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Posts

May 23, 2013

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1:21 PM | Should you worry about vitamin D deficiency? Maybe. Or maybe not.
Since my last blog post, where I shared my thoughts on BRCA1, BRCA2, and preventive mastectomies, I've been asked what else can a woman do to reduce her risk of breast cancer. I've heard a big deal about vitamin D, so I did a bit of research on the matter. As a disclaimer, I should tell you up front that, though many correlations between vitamin D deficiency and cancer risk have been found, just as many have been refuted or found inconclusive. You can read more about it on the wikipedia […]

Crew, K. (2013). Vitamin D: Are We Ready to Supplement for Breast Cancer Prevention and Treatment?, ISRN Oncology, 2013 1-22. DOI:

CHIMERAS
Biology
Citation

May 22, 2013

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1:00 PM | Late Breaking Clinical Trial Results At ERA-EDTA Congress 2013
Nearly 10,000 participants are in Istanbul at  the congress of the ERA-EDTA (European Renal Association - European Dialysis and Transplant Association) to share their knowledge and discuss the latest research findings. New pioneering studies have been presented:  - Gupta, A et al. "SOLUBLE FERRIC PYROPHOSPHATE (SFP) ADMINISTERED VIA HEMODIALYSATE REDUCES ESA USE"  By SFP-iron administration, the ESA dose could be reduced by 35% while maintaining stable Hb levels. There were no […]
Science 2.0
Science Communication | Neuroscience

May 15, 2013

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8:29 AM | A systematic review in non-clinical research: a case of pathogen metabolites
Posted by Kasra Doctors and scientists in the field of clinical research are well acquainted to systematic reviews and their importance in clinical research. The important difference between a normal review and a systematic review is that in the latter the authors make sure (or at least try very hard) to include and cover all the […]

Bos, L., Sterk, P. & Schultz, M. (2013). Volatile Metabolites of Pathogens: A Systematic Review, PLoS Pathogens, 9 (5) DOI:

The Parasite Diary
Biology | Microbiology
Citation

May 14, 2013

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4:43 PM | Rethinking treatment goals improves results for those with persistent anorexia
A clinical trial for patients with anorexia nervosa shows that patients are three times more likely to stick with treatment when they are involved in setting its goals.

Touyz S, Le Grange D, Lacey H, Hay P, Smith R, Maguire S, Bamford B, Pike KM & Crosby RD (2013). Treating severe and enduring anorexia nervosa: a randomized controlled trial., Psychological medicine, 1-11. PMID:

ScienceLife
Biology | Medicine
Citation

May 09, 2013

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3:21 PM | Biomarkers for Psychosis and Schizophrenia Risk
Prefrontal Cortex Highlighted in RedIdentifying valid biomarkers for psychosis and schizophrenia is an active focus in brain research.Tyronne Cannon, Ph.D. from Yale University recently presented a summary of research on this topic at the William K. Warren Neuroscience Symposium in Tulsa, Oklahoma. Here are my notes from his presentation along with related free full-text research references.Biomarker research in psychosis is important because current treatment for psychosis with the […]

Sun D, van Erp TG, Thompson PM, Bearden CE, Daley M, Kushan L, Hardt ME, Nuechterlein KH, Toga AW & Cannon TD & (2009). Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms., Biological psychiatry, 66 (11) 1055-60. PMID:

Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF & Woods SW (2010). Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis., Archives of general psychiatry, 67 (6) 578-88. PMID:

Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T & Woods SW (2012). Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study., Schizophrenia research, 134 (1) 1-9. PMID:

Brain Posts
Medicine | Neuroscience
Citation
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3:21 PM | Biomarkers for Psychosis and Schizophrenia Risk
Prefrontal Cortex Highlighted in RedIdentifying valid biomarkers for psychosis and schizophrenia is an active focus in brain research.Tyronne Cannon, Ph.D. from Yale University recently presented a summary of research on this topic at the William K. Warren Neuroscience Symposium in Tulsa, Oklahoma. Here are my notes from his presentation along with related free full-text research references.Biomarker research in psychosis is important because current treatment for psychosis with the […]

Sun D, van Erp TG, Thompson PM, Bearden CE, Daley M, Kushan L, Hardt ME, Nuechterlein KH, Toga AW & Cannon TD & (2009). Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms., Biological psychiatry, 66 (11) 1055-60. PMID:

Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF & Woods SW (2010). Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis., Archives of general psychiatry, 67 (6) 578-88. PMID:

Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T & Woods SW (2012). Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study., Schizophrenia research, 134 (1) 1-9. PMID:

Brain Posts
Medicine | Neuroscience
Citation
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3:21 PM | Biomarkers for Psychosis and Schizophrenia Risk
Prefrontal Cortex Highlighted in RedIdentifying valid biomarkers for psychosis and schizophrenia is an active focus in brain research.Tyronne Cannon, Ph.D. from Yale University recently presented a summary of research on this topic at the William K. Warren Neuroscience Symposium in Tulsa, Oklahoma. Here are my notes from his presentation along with related free full-text research references.Biomarker research in psychosis is important because current treatment for psychosis with the […]

Sun D, van Erp TG, Thompson PM, Bearden CE, Daley M, Kushan L, Hardt ME, Nuechterlein KH, Toga AW & Cannon TD & (2009). Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms., Biological psychiatry, 66 (11) 1055-60. PMID:

Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF & Woods SW (2010). Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis., Archives of general psychiatry, 67 (6) 578-88. PMID:

Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T & Woods SW (2012). Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study., Schizophrenia research, 134 (1) 1-9. PMID:

Brain Posts
Medicine | Neuroscience
Citation
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3:21 PM | Biomarkers for Psychosis and Schizophrenia Risk
Prefrontal Cortex Highlighted in RedIdentifying valid biomarkers for psychosis and schizophrenia is an active focus in brain research.Tyronne Cannon, Ph.D. from Yale University recently presented a summary of research on this topic at the William K. Warren Neuroscience Symposium in Tulsa, Oklahoma. Here are my notes from his presentation along with related free full-text research references.Biomarker research in psychosis is important because current treatment for psychosis with the […]

Sun D, van Erp TG, Thompson PM, Bearden CE, Daley M, Kushan L, Hardt ME, Nuechterlein KH, Toga AW & Cannon TD & (2009). Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms., Biological psychiatry, 66 (11) 1055-60. PMID:

Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF & Woods SW (2010). Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis., Archives of general psychiatry, 67 (6) 578-88. PMID:

Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T & Woods SW (2012). Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study., Schizophrenia research, 134 (1) 1-9. PMID:

Brain Posts
Medicine | Neuroscience
Citation

May 05, 2013

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9:51 AM | More on 'Bugs as Drugs'
This morning, I was just doing a lazy ramble through my favourite blogs and found a post by Carl Zimmer on 'Bugs as Drugs' - primarily on probiotics. And I just came to realise that there is a very interesting tendency these years of using bugs as drugs in a variety of fields. We are all very much aware of the worries about the increase in antibiotic resistance in bacterial and other pathogens. Moreover, it appears that sometimes antibiotic treatment leads to imbalance in the intestinal […]

Hyman P, Atterbury R & Barrow P (2013). Fleas and smaller fleas: virotherapy for parasite infections., Trends in microbiology, PMID:

van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG & Speelman P (2013). Duodenal infusion of donor feces for recurrent Clostridium difficile., The New England journal of medicine, 368 (5) 407-15. PMID:

Weinstock JV (2012). Autoimmunity: The worm returns., Nature, 491 (7423) 183-5. PMID:

Blastocystis Parasite Blog
Biology | Microbiology
Citation
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9:51 AM | More on 'Bugs as Drugs'
This morning, I was just doing a lazy ramble through my favourite blogs and found a post by Carl Zimmer on 'Bugs as Drugs' - primarily on probiotics. And I just came to realise that there is a very interesting tendency these years of using bugs as drugs in a variety of fields. We are all very much aware of the worries about the increase in antibiotic resistance in bacterial and other pathogens. Moreover, it appears that sometimes antibiotic treatment leads to imbalance in the intestinal […]

Hyman P, Atterbury R & Barrow P (2013). Fleas and smaller fleas: virotherapy for parasite infections., Trends in microbiology, PMID:

van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG & Speelman P (2013). Duodenal infusion of donor feces for recurrent Clostridium difficile., The New England journal of medicine, 368 (5) 407-15. PMID:

Weinstock JV (2012). Autoimmunity: The worm returns., Nature, 491 (7423) 183-5. PMID:

Blastocystis Parasite Blog
Biology | Microbiology
Citation

May 02, 2013

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2:33 PM | Redefining Mental Disorders as Brain Disorders: TED Talk of Thomas Insel
Components of Brain Limbic SystemAdvances in the diagnosis and treatment of brain disorders like bipolar disorder, schizophrenia and autism are a public health priority.Dr. Thomas Insel, director at NIMH recently presented a TED talk that emphasized the need to rethink how we conceptualize and study these types of disorders.  He argues for a need to redefine mental disorders as brain disorders.  Advances in brain research tools are likely to provide improvements in early diagnosis and […]

Collins, P., Insel, T., Chockalingam, A., Daar, A. & Maddox, Y. (2013). Grand Challenges in Global Mental Health: Integration in Research, Policy, and Practice, PLoS Medicine, 10 (4) DOI:

Insel, T. (2011). A bridge to somewhere, Translational Psychiatry, 1 (4) DOI:

Brain Posts
Medicine | Neuroscience
Citation
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2:33 PM | Redefining Mental Disorders as Brain Disorders: TED Talk of Thomas Insel
Components of Brain Limbic SystemAdvances in the diagnosis and treatment of brain disorders like bipolar disorder, schizophrenia and autism are a public health priority.Dr. Thomas Insel, director at NIMH recently presented a TED talk that emphasized the need to rethink how we conceptualize and study these types of disorders.  He argues for a need to redefine mental disorders as brain disorders.  Advances in brain research tools are likely to provide improvements in early diagnosis and […]

Collins, P., Insel, T., Chockalingam, A., Daar, A. & Maddox, Y. (2013). Grand Challenges in Global Mental Health: Integration in Research, Policy, and Practice, PLoS Medicine, 10 (4) DOI:

Insel, T. (2011). A bridge to somewhere, Translational Psychiatry, 1 (4) DOI:

Brain Posts
Medicine | Neuroscience
Citation

May 01, 2013

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3:54 PM | Advances In Parkinson's Disease Treatment: Part II
Globus Pallidus Region of Brain Targeted in DBS in YellowIn a previous post, I summarized some of the highlights of a recent review of Parkinson's disease management by the German neurologists Pedrosa and Timmerman.The first post can be located here and was limited to the drug treatment of the motor symptoms of Parkinson's disease.In part II, I want to focus on deep brain stimulation and the treatment of non-motor symptoms.The authors of the review note the following key points regarding deep […]

Pedrosa, D. & Timmermann, . (2013). Review: management of Parkinson's disease, Neuropsychiatric Disease and Treatment, 321. DOI:

Brain Posts
Medicine | Neuroscience
Citation

April 30, 2013

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3:31 PM | Treatment Advances in Parkinson's Disease: Part I
3D Molecular Model of L-DopaDrug treatment of Parkinson's disease is a complex clinical problem.  This complexity relates to several factors including incomplete response, multiple symptom domains and adverse effects of commonly used drugs.David Pedrosa and Lars Timmerman from the Department of Neurology at University Hospital Cologne in Germany have recently published an excellent review of Parkinson's disease management.The review is packed with comprehensive tables with specific drug […]

Pedrosa, D. & Timmermann, . (2013). Review: management of Parkinson's disease, Neuropsychiatric Disease and Treatment, 321. DOI:

Brain Posts
Medicine | Neuroscience
Citation

April 29, 2013

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2:37 PM | Essential Tremor as a Risk Factor for Parkinson's Disease
The number people suffereing from Parkison's disease in the United States is estimated to be between 500,000 and 1,000,000.The key symptoms of Parkinson's disease include tremor and slowed movement or bradykinesia.Known risk factors for Parkinson's disease include advanced age, male gender, family history of Parkinson's disease and exposure to pesticides.Of note, smokers appear to have a reduced risk of Parkinson's disease although the mechanism for this protective effect is unknown.Romero and […]

Romero JP, Benito-León J & Bermejo-Pareja F (2012). The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor., Tremor and other hyperkinetic movements (New York, N.Y.), 2 PMID:

Brain Posts
Medicine | Neuroscience
Citation

April 28, 2013

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8:00 PM | New Drug Causes Immune System To Kill Hepatitis B Infected Cells In Animal Model
A drug developed by Gilead Sciences and tested in an animal model at the Texas Biomedical Research Institute in San Antonio suppresses hepatitis B virus infection by stimulating the immune system and inducing loss of infected cells.   read more
Science 2.0
Science Communication | Neuroscience

April 26, 2013

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2:51 PM | MRI Biomarker for Parkinson's Disease Progression
Brain Putamen Highlighted in OrangeThe search for biomarkers for Alzheimer's disease is very active.  I have summarized some of the relevant Alzheimer's biomarker research here and here.Biomarker research in Parkinson's disease has been less active.However, a recent research study published in Plos One demonstrated the potential for brain magnetic resonance imaging in Parkinson's disease.Miguel Ulla and colleagues in France conducted a prospective MRI study of 27 subjects with Parkinson's […]

Ulla M, Bonny JM, Ouchchane L, Rieu I, Claise B & Durif F (2013). Is R2* a new MRI biomarker for the progression of Parkinson's disease? A longitudinal follow-up., PloS one, 8 (3) PMID:

Brain Posts
Medicine | Neuroscience
Citation

April 25, 2013

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3:15 PM | Brain White Matter Changes in Schizophrenia
Schizophrenia is a disabling brain disorder characterized by psychotic symptoms such as hallucinations and delusions.Schizophrenia has a prevalence rate of about 1% of the population with relatively stable rates across nations and cultures.Early brain imaging studies focused on regional evidence of brain atrophy primarily in brain gray matter.  However, with the development of diffusion tensor imaging, there is a growing body of research examining white matter changes in schizophrenia. […]

Alba-Ferrara, L. & de Erausquin, G. (2013). What does anisotropy measure? Insights from increased and decreased anisotropy in selective fiber tracts in schizophrenia, Frontiers in Integrative Neuroscience, 7 DOI:

Brain Posts
Medicine | Neuroscience
Citation

April 24, 2013

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3:12 PM | DTI Identifies Brain Aging Changes
Brain white matter plays a key role in connecting functional brain areas.  These connections are required for complex brain processing required for memory and executive functions, i.e planning and problem solving.Diffusion tensor imaging (DTI) is a relatively recent brain imaging tool that provides a method of analyzing regional human white matter function.  Additionally, when DTI is paired with cognitive testing it allows for study of the brain regions and circuits responsible for […]

Sasson E, Doniger GM, Pasternak O, Tarrasch R & Assaf Y (2013). White matter correlates of cognitive domains in normal aging with diffusion tensor imaging., Frontiers in neuroscience, 7 32. PMID:

Brain Posts
Medicine | Neuroscience
Citation

April 23, 2013

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3:13 PM | Hypothalaumus Connectivity Changes in Cluster Headaches
Cluster headaches are a relatively rare but serious pain disorder.  Unlike the female-predominant migraine headache, cluster headaches occur predominantly in men.  These headaches tend to be acute in onset and affect only one side of the head.The term cluster describes the typical chronological pattern of these headaches.  The tend to occur regularly for days or weeks and are then separated by periods of remission lasting months or years.Attacks typically last between 15 minutes […]

Qiu E, Wang Y, Ma L, Tian L, Liu R, Dong Z, Xu X, Zou Z & Yu S (2013). Abnormal brain functional connectivity of the hypothalamus in cluster headaches., PloS one, 8 (2) PMID:

Brain Posts
Medicine | Neuroscience
Citation

April 22, 2013

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4:12 PM | Exercise Boosts Brain Prefrontal Cortex in Children
Regular aerobic exercise has been associated with enhanced cognition in both children and adults.  Most of these types of studies have been cross-sectional in design.  Cross-sectional studies do a good job of examining association but do not prove causality.  Prospective randomized control trials are better at examining the cause-effect relationship.So an important research question in the exercise-cognition domain is: Can an exercise intervention improve cognition in a […]

Chaddock-Heyman, L., Erickson, K., Voss, M., Knecht, A., Pontifex, M., Castelli, D., Hillman, C. & Kramer, A. (2013). The effects of physical activity on functional MRI activation associated with cognitive control in children: a randomized controlled intervention, Frontiers in Human Neuroscience, 7 DOI:

Brain Posts
Medicine | Neuroscience
Citation

April 18, 2013

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11:11 PM | Bone Marrow Cell Infusions Do NOT Improve Cardiac Function After Heart Attack
For over a decade, cardiologists have been conducting trials in patients using cells extracted from the bone marrow and infusing them into the blood vessels of the heart in patients who have suffered a heart attack. This type of a procedure is not without risks, because it involves multiple invasive procedures in patients who are already quite ill, because they are experiencing a major heart attack: 1) Patients with a major heart attack (also referred to as ST-elevation Myocardial Infarction... […]

Surder, D., Manka, R., Lo Cicero, V., Moccetti, T., Rufibach, K., Soncin, S., Turchetto, L., Radrizzani, M., Astori, G., Schwitter, J. & Erne, P. (2013). Intracoronary Injection of Bone Marrow Derived Mononuclear Cells, Early or Late after Acute Myocardial Infarction: Effects on Global Left Ventricular Function Four months results of the SWISS-AMI trial, Circulation, DOI:

Rehman, J. (2013). Bone Marrow Tinctures for Cardiovascular Disease: Lost in Translation, Circulation, DOI:

The Next Regeneration
Cell Biology | Biology
Citation
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11:11 PM | Bone Marrow Cell Infusions Do NOT Improve Cardiac Function After Heart Attack
For over a decade, cardiologists have been conducting trials in patients using cells extracted from the bone marrow and infusing them into the blood vessels of the heart in patients who have suffered a heart attack. This type of a procedure is not without risks, because it involves multiple invasive procedures in patients who are already quite ill, because they are experiencing a major heart attack: 1) Patients with a major heart attack (also referred to as ST-elevation Myocardial Infarction... […]

Surder, D., Manka, R., Lo Cicero, V., Moccetti, T., Rufibach, K., Soncin, S., Turchetto, L., Radrizzani, M., Astori, G., Schwitter, J. & Erne, P. (2013). Intracoronary Injection of Bone Marrow Derived Mononuclear Cells, Early or Late after Acute Myocardial Infarction: Effects on Global Left Ventricular Function Four months results of the SWISS-AMI trial, Circulation, DOI:

Rehman, J. (2013). Bone Marrow Tinctures for Cardiovascular Disease: Lost in Translation, Circulation, DOI:

The Next Regeneration
Cell Biology | Biology
Citation

April 17, 2013

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3:16 PM | EEG Differentiates Adjustment Disorder From Depression
A key element in discovering valid mental disorder categories is to differentiate a mental disorder from other valid mental disorder categories.Biological markers for mental disorders have been slow to develop.  Functional brain imaging techniques and other research tools are evolving to help in the important task of improving the validity of clinical neuroscience disorders.Adjustment disorder is a relatively common condition that has lagged in research attention.  Adjustment disorder […]

Jeong HG, Ko YH, Han C, Kim YK & Joe SH (2013). Distinguishing Quantitative Electroencephalogram Findings between Adjustment Disorder and Major Depressive Disorder., Psychiatry investigation, 10 (1) 62-8. PMID:

Brain Posts
Medicine | Neuroscience
Citation

April 08, 2013

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8:22 PM | SMIM1 Blood Protein Solves 61-Year-Old Vel Group Riddle
Discovery of a new protein that controls the presence of the Vel blood group antigen on our red blood cells will make it possible to use simple DNA testing to find blood donors for patients who lack the Vel antigen and need a blood transfusion, say researchers.  read more
Science 2.0
Science Communication | Neuroscience

March 29, 2013

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3:26 PM | Blast-related Traumatic Brain Injury and fMRI
Blast-related traumatic brain injury (TBI) is an important research topic.  Over 100,000 armed services personnel experienced a significant traumatic brain event in the last decade.  A majority of these were explosion or blast-related in nature.However, standard brain imaging techniques (computed tomographay, structural MRI) typically fail to demonstrate changes following blast TBI.  New imaging strategies are needed to assess severity and progression.Graner and colleagues from […]

Graner J, Oakes TR, French LM & Riedy G (2013). Functional MRI in the investigation of blast-related traumatic brain injury., Frontiers in neurology, 4 16. PMID:

Brain Posts
Medicine | Neuroscience
Citation

March 28, 2013

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4:09 PM | Football and the Blood Brain Barrier
A variety of research tools are being utilized to study the effect of trauma on the brain.  In a previous post, I summarized some of the research using diffusion brain imaging or DTI.A recent study looked at the function of the blood-brain barrier (BBB) in a group of football players.  The BBB is an important brain protective mechanism.  A variety of blood proteins and other compounds have the potential to cause inflammation and other damage to neurons and other brain […]

Marchi N, Bazarian JJ, Puvenna V, Janigro M, Ghosh C, Zhong J, Zhu T, Blackman E, Stewart D, Ellis J & Butler R (2013). Consequences of repeated blood-brain barrier disruption in football players., PloS one, 8 (3) PMID:

Brain Posts
Medicine | Neuroscience
Citation

March 13, 2013

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2:12 PM | ECT Reverses Depression Brain Connectivity Deficit
Electroconvulsive treatment (ECT) remains one of the most effective treatments for major depressive disorder (MDD).The mechanism of action for ECT in MDD is unclear.   Research targeting brain changes in ECT is an important pathway to understanding the mechanism of action for ECT.Patients with MDD show disruptions in brain functional connectivity as measures by functional magnetic resonance imaging (fMRI).  The connectivity abnormalities in MDD have included changes in limbic, […]

Abbott, C., Lemke, N., Gopal, S., Thoma, R., Bustillo, J., Calhoun, V. & Turner, J. (2013). Electroconvulsive Therapy Response in Major Depressive Disorder: A Pilot Functional Network Connectivity Resting State fMRI Investigation, Frontiers in Psychiatry, 4 DOI:

Brain Posts
Medicine | Neuroscience
Citation

March 11, 2013

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5:49 PM | Bromodomain Inhibitors – an exciting new target in cancer research?
One of the interesting things about basic cancer research is that new targets emerge all the time, offering fresh opportunities…

Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W., Fedorov, O., Morse, E., Keates, T., Hickman, T., Felletar, I. & Philpott, M. (2010). Selective inhibition of BET bromodomains, Nature, 468 (7327) 1067-1073. DOI:

Puissant, A., Frumm, S., Alexe, G., Bassil, C., Qi, J., Chanthery, Y., Nekritz, E., Zeid, R., Gustafson, W., Greninger, P. & Garnett, M. (2013). Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition, Cancer Discovery, 3 (3) 308-323. DOI:

Lin, C., Lovén, J., Rahl, P., Paranal, R., Burge, C., Bradner, J., Lee, T. & Young, R. (2012). Transcriptional Amplification in Tumor Cells with Elevated c-Myc, Cell, 151 (1) 56-67. DOI:

Mertz, J., Conery, A., Bryant, B., Sandy, P., Balasubramanian, S., Mele, D., Bergeron, L. & Sims, R. (2011). Targeting MYC dependence in cancer by inhibiting BET bromodomains, Proceedings of the National Academy of Sciences, 108 (40) 16669-16674. DOI:

Schnepp, R. & Maris, J. (2013). Targeting MYCN: A Good BET for Improving Neuroblastoma Therapy?, Cancer Discovery, 3 (3) 255-257. DOI:

Pharma Strategy Blog
Cell Biology | Medicine
Citation

March 07, 2013

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1:16 AM | Roche grants access to clinical trial data
NEWSFLASH Pharmaceutical company Roche announced last week that it would allow members of the public to access anonymised clinical trial data, after independent review of each request for access. The review process will be presided by a committee appointed by Roche, which is expected to include both external experts and company representatives, and will result [...]The post Roche grants access to clinical trial data appeared first on Oxbridge Biotech.
Roundtable Review
Biotechnology | Career
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