRI’s) are not helped by these medications. Sadly, they […]

Coplan, J., Fulton, S., Reiner, W., Jackowski, A., Panthangi, V., Perera, T., Gorman, J., Huang, Y., Tang, C., Hof, P. & Kaffman, A. (2014). Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00440

Coplan, J., Gopinath, S., Abdallah, C. & Berry, B. (2014). A Neurobiological Hypothesis of Treatment-Resistant Depression -- Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00189

Citation
+
7:41 PM | Early life stress may result in a serotonin deficit later
If you have experienced — or are experiencing — mood disorders like anxiety or depression, you know about SSRI’s and chances are they didn’t do much for you. In fact studies indicate that the majority of people with mood and anxiety disorders who receive Selective Serotonin Reuptake Inhibitors (SSRI’s) are not helped by these medications. Sadly, they […]

Coplan, J., Fulton, S., Reiner, W., Jackowski, A., Panthangi, V., Perera, T., Gorman, J., Huang, Y., Tang, C., Hof, P. & Kaffman, A. (2014). Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00440

Coplan, J., Gopinath, S., Abdallah, C. & Berry, B. (2014). A Neurobiological Hypothesis of Treatment-Resistant Depression -- Mechanisms for Selective Serotonin Reuptake Inhibitor Non-Efficacy, Frontiers in Behavioral Neuroscience, 8 DOI: 10.3389/fnbeh.2014.00189

Citation
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