Posts

August 04, 2014

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2:43 PM | Unpacking Eating Disorder Recovery Part 1: The Recovery Model
What does eating disorder recovery really look like? When you say the word “recovery,” differences of opinion loom large. The lack of definitional clarity around the concept of recovery came up many times at ICED, and continues to surface in discussions among researchers, clinicians, and individuals with eating disorders themselves. We’ve looked at recovery on the blog before (for example, Gina looked at how patients define recovery here; Tetyana surveyed […]

Dawson L, Rhodes P & Touyz S (2014). The recovery model and anorexia nervosa., The Australian and New Zealand journal of psychiatry, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24927735

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1:07 PM | Coxsackie Virus Depletes Cardiac Stem Cells
There is epidemiological evidence that links type B coxsackie virus (CVB) infection with heart disease, and research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress at later stages of life.CVB infection is very common and affects mostly children. The symptoms range widely: over half of the infections are thought to be asymptomatic, the majority of children who get sick have only a mild fever, and a very […]

Sin, J., Puccini, J., Huang, C., Konstandin, M., Gilbert, P., Sussman, M., Gottlieb, R. & Feuer, R. (2014). The Impact of Juvenile Coxsackievirus Infection on Cardiac Progenitor Cells and Postnatal Heart Development, PLoS Pathogens, 10 (7) DOI: 10.1371/journal.ppat.1004249

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8:30 AM | The iPhone Effect - when mobile devices intrude on our face-to-face encounters
You've probably experienced this. You're in the middle of telling your friend a story when his eyes flick across to his phone. Perhaps he even picks it up, checks the screen. "Sorry, go on," he says. But your flow is interrupted. And you know his mind is at least half elsewhere.Shalini Misra and her team approached 100 pairs of people (109 women; average age 33) in cafes across Washington DC and neighbouring districts. They asked them to chat for ten minutes at a table in the cafe about a […]

Misra, S., Cheng, L., Genevie, J. & Yuan, M. (2014). The iPhone Effect: The Quality of In-Person Social Interactions in the Presence of Mobile Devices, Environment and Behavior, DOI: 10.1177/0013916514539755

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August 03, 2014

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6:37 PM | Is Fat making you… Fat?
Fast food, let’s face it, it’s not the best for you. Yet Mcdonalds and Pizza hut are known practically world wide [although menu options differ]. With the rise of our […]

Long L, Toda C, Jeong JK, Horvath TL & Diano S (2014). PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding., The Journal of clinical investigation, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25083994

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3:33 PM | Ignoring the dangers: fracking development outpacing knowledge of biotic impacts
I’m not uniformly against fracking as many other environmental scientists may be.  Although my initial impressions of fracking were extremely negative, I’ve come to see the need for transitional energy sources as we move away from fossil fuels toward a … Continue reading →

Souther, S., Tingley, M., Popescu, V., Hayman, D., Ryan, M., Graves, T., Hartl, B. & Terrell, K. (2014). Biotic impacts of energy development from shale: research priorities and knowledge gaps, Frontiers in Ecology and the Environment, 12 (6) 330-338. DOI: 10.1890/130324

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August 02, 2014

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5:53 PM | At risk for Cancer? Try Spicy Food!
Like spicy food? Well next time you eat some you should hug that chili pepper, because he might just save your life. This is an interesting find, researchers have found that […]

de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J & Niv Y (2014). Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis., The Journal of clinical investigation, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25083990

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1:44 PM | Metamorphic petrology: under pressure and getting stressed?
High pressure (HP) terranes are areas containing eclogites and other eclogite-facies rocks found within many mountains belts, including the Himalaya and the Alps. HP rocks were metamorphosed at extreme pressures, up to 3 or even 4 billion Pascals (or GPa. Atmospheric … Continue reading →

Mancktelow N.S. (2008). Tectonic pressure: Theoretical concepts and modelled examples, Lithos, 103 (1-2) 149-177. DOI: http://dx.doi.org/10.1016/j.lithos.2007.09.013

Wheeler J. (2014). Dramatic effects of stress on metamorphic reactions, Geology, DOI: http://dx.doi.org/10.1130/g35718.1

Viete D.R., G. S. Lister & I. R. Stenhouse (2011). The nature and origin of the Barrovian metamorphism, Scotland: diffusion length scales in garnet and inferred thermal time scales, Journal of the Geological Society, 168 (1) 115-132. DOI: http://dx.doi.org/10.1144/0016-76492009-087

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August 01, 2014

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5:12 PM | Possible treatment and Prevention for Parkinson’s
Parkinson’s disease affects neurons in a particular brain region, when it develops brain cells have their mitochondrial activity cease and then the cells die. But now researchers have shown that supplying D-lactate […]

Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA & Kurzchalia TV (2014). Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival., Biology open, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25063200

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1:35 PM | Fly Life: Why fruit flies are a good model organism for research
Since this is my first post, I’d like to start by talking about the basics: Why are we doing research with fruit flies, or even animal models in general? How can these simple organisms possibly provide us with relevant data for future human research? Generally speaking, animal models are important for biological research because they […]

Valente EM, Salvi S, Ialongo T, Marongiu R, Elia AE, Caputo V, Romito L, Albanese A, Dallapiccola B & Bentivoglio AR & (2004). PINK1 mutations are associated with sporadic early-onset parkinsonism., Annals of neurology, 56 (3) 336-41. PMID: http://www.ncbi.nlm.nih.gov/pubmed/15349860

Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF & George RA (2000). The genome sequence of Drosophila melanogaster., Science (New York, N.Y.), 287 (5461) 2185-95. PMID: http://www.ncbi.nlm.nih.gov/pubmed/10731132

Reiter LT, Potocki L, Chien S, Gribskov M & Bier E (2001). A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster., Genome research, 11 (6) 1114-25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/11381037

Lloyd TE & Taylor JP (2010). Flightless flies: Drosophila models of neuromuscular disease., Annals of the New York Academy of Sciences, 1184 20. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20329357

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8:32 AM | Psychologists investigate a major, ignored reason for our lack of sleep - bedtime procrastination
Short term, lack of sleep scrambles our mental functioning. Long term, the health consequences can be dire. What's stopping us from getting enough?For many, adequate sleep is elusive because of sleep disorders, including varieties of insomnia. For others there are practical challenges - baby care or night shifts, for example. A new study focuses on another major, yet strangely overlooked, reason - bedtime procrastination. You want to go to bed early. You know you need to get to bed. And yet you […]

Kroese, F., Evers, C., Adriaanse, M. & de Ridder, D. (2014). Bedtime procrastination: A self-regulation perspective on sleep insufficiency in the general population, Journal of Health Psychology, DOI: 10.1177/1359105314540014

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7:11 AM | Floating Fried Eggs
Fried Egg JellyfishCotylorhiza tuberculataThe common name says it all. This weird-looking jellyfish literally looks like a fried egg! Scientifically known as Cotylorhiza tuberculata, it is one of the two jellyfish species that resemble a fried egg. The other one is Phacellophora camtschatica. Not surprisingly, it also goes by the same name.They may look tasty, but you probably don't want to have one for breakfast! However, you can have a lot of fun with C. tuberculata. This jellyfish has a […]

Reum, J., Hunsicker, M. & Paulsen, C. (2010). Species Composition and Relative Abundance of Large Medusae in Puget Sound, Washington, Northwest Science, 84 (2) 131-140. DOI: 10.3955/046.084.0202

Widmer, C. (2006). Life cycle of Phacellophora camtschatica (Cnidaria: Scyphozoa), Invertebrate Biology, 125 (2) 83-90. DOI: 10.1111/j.1744-7410.2006.00043.x

Towanda, T. & Thuesen, E. (2006). Ectosymbiotic behavior of Cancer gracilis and its trophic relationships with its host Phacellophora camtschatica and the parasitoid Hyperia medusarum, Marine Ecology Progress Series, 315 221-236. DOI: 10.3354/meps315221

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July 31, 2014

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11:18 PM | Serious Restrictive Eating Disorders Occur at Any Weight
Although the words “anorexia nervosa” typically conjure up images of emaciated bodies, eating disorders characterized by dietary restriction or weight loss can — and do — occur at any weight. However, precisely because anorexia nervosa is associated with underweight, doctors are less likely to identify eating disorders among individuals who are in the so-called “normal” or above normal weight range, even if they […]

Lebow, J., Sim, L. & Kransdorf, L. (2014). Prevalence of a History of Overweight and Obesity in Adolescents With Restrictive Eating Disorders, Journal of Adolescent Health, DOI: 10.1016/j.jadohealth.2014.06.005

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10:36 PM | Twitter Psychosis as a Cultural Artifact
The creation of the category “Twitter Psychosis" tells us more about the culture of contemporary psychiatry than it does about the purported dangers of social media overuse. Can Twitter really “cause” psychotic symptoms in predisposed individuals? Or is Twitter merely the latest technical innovation that influences “the form, origin and content of delusional beliefs” (Bell et al., 2005)? Twitter as the new telephone tower, radio waves, microchip implant or […]

Kalbitzer J, Mell T, Bermpohl F, Rapp MA & Heinz A (2014). Twitter Psychosis: A Rare Variation or a Distinct Syndrome?, The Journal of nervous and mental disease, 202 (8) 623. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25075647

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9:26 PM | Functional Neuroimaging’s Neymar Problem
As a “World Cup tie in post” this one’s a bit late, but here’s a story that’s been getting a lot of attention: According to scientists, Neymar uses instinct and not his brain when playing football Yes, if you believe the headlines, research has shown that legendary Brazilian forward Neymar da Silva Santos is so […]The post Functional Neuroimaging’s Neymar Problem appeared first on Neuroskeptic.

Eiichi Naito & Satoshi Hirose (2014). Efficient foot motor control by Neymar’s brain, Front. Hum. Neurosci., Other:

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Editor's Pick
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5:33 PM | Mitochondria and Anti Aging
I’m sure you can all relate, you go to fix the sink and in the process you build a new kitchen on accident. Anyone… no? Well that is sort of […]

Lisanti, S., Tavecchio, M., Chae, Y., Liu, Q., Brice, A., Thakur, M., Languino, L. & Altieri, D. (2014). Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks, Cell Reports, DOI: 10.1016/j.celrep.2014.06.061

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2:43 PM | Payment System Protects Privacy of EV Owners
A new electronic payment system created at A*STAR aims to protect the privacy of EV owners recharging their electric cars.

Au, M., Liu, J., Fang, J., Jiang, Z., Susilo, W. & Zhou, J. (2014). A New Payment System for Enhancing Location Privacy of Electric Vehicles, IEEE Transactions on Vehicular Technology, 63 (1) 3-18. DOI: 10.1109/TVT.2013.2274288

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1:22 PM | What’s the Answer? (electronic lab notebooks)
Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]

Voegele C., N. Robinot, J. McKay, P. Damiecki & L. Alteyrac (2013). A universal open-source Electronic Laboratory Notebook, Bioinformatics, 29 (13) 1710-1712. DOI: http://dx.doi.org/10.1093/bioinformatics/btt253

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8:33 AM | The voices heard by people with schizophrenia are friendlier in India and Africa, than in the US
When a patient with schizophrenia hears voices in their head, is the experience shaped by the culture they live in? Tanya Luhrmann and her colleagues investigated by interviewing twenty people diagnosed with schizophrenia living in San Mateo, California; twenty in Accra, Ghana; and twenty others in Chennai India. There were similarities across cultures, including descriptions of good and bad voices, but also striking differences.In San Mateo the interviewees talked about their condition as a […]

Luhrmann, T., Padmavati, R., Tharoor, H. & Osei, A. (2014). Differences in voice-hearing experiences of people with psychosis in the USA, India and Ghana: interview-based study, The British Journal of Psychiatry, DOI: 10.1192/bjp.bp.113.139048

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8:18 AM | Dipeptidyl peptidase (DPP) IV and autism: supporting opioid-excess?
Serum levels of dipeptidyl peptidase (DPP) IV were found to be lower in children with autism compared to asymptomatic controls according to the study by Shahid Bashira & Laila AL-Ayadhi [1]. Based on analysis by ELISA, researchers concluded that "alterations in the plasma level of DPP IV play a role in the pathophysiology of autism".A sailor went to sea, sea, sea... @ Wikipedia Anyone who has followed the autism research scene for any length of time might have already heard […]

Bashir, S. & AL-Ayadhi, L. (2014). Alterations in plasma dipeptidyl peptidase IV in autism: A pilot study, Neurology, Psychiatry and Brain Research, 20 (2) 41-44. DOI: 10.1016/j.npbr.2014.03.001

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July 30, 2014

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10:45 PM | Keeping lithium contained: new design allows for high energy-density anode in Li-ion batteries
Lithium ion batteries – they’re everywhere, and their name has become mainstream enough that non-scientists know they’re in our laptops and electronics.  These types of batteries are so popular because lithium boasts a high energy density and they don’t lose charge … Continue reading →

Zheng, G., Lee, S., Liang, Z., Lee, H., Yan, K., Yao, H., Wang, H., Li, W., Chu, S. & Cui, Y. & (2014). Interconnected hollow carbon nanospheres for stable lithium metal anodes, Nature Nanotechnology, DOI: 10.1038/nnano.2014.152

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5:31 PM | Suicide, it might be in the blood
I tried to kill myself, more than once in fact. It was a troubling time for me and as a former active duty Marine that might not be too surprising […]

Guintivano, J., Brown, T., Newcomer, A., Jones, M., Cox, O., Maher, B., Eaton, W., Payne, J., Wilcox, H. & Kaminsky, Z. & (2014). Identification and Replication of a Combined Epigenetic and Genetic Biomarker Predicting Suicide and Suicidal Behaviors, American Journal of Psychiatry, DOI: 10.1176/appi.ajp.2014.14010008

Guintivano, J., Arad, M., Gould, T., Payne, J. & Kaminsky, Z. (2013). Antenatal prediction of postpartum depression with blood DNA methylation biomarkers, Molecular Psychiatry, 19 (5) 560-567. DOI: 10.1038/mp.2013.62

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4:02 PM | Cool Burning Flames Could Lead to Better Engines
A team of international researchers has discovered a new type of cool burning flames that could lead to greener, more efficient combustion engines.

Dietrich, D., Nayagam, V., Hicks, M., Ferkul, P., Dryer, F., Farouk, T., Shaw, B., Suh, H., Choi, M., Liu, Y. & Avedisian, C. (2014). Droplet Combustion Experiments Aboard the International Space Station, Microgravity Science and Technology, DOI: 10.1007/s12217-014-9372-2

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4:00 PM | Oh, Rats! They’ll Regret This.
We often find ourselves in decision-making dilemmas along the day. For instance, to reach work on time, would you rather take the shorter, faster route or the longer, scenic route? In deciding these actions, the brain promptly fits in a reward versus risk equation, but sometimes the outcome isn’t quite favorable! What if there was … Continue reading →

Steiner A.P. (2014). Behavioral and neurophysiological correlates of regret in rat decision-making on a neuroeconomic task, Nature Neuroscience, 17 (7) 995-1002. DOI: http://dx.doi.org/10.1038/nn.3740

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2:46 PM | Influenza: How the Great War helped create the greatest pandemic the world has ever known | @GrrlScientist
The Great War helped create the influenza pandemic of 1918, which eventually brought an early end to the Great War.I had a little bird,Its name was Enza. I opened the window,And in-flu-enza. ~ Children's Skipping Rhyme, 1918 Like most rhymes that one learns as a child, I had no idea at the time what this one meant, nor did I ponder its possible meaning as I grew older. But one afternoon, this poem's significance became startlingly clear to me. As I sat in a large university lecture hall where […]

Taubenberger J.K. (2006). 1918 Influenza: the Mother of All Pandemics, Emerging Infectious Diseases, 12 (1) 15-22. DOI: http://dx.doi.org/10.3201/eid1201.050979

Gamblin S.J. (2004). The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin, Science, 303 (5665) 1838-1842. DOI: http://dx.doi.org/10.1126/science.1093155

Barry J.M. (2004). The site of origin of the 1918 influenza pandemic and its public health implications (Commentary), Journal of Translational Medicine, 2 (3) DOI: 10.1186/1479-5876-2-3

Humphries M.O. (2014). Paths of Infection: The First World War and the Origins of the 1918 Influenza Pandemic, War in History, 21 (1) 55-81. DOI: http://dx.doi.org/10.1177/0968344513504525

Osterholm M.T. (2005). Preparing for the Next Pandemic, New England Journal of Medicine, 352 1839-1842. DOI: 10.1056/NEJMp058068

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1:42 PM | Science in the News: The 2014 Ebola Outbreak
If you’ve been watching the news recently, you’ll probably have seen reports on the Ebola outbreak in West Africa. Around 673 people in Guinea and Liberia have died so far […]

Dixon MG, Schafer IJ & EIS officer, CDC (2014). Ebola viral disease outbreak - west Africa, 2014., MMWR. Morbidity and mortality weekly report, 63 (25) 548-51. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24964881

Gatherer, D. (2014). The 2014 Ebola virus disease outbreak in West Africa, Journal of General Virology, 95 (Pt_8) 1619-1624. DOI: 10.1099/vir.0.067199-0

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1:41 PM | Video Tip of the Week: PhenDisco, “phenotype discoverer” for dbGap data
The dbGaP, database of Genotypes and Phenotypes, repository at NCBI collects information from research projects that link genotype and phenotype information and human variation, across many different types of studies, providing leads on variation that may be important to understand clinical issues. Some of the data is publicly available de-identified patient information, and some of the […]

Doan S., Lin K.W., Conway M., Ohno-Machado L., Hsieh A., Feupe S.F., Garland A., Ross M.K., Jiang X. & Farzaneh S. & (2013). PhenDisco: phenotype discovery system for the database of genotypes and phenotypes., Journal of the American Medical Informatics Association : JAMIA, PMID: http://www.ncbi.nlm.nih.gov/pubmed/23989082

Tryka K.A., A. Sturcke, Y. Jin, Z. Y. Wang, L. Ziyabari, M. Lee, N. Popova, N. Sharopova, M. Kimura & M. Feolo & (2013). NCBI's Database of Genotypes and Phenotypes: dbGaP, Nucleic Acids Research, 42 (D1) D975-D979. DOI: http://dx.doi.org/10.1093/nar/gkt1211

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12:30 PM | The Attentive Look of a Dog in Training
Researchers investigate the body language of a dog that is performing well in training.Photo: Markus Balint / ShutterstockA new study puts dogs through the first stage of a basic training task and analyzes eye contact and posture in the most successful dogs. The research by Masashi Hasegawa et al (Azabu University School of Veterinary Medicine) is motivated by a desire to improve people’s training abilities by helping them recognize the posture associated with successful […]

Braem, M. & Mills, D. (2010). Factors affecting response of dogs to obedience instruction: A field and experimental study, Applied Animal Behaviour Science, 125 (1-2) 47-55. DOI: 10.1016/j.applanim.2010.03.004

Deldalle, S. & Gaunet, F. (2014). Effects of 2 training methods on stress-related behaviors of the dog (Canis familiaris) and on the dog–owner relationship, Journal of Veterinary Behavior: Clinical Applications and Research, 9 (2) 58-65. DOI: 10.1016/j.jveb.2013.11.004

Hasegawa, M., Ohtani, N. & Ohta, M. (2014). Dogs’ Body Language Relevant to Learning Achievement, Animals, 4 (1) 45-58. DOI: 10.3390/ani4010045

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12:00 PM | Does Life Come In XXXS?
Biology concepts – characteristics of life, archaea, bacteria, mycoplasma, synthetic biology, symbiosis, parasitism, nanobacteria, genomeAs part of this blog, we have talked about some pretty small life. Wolffia globosa is the smallest flowering plant, only 0.6 mm long. We also talked about archaea, a different kingdom than bacteria, but still on the smallish side of life. The tardigrade is the toughest animal, but is also one of the smallest, at 100 µm (0.00394 inch).The organism […]

Manhart LE (2013). Mycoplasma genitalium: An emergent sexually transmitted disease?, Infectious disease clinics of North America, 27 (4) 779-92. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24275270

Wu CY, Young L, Young D, Martel J & Young JD (2013). Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids., PloS one, 8 (9) PMID: http://www.ncbi.nlm.nih.gov/pubmed/24086546

Gibson DG, Glass JI, Lartigue C, Noskov VN, Chuang RY, Algire MA, Benders GA, Montague MG, Ma L, Moodie MM & Merryman C (2010). Creation of a bacterial cell controlled by a chemically synthesized genome., Science (New York, N.Y.), 329 (5987) 52-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/20488990

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8:52 AM | Immunological effects from risperidone treatment in autism
The findings from Jai Eun Choi and colleagues [1] suggesting that use of the antipsychotic risperidone may impact on levels of certain cytokines - messenger cells of the immune system - in some cases of autism spectrum disorder (ASD) grabbed my attention recently. I've always been pretty interested in the complexity of the immune system when it comes to something like autism (see here) as well as the various examples of how many of the medications used to 'manage' aspects of […]

Choi JE, Widjaja F, Careaga M, Bent S, Ashwood P & Hendren RL (2014). Change in Plasma Cytokine Levels During Risperidone Treatment in Children with Autism., Journal of child and adolescent psychopharmacology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24828014

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8:23 AM | When the cuddle hormone turns nasty - oxytocin linked with violent intentions
For many years, the hormone oxytocin was caricatured as the source of all human goodness - trust, altruism, love, and morality. Among the findings that contributed to this picture were the discovery that sniffing oxytocin increases people's trust and generosity in financial games; that it aids face recognition; and that its release is associated with maternal bonding; and with orgasm.However, the picture has grown a lot more complicated of late, with findings showing that […]

DeWall, C., Gillath, O., Pressman, S., Black, L., Bartz, J., Moskovitz, J. & Stetler, D. (2014). When the Love Hormone Leads to Violence: Oxytocin Increases Intimate Partner Violence Inclinations Among High Trait Aggressive People, Social Psychological and Personality Science, 5 (6) 691-697. DOI: 10.1177/1948550613516876

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