Posts

July 08, 2014

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9:25 AM | Coenzyme Q10 and autism
The paper by Frederick Crane and colleagues [1] (open-access here) caught my eye recently and their suggestion that when it comes to autism there may be more research to do on coenzyme Q10. Indeed, the old grey-pinkish matter started grinding into action as to whether there may be a wider research literature on CoQ10 with a focus on autism...A helping hand? @ Wikipedia Coenzyme Q10 otherwise known as ubiquinone, has appeared before on this blog for various reasons (see here and […]

Crane FL, Löw H, Sun I, Navas P & Gvozdjáková A (2014). Plasma membrane coenzyme Q: evidence for a role in autism., Biologics : targets & therapy, 8 199-205. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24920882

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8:17 AM | Researchers discover important piece in the brain tumour puzzle
Researchers at the Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre have shown that a member of the protein family known as SUMO (small ubiquitin-like modifier) is a key to why tumour cells multiply uncontrollably, especially in the case of glioblastoma. The SUMO family proteins modify other proteins and the SUMOylation of proteins are critical for many cellular processes. Identifying SUMO's role in the cancer cell growth will lead to a new […]

Bellail, A., Olson, J. & Hao, C. (2014). SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression, Nature Communications, 5 DOI: 10.1038/ncomms5234

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July 07, 2014

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8:09 PM | Is there such a thing as an anti-depression diet?
Summary: People who suffer from depression seem to experience more oxidative stress and inflammation than others.  A diet high in anti-oxidants, fermentable fiber and low in saturated and transfats may protect against inflammatory stress in the brain and elsewhere.  More research needed.  The topic is under investigation. Introduction: We recently posted an article about the […] The post Is there such a thing as an anti-depression diet? appeared first on WODMasters: Stiff […]

Moylan S, Berk M, Dean OM, Samuni Y, Williams LJ, O'Neil A, Hayley AC, Pasco JA, Anderson G, Jacka FN & Maes M (2014). Oxidative & nitrosative stress in depression: Why so much stress?, Neuroscience and biobehavioral reviews, 45C 46-62. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24858007

Maes M, Kubera M, Leunis JC & Berk M (2012). Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut., Journal of affective disorders, 141 (1) 55-62. PMID: http://www.ncbi.nlm.nih.gov/pubmed/22410503

Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D & Xavier RJ (2009). Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43., Nature, 461 (7268) 1282-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/19865172

Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK & Bruce-Keller AJ (2010). Cognitive impairment following high fat diet consumption is associated with brain inflammation., Journal of neuroimmunology, 219 (1-2) 25-32. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20004026

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5:27 PM | Staying up late? You’re going Crazy
All night cram sessions, anyone in college has probably had more than just a few of these [okay maybe only if you are a procrastinator like me]. If you have […]

Phillips, K., Bartsch, U., McCarthy, A., Edgar, D., Tricklebank, M., Wafford, K. & Jones, M. (2012). Decoupling of Sleep-Dependent Cortical and Hippocampal Interactions in a Neurodevelopmental Model of Schizophrenia, Neuron, 76 (3) 526-533. DOI: 10.1016/j.neuron.2012.09.016

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4:04 PM | The Bone-house Wasp
The newly discovered Bone-house wasp, Deuteragenia ossarium, builds a unique nest for its young. Unlike species which excavate their own …Continue reading →

Staab, M., Ohl, M., Zhu, C. & Klein, A. (2014). A Unique Nest-Protection Strategy in a New Species of Spider Wasp, PLoS ONE, 9 (7) DOI: 10.1371/journal.pone.0101592

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Editor's Pick
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3:05 PM | Florida Clampdown on Pain Pills Lowers Drug-Related Mortality
Ever since I started working with the homeless youth of Delhi, I have noticed their drug and substance dependence issues and how, despite knowing the ill-effects, they have not been able to get out from under the chemical spell. Thus, when I came across a short report in the CDC’s Morbidity and Mortality Weekly Reports that Florida…

Johnson H, Paulozzi L, Porucznik C, Mack K, Herter B & Hal Johnson Consulting and Division of Disease Control and Health Promotion, Florida Department of Health (2014). Decline in drug overdose deaths after state policy changes - Florida, 2010-2012., MMWR. Morbidity and mortality weekly report, 63 (26) 569-74. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24990490

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2:41 PM | Mathematical Model Helps Identify Gas Hydrate Pockets
Scientists at Rice University have developed a mathematical model that simulates gas hydrate and free gas accumulation under the ocean floor.

Chatterjee, S., Bhatnagar, G., Dugan, B., Dickens, G., Chapman, W. & Hirasaki, G. (2014). The Impact of Lithologic Heterogeneity and Focused Fluid Flow upon Gas Hydrate Distribution in Marine Sediments, Journal of Geophysical Research: Solid Earth, DOI: 10.1002/2014JB011236

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2:33 PM | MERS CoV: Can it spread from camels to man?
The Middle Eastern Respiratory Syndrome coronavirus (MERS CoV) is a novel single stranded RNA virus that has been doing the rounds in the Middle East, bits of Europe and North America. Given our experiences the last time we had a new respiratory virus (remember the pandemic?), things have moved rather fast this time once the…

Azhar, E., El-Kafrawy, S., Farraj, S., Hassan, A., Al-Saeed, M., Hashem, A. & Madani, T. (2014). Evidence for Camel-to-Human Transmission of MERS Coronavirus, New England Journal of Medicine, 370 (26) 2499-2505. DOI: 10.1056/NEJMoa1401505

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7:18 AM | Reproductive stoppage related to autism
The paper by Thomas Hoffmann and colleagues [1] on reproductive stoppage - the decision to not have more children - in couples with a child already diagnosed with an autism spectrum disorder (ASD) is the source for today's post. This is both an important and delicate area to talk about so I tread very carefully in my discussions.The Holy Infants @ Wikipedia A few details first:Based on records held at the California Department of Developmental Services, children born between 1990 […]

Hoffmann, T., Windham, G., Anderson, M., Croen, L., Grether, J. & Risch, N. (2014). Evidence of Reproductive Stoppage in Families With Autism Spectrum Disorder, JAMA Psychiatry, DOI: 10.1001/jamapsychiatry.2014.420

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July 06, 2014

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6:13 PM | fMRI Motion Correction: The Quick and the Dead
The infamous dead salmon brain scan study may just have been eclipsed, in the ‘most ghoulish demonstration of a methodological pitfall in fMRI‘ stakes. A new study examines the issue of motion artifacts, a major concern in much neuroimaging research – and it does so by scanning dead people. The new paper has the unwieldy […]The post fMRI Motion Correction: The Quick and the Dead appeared first on Neuroskeptic.

Beall EB & Lowe MJ (2014). SimPACE: Generating simulated motion corrupted BOLD data with synthetic-navigated acquisition for the development and evaluation of SLOMOCO: A new, highly effective slicewise motion correction., NeuroImage, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24969568

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5:10 PM | New tool helps Doctors treat Menopause
With the SCOTUS ruling for the Hobby Lobby case [if you have no idea what I am talking about you can read about that anywhere on the net, like here] […]

Jane, F. & Davis, S. (2014). A Practitioner's Toolkit for Managing the Menopause , Climacteric, 1-16. DOI: 10.3109/13697137.2014.929651

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5:03 PM | Emperors in danger: penguin populations predicted to decline due to climate change and sea ice loss
If pop culture is any indication, we hold a special place in our heart for penguins compared to the many other denizens of the animal kingdom. Maybe it is something about the close-knit familial communities that have been portrayed in documentaries … Continue reading →

Jenouvrier, S., Holland, M., Stroeve, J., Serreze, M., Barbraud, C., Weimerskirch, H. & Caswell, H. (2014). Projected continent-wide declines of the emperor penguin under climate change, Nature Climate Change, DOI: 10.1038/nclimate2280

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3:07 PM | New Species of Spider Wasp Uses Ant Corpses to Protect Its Nests
A newly discovered wasp species uses the corpses of dead ants as scarecrows, to protect its nest from predators, according to a new study by researchers at the University of Freiburg. Scientifically described as Deuteragenia ossarium and dubbed as the Bone-house wasp, the species uses the chemical cues from ant corpses to ward off predators, by stuffing them into the crevices of its home. The species was discovered in Jiangxi Province in south east China.Wasps use a wide range of […]

Staab, M., Ohl, M., Zhu, C. & Klein, A. (2014). A Unique Nest-Protection Strategy in a New Species of Spider Wasp, PLoS ONE, 9 (7) DOI: 10.1371/journal.pone.0101592

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July 05, 2014

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5:00 PM | Breast Cancer… and Cholesterol?!
Cholesterol, it’s bad for the heart. We know LDL bad, HDL good, eat healthier or ruin your arteries. I’m sure most of us have seen the public service announcements [at […]

Potluri, R., Lavu, D., Uppal, H. & Chandran, S. (2014). P740 Hyperlipidaemia as a risk factor for breast cancer?, Cardiovascular Research, 103 (suppl 1) DOI: 10.1093/cvr/cvu098.160

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11:12 AM | Who can afford to hold back rising seas?
Though using dikes to protect the world from rising sea levels will generally make economic sense, explains Jochen Hinkel from the Global Climate Forum, poor countries may not have the resources to do so.

Hinkel, J., Lincke, D., Vafeidis, A., Perrette, M., Nicholls, R., Tol, R., Marzeion, B., Fettweis, X., Ionescu, C. & Levermann, A. & (2014). Coastal flood damage and adaptation costs under 21st century sea-level rise, Proceedings of the National Academy of Sciences, 111 (9) 3292-3297. DOI: 10.1073/pnas.1222469111

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July 04, 2014

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5:00 PM | Finally! A Definite Cause of Autism: Hint it isn’t Vaccines
Autism, not caused by vaccines. In fact I’ve written several posts on the genetic clues to autism, now a new study offers more proof that it is purely genetic [at […]

Bernier, R., Golzio, C., Xiong, B., Stessman, H., Coe, B., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Vulto-van Silfhout, A. & Schuurs-Hoeijmakers, J. (2014). Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development, Cell, DOI: 10.1016/j.cell.2014.06.017

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July 03, 2014

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6:02 PM | Transparent Graphite Can Be Used to Make Better Solar Cells
Scientists at the University of Maryland Energy Research Center and Monash University, Australia, have used lithium to make a graphite sheet transparent and highly conductive. This new material shows promise for applications in solar cells, flexible displays and touchscreens.

Bao, W., Wan, J., Han, X., Cai, X., Zhu, H., Kim, D., Ma, D., Xu, Y., Munday, J., Drew, H. & Fuhrer, M. (2014). Approaching the limits of transparency and conductivity in graphitic materials through lithium intercalation, Nature Communications, 5 DOI: 10.1038/ncomms5224

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5:00 PM | Why you Should Not Fear Testosterone Therapy
Testosterone, to some it’s a bad word, bringing crazy images like “roid rage” and the like. To others with more than just a pop culture understanding it is a lifesaver. […]

Baillargeon J., Urban R.J., Kuo Y.F., Ottenbacher K.J. & Raji M.A. (2014). Risk of Myocardial Infarction in Older Men Receiving Testosterone Therapy, The Annals of Pharmacotherapy, DOI: 10.1177/1060028014539918

Miner M., Gary Blick, Harvey Kushner & Mohit Khera (2013). 12-Month Observation of Testosterone Replacement Effectiveness in a General Population of Men, Postgraduate Medicine, 125 (2) 8-18. DOI: http://dx.doi.org/10.3810/pgm.2013.03.2637

Almeida O.P., Graeme J. Hankey, Konrad Jamrozik & Leon Flicker (2008). Low Free Testosterone Concentration as a Potentially Treatable Cause of Depressive Symptoms in Older Men, Archives of General Psychiatry, 65 (3) 283. DOI: http://dx.doi.org/10.1001/archgenpsychiatry.2007.33

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2:20 PM | Simple Process Improves Manufacturing of Silicon Nanoholes
Scientists at the A*STAR Singapore Institute of Manufacturing Technology and Nanyang Technological University have invented a simple procedure that transforms silver nanospheres into silicon nanoholes. The process can significantly increase the cost-effectiveness of nanowire-based solar cells.

Hong, L., Wang, X., Zheng, H., He, L., Wang, H., Yu, H. & Rusli, . (2014). High efficiency silicon nanohole/organic heterojunction hybrid solar cell, Applied Physics Letters, 104 (5) 53104. DOI: 10.1063/1.4863965

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1:59 PM | What’s the Answer? (mutation nomenclature)
Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]

Laros J.F.J., Johan T den Dunnen & Peter E M Taschner (2011). A formalized description of the standard human variant nomenclature in Extended Backus-Naur Form, BMC Bioinformatics, 12 (Suppl 4) S5. DOI: http://dx.doi.org/10.1186/1471-2105-12-s4-s5

Soussi T. & Peter E.M. Taschner (2014). Recommendations for Analyzing and Reporting TP53 Gene Variants in the High-Throughput Sequencing Era , Human Mutation, 35 (6) 766-778. DOI: http://dx.doi.org/10.1002/humu.22561

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11:55 AM | Goalward-bound: why biological research is like football
The 2014 FIFA World Cup has mesmerised football fans all around the world over the past weeks, but besides just the fancy footwork on display, we’ve also seen some amazing athleticism. Many of the matches have taken place under scorching, highly humid conditions! Though this might not be foremost in our minds as marvel at […]

Ciglar, L., Girardot, C., Wilczy ski, B., Braun, M. & Furlong, E. (2014). Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis, Development, 141 (13) 2633-2643. DOI: 10.1242/dev.101956

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July 02, 2014

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7:32 PM | Novel Biosensor to Optimize Bio-Refining Processes
Scientists at the University of British Columbia have developed a new type of biosensor that can help optimize bio-refining processes that produce chemicals, fuels and advanced materials.

Strachan, C., Singh, R., VanInsberghe, D., Ievdokymenko, K., Budwill, K., Mohn, W., Eltis, L. & Hallam, S. (2014). Metagenomic scaffolds enable combinatorial lignin transformation, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1401631111

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5:48 PM | Scientists Uncover Mechanism for Soot Formation
Scientists at the University of Hawaii and the Lawrence Berkeley National Lab (Berkeley Lab) have uncovered the first step in the process that transforms gas-phase molecules into solid particles like soot and other carbon-based compounds.

Parker, D., Kaiser, R., Troy, T. & Ahmed, M. (2014). Hydrogen Abstraction-Acetylene Addition Revealed, Angewandte Chemie, DOI: 10.1002/ange.201404537

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5:13 PM | Saving the Rainforest and the Consequences
The road to hell is paved with good intentions. This seems even more true when a new study came out that shows, when it comes to fixing deforestation and forest degradation, […]

Putz, F. & Romero, C. (2014). Futures of Tropical Forests , Biotropica, 46 (4) 495-505. DOI: 10.1111/btp.12124

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3:46 PM | Chimps stick grass in their ears to be cool: notes on cultural transmission
1. In 2010, a female chimpanzee named Julie began repeatedly stuffing a stiff blade of grass into her ear. This Grass-in-ear behavior has affectionately been dubbed “GIEB” by the scientists who observed it. 2. Out of a group of twelve chimpanzees, eight engaged in GIEB. In three other groups of chimpanzees found in other locations in […]

Huffman, M., Nahallage, C. & Leca, J. (2008). Cultured Monkeys: Social Learning Cast in Stones, Current Directions in Psychological Science, 17 (6) 410-414. DOI: 10.1111/j.1467-8721.2008.00616.x

van Leeuwen, E., Cronin, K. & Haun, D. (2014). A group-specific arbitrary tradition in chimpanzees (Pan troglodytes), Animal Cognition, DOI: 10.1007/s10071-014-0766-8

Laland, K. & Williams, K. (1998). Social transmission of maladaptive information in the guppy, Behavioral Ecology, 9 (5) 493-499. DOI: 10.1093/beheco/9.5.493

Nunn, C., Thrall, P., Bartz, K., Dasgupta, T. & Boesch, C. (2009). Do transmission mechanisms or social systems drive cultural dynamics in socially structured populations?, Animal Behaviour, 77 (6) 1515-1524. DOI: 10.1016/j.anbehav.2009.02.023

Stocker R, Green DG & Newth D (2001). Consensus and cohesion in simulated social networks, Journal of Artificial Societies and Social Simulation, 4 (4) Other:

Rendell L, Fogarty L, Hoppitt WJ, Morgan TJ, Webster MM & Laland KN (2011). Cognitive culture: theoretical and empirical insights into social learning strategies., Trends in cognitive sciences, 15 (2) 68-76. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21215677

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3:31 PM | Pasta e geometria
Il ristorante Bocca di Lupo, del cuoco Jacob Kennedy, ha portato a Londra la cucina italiana. Il giovane cuoco britannico, però, non si accontenta di trafficare tra i fornelli e, come moltissimi cuochi di questo secondo decennio del terzo millennio, ha scritto un libro, dedicato a uno degli alimenti più diffusi del mondo, sinonimo di italianità: la pasta. Coautrice del libro è la designer Caz Hildebrand, creando così un mix tra la forma perfetta e la salsa […]

Legendre, G. (2011). IJP Explained: Parametric Mathematics in Practice, Architectural Design, 81 (4) 44-53. DOI: 10.1002/ad.1267

Legendre, G. (2011). Pasta by Design, Architectural Design, 81 (4) 100-101. DOI: 10.1002/ad.1274

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1:36 PM | Video Tip of the Week: NCBI Variation Viewer
The folks at NCBI recently hosted a webinar that covered a number of resources: GTR, ClinVar, and MedGen. It was a nice introduction to these resources using a case study of exploring information about a 9-year-old child who needed to get clearance for participation in sports. So they follow the course of some details about […]

Landrum M.J., G. R. Riley, W. Jang, W. S. Rubinstein, D. M. Church & D. R. Maglott (2014). ClinVar: public archive of relationships among sequence variation and human phenotype, Nucleic Acids Research, 42 (D1) D980-D985. DOI: http://dx.doi.org/10.1093/nar/gkt1113

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12:00 PM | How Do Mosquitoes Find You?
Biology concepts – semiochemicals, hematophagy, proboscis, thermosensing, TRPA1Sure, mosquitoes suck blood and pass along malaria that kill more humans than any other infectious disease. But would it be good to get rid of them. They provide food for birds – one scientist suggests that elimination of Arctic mosquitoes could reduce northern bird populations by 50%. And mosquitoes pollinate flowers too, like blueberries and cranberries. See, they’re not all bad.We can start our […]

Maekawa E, Aonuma H, Nelson B, Yoshimura A, Tokunaga F, Fukumoto S & Kanuka H (2011). The role of proboscis of the malaria vector mosquito Anopheles stephensi in host-seeking behavior., Parasites & vectors, 4 10. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21272298

Albeny-Simões D, Murrell EG, Elliot SL, Andrade MR, Lima E, Juliano SA & Vilela EF (2014). Attracted to the enemy: Aedes aegypti prefers oviposition sites with predator-killed conspecifics., Oecologia, 175 (2) 481-92. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24590205

Olanga EA, Okal MN, Mbadi PA, Kokwaro ED & Mukabana WR (2010). Attraction of Anopheles gambiae to odour baits augmented with heat and moisture., Malaria journal, 9 6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20051143

Liu C & Zwiebel LJ (2013). Molecular characterization of larval peripheral thermosensory responses of the malaria vector mosquito Anopheles gambiae., PloS one, 8 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/23940815

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11:51 AM | What happens to the cool kids when they grow up?
"Cool kids", according to a new study, are those early teens (aged 13 to 15) who want to be popular, and try to impress their peers by acting older than their years. They have precocious romantic relationships, commit relatively minor acts of bad behaviour (such as sneaking into the cinema without paying), and surround themselves with good-looking friends. These teenagers attract respect from their peers at first, but what's the story by the time they reach early adulthood?Joseph Allen and his […]

Allen JP, Schad MM, Oudekerk B & Chango J (2014). What Ever Happened to the "Cool" Kids? Long-Term Sequelae of Early Adolescent Pseudomature Behavior., Child development, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24919537

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7:40 AM | Quality of life and autism
The BBC ran an interesting article on their website recently titled: Happiness and disability. Discussions about the disability paradox - whereby some people with often significant and persistent disability report experiencing a good or excellent quality of life (QoL) - got me thinking about QoL and in particular, how it might relate to the very wide and very heterogeneous autism spectrum. I might add that I am not insinuating that everyone diagnosed on the autism spectrum are 'disabled' but […]

Chiang, H. & Wineman, I. (2014). Factors associated with quality of life in individuals with autism spectrum disorders: A review of literature, Research in Autism Spectrum Disorders, 8 (8) 974-986. DOI: 10.1016/j.rasd.2014.05.003

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