Posts

December 15, 2014

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6:36 AM | Treatment for Elderly with Breast Cancer May Not Be as Effective
claimtoken-548f952b76556 A new analysis has found that while clinical trial data support omitting radiation treatments in elderly women with early stage breast cancer, nearly two-thirds of these women continue to receive it. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Results published in 2004 from a large, […] The post Treatment for Elderly with Breast Cancer May Not Be as Effective appeared first on Wiley Asia Blog.

Palta, M., Palta, P., Bhavsar, N., Horton, J. & Blitzblau, R. (2014). The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: Changes in practice patterns after publication of Cancer and Leukemia Group B 9343, Cancer, DOI: 10.1002/cncr.28937

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6:36 AM | Treatment for Elderly with Breast Cancer May Not Be as Effective
A new analysis has found that while clinical trial data support omitting radiation treatments in elderly women with early stage breast cancer, nearly two-thirds of these women continue to receive it. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Results published in 2004 from a large, randomized […] The post Treatment for Elderly with Breast Cancer May Not Be as Effective appeared first on Wiley Asia Blog.

Palta, M., Palta, P., Bhavsar, N., Horton, J. & Blitzblau, R. (2014). The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: Changes in practice patterns after publication of Cancer and Leukemia Group B 9343, Cancer, DOI: 10.1002/cncr.28937

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December 14, 2014

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6:28 PM | Scientists find a drug (currently used) to turn white fat to brown
It seems like we’ve been on a weight loss campaign here at the labs, but there just has been so much new and interesting research on the subject to report […]

Anne Loft, Isabel Forss, Majken Storm Siersbæk, Søren Fisker Schmidt, Ann-Sofie Bøgh Larsen, Jesper Grud Skat Madsen, Didier F. Pisani, Ronni Nielsen, Mads Malik Aagaard, Angela Mathison & Matt J. Neville (2014). Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers, Genes & Development, Other:

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5:47 PM | Sulfur hydride blows away previous critical temperature limits for conventional superconductivity
Superconductivity, the phenomenon in which a material conducts electrons without resistance, is the tantalizing theoretical mystery of condensed matter physics attracting some of the greatest minds in the field.  Now, some incredible news has come out of the Max Planck … Continue reading →

A. P. Drozdov, M. I. Eremets & I. A. Troyan (2014). Conventional superconductivity at 190 K at high pressures, arXiv, arXiv: http://arxiv.org/abs/1412.0460v1

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12:57 PM | Increasing Rigor in Huntington’s Disease Research
The CHDI Foundation, a charitable organization who fund a lot of research into Huntington's disease, are interested in reforming the scientific process. The story comes from a paper written by British neuroscientist Marcus Munafo and colleagues (the authors including CHDI staff) published in Nature Biotechnology a couple of months ago: Scientific rigor and the art of motorcycle maintenance. Munafo et al. begin by pointing to the history of car manufacturing as an analogy for the scie

Munafo M, Noble S, Browne WJ, Brunner D, Button K, Ferreira J, Holmans P, Langbehn D, Lewis G, Lindquist M & Tilling K (2014). Scientific rigor and the art of motorcycle maintenance., Nature Biotechnology, 32 (9) 871-3. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25203032

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9:48 AM | Beware the inflated science related press release!
I'm not normally minded to post on a Sunday (day of rest and all that) but I did want to bring your attention to the results presented by Petroc Sumner and colleagues [1] (open-access) concluding that: "Exaggeration in news is strongly associated with exaggeration in press releases" when it comes to the media reporting of [some] health-related science news.The idea behind this particular study - which has been summarised pretty well in some of the accompanying media and in an […]

Sumner, P., Vivian-Griffiths, S., Boivin, J., Williams, A., Venetis, C., Davies, A., Ogden, J., Whelan, L., Hughes, B., Dalton, B. & Boy, F. (2014). The association between exaggeration in health related science news and academic press releases: retrospective observational study, BMJ, 349 (dec09 7) DOI: 10.1136/bmj.g7015

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December 13, 2014

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6:51 PM | High fat diet leads to brain inflammation and obesity
The stomach strikes again, or so it seems. We’ve already covered how your stomach seemingly controls your brain and your blood-brain barrier, but now it seems that what you eat –not […]

Valdearcos, M., Robblee, M., Benjamin, D., Nomura, D., Xu, A. & Koliwad, S. (2014). Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function, Cell Reports, DOI: 10.1016/j.celrep.2014.11.018

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10:19 AM | Social communication disorder (SCD) reviewed
Sometimes I believe in as many as six impossible things before breakfast.A micropost if you will, for today, and a link to a potentially very important paper by Lauren Swineford and colleagues [1] (open-access) talking about the diagnostic concept: social (pragmatic) communication disorder (SCD) and it's various crossings with language impairments and autism spectrum disorder (ASD).SCD, as I've indicated in other posts (see here and see here) is something that the autism community in […]

Swineford, L., Thurm, A., Baird, G., Wetherby, A. & Swedo, S. (2014). Social (pragmatic) communication disorder: a research review of this new DSM-5 diagnostic category, Journal of Neurodevelopmental Disorders, 6 (1) 41. DOI: 10.1186/1866-1955-6-41

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3:56 AM | Animal Research Sheds Light on Harmful Mood Disorders in New Mothers
In the days shortly after giving birth, most mothers experience a period of increased calmness and decreased stress responses, but around 20% of mothers experience anxiety. Some women may become depressed, and around one in a thousand can develop psychosis. The latest evidence indicates that these distressing responses to motherhood are still poorly understood, but […] The post Animal Research Sheds Light on Harmful Mood Disorders in New Mothers appeared first on Wiley Asia Blog.

Perani, C. & Slattery, D. (2014). Using animal models to study post-partum psychiatric disorders, British Journal of Pharmacology, 171 (20) 4539-4555. DOI: 10.1111/bph.12640

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3:56 AM | Animal Research Sheds Light on Harmful Mood Disorders in New Mothers
In the days shortly after giving birth, most mothers experience a period of increased calmness and decreased stress responses, but around 20% of mothers experience anxiety. Some women may become depressed, and around one in a thousand can develop psychosis. The latest evidence indicates that these distressing responses to motherhood are still poorly understood, but […] The post Animal Research Sheds Light on Harmful Mood Disorders in New Mothers appeared first on Wiley Asia Blog.

Perani, C. & Slattery, D. (2014). Using animal models to study post-partum psychiatric disorders, British Journal of Pharmacology, 171 (20) 4539-4555. DOI: 10.1111/bph.12640

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December 12, 2014

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10:30 PM | Diversity working together: cancer, immune system, and microbiome
After a much needed few weeks of recovery, I’ve found some time to post about our annual IMO workshop held this year on the topic of viruses in cancer. Our group had the challenge of learning about all of the complexities of the human microbiome and its interactions with a cancerous lesion. The human microbiome, […]

Human Microbiome Project Consortium (2012). Structure, function and diversity of the healthy human microbiome, Nature, 486 (7402) 207-214. DOI: 10.1038/nature11234

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9:00 PM | Breaking Research: A new technique for studying axon death using fruit fly wings
The axon is the part of a neuron that carries outgoing information. (cb = cell body) In neurodegenerative diseases such as Parkinson’s disease or amyotrophic lateral sclerosis (ALS), a genetic mutation leads to widespread neuron damage. When a neuron is damaged, its axon—the part of the neuron that carries outgoing signals—is actively broken down and […]

Neukomm L.J., M. A. Gonzalez, S. Zuchner & M. R. Freeman (2014). Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila, Proceedings of the National Academy of Sciences, 111 (27) 9965-9970. DOI: http://dx.doi.org/10.1073/pnas.1406230111

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7:13 PM | A new type of memory storage on the horrizon
For those of us old enough to remember the days of the Apple II, you know that storage has exponentially increased. Even just 10 years ago 20+ gigs of data […]

Shimizu, T., Jung, J., Imada, H. & Kim, Y. (2014). Supramolecular Assembly through Interactions between Molecular Dipoles and Alkali Metal Ions, Angewandte Chemie International Edition, 53 (50) 13729-13733. DOI: 10.1002/anie.201407555

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9:00 AM | Why do friendly people usually lead happier lives?
High scorers on the personality trait of agreeableness are eager to please, concerned for others, and compliant to other perspectives. On average, they live happier lives too. A new study suggests a possible reason: when they have the chance, friendly people tend to avoid engaging with negative things.The researchers, Konrad Bresin and Michael Robinson, began by asking participants to view a series of positive and negative images, spending as much time as they wanted on each one. Most people […]

Bresin K & Robinson MD (2014). You Are What You See and Choose: Agreeableness and Situation Selection., Journal of personality, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25109246

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8:32 AM | Party On! (If You're Middle-Class and Young): Age Differences Explain Social Class Differences in University Friendships
In a recent meta-analytic review, I found that working-class students are less integrated at university than their middle-class peers. I offered up nine potential explanations for this working-class exclusion effect. It turns out that one of the simplest explanations in this list is also the most promising. It’s all to do with age.Working-class students tend to be older than middle-class students. Why? Most likely because they don’t tend to go to university immediately after […]

Rubin, M. & Wright, C. (2014). Age differences explain social class differences in students’ friendship at university: Implications for transition and retention, Higher Education, DOI: 10.1007/s10734-014-9844-8

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7:58 AM | Researchers Discover Well-Endowed Bone Eating Worm
Male Osedax priapusThe entire body of males has evolved as a tool for mating Osedax is a genus of weird, deep-sea polychaetes worms, commonly known as boneworms, zombie worms, or bone-eating worms. The story of these creatures began twelve years ago, when researchers from the Monterey Bay Aquarium Research Institute (MBARI) first discovered them, using the submarine ROV Tiburon in Monterey

Rouse, G., Wilson, N., Worsaae, K. & Vrijenhoek, R. (2014). A Dwarf Male Reversal in Bone-Eating Worms, Current Biology, DOI: 10.1016/j.cub.2014.11.032

Rouse GW, Worsaae K, Johnson SB, Jones WJ & Vrijenhoek RC (2008). Acquisition of dwarf male "harems" by recently settled females of Osedax roseus n. sp. (Siboglinidae; Annelida)., The Biological bulletin, 214 (1) 67-82. PMID: http://www.ncbi.nlm.nih.gov/pubmed/18258777

Vrijenhoek RC, Johnson SB & Rouse GW (2008). Bone-eating Osedax females and their 'harems' of dwarf males are recruited from a common larval pool., Molecular ecology, 17 (20) 4535-44. PMID: http://www.ncbi.nlm.nih.gov/pubmed/18986498

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4:15 AM | The Male Idiot Theory
Image credits: bilbypdalgyte.deviantart.com Yes, that’s a thing. According to hospital emergency departments and mortality stats, men are far likelier than women to experience accidental and sporting injuries, as well as...

Ben Alexander, Daniel Lendrem, Dennis William Lendrem, Andy Gray & John Dudley Isaacs (2014). The Darwin Awards: sex differences in idiotic behaviour, BMJ, 349. Other:

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12:14 AM | Chronic fatigue syndrome by ASIA?
Unicorns, I love them. Unicorns, I love them. ASIA, in the context of this post, does not refer to the continent but rather the suggestion of an: ‘autoimmune (auto-inflammatory) syndrome induced by adjuvants’ and some potentially contentious findings reported by Nancy Agmon-Levin and colleagues [1].Describing a small cohort of participants diagnosed with chronic fatigue syndrome (CFS) and/or fibromyalgia (FM), the authors put forward the idea that "some cases CFS and […]

Agmon-Levin N, Zafrir Y, Kivity S, Balofsky A, Amital H & Shoenfeld Y (2014). Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the 'autoimmune (auto-inflammatory) syndrome induced by adjuvants' (ASIA)., Immunologic research, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25427994

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December 11, 2014

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7:32 PM | The Headless Romans: Headhunting, Defeated Gladiators or Natural River Movement?
In the Walbrook Valley near the city of London, large numbers of human remains, dating to the Roman occupation of England, have been recovered over the past 175 years- and […]

Redfern, R. & Bonney, H. (2014). Headhunting and amphitheatre combat in Roman London, England: new evidence from the Walbrook Valley, Journal of Archaeological Science, 43 214-226. DOI: 10.1016/j.jas.2013.12.013

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5:08 PM | What makes us fat, OR food vs. physiology
There is a heir of mystery surrounding weight loss and fat in general. Have you ever heard you have all the fat cells you’ll ever have — that’s false by […]

Woeller CF, O'loughlin CW, Pollock SJ, Thatcher TH, Feldon SE & Phipps RP (2014). Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25416548

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3:54 PM | Disney Research: alla ricerca dell'occhio realistico
Per molti potrà suonare come una curiosità fine a se stessa, quasi inutile, ma nei fatti è interessante per capire come l'idea di innovazione tecnica e tecnologica sia presente, in modi differenti, in moltissimi campi, inclusa l'animazione.Con l'avvento della computer grafica, non solo la realizzazione dei videogiochi è diventata più precisa e dettagliata per personaggi e ambienti, ma anche l'animazione stessa si è giovata delle innovazioni […]

Marquardt D.W. (1963). An Algorithm for Least-Squares Estimation of Nonlinear Parameters, Journal of the Society for Industrial and Applied Mathematics, 11 (2) 431-441. DOI: http://dx.doi.org/10.1137/0111030

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2:39 PM | What’s the Answer? (tidy data format)
Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]

Wickham H.W. (2014). Tidy Data, Journal of Statistical Software, 59 (10) Other:

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10:09 AM | Low bone mineral density and non-coeliac gluten sensitivity and autism?
"An elevated frequency of bone mass loss in NCWS [non-celiac wheat sensitivity] patients was found; this was related to low BMI [body mass index] and was more frequent in patients with NCWS associated with other food sensitivity".There is no Easter Bunny. There is no Tooth Fairy. There is no Queen of England.That was the conclusion reached by Antonio Carroccio and colleagues [1] (open-access) looking at a small group of participants diagnosed with something which seems to […]

Carroccio A, Soresi M, D Alcamo A, Sciumè C, Iacono G, Geraci G, Brusca I, Seidita A, Adragna F, Carta M & Mansueto P (2014). Risk of low bone mineral density and low body mass index in patients with non-celiac wheat-sensitivity: a prospective observation study., BMC medicine, 12 (1) 230. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25430806

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December 10, 2014

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9:51 PM | Worms’ “mental GPS” could help improve mental health
Imagine this, you’ve misplaced your cell phone. You start by scanning where you remember leaving it: on your bureau. You check and double-check the bureau before expanding your search around […]

Adam J Calhoun, Sreekanth H Chalasani, Tatyana O Sharpee (2014). Maximally informative foraging by Caenorhabditis elegans, eLife, Other:

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3:27 PM | Is the "ticking time bomb scenario" a valid defence of torture?
In the wake of a report published yesterday into the CIA's use of torture, many people are shocked and appalled. Yet one defence of the practice remains popular - "the ticking time bomb scenario".This is the idea that torture is justified if a suspect knows the location of bomb in a public place, and many lives would be saved if he or she were coerced into telling authorities the location in time for it to be deactivated. The new Senate Intelligence Committee report describes how the ticking […]

Spino, J. & Cummins, D. (2014). The Ticking Time Bomb: When the Use of Torture Is and Is Not Endorsed, Review of Philosophy and Psychology, 5 (4) 543-563. DOI: 10.1007/s13164-014-0199-y

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2:38 PM | Video Tip of the Week: “Virtually Immune” computational immune system modeling
This week’s video tip of the week is the next in a series. It began when I took a look at GeneFriends, and their option to output the data for use in BioLayout Express3D. So of course we had to then take a look at BioLayout. While I was exploring BioLayout, I came across Virtually […]

Enright, A. & Ouzounis, C. (2001). BioLayout--an automatic graph layout algorithm for similarity visualization, Bioinformatics, 17 (9) 853-854. DOI: 10.1093/bioinformatics/17.9.853

Theocharidis A., Anton J Enright & Tom C Freeman (2009). Network visualization and analysis of gene expression data using BioLayout Express3D, Nature Protocols, 4 (10) 1535-1550. DOI: http://dx.doi.org/10.1038/nprot.2009.177

Wright D.W., Anton J. Enright & Tom C. Freeman (2014). Visualisation of BioPAX Networks using BioLayout Express3D, F1000Research, DOI: http://dx.doi.org/10.12688/f1000research.5499.1

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1:59 PM | Pacific barreleye: Weird Fish with Transparent Head
Pacific barreleye fish By Isa2014 (Own work) [CC-BY-SA-4.0], via Wikimedia Commons Kingdom: Animalia Phylum: Chordata Class: Actinopterygii Order: Argentiniformes Family: Opisthoproctidae Genus: Macropinna Species: Macropinna microstoma Common Name(s): Pacific barreleye The Pacific barreleye fish is one the weirdest creatures lurking deep in the ocean. Named after its eyes that are

Robison, B. & Reisenbichler, K. (2008). Macropinna microstoma and the Paradox of Its Tubular Eyes, Copeia, 2008 (4) 780-784. DOI: 10.1643/CG-07-082

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1:30 PM | The Companion Animal Science Story of the Year?
Dogs love learning. Eureka!Photo: Anna Tyurina / ShutterstockScience Borealis challenged Canadian science bloggers to write about the most important science news of the year in their field. It’s incredibly tough to choose one single study. Every week we cover fascinating research about people’s relationships with their pets, and every one of those studies deserves to be chosen. But there was one paper that really captured our readers’ imagination. It’s one of our […]

McGowan RT, Rehn T, Norling Y & Keeling LJ (2014). Positive affect and learning: exploring the "Eureka Effect" in dogs., Animal cognition, 17 (3) 577-87. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24096703

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1:00 PM | Christmas Trees Have Trouble Seeing The Light
Biology concepts – photoprotection, photosynthesis, non-photochemical quenching, reaction center, yule, evergreen, chlorophyllYule was/is a pagan celebration in midwinter. Krampus was the spirit who came during Yule to punish children who had misbehaved. Yule celebrations used evergreens (note his headdress) and this has continued in the modern Christmas celebration, but the Krampus became paired with good Saint Nicholas, so they kind of went the other way with that one.Christmas trees […]

Lysenko EA, Klaus AA, Pshybytko NL & Kusnetsov VV (2014). Cadmium accumulation in chloroplasts and its impact on chloroplastic processes in barley and maize., Photosynthesis research, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25315190

Demmig, B., Winter, K., Kruger, A. & Czygan, F. (1987). Photoinhibition and Zeaxanthin Formation in Intact Leaves : A Possible Role of the Xanthophyll Cycle in the Dissipation of Excess Light Energy, PLANT PHYSIOLOGY, 84 (2) 218-224. DOI: 10.1104/pp.84.2.218

Ottander C, Campbell D, Öquist G (1995). Seasonal changes in photosystem II organization and pigment composition in Pinus sylvestris. , Planta , 197 176-183. Other:

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12:43 AM | Anatomy of a “Serving”
Is it how much you’re expected to eat? How much you should eat? Pardon me, but if I want to eat an entire bag of potato chips, that’s exactly what I’m going to do. I say this as the guy who helps create nutrition facts panels for food products for a living. I have read, […]

Choinière C. & Lando A. (2008). 2008 Health and Diet Survey, Other:

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