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Posts

April 23, 2014

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3:40 PM | Old champions get new help
Greetings     So often has been antibiotic resistance been talked about in this page, that it needs no introduction. There is a huge list of antibiotics that is currently in research. There are all sorts of chemicals, that has been investigated. It is now almost impossible to keep track of the growing list (I probably have even lost the count). The whole story of magic medicine bullet (Antibiotics I mean), has started from the discovery of penicillin (Not by Alexander Fleming, […]

Zhang J., Chen Y.P., Miller K.P., Ganewatta M.S., Bam M., Yan Y., Nagarkatti M., Decho A.W. & Tang C. (2014). Antimicrobial Metallopolymers and Their Bioconjugates with Conventional Antibiotics against Multidrug-Resistant Bacteria., Journal of the American Chemical Society, PMID:

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April 21, 2014

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8:38 PM | Developing Gain Control in Single Cortical Neurons
If you are reading this sentence, it is quite likely that you have heard of “gain control” in a neuroscience context. You may notice that the picture provided above has very little to do with the context in which this blog post shall discuss “gain control”. You may also notice that this blog post has […]

Mease R.A., Famulare M., Gjorgjieva J., Moody W.J. & Fairhall A.L. (2013). Emergence of Adaptive Computation by Single Neurons in the Developing Cortex, Journal of Neuroscience, 33 (30) 12154-12170. DOI:

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April 18, 2014

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4:39 PM | Can Fruit Flies Glow in the Dark?
Question: How is a fruit fly like a firefly? No, this is not an obvious answer (their names start with the letter “f”) or the beginning of a bad entomology joke. These two organisms may both be winged insects, but as it turns out, what makes the firefly light show such a special treat on […]

Mofford D.M., Reddy G.R. & Miller S.C. (2014). Latent luciferase activity in the fruit fly revealed by a synthetic luciferin., Proceedings of the National Academy of Sciences of the United States of America, PMID:

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April 10, 2014

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5:02 AM | Resources For Blastocystis Epidemiology Research
 I often get questions related to Blastocystis epidemiology research, and many of these are 'how-to' questions.And as announced, I've chosen to dedicate a separate post listing some easy-to-use tools for subtyping Blastocystis from humans and animals.First, I want to guide your attention to the YouTube video that I made; it takes you through various important steps of subtyping and introduces you to the online database that can be used to call subtypes by BLASTing batches of fasta files - […]

Stensvold CR (2013). Comparison of sequencing (barcode region) and sequence-tagged-site PCR for Blastocystis subtyping., Journal of clinical microbiology, 51 (1) 190-4. PMID:

Alfellani MA, Taner-Mulla D, Jacob AS, Imeede CA, Yoshikawa H, Stensvold CR & Clark CG (2013). Genetic Diversity of Blastocystis in Livestock and Zoo Animals., Protist, 164 (4) 497-509. PMID:

Stensvold CR (2013). Blastocystis: Genetic diversity and molecular methods for diagnosis and epidemiology., Tropical parasitology, 3 (1) 26-34. PMID:

Alfellani MA, Stensvold CR, Vidal-Lapiedra A, Onuoha ES, Fagbenro-Beyioku AF & Clark CG (2013). Variable geographic distribution of Blastocystis subtypes and its potential implications., Acta tropica, 126 (1) 11-8. PMID:

Clark CG, van der Giezen M, Alfellani MA & Stensvold CR (2013). Recent developments in blastocystis research., Advances in parasitology, 82 1-32. PMID:

Stensvold CR, Ahmed UN, Andersen LO & Nielsen HV (2012). Development and Evaluation of a Genus-Specific, Probe-Based, Internal-Process-Controlled Real-Time PCR Assay for Sensitive and Specific Detection of Blastocystis spp., Journal of clinical microbiology, 50 (6) 1847-51. PMID:

Stensvold CR, Suresh GK, Tan KS, Thompson RC, Traub RJ, Viscogliosi E, Yoshikawa H & Clark CG (2007). Terminology for Blastocystis subtypes--a consensus., Trends in parasitology, 23 (3) 93-6. PMID:

Citation
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5:02 AM | Resources For Blastocystis Epidemiology Research
 I often get questions related to Blastocystis epidemiology research, and many of these are 'how-to' questions.And as announced, I've chosen to dedicate a separate post listing some easy-to-use tools for subtyping Blastocystis from humans and animals.First, I want to guide your attention to the YouTube video that I made; it takes you through various important steps of subtyping and introduces you to the online database that can be used to call subtypes by BLASTing batches of fasta files - […]

Stensvold CR (2013). Comparison of sequencing (barcode region) and sequence-tagged-site PCR for Blastocystis subtyping., Journal of clinical microbiology, 51 (1) 190-4. PMID:

Alfellani MA, Taner-Mulla D, Jacob AS, Imeede CA, Yoshikawa H, Stensvold CR & Clark CG (2013). Genetic Diversity of Blastocystis in Livestock and Zoo Animals., Protist, 164 (4) 497-509. PMID:

Stensvold CR (2013). Blastocystis: Genetic diversity and molecular methods for diagnosis and epidemiology., Tropical parasitology, 3 (1) 26-34. PMID:

Alfellani MA, Stensvold CR, Vidal-Lapiedra A, Onuoha ES, Fagbenro-Beyioku AF & Clark CG (2013). Variable geographic distribution of Blastocystis subtypes and its potential implications., Acta tropica, 126 (1) 11-8. PMID:

Clark CG, van der Giezen M, Alfellani MA & Stensvold CR (2013). Recent developments in blastocystis research., Advances in parasitology, 82 1-32. PMID:

Stensvold CR, Ahmed UN, Andersen LO & Nielsen HV (2012). Development and Evaluation of a Genus-Specific, Probe-Based, Internal-Process-Controlled Real-Time PCR Assay for Sensitive and Specific Detection of Blastocystis spp., Journal of clinical microbiology, 50 (6) 1847-51. PMID:

Stensvold CR, Suresh GK, Tan KS, Thompson RC, Traub RJ, Viscogliosi E, Yoshikawa H & Clark CG (2007). Terminology for Blastocystis subtypes--a consensus., Trends in parasitology, 23 (3) 93-6. PMID:

Citation

April 07, 2014

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4:58 PM | Neuronal memory
Francis Crick‘s astonishing hypothesis (1995) is that “You, your joys and your sorrows, your memories and your ambitions, your sense of personal identity and free will, are in fact no more than the behavior of a vast assembly of nerve cells and their associated molecules.” Actually, more than a hypothesis, this is the basis of […]

Larimer P. & Strowbridge B.W. (2009). Representing information in cell assemblies: persistent activity mediated by semilunar granule cells, Nature Neuroscience, 13 (2) 213-222. DOI:

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April 04, 2014

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12:36 PM | Evidence indicates that VSELs from human adult tissues are multipotent
Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two new papers published in Stem Cells and Development, a peer-reviewed […]

Havens A.M., Sun H., Shiozawa Y., Jung Y., Wang J., Mishra A., Jiang Y., O'Neill D.W., Krebsbach P.H. & Rodgerson D.O. & (2014). Human and Murine Very Small Embryonic-Like Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo, Stem Cells and Development, 23 (7) 689-701. DOI:

Suszynska M., Zuba-Surma E.K., Maj M., Mierzejewska K., Ratajczak J., Kucia M. & Ratajczak M.Z. (2014). The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells, and Some Nomenclature Issues, Stem Cells and Development, 23 (7) 702-713. DOI:

Citation
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12:36 PM | Evidence indicates that VSELs from human adult tissues are multipotent
Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two new papers published in Stem Cells and Development, a peer-reviewed […]

Havens A.M., Sun H., Shiozawa Y., Jung Y., Wang J., Mishra A., Jiang Y., O'Neill D.W., Krebsbach P.H. & Rodgerson D.O. & (2014). Human and Murine Very Small Embryonic-Like Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo, Stem Cells and Development, 23 (7) 689-701. DOI:

Suszynska M., Zuba-Surma E.K., Maj M., Mierzejewska K., Ratajczak J., Kucia M. & Ratajczak M.Z. (2014). The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells, and Some Nomenclature Issues, Stem Cells and Development, 23 (7) 702-713. DOI:

Citation
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12:36 PM | Evidence indicates that VSELs from human adult tissues are multipotent
Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two new papers published in Stem Cells and Development, a peer-reviewed […]

Havens A.M., Sun H., Shiozawa Y., Jung Y., Wang J., Mishra A., Jiang Y., O'Neill D.W., Krebsbach P.H. & Rodgerson D.O. & (2014). Human and Murine Very Small Embryonic-Like Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo, Stem Cells and Development, 23 (7) 689-701. DOI:

Suszynska M., Zuba-Surma E.K., Maj M., Mierzejewska K., Ratajczak J., Kucia M. & Ratajczak M.Z. (2014). The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells, and Some Nomenclature Issues, Stem Cells and Development, 23 (7) 702-713. DOI:

Citation
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12:36 PM | Evidence indicates that VSELs from human adult tissues are multipotent
Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two new papers published in Stem Cells and Development, a peer-reviewed […]

Havens A.M., Sun H., Shiozawa Y., Jung Y., Wang J., Mishra A., Jiang Y., O'Neill D.W., Krebsbach P.H. & Rodgerson D.O. & (2014). Human and Murine Very Small Embryonic-Like Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo, Stem Cells and Development, 23 (7) 689-701. DOI:

Suszynska M., Zuba-Surma E.K., Maj M., Mierzejewska K., Ratajczak J., Kucia M. & Ratajczak M.Z. (2014). The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells, and Some Nomenclature Issues, Stem Cells and Development, 23 (7) 702-713. DOI:

Citation
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12:22 PM | New hope for the treatment of Amyotrophic lateral sclerosis
Kevin EgganHarvard stem cell researchers have discovered that a recently approved medication for epilepsy might be a meaningful treatment for patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital (MGH) to design an initial clinical trial testing the safety of the treatment in ALS patients.The investigators all caution that a great […]

Wainger B., Kiskinis E., Mellin C., Wiskow O., Han S.W., Sandoe J., Perez N., Williams L., Lee S. & Boulting G. & (2014). Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons, Cell Reports, DOI:

Kiskinis E., Sandoe J., Williams L., Boulting G., Moccia R., Wainger B., Han S., Peng T., Thams S. & Mikkilineni S. & (2014). Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1, Cell Stem Cell, DOI:

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12:22 PM | New hope for the treatment of Amyotrophic lateral sclerosis
Kevin EgganHarvard stem cell researchers have discovered that a recently approved medication for epilepsy might be a meaningful treatment for patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital (MGH) to design an initial clinical trial testing the safety of the treatment in ALS patients.The investigators all caution that a great […]

Wainger B., Kiskinis E., Mellin C., Wiskow O., Han S.W., Sandoe J., Perez N., Williams L., Lee S. & Boulting G. & (2014). Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons, Cell Reports, DOI:

Kiskinis E., Sandoe J., Williams L., Boulting G., Moccia R., Wainger B., Han S., Peng T., Thams S. & Mikkilineni S. & (2014). Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1, Cell Stem Cell, DOI:

Citation
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12:22 PM | New hope for the treatment of Amyotrophic lateral sclerosis
Kevin EgganHarvard stem cell researchers have discovered that a recently approved medication for epilepsy might be a meaningful treatment for patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital (MGH) to design an initial clinical trial testing the safety of the treatment in ALS patients.The investigators all caution that a great […]

Wainger B., Kiskinis E., Mellin C., Wiskow O., Han S.W., Sandoe J., Perez N., Williams L., Lee S. & Boulting G. & (2014). Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons, Cell Reports, DOI:

Kiskinis E., Sandoe J., Williams L., Boulting G., Moccia R., Wainger B., Han S., Peng T., Thams S. & Mikkilineni S. & (2014). Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1, Cell Stem Cell, DOI:

Citation
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12:22 PM | New hope for the treatment of Amyotrophic lateral sclerosis
Kevin EgganHarvard stem cell researchers have discovered that a recently approved medication for epilepsy might be a meaningful treatment for patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital (MGH) to design an initial clinical trial testing the safety of the treatment in ALS patients.The investigators all caution that a great […]

Wainger B., Kiskinis E., Mellin C., Wiskow O., Han S.W., Sandoe J., Perez N., Williams L., Lee S. & Boulting G. & (2014). Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons, Cell Reports, DOI:

Kiskinis E., Sandoe J., Williams L., Boulting G., Moccia R., Wainger B., Han S., Peng T., Thams S. & Mikkilineni S. & (2014). Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1, Cell Stem Cell, DOI:

Citation

March 28, 2014

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2:56 PM | Parenthood, Trial or Tribulation? Part 2
On New Year’s Day I became a parent, sparking my curiosity in the research on parenting and well-being and inspiring a four-part series on parenthood and happiness. This is the second post. Check out the first post here.Are parents happier than non-parents? Researchers have generally set about trying to answer this deceptively simple question in three ways:Are people with children happier than those without children?This is the most common approach to research on parenthood and […]

Callan, V. (1987). The Personal and Marital Adjustment of Mothers and of Voluntarily and Involuntarily Childless Wives, Journal of Marriage and the Family, 49 (4) 847. DOI:

Kahneman, D. (2004). A Survey Method for Characterizing Daily Life Experience: The Day Reconstruction Method, Science, 306 (5702) 1776-1780. DOI:

Lucas, R., Clark, A., Georgellis, Y. & Diener, E. (2003). Reexamining adaptation and the set point model of happiness: Reactions to changes in marital status., Journal of Personality and Social Psychology, 84 (3) 527-539. DOI:

Luhmann, M., Hofmann, W., Eid, M. & Lucas, R. (2012). Subjective well-being and adaptation to life events: A meta-analysis., Journal of Personality and Social Psychology, 102 (3) 592-615. DOI:

Nelson, S., Kushlev, K., English, T., Dunn, E. & Lyubomirsky, S. (2012). In Defense of Parenthood: Children Are Associated With More Joy Than Misery, Psychological Science, 24 (1) 3-10. DOI:

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