Posts

September 03, 2014

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8:36 AM | An observation-based classifier for rapid detection of autism risk
"Keep clear of the moors"Among the many researchers and research groups admired on this blog for their contribution to the world of autism research, the name Dennis Wall is fast becoming a real favourite. Aside from mention of the words 'systems biology' in his profile at Stanford University, I'm particularly interested in the way the Wall research group are looking at trying to apply machine-learning approaches to things like autism assessment.I've covered a few of their past research reports […]

M Duda, J A Kosmicki & D P Wall (2014). Testing the accuracy of an observation-based classifier for rapid detection of autism risk, Translational Psychiatry, 4 Other:

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September 02, 2014

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4:52 PM | Epigenetics: Taking Control of the Music
When I try to explain epigenetics to someone, I like to use the musician metaphor. Your genes are the sheet music and how your body reads those genes, that is your […]

Müller-Ott K, Erdel F, Matveeva A, Mallm JP, Rademacher A, Hahn M, Bauer C, Zhang Q, Kaltofen S, Schotta G & Höfer T (2014). Specificity, propagation, and memory of pericentric heterochromatin., Molecular systems biology, 10 (8) 746. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25134515

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2:41 PM | Pigeon Gamblers Treat Risk Just Like Humans Do
If you watch poker coverage on television, you probably won’t hear the commentators compare players to pigeons. Maybe they should. The birds don’t play a great game of hold ‘em, but the way they think about risk might be strikingly similar to the way we do. Researchers discovered this by putting humans and birds through […]The post Pigeon Gamblers Treat Risk Just Like Humans Do appeared first on Inkfish.

Ludvig EA, Madan CR, Pisklak JM & Spetch ML (2014). Reward context determines risky choice in pigeons and humans., Biology letters, 10 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25165453

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8:33 AM | The epigenetics of Chronic Fatigue Syndrome?
"These data are consistent with evidence of multisystem dysregulation in CFS [Chronic Fatigue Syndrome] and implicate the involvement of DNA modifications in CFS pathology". So said the paper by Wilfred de Vega and colleagues [1] (open-access here) which, I think, represents a bit of a first for CFS with their examination of the possible role of epigenetic modifications in relation to the condition(s) [2].Ladies first @ Wikipedia I have to say that I was really quite excited […]

de Vega WC, Vernon SD & McGowan PO (2014). DNA Methylation Modifications Associated with Chronic Fatigue Syndrome., PloS one, 9 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25111603

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3:46 AM | Unpacking Recovery Part 4: Are We All on the Same Page?
Another issue in defining and understanding recovery is that patients and clinicians may have different opinions about what recovery looks like and how to get there. Certainly, there is a body of literature from the critical feminist tradition in particular that explores how at times, patients can “follow the rules” of treatment systems to achieve a semblance of “recovery,” from a weight restoration and nutrition stabilization perspective, but feels nothing like a full […]

Noordenbos, G. & Seubring, A. (2006). Criteria for Recovery from Eating Disorders According to Patients and Therapists, Eating Disorders, 14 (1) 41-54. DOI: 10.1080/10640260500296756

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3:15 AM | Falsifiability and Gandy’s variant of the Church-Turing thesis
In 1936, two years after Karl Popper published the first German version of The Logic of Scientific Discovery and introduced falsifiability; Alonzo Church, Alan Turing, and Emil Post each published independent papers on the Entscheidungsproblem and introducing the lambda calculus, Turing machines, and Post-Turing machines as mathematical models of computation. The years after saw many […]

Gandy, R. (1980). Church's thesis and principles for mechanisms., Studies in Logic and the Foundations of Mathematics, (101) 123-148. DOI: 10.1016/S0049-237X(08)71257-6

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September 01, 2014

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7:09 PM | The hope behind climate change: adaptation strategies for coastal regions
Happy Labor Day!  In honor of a day traditionally taken off (except for retail employees, unfortunately) to enjoy grilling and relaxing outside, I thought I’d discuss something a bit more upbeat.  Climate change research can often be gloomy.  It is … Continue reading →

Brown, S., Nicholls, R., Hanson, S., Brundrit, G., Dearing, J., Dickson, M., Gallop, S., Gao, S., Haigh, I., Hinkel, J. & Jiménez, J. (2014). Shifting perspectives on coastal impacts and adaptation, Nature Climate Change, 4 (9) 752-755. DOI: 10.1038/nclimate2344

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6:12 PM | Assemblages: 50 Years Later, We Know Nothing About Them
You would think we learn about every part of a cell in biology, but we really don’t. Case in point, about 50 years ago, electron microscopy revealed the presence of […]

Toretsky, J. & Wright, P. (2014). Assemblages: Functional units formed by cellular phase separation, The Journal of Cell Biology, 206 (5) 579-588. DOI: 10.1083/jcb.201404124

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12:28 PM | Tracking the Daily Microbiome
Humans are essentially 90% bacteria. These bacteria pepper our skin and hang out in our digestive tracts, helping to break down complex carbohydrates and keeping bad bugs in check. We know how the human microbiome (our collection of bacteria) gets … Continue reading →

David LA, Materna AC, Friedman J, Campos-Baptista MI, Blackburn MC, Perrotta A, Erdman SE & Alm EJ (2014). Host lifestyle affects human microbiota on daily timescales., Genome biology, 15 (7) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25146375

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11:56 AM | New Clues Revealed about the Longevity of Naked Mole Rats
Naked Mole RatCredit: UT Health Science Center at San AntonioThe hairless, odd-looking creature in the photo is a naked mole rat (Heterocephalus glaber).Among many weird traits, the species also holds the record for longest living rodent. For comparison, the house mouse (Mus musculus) has a maximum lifespan of just 2-3 years, whereas naked mole rats have been recorded to live as much as 32 years!The exact mechanisms behind the species remarkable longevity have yet to be clearly unveiled, […]

Rodriguez KA, Osmulski PA, Pierce A, Weintraub ST, Gaczynska M & Buffenstein R (2014). A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition., Biochimica et biophysica acta, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25018089

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8:34 AM | Students with more autistic traits make fewer altruistic choices
Most people with autism have difficulties socialising and connecting with others. It's generally agreed that part of this has to do with an impairment in taking other people's perspective. More specifically, an emerging consensus suggests that autism is associated with having normal feelings for other people, but an impaired understanding of them. Little explored before now is how this affects the behaviour of people with autism towards others who need help.Leila Jameel and her colleagues […]

Jameel L, Vyas K, Bellesi G, Roberts V & Channon S (2014). Going 'Above and Beyond': Are Those High in Autistic Traits Less Pro-social?, Journal of autism and developmental disorders, 44 (8) 1846-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24522968

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7:32 AM | Lithium for mood disorder symptoms in autism?
Modern classroom? @ Wikipedia The paper published by Matthew Siegel and colleagues [1] talking about some preliminary observations on the use of lithium where symptoms of mood disorder might be present in cases of autism spectrum disorder (ASD) caught my eye recently. Concluding that: "lithium may be a medication of interest for those who exhibit two or more mood disorder symptoms, particularly mania or euphoria/elevated mood" the sentiments of more research-to-do in this area […]

Siegel M, Beresford CA, Bunker M, Verdi M, Vishnevetsky D, Karlsson C, Teer O, Stedman A & Smith KA (2014). Preliminary Investigation of Lithium for Mood Disorder Symptoms in Children and Adolescents with Autism Spectrum Disorder., Journal of child and adolescent psychopharmacology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25093602

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3:25 AM | August lives up to its definition: respected and impressive
The things we noticed in and around canine science over the past two weeks, Storified in one neat location for your convenience:[View the story "Do You Believe in Dog? [16-31 August 2014]" on Storify] Further reading:Feuerbacher E.N. (2014). Shut up and pet me! Domestic dogs (Canis lupus familiaris) prefer petting to vocal praise in concurrent and single-alternative choice procedures, Behavioural Processes, DOI: http://dx.doi.org/10.1016/j.beproc.2014.08.019 Gygax L. (2014). The A to Z of […]

Gygax L. (2014). The A to Z of statistics for testing cognitive judgement bias, Animal Behaviour, 95 59-69. DOI: http://dx.doi.org/10.1016/j.anbehav.2014.06.013

Arnott E.R., Claire M. Wade & Paul D. McGreevy (2014). Environmental Factors Associated with Success Rates of Australian Stock Herding Dogs, PLoS ONE, 9 (8) e104457. DOI: http://dx.doi.org/10.1371/journal.pone.0104457

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August 31, 2014

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10:18 PM | Whitman Was Not a Neuroscientist
Do I contradict myself?Very well then I contradict myself,(I am large, I contain multitudes.)-Walt Whitman, "Song of Myself" (from Leaves of Grass)Science is the search for objective truth based on physical laws of the universe. Scientific theories try to explain the consistent and predictable behavior of natural systems. They are generally reductionist, meaning that complex systems are reduced to simpler and more fundamental elements. The principles of physics, for instance, are expressed in […]

Chen, C., Huang, M., Yen, J., Chen, C., Liu, G., Yen, C. & Ko, C. (2014). Brain correlates of response inhibition in Internet gaming disorder, Psychiatry and Clinical Neurosciences, DOI: 10.1111/pcn.12224

Daniel Z. Freedman (1994). Some beautiful equations of mathematical physics, CERN-TH.7367/94, arXiv: http://arxiv.org/abs/hep-th/9408175v1

Ko, C., Hsieh, T., Chen, C., Yen, C., Chen, C., Yen, J., Wang, P. & Liu, G. (2014). Altered brain activation during response inhibition and error processing in subjects with Internet gaming disorder: a functional magnetic imaging study, European Archives of Psychiatry and Clinical Neuroscience, DOI: 10.1007/s00406-013-0483-3

Zeki, S., Romaya, J., Benincasa, D. & Atiyah, M. (2014). The experience of mathematical beauty and its neural correlates, Frontiers in Human Neuroscience, 8 DOI: 10.3389/fnhum.2014.00068

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7:47 PM | Mushroom extracts might prevent dental cavities
Recently published research suggests red camphor mushroom extracts might prevent the proliferation of bacteria that cause dental cavities and gum disease.1 * The Taiwanese red camphor mushroom (scientific name: Antrodia camphorata) is a herbal medicine traditionally used for treating conditions such as twisted tendons, muscle damage and liver diseases. Studies using human cells grown in […]

Lien HM, Tseng CJ, Huang CL, Lin YT, Chen CC & Lai YY (2014). Antimicrobial Activity of Antrodia camphorata Extracts against Oral Bacteria., PloS one, 9 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25144619

Geethangili M & Tzeng YM (2011). Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds., Evidence-based complementary and alternative medicine : eCAM, 2011 212641. PMID: http://www.ncbi.nlm.nih.gov/pubmed/19687189

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6:38 PM | New Synthetic Amino Acid for a New Class of Drugs
Creating new drug molecules is challenging, developing drugs that are highly effective against a target, but with minimal (or no) toxicity and side-effects to the patient can be an exercise in […]

Chen S. Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C (2014). Di-thiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, Nature Chemistry, Other:

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August 30, 2014

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6:54 PM | Direct mind-to-mind communication in humans
Image credit: www.techspot.com Here’s something right out of science fiction: a team of neuroscientists in Spain developed a system that allows a person to transmit the...

Grau C, Ginhoux R, Riera A, Nguyen TL, Chauvat H, Berg M, Amengual JL, Pascual-Leone A & Ruffini G (2014). Conscious Brain-to-Brain Communication in Humans Using Non-Invasive Technologies., PloS one, 9 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25137064

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6:23 PM | Predictor of Sudden Death helps identify ICD candidates
New guidelines for patients with hypertrophic cardiomyopathy (HCM) identifies candidates for implantable cardioverter defibrillators. These devices help protect patients from arrhythmias (an irregular heartbeat) which can limit blood flow to vital organs, like the […]

Perry M. Elliott, (Chairperson) (UK)*, Aris Anastasakis, (Greece), Michael A. Borger, (Germany), Martin Borggrefe, (Germany), Franco Cecchi, (Italy), Philippe Charron, (France), Albert Alain Hagege, (France), Antoine Lafont, (France), Giuseppe Limongelli, (2014). 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC), European Heart Journal , Other:

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12:12 PM | The Myth Of “Roid Rage”?
Are men who inject testosterone and other anabolic steroids at risk of entering a violent “roid rage“? Many people think so. Whenever a professional athlete commits a violent crime, it’s not long before someone suggests that steroids may have been involved. The most recent example of this is the case of Jonathan “War Machine” Koppenhaver. […]The post The Myth Of “Roid Rage”? appeared first on Neuroskeptic.

Lundholm L, Frisell T, Lichtenstein P & Långström N (2014). Anabolic androgenic steroids and violent offending: Confounding by polysubstance abuse among 10,365 general population men., Addiction (Abingdon, England), PMID: http://www.ncbi.nlm.nih.gov/pubmed/25170826

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7:31 AM | Neurobiological Basis of Music Therapy
The basic and one of oldest socio-cognitive domains of Human species is music. Listening to music regularly helps to keep the neurons and synapses more active. Depending on the way sound waves are heard or pronounced, they have an impact in the way neurological (brain and nerve) system work in the human body. Neurological studies have identified that music is a valuable tool for evaluating the brain system [1]. Its observed that while listening to music, different parts of the brain are […]

Peretz, I. & Zatorre, R. (2005). Brain Organization for Music Processing, Annual Review of Psychology, 56 (1) 89-114. DOI: 10.1146/annurev.psych.56.091103.070225

Kristeva R, Chakarov V, Schulte-Mönting J & Spreer J (2003). Activation of cortical areas in music execution and imagining: a high-resolution EEG study., NeuroImage, 20 (3) 1872-83. PMID: http://www.ncbi.nlm.nih.gov/pubmed/14642497

Schellenberg, E., Nakata, T., Hunter, P. & Tamoto, S. (2007). Exposure to music and cognitive performance: tests of children and adults, Psychology of Music, 35 (1) 5-19. DOI: 10.1177/0305735607068885

Patton, J., Routh, D. & Stinard, T. (2013). Where do children study? Behavioral observations, Bulletin of the Psychonomic Society, 24 (6) 439-440. DOI: 10.3758/BF03330575

Chan AS, Ho YC & Cheung MC (1998). Music training improves verbal memory., Nature, 396 (6707) 128. PMID: http://www.ncbi.nlm.nih.gov/pubmed/9823892

Asada H, Fukuda Y, Tsunoda S, Yamaguchi M & Tonoike M (1999). Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans., Neuroscience letters, 274 (1) 29-32. PMID: http://www.ncbi.nlm.nih.gov/pubmed/10530512

TSANG, C., TRAINOR, L., SANTESSO, D., TASKER, S. & SCHMIDT, L. (2006). Frontal EEG Responses as a Function of Affective Musical Features, Annals of the New York Academy of Sciences, 930 (1) 439-442. DOI: 10.1111/j.1749-6632.2001.tb05764.x

Sammler D, Grigutsch M, Fritz T & Koelsch S (2007). Music and emotion: electrophysiological correlates of the processing of pleasant and unpleasant music., Psychophysiology, 44 (2) 293-304. PMID: http://www.ncbi.nlm.nih.gov/pubmed/17343712

Luu P, Tucker DM & Makeig S (2004). Frontal midline theta and the error-related negativity: neurophysiological mechanisms of action regulation., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 115 (8) 1821-35. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15261861

Kubota Y, Sato W, Toichi M, Murai T, Okada T, Hayashi A & Sengoku A (2001). Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure., Brain research. Cognitive brain research, 11 (2) 281-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11275489

Pavlygina RA, Sakharov DS & Davydov VI (2004). [Spectral analysis of the human EEG during listening to musical compositions]., Fiziologiia cheloveka, 30 (1) 62-9. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15040288

Koelsch S (2010). Towards a neural basis of music-evoked emotions., Trends in cognitive sciences, 14 (3) 131-7. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20153242

Lonsdale, A. & North, A. (2011). Why do we listen to music? A uses and gratifications analysis, British Journal of Psychology, 102 (1) 108-134. DOI: 10.1348/000712610X506831

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August 29, 2014

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11:15 PM | A change of mind: from bitter recollections to sweet memories
There are a LOT of articles on this study already, but most don’t go into the technical details – the part that, in my opinion,...

Redondo RL, Kim J, Arons AL, Ramirez S, Liu X & Tonegawa S (2014). Bidirectional switch of the valence associated with a hippocampal contextual memory engram., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162525

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7:10 PM | The Ever Mutating Ebola Virus
Ebola has a nasty reputation for the way it damages the body. It’s rightfully earned when you look at the death rate. But when you look at the actual details of an […]

Gire, S., Goba, A., Andersen, K., Sealfon, R., Park, D., Kanneh, L., Jalloh, S., Momoh, M., Fullah, M., Dudas, G. & Wohl, S. (2014). Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak, Science, DOI: 10.1126/science.1259657

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1:26 PM | Breaking research: A study in fruit flies finds a possible drug target to compensate for symptoms of Parkinson’s disease
Parkinson’s disease is caused by the progressive death of neurons important for movement and results in symptoms such as shaking or rigidity in the limbs, slow movements, and difficulty walking. The primary treatment is a drug called L-Dopa, which compensates for the neuron loss but eventually becomes less effective as more and more neurons die […]

Yun J., Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng & Ming Guo (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin, eLife, 3 DOI: http://dx.doi.org/10.7554/elife.01958

Diedrich M., Grit Nebrich, Andrea Koppelstaetter, Jie Shen, Claus Zabel, Joachim Klose & Lei Mao (2011). Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease, Proteome Science, 9 (1) 59. DOI: http://dx.doi.org/10.1186/1477-5956-9-59

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10:38 AM | Fish with Lungs Gives Clues to the Origin of Tetrapods
Juvenile Polypterus senegalusAbout 400 million years ago, fish left the water and began to evolve into land-living creatures. But how did this transition happen? In a new and unusual study, researchers from the McGill University took a fish species known to be able to occasionally walk using its fins and raised it on land. The scientists found that when raised on land, this primitive strange fish with lungs, walks much better than its water-raised friends. The experiment could […]

Standen EM, Du TY & Larsson HC (2014). Developmental plasticity and the origin of tetrapods., Nature, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25162530

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7:52 AM | Oxytocin and autism: the hype?
Consider some excerpts from two recent papers looking at oxytocin (OXT) - the "love hormone"(!) - and the autism spectrum disorders (ASDs)...“It’s not the years, honey. It’s the mileage”"These findings indicate that dysregulated OXT biology is not uniquely associated with ASD social phenotypes as widely theorized, but instead variation in OXT biology contributes to important individual differences in human social functioning, including the severe social impairments which […]

Parker, K., Garner, J., Libove, R., Hyde, S., Hornbeak, K., Carson, D., Liao, C., Phillips, J., Hallmayer, J. & Hardan, A. & (2014). Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1402236111

Guastella AJ, Gray KM, Rinehart NJ, Alvares GA, Tonge BJ, Hickie IB, Keating CM, Cacciotti-Saija C & Einfeld SL (2014). The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial., Journal of child psychology and psychiatry, and allied disciplines, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25087908

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3:48 AM | A Map to Build Roads to a Better Future
When I learned that the pesticide DDT–widely toxic and now widely banned–has snaked its way into polar bears and beluga whales, I questioned if any environment remains pristine on terrestrial Earth. Perhaps, the thick, hostile and unyielding rainforests of Borneo might prove a bastion? Then in 2013, satellite images showed roads penetrating deep into Borneo. […]

Laurance, W., Clements, G., Sloan, S., O’Connell, C., Mueller, N., Goosem, M., Venter, O., Edwards, D., Phalan, B., Balmford, A. & Van Der Ree, R. (2014). A global strategy for road building, Nature, DOI: 10.1038/nature13717

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August 28, 2014

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8:53 PM | This is your Brain. This is your Brain on Drugs
Drugs are bad for the brain. That is (excuse the horrible pun) a no-brainer, but while scientists have seen the after effect drugs have on the brain, we have never […]

You, J., Du, C., Volkow, N. & Pan, Y. (2014). Optical coherence Doppler tomography for quantitative cerebral blood flow imaging, Biomedical Optics Express, 5 (9) 3217. DOI: 10.1364/BOE.5.003217

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4:52 PM | The Things Living on your Toothbrush…
Did you remember to brush? I hope you did, but you may be throwing away your toothbrush soon. Get ready for your daily amount of gross, because have I got […]

Morris DW, Goldschmidt M, Keene H & Cron SG (2014). Microbial contamination of power toothbrushes: a comparison of solid-head versus hollow-head designs., Journal of dental hygiene : JDH / American Dental Hygienists' Association, 88 (4) 237-42. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25134956

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8:29 AM | Minocycline for schizophrenia?
"Minocycline may improve the psychopathology of schizophrenia, especially the negative symptoms, and seems to be well tolerated".A Bachelors Drawer (apparently) @ Wikipedia That was the finding from the systematic review and meta-analysis undertaken by Oya and colleagues [1] looking at the collected literature on the use of "minocycline augmentation therapy in patients with schizophrenia receiving antipsychotic agents". Augmentation therapy by the way, refers to the addition of minocycline […]

Oya K, Kishi T & Iwata N (2014). Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta-analysis of randomized controlled trials., Human psychopharmacology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25087702

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August 27, 2014

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11:35 PM | (False?) Positive Psychology Meets Genomics
Academic bunfight ahoy! A new paper from Nick Brown – famed debunker of the “Positivity Ratio” – and his colleagues, takes aim at another piece of research on feel-good emotions. The target is a 2013 paper published in PNAS from positive psychology leader Barbara Fredrickson and colleagues: A functional genomic perspective on human well-being. The […]The post (False?) Positive Psychology Meets Genomics appeared first on Neuroskeptic.

Brown, N., MacDonald, D., Samanta, M., Friedman, H. & Coyne, J. (2014). A critical reanalysis of the relationship between genomics and well-being, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1407057111

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