Posts

September 09, 2014

+
9:31 AM | Punning with the Pub in PubMed: Are there any decent NCBI puns left? #PubMedPuns
Many people claim they get all their best ideas in the pub, but for lots of scientists their best ideas probably come from PubMed.gov – the NCBI’s monster database of biomedical literature. Consequently, the database has spawned a whole slew of tools that riff off the PubMed name, with many puns and portmanteaus (aka “PubManteaus”), and the pub-based wordplays are very common. [1,2] […]

Lu Z. (2011). PubMed and beyond: a survey of web tools for searching biomedical literature., Database : the journal of biological databases and curation, PMID: http://www.ncbi.nlm.nih.gov/pubmed/21245076

Hull D., Pettifer S.R. & Kell D.B. (2008). Defrosting the digital library: bibliographic tools for the next generation web., PLoS computational biology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/18974831

Hokamp K. & Wolfe K.H. PubCrawler: keeping up comfortably with PubMed and GenBank., Nucleic acids research, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15215341

Hokamp K. & Wolfe K. What's new in the library? What's new in GenBank? let PubCrawler tell you., Trends in genetics : TIG, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10529811

Gibney E. (2014). How to tame the flood of literature., Nature, 513 (7516) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25186906

Bourne P. & Chalupa L. (2008). A new approach to scientific dissemination, Materials Today, 11 (6) 48-48. DOI: http://dx.doi.org/10.1016/s1369-7021(08)70131-7

Kumar N., Berg A., Belhumeur P.N. & Nayar S. (2011). Describable Visual Attributes for Face Verification and Image Search., IEEE transactions on pattern analysis and machine intelligence, PMID: http://www.ncbi.nlm.nih.gov/pubmed/21383395

Featherstone R. & Hersey D. (2010). The quest for full text: an in-depth examination of Pubget for medical searchers., Medical reference services quarterly, 29 (4) 307-319. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21058175

Kim T.K., Wan-Sup Cho, Gun Hwan Ko, Sanghyuk Lee & Bo Kyeng Hou (2011). PubMine: An Ontology-Based Text Mining System for Deducing Relationships among Biological Entities, Interdisciplinary Bio Central, 3 (2) 1-6. DOI: http://dx.doi.org/10.4051/ibc.2011.3.2.0007

Douglas S.M., Montelione G.T. & Gerstein M. (2005). PubNet: a flexible system for visualizing literature derived networks., Genome biology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/16168087

Yoo D., Xu I., Berardini T.Z., Rhee S.Y., Narayanasamy V. & Twigger S. (2006). PubSearch and PubFetch: a simple management system for semiautomated retrieval and annotation of biological information from the literature., Current protocols in bioinformatics , PMID: http://www.ncbi.nlm.nih.gov/pubmed/18428773

Seife C. (2002). Electronic publishing. DOE cites competition in killing PubSCIENCE., Science (New York, N.Y.), 297 (5585) 1257-1259. PMID: http://www.ncbi.nlm.nih.gov/pubmed/12193762

Jensen M. (2003). Another loss in the privatisation war: PubScience., Lancet, 361 (9354) 274. PMID: http://www.ncbi.nlm.nih.gov/pubmed/12559859

Dubuque E.M. (2011). Automating academic literature searches with RSS Feeds and Google Reader(™)., Behavior analysis in practice, 4 (1) PMID: http://www.ncbi.nlm.nih.gov/pubmed/22532905

McEntyre J.R., Ananiadou S., Andrews S., Black W.J., Boulderstone R., Buttery P., Chaplin D., Chevuru S., Cobley N. & Coleman L.A. & (2010). UKPMC: a full text article resource for the life sciences., Nucleic acids research, PMID: http://www.ncbi.nlm.nih.gov/pubmed/21062818

Citation
+
8:53 AM | When you set sad lyrics against happy music, the music wins
The Beatles' Hello, Goodbye featuressad lyrics and a happy tuneIt's a quirk of human nature that many of us enjoy sad music. Research last year uncovered some reasons why, including feeling a sense of connection, and the aesthetic appeal. For a new study, Kazuma Mori and Makoto Iwanaga drilled down into the specific situation where sad lyrics are combined with happy music, as in the Beatles' Hello, Goodbye. They wanted to see how people would respond to the music or lyrics in isolation, and how […]

Mori, K. & Iwanaga, M. (2013). Pleasure generated by sadness: Effect of sad lyrics on the emotions induced by happy music, Psychology of Music, 42 (5) 643-652. DOI: 10.1177/0305735613483667

Citation
+
8:53 AM | When you set sad lyrics against happy music, the music wins
The Beatles' Hello, Goodbye featuressad lyrics and a happy tuneIt's a quirk of human nature that many of us enjoy sad music. Research last year uncovered some reasons why, including feeling a sense of connection, and the aesthetic appeal. For a new study, Kazuma Mori and Makoto Iwanaga drilled down into the specific situation where sad lyrics are combined with happy music, as in the Beatles' Hello, Goodbye. They wanted to see how people would respond to the music or lyrics in isolation, and how […]

Mori, K. & Iwanaga, M. (2013). Pleasure generated by sadness: Effect of sad lyrics on the emotions induced by happy music, Psychology of Music, 42 (5) 643-652. DOI: 10.1177/0305735613483667

Citation
+
8:53 AM | When you set sad lyrics against happy music, the music wins
The Beatles' Hello, Goodbye featuressad lyrics and a happy tuneIt's a quirk of human nature that many of us enjoy sad music. Research last year uncovered some reasons why, including feeling a sense of connection, and the aesthetic appeal. For a new study, Kazuma Mori and Makoto Iwanaga drilled down into the specific situation where sad lyrics are combined with happy music, as in the Beatles' Hello, Goodbye. They wanted to see how people would respond to the music or lyrics in isolation, and how […]

Mori, K. & Iwanaga, M. (2013). Pleasure generated by sadness: Effect of sad lyrics on the emotions induced by happy music, Psychology of Music, 42 (5) 643-652. DOI: 10.1177/0305735613483667

Citation
+
8:53 AM | When you set sad lyrics against happy music, the music wins
The Beatles' Hello, Goodbye featuressad lyrics and a happy tuneIt's a quirk of human nature that many of us enjoy sad music. Research last year uncovered some reasons why, including feeling a sense of connection, and the aesthetic appeal. For a new study, Kazuma Mori and Makoto Iwanaga drilled down into the specific situation where sad lyrics are combined with happy music, as in the Beatles' Hello, Goodbye. They wanted to see how people would respond to the music or lyrics in isolation, and how […]

Mori, K. & Iwanaga, M. (2013). Pleasure generated by sadness: Effect of sad lyrics on the emotions induced by happy music, Psychology of Music, 42 (5) 643-652. DOI: 10.1177/0305735613483667

Citation

September 05, 2014

+
10:28 PM | Breaking research: A recent study in fruit flies suggests that sleep loss during childhood could lead to abnormal brain development
Discussions about whether schools for children should start later have been making headlines recently, highlighting the importance of getting enough sleep at night. We all know how important sleep is for day-to-day performance—you’ve likely experienced firsthand how hard it can be to think and focus after a bad night’s sleep. Luckily, these effects are reversible: […]

Kayser M.S. & A. Sehgal (2014). A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila, Science, 344 (6181) 269-274. DOI: http://dx.doi.org/10.1126/science.1250553

Citation
+
10:28 PM | Breaking research: A recent study in fruit flies suggests that sleep loss during childhood could lead to abnormal brain development
Discussions about whether schools for children should start later have been making headlines recently, highlighting the importance of getting enough sleep at night. We all know how important sleep is for day-to-day performance—you’ve likely experienced firsthand how hard it can be to think and focus after a bad night’s sleep. Luckily, these effects are reversible: […]

Kayser M.S. & A. Sehgal (2014). A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila, Science, 344 (6181) 269-274. DOI: http://dx.doi.org/10.1126/science.1250553

Citation

August 30, 2014

+
7:31 AM | Neurobiological Basis of Music Therapy
The basic and one of oldest socio-cognitive domains of Human species is music. Listening to music regularly helps to keep the neurons and synapses more active. Depending on the way sound waves are heard or pronounced, they have an impact in the way neurological (brain and nerve) system work in the human body. Neurological studies have identified that music is a valuable tool for evaluating the brain system [1]. Its observed that while listening to music, different parts of the brain are […]

Peretz, I. & Zatorre, R. (2005). Brain Organization for Music Processing, Annual Review of Psychology, 56 (1) 89-114. DOI: 10.1146/annurev.psych.56.091103.070225

Kristeva R, Chakarov V, Schulte-Mönting J & Spreer J (2003). Activation of cortical areas in music execution and imagining: a high-resolution EEG study., NeuroImage, 20 (3) 1872-83. PMID: http://www.ncbi.nlm.nih.gov/pubmed/14642497

Schellenberg, E., Nakata, T., Hunter, P. & Tamoto, S. (2007). Exposure to music and cognitive performance: tests of children and adults, Psychology of Music, 35 (1) 5-19. DOI: 10.1177/0305735607068885

Patton, J., Routh, D. & Stinard, T. (2013). Where do children study? Behavioral observations, Bulletin of the Psychonomic Society, 24 (6) 439-440. DOI: 10.3758/BF03330575

Chan AS, Ho YC & Cheung MC (1998). Music training improves verbal memory., Nature, 396 (6707) 128. PMID: http://www.ncbi.nlm.nih.gov/pubmed/9823892

Asada H, Fukuda Y, Tsunoda S, Yamaguchi M & Tonoike M (1999). Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans., Neuroscience letters, 274 (1) 29-32. PMID: http://www.ncbi.nlm.nih.gov/pubmed/10530512

TSANG, C., TRAINOR, L., SANTESSO, D., TASKER, S. & SCHMIDT, L. (2006). Frontal EEG Responses as a Function of Affective Musical Features, Annals of the New York Academy of Sciences, 930 (1) 439-442. DOI: 10.1111/j.1749-6632.2001.tb05764.x

Sammler D, Grigutsch M, Fritz T & Koelsch S (2007). Music and emotion: electrophysiological correlates of the processing of pleasant and unpleasant music., Psychophysiology, 44 (2) 293-304. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17343712

Luu P, Tucker DM & Makeig S (2004). Frontal midline theta and the error-related negativity: neurophysiological mechanisms of action regulation., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 115 (8) 1821-35. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15261861

Kubota Y, Sato W, Toichi M, Murai T, Okada T, Hayashi A & Sengoku A (2001). Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure., Brain research. Cognitive brain research, 11 (2) 281-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11275489

Pavlygina RA, Sakharov DS & Davydov VI (2004). [Spectral analysis of the human EEG during listening to musical compositions]., Fiziologiia cheloveka, 30 (1) 62-9. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15040288

Koelsch S (2010). Towards a neural basis of music-evoked emotions., Trends in cognitive sciences, 14 (3) 131-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20153242

Lonsdale, A. & North, A. (2011). Why do we listen to music? A uses and gratifications analysis, British Journal of Psychology, 102 (1) 108-134. DOI: 10.1348/000712610X506831

Citation
+
7:31 AM | Neurobiological Basis of Music Therapy
The basic and one of oldest socio-cognitive domains of Human species is music. Listening to music regularly helps to keep the neurons and synapses more active. Depending on the way sound waves are heard or pronounced, they have an impact in the way neurological (brain and nerve) system work in the human body. Neurological studies have identified that music is a valuable tool for evaluating the brain system [1]. Its observed that while listening to music, different parts of the brain are […]

Peretz, I. & Zatorre, R. (2005). Brain Organization for Music Processing, Annual Review of Psychology, 56 (1) 89-114. DOI: 10.1146/annurev.psych.56.091103.070225

Kristeva R, Chakarov V, Schulte-Mönting J & Spreer J (2003). Activation of cortical areas in music execution and imagining: a high-resolution EEG study., NeuroImage, 20 (3) 1872-83. PMID: http://www.ncbi.nlm.nih.gov/pubmed/14642497

Schellenberg, E., Nakata, T., Hunter, P. & Tamoto, S. (2007). Exposure to music and cognitive performance: tests of children and adults, Psychology of Music, 35 (1) 5-19. DOI: 10.1177/0305735607068885

Patton, J., Routh, D. & Stinard, T. (2013). Where do children study? Behavioral observations, Bulletin of the Psychonomic Society, 24 (6) 439-440. DOI: 10.3758/BF03330575

Chan AS, Ho YC & Cheung MC (1998). Music training improves verbal memory., Nature, 396 (6707) 128. PMID: http://www.ncbi.nlm.nih.gov/pubmed/9823892

Asada H, Fukuda Y, Tsunoda S, Yamaguchi M & Tonoike M (1999). Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans., Neuroscience letters, 274 (1) 29-32. PMID: http://www.ncbi.nlm.nih.gov/pubmed/10530512

TSANG, C., TRAINOR, L., SANTESSO, D., TASKER, S. & SCHMIDT, L. (2006). Frontal EEG Responses as a Function of Affective Musical Features, Annals of the New York Academy of Sciences, 930 (1) 439-442. DOI: 10.1111/j.1749-6632.2001.tb05764.x

Sammler D, Grigutsch M, Fritz T & Koelsch S (2007). Music and emotion: electrophysiological correlates of the processing of pleasant and unpleasant music., Psychophysiology, 44 (2) 293-304. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17343712

Luu P, Tucker DM & Makeig S (2004). Frontal midline theta and the error-related negativity: neurophysiological mechanisms of action regulation., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 115 (8) 1821-35. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15261861

Kubota Y, Sato W, Toichi M, Murai T, Okada T, Hayashi A & Sengoku A (2001). Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure., Brain research. Cognitive brain research, 11 (2) 281-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11275489

Pavlygina RA, Sakharov DS & Davydov VI (2004). [Spectral analysis of the human EEG during listening to musical compositions]., Fiziologiia cheloveka, 30 (1) 62-9. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15040288

Koelsch S (2010). Towards a neural basis of music-evoked emotions., Trends in cognitive sciences, 14 (3) 131-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20153242

Lonsdale, A. & North, A. (2011). Why do we listen to music? A uses and gratifications analysis, British Journal of Psychology, 102 (1) 108-134. DOI: 10.1348/000712610X506831

Citation
+
7:31 AM | Neurobiological Basis of Music Therapy
The basic and one of oldest socio-cognitive domains of Human species is music. Listening to music regularly helps to keep the neurons and synapses more active. Depending on the way sound waves are heard or pronounced, they have an impact in the way neurological (brain and nerve) system work in the human body. Neurological studies have identified that music is a valuable tool for evaluating the brain system [1]. Its observed that while listening to music, different parts of the brain are […]

Peretz, I. & Zatorre, R. (2005). Brain Organization for Music Processing, Annual Review of Psychology, 56 (1) 89-114. DOI: 10.1146/annurev.psych.56.091103.070225

Kristeva R, Chakarov V, Schulte-Mönting J & Spreer J (2003). Activation of cortical areas in music execution and imagining: a high-resolution EEG study., NeuroImage, 20 (3) 1872-83. PMID: http://www.ncbi.nlm.nih.gov/pubmed/14642497

Schellenberg, E., Nakata, T., Hunter, P. & Tamoto, S. (2007). Exposure to music and cognitive performance: tests of children and adults, Psychology of Music, 35 (1) 5-19. DOI: 10.1177/0305735607068885

Patton, J., Routh, D. & Stinard, T. (2013). Where do children study? Behavioral observations, Bulletin of the Psychonomic Society, 24 (6) 439-440. DOI: 10.3758/BF03330575

Chan AS, Ho YC & Cheung MC (1998). Music training improves verbal memory., Nature, 396 (6707) 128. PMID: http://www.ncbi.nlm.nih.gov/pubmed/9823892

Asada H, Fukuda Y, Tsunoda S, Yamaguchi M & Tonoike M (1999). Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans., Neuroscience letters, 274 (1) 29-32. PMID: http://www.ncbi.nlm.nih.gov/pubmed/10530512

TSANG, C., TRAINOR, L., SANTESSO, D., TASKER, S. & SCHMIDT, L. (2006). Frontal EEG Responses as a Function of Affective Musical Features, Annals of the New York Academy of Sciences, 930 (1) 439-442. DOI: 10.1111/j.1749-6632.2001.tb05764.x

Sammler D, Grigutsch M, Fritz T & Koelsch S (2007). Music and emotion: electrophysiological correlates of the processing of pleasant and unpleasant music., Psychophysiology, 44 (2) 293-304. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17343712

Luu P, Tucker DM & Makeig S (2004). Frontal midline theta and the error-related negativity: neurophysiological mechanisms of action regulation., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 115 (8) 1821-35. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15261861

Kubota Y, Sato W, Toichi M, Murai T, Okada T, Hayashi A & Sengoku A (2001). Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure., Brain research. Cognitive brain research, 11 (2) 281-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11275489

Pavlygina RA, Sakharov DS & Davydov VI (2004). [Spectral analysis of the human EEG during listening to musical compositions]., Fiziologiia cheloveka, 30 (1) 62-9. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15040288

Koelsch S (2010). Towards a neural basis of music-evoked emotions., Trends in cognitive sciences, 14 (3) 131-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20153242

Lonsdale, A. & North, A. (2011). Why do we listen to music? A uses and gratifications analysis, British Journal of Psychology, 102 (1) 108-134. DOI: 10.1348/000712610X506831

Citation

August 29, 2014

+
1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

Citation
+
1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

Citation
+
1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

Citation
+
1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

Citation
+
1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

Citation
+
1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation
+
10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

Citation

August 22, 2014

+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
+
2:38 PM | Translational Findings: How fruit flies are helping us understand Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disorder, and patients experience primarily movement-related symptoms including shaking and rigidity in their limbs, slow movements, and difficulty walking, all of which progressively worsen over time. It was formally recognized as a disease in 18171, but didn’t receive much attention until it was given its name in […]

Parkinson J. An essay on the shaking palsy. 1817., The Journal of neuropsychiatry and clinical neurosciences, PMID: http://www.ncbi.nlm.nih.gov/pubmed/11983801

Cotzias G.C. (1967). Dopa and Parkinsonism, BMJ, 3 (5563) 497-497. DOI: http://dx.doi.org/10.1136/bmj.3.5563.497

Blandini F., Cristina Tassorelli & Emilia Martignoni (2000). Functional changes of the basal ganglia circuitry in Parkinson's disease, Progress in Neurobiology, 62 (1) 63-88. DOI: http://dx.doi.org/10.1016/s0301-0082(99)00067-2

Polymeropoulos M.H. (1997). Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease, Science, 276 (5321) 2045-2047. DOI: http://dx.doi.org/10.1126/science.276.5321.2045

Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y. & Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/9560156

Valente E.M. (2004). Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, 304 (5674) 1158-1160. DOI: http://dx.doi.org/10.1126/science.1096284

Bonifati V. (2003). Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism, Science, 299 (5604) 256-259. DOI: http://dx.doi.org/10.1126/science.1077209

Paisán-Ruı́z C., E.Whitney Evans, William P. Gilks, Javier Simón, Marcel van der Brug, Adolfo López de Munain, Silvia Aparicio, Angel Martı́nez Gil, Naheed Khan & Janel Johnson & (2004). Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease, Neuron, 44 (4) 595-600. DOI: http://dx.doi.org/10.1016/j.neuron.2004.10.023

Zimprich A., Petra Leitner, Peter Lichtner, Matthew Farrer, Sarah Lincoln, Jennifer Kachergus, Mary Hulihan, Ryan J. Uitti, Donald B. Calne & A.Jon Stoessl & (2004). Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology, Neuron, 44 (4) 601-607. DOI: http://dx.doi.org/10.1016/j.neuron.2004.11.005

Clark I.E., Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay & Ming Guo (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441 (7097) 1162-1166. DOI: http://dx.doi.org/10.1038/nature04779

Park J., Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim & Jongkyeong Chung & (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441 (7097) 1157-1161. DOI: http://dx.doi.org/10.1038/nature04788

Yang Y., Y. Imai, Z. Huang, Y. Ouyang, J.-W. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu (2006). Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, 103 (28) 10793-10798. DOI: http://dx.doi.org/10.1073/pnas.0602493103

Feany M.B. & Bender W.W. A Drosophila model of Parkinson's disease., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/10746727

Bell J. & Brian E. Staveley (2008). Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson’s disease , Genome, 51 (12) 1040-1046. DOI: http://dx.doi.org/10.1139/g08-085

Haywood A.F.M. & Staveley B.E. (2004). Parkin counteracts symptoms in a Drosophila model of Parkinson's disease., BMC neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/15090075

Yang Y., Md. E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito & R. Takahashi & (2005). Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling, Proceedings of the National Academy of Sciences, 102 (38) 13670-13675. DOI: http://dx.doi.org/10.1073/pnas.0504610102

Meulener M., Cecilia E. Armstrong-Gold, Patrizia Rizzu, Peter Heutink, Paul D. Wes, Leo J. Pallanck & Nancy M. Bonini (2005). Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease, Current Biology, 15 (17) 1572-1577. DOI: http://dx.doi.org/10.1016/j.cub.2005.07.064

Hao L.Y. & N. M. Bonini (2010). DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function, Proceedings of the National Academy of Sciences, 107 (21) 9747-9752. DOI: http://dx.doi.org/10.1073/pnas.0911175107

Muñoz-Soriano V. (2011). Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies, Parkinson's Disease, 2011 1-14. DOI: http://dx.doi.org/10.4061/2011/520640

Guo M. (2010). What have we learned from Drosophila models of Parkinson’s disease?, Progress in Brain Research, 2-16. DOI: http://dx.doi.org/10.1016/s0079-6123(10)84001-4

Haelterman N.A., Yoon W.H., Sandoval H., Jaiswal M., Shulman J.M. & Bellen H.J. (2014). A mitocentric view of Parkinson's disease., Annual review of neuroscience, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24821430

Citation
12
57 Results