Posts

August 29, 2014

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1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

Citation
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1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

Citation
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10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation

August 22, 2014

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2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
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2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
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2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation

August 14, 2014

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7:50 AM | Australian Researchers Unravel the Mystery of Hematopoietic Stem Cell Generation
Professor Peter CurrieCreditA cure for a range of blood disorders and immune diseases is in sight, according to a team of scientists who have unravelled the mystery of hematopoietic stem cell generation. The new study, led by researchers at the Australian Regenerative Medicine Institute (ARMI) at Monash University and the Garvan Institute of Medical Research, appeared yesterday in Nature. It identifies for the first time mechanisms in the body that trigger hematopoietic stem cell […]

Nguyen P.D., Carmen Sonntag, Lee Barry Miles, Thomas Edward Hall, Silke Berger, Kristine Joy Fernandez, David Baruch Gurevich, Nicholas James Cole, Sara Alaei & Mirana Ramialison & (2014). Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1, Nature, DOI: http://dx.doi.org/10.1038/nature13678

Citation

August 06, 2014

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12:00 PM | Fall Leaves And Orange Flamingos
Biology concepts – pigment, carotenoids, flamingos, cyanobacteria, bacteriophage, trophic cascade effect, spirulina, algaThese are the two species of Old World flamingos, the greater (upper left) and the lesser (bottom right). Their ranges are included, pointed out by the convenient arrows. Even though the pictures don’t show it because I couldn’t get them to stand next to one another, the greater is twice the height of the lesser, hence the names. Notice the color variation […]

Anderson MJ & Williams SA (2010). Why do flamingos stand on one leg?, Zoo biology, 29 (3) 365-74. PMID: http://www.ncbi.nlm.nih.gov/pubmed/19637281

Peduzzi P, Gruber M, Gruber M, Schagerl M. (2014). The virus's tooth: cyanophages affect an African flamingo population in a bottom-up cascade., ISME J. , 8 (6) 1346-1351. Other:

Kotut K, Ballot A & Krienitz L (2006). Toxic cyanobacteria and their toxins in standing waters of Kenya: implications for water resource use., Journal of water and health, 4 (2) 233-45. PMID: http://www.ncbi.nlm.nih.gov/pubmed/16813016

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