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Posts

April 16, 2014

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1:36 AM | New Study Shows Surgical Checklists In Operating Rooms Are Less Effective Than Assumed
The patient has verified his or her identity, the surgical site, the type of procedure, and his or her consent. Check. The surgical site is marked on a patient if such marking is appropriate for the procedure. Check. The probe measuring blood oxygen content has been placed on the patient and is functioning. Check. All members of the surgical and anesthesia team are aware of whether the patient has a known allergy? Check. These were the first items on a... Read more

Urbach DR, Govindarajan A, Saskin R, Wilton AS & Baxter NN (2014). Introduction of surgical safety checklists in Ontario, Canada., The New England Journal of Medicine, 370 (11) 1029-38. PMID:

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1:36 AM | New Study Shows Surgical Checklists In Operating Rooms Are Less Effective Than Assumed
The patient has verified his or her identity, the surgical site, the type of procedure, and his or her consent. Check. The surgical site is marked on a patient if such marking is appropriate for the procedure. Check. The probe measuring blood oxygen content has been placed on the patient and is functioning. Check. All members of the surgical and anesthesia team are aware of whether the patient has a known allergy? Check. These were the first items on a... Read more

Urbach DR, Govindarajan A, Saskin R, Wilton AS & Baxter NN (2014). Introduction of surgical safety checklists in Ontario, Canada., The New England Journal of Medicine, 370 (11) 1029-38. PMID:

Citation
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12:00 AM | Fialuridine Redux: New Mouse Model Would Have Predicted Fatal Outcome In Human Clinical Trial
In 1993, five people died in a clinical trial of fialuridine, a nucleoside analogue to treat hepatitis B virus infection. An analysis by the US National Academy of Sciences of all preclinical fialuridine toxicity tests, which included studies in mice, rats, dogs, and monkeys, concluded that the available animal data provided no indication that the drug would cause liver failure in humans. So it's been a 21 year search to try and find ways to make trials safer. read more

April 15, 2014

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3:43 PM | Religious Belief and Depression Resilience
Identifying risk factors for brain disorders is a key element in clinical research.Understanding protective or resilience factors for brain disorders is also important and receiving increased attention in clinical research.Factors that promote resilience to brain disorders may come from a variety of domains. Religious belief is one domain receiving attention as a potential resilience factor.Miller and colleagues recently published a longitudinal study of religious belief and risk for major […]

April 11, 2014

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4:34 AM | Lab-Grown Vaginas Implanted In 4 Young Patients
A report in The Lancet describes the first instance of human recipients receiving laboratory-grown vaginal organs. The research team describes long-term success in four teenage girls who received the vaginal organs, engineered with their own cells.read more
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12:49 AM | 5 Patients Get Nose Reconstruction With Cartilage Grown From Their Own Cells
The first ever successful nose reconstruction surgery using cartilage grown in the laboratory has been done by the University of Basel.  The details are upcoming in The Lancet. The cartilage cells were extracted from the patient's nasal septum, multiplied and expanded onto a collagen membrane and then the engineered cartilage was then shaped according to the defect and implanted. The cartilage was grown from the patient's own adult stem cells and the technique was used with five patients, […]

April 09, 2014

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8:30 AM | New: Better Tissue Trauma Repair Than Grafts And Synthetic Material
A breakthrough could speed recovery and limit disfigurement for patients who have suffered large soft tissue trauma, as occurs with serious injury or cancer surgery.  By biomedically engineering a muscle flap that includes a patient's own blood vessels, the team created tissue that could be transferred to other parts of the body along with the patient's blood supply. Current techniques – including grafts and synthetic material – for reconstructing such trauma often fail because […]

April 03, 2014

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4:02 AM | Vaccination Changes Body Odor
Body odor can convey a lot of personal information, according to new research from the Monell Chemical Senses Center and the U.S. Department of Agriculture (USDA) which reveals that immunization can trigger a distinct change in body odor. This is the first demonstration of a bodily odor change due to immune activation.  In the study, 'biosensor' mice were trained to discriminate between urine odors from mice vaccinated against either the rabies virus (RV) or the West Nile virus (WNV). All […]

March 28, 2014

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11:36 AM | Why we work with industry
There was a time when the paths of academic and industry researchers rarely crossed. But developing treatments for patients requires a much closer relationship between the two sectors than ever […]

March 25, 2014

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9:42 PM | Blood Glucose Doesn't Predict Risk Of Cardiovascular Disease
It's hard to find an article on food or metabolism that doesn't imply it has implications for predicting cardiovascular disease (CVD) or diabetes.  Because higher glucose levels have been associated with higher CVD incidence, it has been proposed that information on blood sugar control might improve doctors' ability to predict who will develop CVD, according to background information in the article. But an analysis of nearly 300,000 adults without a known history of diabetes or […]

March 20, 2014

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10:57 AM | Q&A: Research on the wards
We know that clinical research relies on doctors and willing patients, but what about nurses? Chris Lerpiniere is a Senior Research Nurse on the MRC-funded RUSH, ‘Research to Understand Stroke […]

March 18, 2014

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3:46 PM | Short Sleep Duration in Children with Autism
Parents of children with autism and autism spectrum disorder commonly report sleep problems in their child.However, there have been few prospective systematic studies of sleep in this disorder.Joanna Humphreys from Canada and colleagues from England recently published an important manuscript addressing this topic.They used data from the Avon Longitudinal Study of Parents and Children. This data set includes prospective data collected from a cohort of over 14,000 children born between April 1991 […]

Humphreys JS, Gringras P, Blair PS, Scott N, Henderson J, Fleming PJ & Emond AM (2014). Sleep patterns in children with autistic spectrum disorders: a prospective cohort study., Archives of disease in childhood, 99 (2) 114-8. PMID:

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