Posts

January 09, 2015

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9:35 AM | Early mortality in mums of children with autism or intellectual disability
I know the paper by Jenny Fairthorne and colleagues [1] (open-access) is probably not the happiest thing to read with their conclusion that: "During the study period, mothers of children with intellectual disability or ASD [autism spectrum disorder] had more than twice the risk of death" but their message is nonetheless an important one.Based on data derived from "state-wide databases" covering women living in Western Australia who gave birth between 1983 and 2005, […]

Fairthorne J, Hammond G, Bourke J, Jacoby P & Leonard H (2014). Early Mortality and Primary Causes of Death in Mothers of Children with Intellectual Disability or Autism Spectrum Disorder: A Retrospective Cohort Study., PloS one, 9 (12) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25535971

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8:00 AM | Six out of ten GP surgeries are signed up to the Directed Enhanced Scheme in England, but 40% of patients with learning disabilities did not get a health check
The Directed Enhanced Scheme offers reimbursement to GP surgeries to carry out annual health checks for people with learning disabilities. Here, we report on a cohort study which looked at the impact of the scheme over a three year period. The post Six out of ten GP surgeries are signed up to the Directed Enhanced Scheme in England, but 40% of patients with learning disabilities did not get a health check appeared first on The Learning Disabilities Elf.
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7:30 AM | Family experiences of help seeking in first episode psychosis
Andrew Shepherd explores the complex issue of families seeking help for first episode psychosis, investigated by researchers in a recent family narrative study, which concludes that help seeking attempts are often derailed by complex family responses to illness. The post Family experiences of help seeking in first episode psychosis appeared first on The Mental Elf.
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2:21 AM | Temperament in Eating Disorders (A Meta-Analysis)
Much research has been done on personality traits associated with eating disorders, and, as I’ve blogged about here and here, on personality subtypes among patients with EDs. For example, researchers have found that individuals with AN tend to have higher levels of neuroticism and perfectionism than healthy controls (Bulik et al., 2006; Strober, 1981). Moreover, some traits, such as anxiety, have been associated with a lower likelihood of recovery, whereas others, such as impulsivity, […]

Atiye M, Miettunen J & Raevuori-Helkamaa A (2014). A Meta-Analysis of Temperament in Eating Disorders., European eating disorders review : the journal of the Eating Disorders Association, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25546554

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2:21 AM | Temperament in Eating Disorders
Much research has been done on personality traits associated with eating disorders, and, as I’ve blogged about here and here, on personality subtypes among patients with EDs. For example, researchers have found that individuals with AN tend to have higher levels of neuroticism and perfectionism than healthy controls (Bulik et al., 2006; Strober, 1981). Moreover, some traits, such as anxiety, have been associated with a lower likelihood of recovery, whereas others, such as impulsivity, […]

January 08, 2015

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11:36 AM | Insecure attachment affects emotion regulation in alcoholics?
I have blogged recently about how insecure attachment is linked to various addictive behaviours. What is important is to establish a mechanism by which insecure attachment contributes to later addictive disorders. It may not be enough to say attachment and addiction are … Continue reading →
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9:49 AM | Abdominal discomfort syndrome in a subset of ME/CFS
"The findings show that ADS [abdominal discomfort syndrome] is a characteristic of a subset of patients with ME/CFS [Myalgic Encephalomyelitis / Chronic Fatigue Syndrome] and that increased bacterial translocation (leaky gut) is associated with ADS symptoms."Right there. God does not build in straight lines.So said the study by Michael Maes and colleagues [1] looking at both gastrointestinal (GI) symptom presentation in diagnosed cases of ME/CFS and "the IgA and IgM responses […]

Maes M, Leunis JC, Geffard M & Berk M (2014). Evidence for the existence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome., Neuro endocrinology letters, 35 (6) 445-453. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25433843

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7:30 AM | Peer support for perinatal mental illness: what makes a peer?
Lucy Simons reports on a meta-ethnography that explores what facilitates peer support for perinatal mental illness. Her key finding from appraising the review is that women who experience perinatal mental illness need support from the right sort of peer (i.e. women who have had mental distress in the context of motherhood) to make the relationship beneficial and to aid recovery. The post Peer support for perinatal mental illness: what makes a peer? appeared first on The Mental Elf.

January 07, 2015

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9:55 AM | Inflaming inflammation and autism: linking microglial activation and neuronal activity
It has been quite a few weeks since the publication of the paper by Simone Gupta and colleagues [1] (open-access) talking about "observations [that] provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism."I'm a wrecker. I wreck things, professionally. I mean.At the time of publication in early December (2014), there was quite a bit of media interest in the findings as per reports such as this one and […]

Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J, West AB & Arking DE (2014). Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism., Nature communications, 5 5748. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25494366

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7:30 AM | Mental health therapy for refugee and asylum seeking children: a small evidence base for a big problem
Laurence Palfreyman considers the very small and mixed evidence base of mental health interventions for refugee and asylum seeking children presented in a well conducted systematic review from last year. The post Mental health therapy for refugee and asylum seeking children: a small evidence base for a big problem appeared first on The Mental Elf.

January 06, 2015

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9:39 PM | Blood Test Tells How Long Concussion Symptoms Will Last
The Sunday after Thanksgiving last year proved tragic for family and friends of 22-year-old Kosta Karageorge. The defensive tackle for the Ohio State Buckeyes was found dead that day after apparently... -- Read more on ScientificAmerican.com
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9:40 AM | Olanzapine, gut bacteria and weight gain in mice
"These results collectively provide strong evidence for a mechanism underlying olanzapine-induced weight gain in mouse and a hypothesis for clinical translation in human patients."That was the summary statement derived from data published by Andrew Morgan and colleagues [1] (open-access) looking at how some of those trillions of wee beasties which colonise humans and animals (the microbiome) may very well influence response to medicines... at least in mice. The authors' specific focus on […]

Morgan AP, Crowley JJ, Nonneman RJ, Quackenbush CR, Miller CN, Ryan AK, Bogue MA, Paredes SH, Yourstone S, Carroll IM & Kawula TH (2014). The Antipsychotic Olanzapine Interacts with the Gut Microbiome to Cause Weight Gain in Mouse., PloS one, 9 (12) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25506936

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7:30 AM | Coproduction of secure mental health services: design, development and delivery
Sarah Carr summarises a study of user involvement and coproduction initiatives in secure mental health settings, which recommends schemes that build alliances, garner mutual respect and support communication between staff and service users in shared forums. The post Coproduction of secure mental health services: design, development and delivery appeared first on The Mental Elf.
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6:28 AM | Do coincidences exist?
Our brains are very good at explaining from being hyper attentive putting things together for avoiding harmful situations. Nice video, learn about magical thinking, palindrome, pareidolia and biases such as the selection bias, confirmation bias. These last two are not very strange to doctors especially those seasoned in clinical reasoning.   Related posts:Why are doctors more accurate with difficult cases? How Doctors Think, a book review Explaining Diagnostic Errors

January 05, 2015

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1:00 PM | How do you keep up to date with reliable research? #WeNurses tweet chat summary
André Tomlin summarises the WeNurses tweet chat that he ran with Teresa Chinn on 11/12/14. The chat saw contributions from a diverse group of 96 people who discussed the barriers to keeping up to date with reliable research, literature searching, critical appraisal, Twitter journal clubs and much more. The post How do you keep up to date with reliable research? #WeNurses tweet chat summary appeared first on The Mental Elf.
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10:50 AM | Depression and its treatment
Excellent video explaining depression from a neurobiological perspective. Around one in every 10 people will suffer from depression. Brain regions that control mood are often disrupted in depression. Antidepressant drugs or behavioral therapy can offer some relief. By understanding the brain better, our ability to treat depression should also get a boost. Watch the video […] Related posts:Deep Brain Stimulation for Depression New Kind of Brain Stimulation for Treatment Resistant […]
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9:27 AM | Systematic reviews and autism
There were a few reasons why I wanted to bring the commentary from Sven Bölte [1] on the topic of systematic reviews and autism research to your attention. One particular sentence included in the text stuck out for me: "... systematic reviews do not always tell the whole truth either" reflective of how we perhaps should always be a little cautious in the way we interpret science even when faced with the platinum standard that is the systematic review (with or without […]
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8:00 AM | People with learning disabilities not getting free flu jabs at GP surgeries according to Mencap survey
This year, for the first time, people with learning disabilities were identified as a clinical risk group in the guidance for flu vaccinations, but a telephone survey carried out by Mencap suggested that many GP surgeries were not offering this free jab. The post People with learning disabilities not getting free flu jabs at GP surgeries according to Mencap survey appeared first on The Learning Disabilities Elf.

January 03, 2015

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10:17 AM | Anti-epileptic meds and pediatric serum vitamin D levels
No, I am not becoming obsessed with the sunshine vitamin/hormone despite us being only a few days into 2015 and this being my second post on vitamin D. It's just the way that the research posts fall; although regular readers will probably have noticed I do enjoy reading the various research on all-things vitamin D.There has been an awakening...The research fodder for today's post is the paper by Yun-Jin Lee and colleagues [1] who measured 25-hydroxy vitamin D levels (in serum) for […]

Lee YJ, Park KM, Kim YM, Yeon GM & Nam SO (2014). Longitudinal Change of Vitamin D Status in Children With Epilepsy on Antiepileptic Drugs: Prevalence and Risk Factors., Pediatric neurology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25492388

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January 02, 2015

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11:46 PM | Resistance is (not so) Futile? Exploring Treatment Resistance in Eating Disorders
To me, the idea of “treatment resistance” in eating disorders sparks some ill feelings. While many have suggested that treatment resistance is common among those with eating disorders, others have noted how receiving the label of “treatment resistant” can make it more difficult to receive needed support or impact how one is perceived in treatment settings and how one’s behaviours are interpreted (e.g., Gremillion, 2003). Of course, this is a tricky ground to […]

Abbate-Daga, G., Amianto, F., Delsedime, N., De-Bacco, C. & Fassino, S. (2013). Resistance to treatment in eating disorders: A critical challenge, BMC Psychiatry, 13 (1) 294. DOI: 10.1186/1471-244X-13-294

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8:19 AM | Vitamin D and Chronic Fatigue Syndrome continued
Hello again and a very warm welcome back to Questioning Answers in 2015. The year, according to a popular sequel, we were all supposed to be benefiting from hoverboards and wearing self-drying clothes. It didn't quite work out like that (although there are still 52 weeks left for such dreams to come to fruition).When we got adopted by a bald guy, I thought this would be more like Annie.We start the new blogging year with a few comments on a rather interesting, if disappointing, set of results […]

Witham MD, Adams F, McSwiggan S, Kennedy G, Kabir G, Belch JJ & Khan F (2014). Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome - A randomised controlled trial., Nutrition, metabolism, and cardiovascular diseases : NMCD, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25455721

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