Posts

August 25, 2014

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4:11 PM | Are most co-morbidities really substance-induced disorders?
In this blog we re-emphasize the need for accurate diagnosis of co-morbidity with a substance use disorder. It appears form the article cited here (1) that diagnosis is often flawed in many studies and that the so-called diagnosis of co-morbidity … Continue reading →
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8:40 AM | mTOR-regulated autophagy and autism mouse models
I was intrigued to read the paper by Guomei Tang and colleagues [1] (open-access) and their assertion that: "mTOR [mammalian target of rapamycin]-regulated autophagy is required for developmental spine pruning, and activation of neuronal autophagy corrects synaptic pathology and social behavior deficits in ASD [autism spectrum disorder] models with hyperactivated mTOR"."Re-verify our range to target... one ping only".If that opening paragraph sounds like scientific […]
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6:30 AM | Cognitive and exercise interventions for older adults with and without cognitive impairment
Jake Crawshaw reports on a recent systematic review of cognitive and exercise interventions for older people with and without cognitive impairment. The post Cognitive and exercise interventions for older adults with and without cognitive impairment appeared first on The Mental Elf.

August 23, 2014

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5:47 PM | You heard me right... autism prevalence and meat consumption
"The paper presents some exploratory analyses demonstrating the correlation between particular aspects of meat consumption and autism prevalence". The paper by Wojciech & Ewa Pisula [1] (open-access) does indeed suggest that there may "a correlation between increasing meat consumption and autism prevalence"."Goonies never say die!"Readers are invited to draw their own conclusions on such a correlation. Personally, I'm not yet convinced that meat consumption is the primary driving force […]

Wojciech Pisula & Ewa Pisula (2014). Autism prevalence and meat consumption - a hypothesis that needs to be tested, Medical Hypotheses, Other:

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August 22, 2014

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10:51 PM | Using Animal Research to Justify Eating Disorder Treatment Practices: Are We Going Too Far? (On Eating Junk Food in Treatment – Part II)
As a follow up to Shirley’s post on eating hyper-palatable foods during eating disorder treatment , I asked Liz–SEDs’ resident expert on animal behaviour, particularly in relation to binge eating and drug addiction–to look at some of the studies that Julie O’Toole mentioned as evidence for Kartini Clinic’s guidelines of avoiding hyper-palatable foods for the first year of eating disorder recovery. If you missed Dr. O’Toole’s […]

Hagan, M.M., Wauford, P.K., Chandler, P.C., Jarrett, L.A., Rybak, R.J. & Blackburn, K. (2002). A new animal model of binge eating: key synergistic role of past caloric restriction and stress., Physiology & Behavior, 77 (1) 45-54. PMID: http://www.ncbi.nlm.nih.gov/pubmed/12213501

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12:49 PM | The Science of Depression
Good and short video about the possible explanations for the origin of depression. From serotonin, to neurogenesis and genetics.   Related posts:Science, gender and the emergence of depression in American psychiatry 1950-1980 Genes Predict Reponse to Lithium Addition for Treatment Resistant Depression Why Can’t We find a Gene for Depression?
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7:47 AM | Serum microRNA profiles and autism
I cannot pretend to be an expert on microRNA (miRNA). Indeed, it was only after reading the paper by Mahesh Mundalil Vasu and colleagues [1] (open-access) talking about serum microRNA profiles in children diagnosed with an autism spectrum disorder (ASD), that I started my learning journey about these small non-coding RNAs. So please, go easy with me on this one...Hamlet @ Wikipedia Quite a good [short] introduction to microRNAs can be found here. If you want something a […]

Mundalil Vasu, M., Anitha, A., Thanseem, I., Suzuki, K., Yamada, K., Takahashi, T., Wakuda, T., Iwata, K., Tsujii, M., Sugiyama, T. & Mori, N. (2014). Serum microRNA profiles in children with autism, Molecular Autism, 5 (1) 40. DOI: 10.1186/2040-2392-5-40

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7:00 AM | Visual deficits in adults with Down syndrome explored
Research by Seeability and the RNIB suggests that adults with learning disabilities are ten times more likely to be blind or partially sighted than the rest of the population. If they have severe or profound learning disabilities, then they are likely to have serious sight problems. There already exists some guidance for GPs on responding [read the full story...] The post Visual deficits in adults with Down syndrome explored appeared first on The Learning Disabilities Elf.
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6:30 AM | Guidance to improve service user experience: how NICE is that?
Lucy Simons and Paul Radin summarise the latest Evidence Update from NICE relating to their 2011 guidance to improve service user experience The post Guidance to improve service user experience: how NICE is that? appeared first on The Mental Elf.

August 21, 2014

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7:56 AM | Autism, ADHD and allergy: Taiwan and big data (again)
"Children with ADHD [attention-deficit hyperactivity disorder] or ASD [autism spectrum disorder] had an increased risk of allergic comorbidities, and those with both ADHD and ASD had the highest"."You built a time machine.. out of a DeLorean"That was the conclusion arrived at in the paper by Ting-Yang Lin and colleagues [1]. For regular readers of this blog, this was yet another example of how Taiwan leads the way when it comes to the concept of 'big data' specifically […]

Lin, T., Lin, P., Su, T., Chen, Y., Hsu, J., Huang, K., Chang, W., Chen, T., Pan, T., Chen, M. & Bai, Y. (2014). Autistic spectrum disorder, attention deficit hyperactivity disorder, and allergy: Is there a link? A nationwide study, Research in Autism Spectrum Disorders, 8 (10) 1333-1338. DOI: 10.1016/j.rasd.2014.07.009

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6:30 AM | Mental disorders after critical illness: depression, PTSD and functional disability in survivors of intensive care
The BRAIN-ICU prospective cohort study published in the Lancet Respiratory Medicine looks at mental health outcomes and functional disabilities in a general ICU population. It explores the hypothesis that depressive symptoms after discharge are more often somatic (i.e. bodily complaints) than cognitive-affective (i.e. thought-related and mood-related complaints). The post Mental disorders after critical illness: depression, PTSD and functional disability in survivors of intensive care appeared […]

August 20, 2014

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8:35 AM | ADHD in DSM-5: what did you think would happen?
"Our results, combined with previous findings, suggest a 27% increase in the expected prevalence of ADHD [attention-deficit hyperactivity disorder] among young adults, comparing DSM-IV to DSM-5 criteria". So said the paper by Matte and colleagues [1] who as part of their study looked at "the prevalence of ADHD according to DSM-5 criteria".Europa @ Wikipedia The changes to the diagnosis of ADHD in DSM-5 can be seen here. The main difference between DSM-IV and DSM-5 diagnosis […]
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6:30 AM | Are primary care interventions for intimate partner violence effective? I wish I could tell you
Listen up systematic reviewers. Don't make Sarah Knowles angry; you won't like her when she's angry. Cue a rather frustrated blog about new research on primary care interventions for intimate partner violence. The post Are primary care interventions for intimate partner violence effective? I wish I could tell you appeared first on The Mental Elf.
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6:03 AM | Your Brain and Video Games
This is an interesting video since it uses video games to explain how your brain works. In this instance in video games. For instance Neural Prediction or the way you estimate a ball coming towards you so to be able to catch it in time. At least before it hits you in the face. Neuroscience […]

August 19, 2014

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8:23 AM | Family processes and trajectory in autism
The paper by Woodman and colleagues [1] looking at trajectory and autism in adolescents and adults is the source material for today's post (another micropost). Concluding that: "Overall, autism symptoms and maladaptive behaviors were observed to improve over the study period" of about 8 years, the authors also reported that "greater improvements were associated with higher levels of maternal praise (based on maternal speech samples) and higher quality mother-child relationships". If I remember […]

Woodman AC, Smith LE, Greenberg JS & Mailick MR (2014). Change in Autism Symptoms and Maladaptive Behaviors in Adolescence and Adulthood: The Role of Positive Family Processes., Journal of autism and developmental disorders, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25070471

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8:06 AM | Multimorbidity – NICE guidance scoping consultation
Get involved in the NICE scoping consultation on multimorbidities. Today’s post is a little different in nature – rather than bringing you the evidence, we are asking you to get involved in helping to shape it. NICE are in the process of defining the scope of their guidelines on multimorbidity (a combination of two or [read the full story...] The post Multimorbidity – NICE guidance scoping consultation appeared first on The Learning Disabilities Elf.
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6:30 AM | Combining psychotherapy and antidepressants is best for common mental illnesses
Patrick Kennedy-Williams summarises a recent meta-analysis, which finds that combined treatment with psychotherapy and antidepressants is more effective than treatment with antidepressants alone. The post Combining psychotherapy and antidepressants is best for common mental illnesses appeared first on The Mental Elf.
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