Posts

July 25, 2014

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8:32 AM | Clinical trials: why multi-arms are better than two
In their quest to speed up the discovery of new treatments for patient benefit, MRC researchers at the MRC Clinical Trials Unit propose an efficient solution: the multi-arm clinical trial. […]

July 23, 2014

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7:26 PM | Physicians face difficult choices when treating patients with bipolar and obsessive compulsive disorders
New research suggests patients with both bipolar disorder and obsessive compulsive disorder should receive treatments for bipolar disorder alone.1 Bipolar and obsessive compulsive disorder therapies taken together can cause worsening of disease symptoms, making it difficult for physicians to treat both conditions. This is a concern as over 1 in 5 patients with bipolar disorder […]

Pacchiarotti I, Bond DJ, Baldessarini RJ & et al. (2013). The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders., The American journal of psychiatry, 170 (11) 1249-62. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24030475

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7:26 PM | Physicians face difficult choices when treating patients with bipolar and obsessive compulsive disorders
New research suggests patients with both bipolar disorder and obsessive compulsive disorder should receive treatments for bipolar disorder alone.1 Bipolar and obsessive compulsive disorder therapies taken together can cause worsening of disease symptoms, making it difficult for physicians to treat both conditions. This is a concern as over 1 in 5 patients with bipolar disorder […]

Pacchiarotti I, Bond DJ, Baldessarini RJ & et al. (2013). The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders., The American journal of psychiatry, 170 (11) 1249-62. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24030475

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July 22, 2014

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6:48 PM | Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy
[Note: This is a guest post by Tauseef (@CellSpell)] Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases... […]

Cheng, C., Adams, G., Perin, L., Wei, M., Zhou, X., Lam, B., Da Sacco, S., Mirisola, M., Quinn, D., Dorff, T. & Kopchick, J. (2014). Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression, Cell Stem Cell, 14 (6) 810-823. DOI: 10.1016/j.stem.2014.04.014

Citation
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6:48 PM | Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy
[Note: This is a guest post by Tauseef (@CellSpell)] Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases... […]

Cheng, C., Adams, G., Perin, L., Wei, M., Zhou, X., Lam, B., Da Sacco, S., Mirisola, M., Quinn, D., Dorff, T. & Kopchick, J. (2014). Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression, Cell Stem Cell, 14 (6) 810-823. DOI: 10.1016/j.stem.2014.04.014

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July 19, 2014

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2:35 PM | Join the Brain & Behavior Research Foundation in DC on Sept. 16
The Brain & Behavior Research Foundation will present cutting-edge information on early intervention, relapse prevention and recovery at Discovery to Recovery: A Path to Healthy Minds. The mental health conference for caregivers, family members, people living with mental illness, and mental health professionals takes place Tuesday, September 16, 2014, 9 a.m. to 2:30 p.m., Ronald […]

July 09, 2014

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10:00 PM | Minimally Invasive Heart Stents Are Safer
A study has documented the safety benefits of aortic stent grafts inserted during minimally invasive surgery to repair abdominal aortic aneurysms; weaknesses in the body's largest artery that can rupture, causing potentially lethal internal bleeding.  The study shows that patients who received the minimally invasive aortic repair procedure had a 42 percent reduction in preventable post-operative complications and a 72 percent reduction in mortality, compared with those who had undergone […]
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5:30 PM | Phase I Clinical Trial To Treat Clostridium Difficile Infection Launches
Each year, roughly 250,000 people in the United States require hospital care forClostridium difficile (C. difficile) infection and at least 14,000 people die from it, according to the U.S. Centers for Disease Control and Prevention (CDC). As a result, the CDC identified C. difficile as an urgent public health threat in its 2013 report on antibiotic resistance. The National Institute of Allergy and Infectious Diseases (NIAID) has launched an early-stage clinical trial of CRS3123, an […]
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1:20 PM | Bedsheets, boats and biology: James Lovelock and the MRC
Think James Lovelock, and most people think about Gaia theory, his idea that the Earth is a self-regulating system that keeps the conditions for life in a delicate equilibrium. But […]

July 07, 2014

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3:05 PM | Florida Clampdown on Pain Pills Lowers Drug-Related Mortality
Ever since I started working with the homeless youth of Delhi, I have noticed their drug and substance dependence issues and how, despite knowing the ill-effects, they have not been able to get out from under the chemical spell. Thus, when I came across a short report in the CDC’s Morbidity and Mortality Weekly Reports that Florida…

Johnson H, Paulozzi L, Porucznik C, Mack K, Herter B & Hal Johnson Consulting and Division of Disease Control and Health Promotion, Florida Department of Health (2014). Decline in drug overdose deaths after state policy changes - Florida, 2010-2012., MMWR. Morbidity and mortality weekly report, 63 (26) 569-74. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24990490

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2:33 PM | MERS CoV: Can it spread from camels to man?
The Middle Eastern Respiratory Syndrome coronavirus (MERS CoV) is a novel single stranded RNA virus that has been doing the rounds in the Middle East, bits of Europe and North America. Given our experiences the last time we had a new respiratory virus (remember the pandemic?), things have moved rather fast this time once the…

Azhar, E., El-Kafrawy, S., Farraj, S., Hassan, A., Al-Saeed, M., Hashem, A. & Madani, T. (2014). Evidence for Camel-to-Human Transmission of MERS Coronavirus, New England Journal of Medicine, 370 (26) 2499-2505. DOI: 10.1056/NEJMoa1401505

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