Posts

August 21, 2014

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5:02 PM | Jonas Salk and the Polio Comeback
Jonas Salk, you should know this name, but chances are you don’t. He was the inventor of the polio vaccine, a disease that was feared more than the atomic bomb. […]

Drexler JF, Grard G, Lukashev AN, Kozlovskaya LI, Böttcher S, Uslu G, Reimerink J, Gmyl AP, Taty-Taty R, Lekana-Douki SE & Nkoghe D (2014). Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010., Proceedings of the National Academy of Sciences of the United States of America, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25136105

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5:02 PM | Jonas Salk and the Polio Comeback
Jonas Salk, you should know this name, but chances are you don’t. He was the inventor of the polio vaccine, a disease that was feared more than the atomic bomb. […]

Drexler JF, Grard G, Lukashev AN, Kozlovskaya LI, Böttcher S, Uslu G, Reimerink J, Gmyl AP, Taty-Taty R, Lekana-Douki SE & Nkoghe D (2014). Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010., Proceedings of the National Academy of Sciences of the United States of America, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25136105

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12:00 PM | Seals carried tuberculosis across the Atlantic, gave it to humans
Disease was present in the Americas prior to European contact.
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7:56 AM | Autism, ADHD and allergy: Taiwan and big data (again)
"Children with ADHD [attention-deficit hyperactivity disorder] or ASD [autism spectrum disorder] had an increased risk of allergic comorbidities, and those with both ADHD and ASD had the highest"."You built a time machine.. out of a DeLorean"That was the conclusion arrived at in the paper by Ting-Yang Lin and colleagues [1]. For regular readers of this blog, this was yet another example of how Taiwan leads the way when it comes to the concept of 'big data' specifically […]

Lin, T., Lin, P., Su, T., Chen, Y., Hsu, J., Huang, K., Chang, W., Chen, T., Pan, T., Chen, M. & Bai, Y. (2014). Autistic spectrum disorder, attention deficit hyperactivity disorder, and allergy: Is there a link? A nationwide study, Research in Autism Spectrum Disorders, 8 (10) 1333-1338. DOI: 10.1016/j.rasd.2014.07.009

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5:17 AM | How to prevent a possible concussion from the ALS ice bucket challenge
The ice bucket challenge has swept the nation in an effort to raise awareness for ALS. However, there seems to have been a number of concussions (or mild traumatic brain injury) sustained from performing a seemingly altruistic act. Although some people may find the below video funny, concussions are a serious issue and can lead to serious consequences including executive dysfunction.Two recent meta-analyses (one examining neuropsychological performance while the other examining fMRI data) have […]

Eierud C, Craddock RC, Fletcher S, Aulakh M, King-Casas B, Kuehl D & LaConte SM (2014). Neuroimaging after mild traumatic brain injury: Review and meta-analysis., NeuroImage. Clinical, 4 283-94. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25061565

Karr JE, Areshenkoff CN & Garcia-Barrera MA (2014). The neuropsychological outcomes of concussion: a systematic review of meta-analyses on the cognitive sequelae of mild traumatic brain injury., Neuropsychology, 28 (3) 321-36. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24219611

Rohling, M., Larrabee, G. & Millis, S. (2012). The “Miserable Minority” Following Mild Traumatic Brain Injury: Who Are They and do Meta-Analyses Hide Them?, The Clinical Neuropsychologist, 26 (2) 197-213. DOI: 10.1080/13854046.2011.647085

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4:01 AM | Clinical trials of magic
I’ll partially apologize here. The reason is that I said I’d be back to business dishing out the Insolence as usual, be it in the form of my usual 2,000 word gems, or slightly shorter, or a lot longer. However, fate intervened. First, there were new developments in the Frank Arguello threat machine. Go back…
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1:00 AM | Genetically Altered Pig-Heart Survives More Than A Year Inside Baboon
A pig heart modified to express human genes has survived more than a year grafted to the inside of a baboon's abdomen, according to researchers at the National Heart, Lung and Blood Institute (NHLBI) of the NIH.Read more...

August 20, 2014

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7:59 PM | Retooling for Human Gene Therapy: New and Improved Adenoviral Vectors
Dr Juliana Small of the University of Pennsylvania, Drs Raj Kurupati, Xianqyang Zhou and their colleagues from the Wistar Institute have developed a novel adenoviral vector for delivery of multiple transgenes. With the genetic basis of a number of human diseases known, many attempts have been made to treat the disorders by adding back the [...]
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4:30 PM | The DNA Signature of Lupus
My Uncle suffered from Lupus. The disease itself should have a more sinister sounding name, given the effect it has on the body. Lupus is a form of autoimmune disease […]

Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott & Marco G Casarotto (2014). Whole exome sequencing in early-onset cerebral SLE identifies a pathogenic variant in TREX1, Arthritis & Rheumatology , Other:

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Editor's Pick
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4:30 PM | The DNA Signature of Lupus
My Uncle suffered from Lupus. The disease itself should have a more sinister sounding name, given the effect it has on the body. Lupus is a form of autoimmune disease […]

Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott & Marco G Casarotto (2014). Whole exome sequencing in early-onset cerebral SLE identifies a pathogenic variant in TREX1, Arthritis & Rheumatology , Other:

Citation
Editor's Pick
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4:30 PM | The DNA Signature of Lupus
My Uncle suffered from Lupus. The disease itself should have a more sinister sounding name, given the effect it has on the body. Lupus is a form of autoimmune disease […]

Julia I Ellyard, Rebekka Jerjen, Jaime L Martin, Adrian Lee, Matthew A Field, Simon H Jiang, Jean Cappello, Svenja K Naumann, T Daniel Andrews, Hamish S Scott & Marco G Casarotto (2014). Whole exome sequencing in early-onset cerebral SLE identifies a pathogenic variant in TREX1, Arthritis & Rheumatology , Other:

Citation
Editor's Pick
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12:00 PM | Because He Is The One
Biology Concepts – ommatidia, reflex, fly, arthropod, sensory receptors, sensilla, metabolic rate, life spanNeo (Keanu Reeves) learned that he could dodge bullets at one point in The Matrix. This was before he learned he didn’t have to. Was he speeding himself up so the bullets looked to be going slower, or was he actually slowing down time?Neo from the Matrixfilms had the ability, once he learned to accept it, to react so fast that everything around him seemed to be moving slowly. […]

Muijres FT, Elzinga MJ, Melis JM & Dickinson MH (2014). Flies evade looming targets by executing rapid visually directed banked turns., Science (New York, N.Y.), 344 (6180) 172-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24723606

Healy K, McNally L, Ruxton GD, Cooper N & Jackson AL (2013). Metabolic rate and body size are linked with perception of temporal information., Animal behaviour, 86 (4) 685-696. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24109147

Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG & Krakoff J (2011). Higher energy expenditure in humans predicts natural mortality., The Journal of clinical endocrinology and metabolism, 96 (6) 6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21450984

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12:00 PM | Because He Is The One
Biology Concepts – ommatidia, reflex, fly, arthropod, sensory receptors, sensilla, metabolic rate, life spanNeo (Keanu Reeves) learned that he could dodge bullets at one point in The Matrix. This was before he learned he didn’t have to. Was he speeding himself up so the bullets looked to be going slower, or was he actually slowing down time?Neo from the Matrixfilms had the ability, once he learned to accept it, to react so fast that everything around him seemed to be moving slowly. […]

Muijres FT, Elzinga MJ, Melis JM & Dickinson MH (2014). Flies evade looming targets by executing rapid visually directed banked turns., Science (New York, N.Y.), 344 (6180) 172-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24723606

Healy K, McNally L, Ruxton GD, Cooper N & Jackson AL (2013). Metabolic rate and body size are linked with perception of temporal information., Animal behaviour, 86 (4) 685-696. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24109147

Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG & Krakoff J (2011). Higher energy expenditure in humans predicts natural mortality., The Journal of clinical endocrinology and metabolism, 96 (6) 6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21450984

Citation
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12:00 PM | Because He Is The One
Biology Concepts – ommatidia, reflex, fly, arthropod, sensory receptors, sensilla, metabolic rate, life spanNeo (Keanu Reeves) learned that he could dodge bullets at one point in The Matrix. This was before he learned he didn’t have to. Was he speeding himself up so the bullets looked to be going slower, or was he actually slowing down time?Neo from the Matrixfilms had the ability, once he learned to accept it, to react so fast that everything around him seemed to be moving slowly. […]

Muijres FT, Elzinga MJ, Melis JM & Dickinson MH (2014). Flies evade looming targets by executing rapid visually directed banked turns., Science (New York, N.Y.), 344 (6180) 172-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24723606

Healy K, McNally L, Ruxton GD, Cooper N & Jackson AL (2013). Metabolic rate and body size are linked with perception of temporal information., Animal behaviour, 86 (4) 685-696. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24109147

Jumpertz R, Hanson RL, Sievers ML, Bennett PH, Nelson RG & Krakoff J (2011). Higher energy expenditure in humans predicts natural mortality., The Journal of clinical endocrinology and metabolism, 96 (6) 6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21450984

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4:00 AM | The Man Who Mistook His Wife For A Hat
By Oliver Sacks Other Title: The Man Who Mistook His Wife For A Hat: And Other Clinical Tales Synopsis: In his most extraordinary book, “one of the great clinical writers of the twentieth century” (The New […]
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1:44 AM | Introducing Victoria - Frankenstein MD Episode...
Introducing Victoria - Frankenstein MD Episode 1 Victoria’s show is designed to be sort of a video lab notebook, part educational, part experimental. YouTube already has some pretty great science shows (*cough*cough*) but I’m happy to welcome Victoria to the fold. And Iggy too, I guess. In this episode, in addition to meeting the main characters and hearing some inspiring words about the importance of failure in the scientific method, we learn a bit about cardiac […]

August 19, 2014

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6:17 PM | Hobby Lobby and the War on Race and Women
There is a war going on and it’s not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a […]

Weisman CS & Chuang CH (2014). Making the Most of the Affordable Care Act's Contraceptive Coverage Mandate for Privately-Insured Women., Women's health issues : official publication of the Jacobs Institute of Women's Health, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25128037

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6:17 PM | Hobby Lobby and the War on Race and Women
There is a war going on and it’s not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a […]

Weisman CS & Chuang CH (2014). Making the Most of the Affordable Care Act's Contraceptive Coverage Mandate for Privately-Insured Women., Women's health issues : official publication of the Jacobs Institute of Women's Health, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25128037

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6:17 PM | Hobby Lobby and the War on Race and Women
There is a war going on and it’s not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a […]

Weisman CS & Chuang CH (2014). Making the Most of the Affordable Care Act's Contraceptive Coverage Mandate for Privately-Insured Women., Women's health issues : official publication of the Jacobs Institute of Women's Health, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25128037

Citation
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6:17 PM | Hobby Lobby and the War on Race and Women
There is a war going on and it’s not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a […]

Weisman CS & Chuang CH (2014). Making the Most of the Affordable Care Act's Contraceptive Coverage Mandate for Privately-Insured Women., Women's health issues : official publication of the Jacobs Institute of Women's Health, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25128037

Citation
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6:17 PM | Hobby Lobby and the War on Race and Women
There is a war going on and it’s not on foreign soil. This war is the fight for the status quo, a war where you are only worth your skin color, a […]

Weisman CS & Chuang CH (2014). Making the Most of the Affordable Care Act's Contraceptive Coverage Mandate for Privately-Insured Women., Women's health issues : official publication of the Jacobs Institute of Women's Health, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25128037

Citation
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3:32 PM | How do Nanoparticles Enter Cells?
There is an ovarian cancer drug called DOXIL that is delivered to cells in a nanoparticle made of molecules of fat. But, how does the nanoparticle enter the cell? According to a recent study that uses computers to model this process, there are mainly 3 ways in which scientists think a nanoparticle can enter the […]
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8:23 AM | Family processes and trajectory in autism
The paper by Woodman and colleagues [1] looking at trajectory and autism in adolescents and adults is the source material for today's post (another micropost). Concluding that: "Overall, autism symptoms and maladaptive behaviors were observed to improve over the study period" of about 8 years, the authors also reported that "greater improvements were associated with higher levels of maternal praise (based on maternal speech samples) and higher quality mother-child relationships". If I remember […]

Woodman AC, Smith LE, Greenberg JS & Mailick MR (2014). Change in Autism Symptoms and Maladaptive Behaviors in Adolescence and Adulthood: The Role of Positive Family Processes., Journal of autism and developmental disorders, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25070471

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7:00 AM | USA TODAY flubs it big time over right-to-try laws
I hadn’t expected to write about this topic again so soon, but then I didn’t expect a major newspaper to have written such a boneheaded editorial about it. In a way, I hate to write this post, because USA TODAY did great things once. There, Liz Szabo wrote the single best science-based report on cancer…
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12:53 AM | Deaths That Don’t Have to Happen: The Relationship Between Knowledge and Health
Editor’s note: As part of  a writing class I took this summer, I had to do a group project addressing a social issue within our society. Part of that assignment was writing an essay that promotes activism to address the issue.The research inspired me, so I decided to share that essay with you. Hope you enjoy!  Knowledge, and […]

August 18, 2014

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11:30 PM | ​Chinese Government Fans the Flames of the Ebola Zombie Rumors
In recent weeks, rumors have been spreading on Chinese social media sites that Ebola is transforming its human victims into zombies. The stories became so prolific that China's official new agency, Xinhua, felt compelled to publish a special report that only ended up spreading more disinformation.Read more...
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10:58 PM | At Last, We May Understand What Causes Hangovers
There are a lot of hangover myths. No, they are not caused by dehydration, so drinking lots of water with your booze won't help. And no, they are not caused by blood sugar levels. Scientists do have one hypothesis about what causes them, however — and luckily we have a cure for it.Read more...
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5:21 PM | We can Build it Better: The First Artificial Cell Network
  How does the old saying go? Imitation, is the sincerest form of flattery? Well that is what we’ve been trying to do for a very long time, but mimicking the […]

Karzbrun E, Tayar AM, Noireaux V & Bar-Ziv RH (2014). Programmable on-chip DNA compartments as artificial cells., Science (New York, N.Y.), 345 (6198) 829-32. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25124443

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5:21 PM | We can Build it Better: The First Artificial Cell Network
  How does the old saying go? Imitation, is the sincerest form of flattery? Well that is what we’ve been trying to do for a very long time, but mimicking the […]

Karzbrun E, Tayar AM, Noireaux V & Bar-Ziv RH (2014). Programmable on-chip DNA compartments as artificial cells., Science (New York, N.Y.), 345 (6198) 829-32. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25124443

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5:21 PM | We can Build it Better: The First Artificial Cell Network
  How does the old saying go? Imitation, is the sincerest form of flattery? Well that is what we’ve been trying to do for a very long time, but mimicking the […]

Karzbrun E, Tayar AM, Noireaux V & Bar-Ziv RH (2014). Programmable on-chip DNA compartments as artificial cells., Science (New York, N.Y.), 345 (6198) 829-32. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25124443

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