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Posts

May 24, 2013

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5:13 PM | The Genetics of Thin-Ideal Internalization
The Tripartite Model of body image dissatisfaction postulates that three factors (peers, parents, and media) affect body image dissatisfaction and disordered eating through thin-ideal internalization and appearance comparison. Thin-ideal internalization is the extent to which one accepts or “buys into” socioculturally defined beauty standards of thinness. The idea is that the more someone internalizes these standards, the more likely they are to engage in behaviours to achieve […]

May 23, 2013

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11:28 AM | Some good rules for life in general
Daniel Dennett has posted a fantastic set of "seven tools for thinking" in an article in the Guardian that has gone so viral that if you haven't seen it yet, then you must be doing the internet wrong. Perhaps the most novel involves hitting CTRL-F: "in this age of simple searching by computer ...Read More
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8:33 AM | Big data for autism and the promise of newborn bloodspots
An episode of the BBC program Horizon on 'Big Data' recently caught my attention. The content was a fascinating insight into how we are living in a data-rich age and how trawling/mining/dredging such data has the ability to advance medicine, predict crime and even make someone a few quid/dollars/euros on the stock market.Gone (data) fishing @ Wikipedia  I'm a big believer in big data. In particular how, with the right sources, technology, techniques and people, big data might be able […]

Mizejewski GJ, Lindau-Shepard B & Pass KA (2013). Newborn screening for autism: in search of candidate biomarkers., Biomarkers in medicine, 7 (2) 247-60. PMID:

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May 22, 2013

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10:29 PM | Why Research Is So Important For Dementia Care
This week is Dementia Awareness Week (TM). This is timely point to review why Dementia research is so important. In the Department of Health video above Professor Alistair Burns interviews Professor Martin Rossor, director at DeNDRon (Dementias and Neurodegenerative Diseases Research Network) about Dementia Research. Index: There are indices for the TAWOP site here and […]
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4:03 PM | The Scent of a Feline
*cue perfume commercial music* Dangerous… Stressful… Smells like a cat in heat… …do YOU want to inspire fear in mice? Who doesn’t! LIVE the terror. EXPERIENCE the horror. WEAR…eau d’terror, aka SBT, a potential alarm pheromone released from mice in response to bad situations! Sci is at Neurotic Physiology today, head over and check it [...]
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11:52 AM | The mystery of the missing experiments
Can experimental findings look too good to be true? Last week I wrote a blog post about some experiments showing a counterintuitive finding regarding how the need to urinate affects decision making. It’s since been brought to my attention that these experiments (along with dozens of others) have ...Read More

Francis G. (2012). The Psychology of Replication and Replication in Psychology, Perspectives on Psychological Science, 7 (6) 585-594. DOI:

Francis G. (2012). Publication bias and the failure of replication in experimental psychology, Psychonomic Bulletin & Review, 19 (6) 975-991. DOI:

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May 21, 2013

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9:59 PM | Professor Bruce Miller Discusses Frontotemporal Dementia
Neurologist Professor Bruce Miller is director of the University of California San Francisco Department of Neurology Memory and Aging Centre. There are a series of educational videos about Dementia on the USCSF Memory and Aging YouTube Channel. In the video above, Professor Miller talks about how emotions can be affected in Frontotemporal Dementia with reference […]

May 20, 2013

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7:59 AM | Autism, plasma cytokines and siblings
I'm gonna try and be fairly brief in this post on the paper by Valerio Napolioni and colleagues* (open-access) looking at plasma cytokine profiles in cases of autism and their asymptomatic siblings. Brief because (a) the paper is open-access and (b) the participant groups (autism: n=25; sibling controls n=25) were relatively small so one has to be quite careful in extrapolating the findings with any large degree of confidence.Siblings by Paul Klee @ WikiPaintings  Just in case you are […]

Napolioni V, Ober-Reynolds B, Szelinger S, Corneveaux JJ, Pawlowski T, Ober-Reynolds S, Kirwan J, Persico AM, Melmed RD, Craig DW & Smith CJ (2013). Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder., Journal of neuroinflammation, 10 38. PMID:

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5:07 AM | Becoming an individual twin isn’t about genetics or environment, but how you experience them
Have you ever known a pair of identical twins? Not just the ones that look alike, but identical twins that really were part of, at some point, the same egg and sperm combination, that then split early in development to create two “identical” people, with the same genetics. If genetics really were the be all [...]

May 19, 2013

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9:06 AM | Research into Brain Ageing News Roundup May 3rd Edition 2013
Recent research has clarified how Thioridazine one of the first antipsychotics to be used is also effective in the treatment of antibiotic-resistant bacteria. There is a small case series (n=5)  looking at Ramelteon in Delirium. Ramelteon is a Melatonin receptor agonist. Further studies will be needed to see if this effect is seen in large […]

May 18, 2013

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10:39 PM | Dementia Awareness Week (TM) 2013 May 19-25th
Dementia Awareness Week (TM) Dementia Awareness Week (TM) starts on May 19th and ends on May 25th 2013. This is the annual flagship event of the Alzheimer’s Society.  This is an opportunity of organisations and individuals to get involved in raising awareness of Dementia. What is Dementia? Dementia is a degenerative disease which affects the […]
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4:34 PM | Friday Weird Science: What’s your fart volume?
Have you ever wondered just HOW much you fart per day? Like…would it fill a soda can? A soda bottle? And would you be willing to stick a tight fitting tube up your rectum and wear it around all day to find out? If not, that’s ok! They already wrote a paper on it. Head [...]
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9:33 AM | Darth DSM-5 and autism
Blue Harvest @ Wikipedia @ Family GuyI need to create a suitable atmosphere for this post, so try this music for size and think Blue Harvest...Right. The wait is over. The discussions / arguments / objections / agreements are all confined to history. Drum roll, spotlight centre-stage... enter DSM-5 and into unknown territory we all go, particularly with autism, sorry.. autism spectrum disorders (ASDs) in mind.As you can see from the link above to the new diagnostic guidelines from the […]

Lai M-C, Lombardo MV, Chakrabarti B & Baron-Cohen S (2013). Subgrouping the Autism “Spectrum": Reflections on DSM-5, PLoS Biology, Other: Link

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May 17, 2013

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4:13 PM | Transitioning from Adolescent to Adult Eating Disorder Treatment Programs: What Are The Challenges?
Navigating health service systems can seem daunting, to say the least. Making phone calls, getting doctor appointments and referrals, attending intake appointments, and preparing oneself for treatment can be both mentally and physically draining. When children and adolescents develop eating disorders, their parents become the main navigators in this scenario, making decisions and arrangements for their under-18-year-olds. But what happens when these adolescents reach the age of 18, and still […]
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5:36 AM | Targeted psychiatric medications
Buffer Interesting lecture on the neurobiology of psychiatric disorders and their treatment. Modern psychiatric drugs treat the chemistry of the whole brain, but neurobiologist David Anderson believes in a more nuanced view of how the brain functions. He illuminates new research that could lead to targeted psychiatric medications — that work better and avoid side [...] No related posts.

May 16, 2013

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12:57 PM | How needing a wee affects your decision making
A couple of years ago Dr Mirjam Tuk won an IgNobel prize for the paper “Inhibitory Spill-Over: Increased Urinating Urgency Facilitates Impulse Control in Unrelated Domains" in Psychological Science. Tuk recently discussed her research at Imperial College Science Festival. You might think that your ...Read More
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8:00 AM | Meta-analysing MTHFR and autism
I told you so.I'm talking about the paper by Pu and colleagues* who meta-analysed the currently available literature looking at two SNPs in everyone's favourite Scrabble classic gene, MTHFR in relation to autism spectrum disorders (ASDs). Said gene controls production of methylenetetrahydrofolate reductase (MTHFR) which fits very snugly into the whole one carbon metabolism cycle (see here).Love at first sight? @ Wikipedia  Regular readers might know that I have a […]

Pu D, Shen Y & Wu J (2013). Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis., Autism research : official journal of the International Society for Autism Research, PMID:

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May 15, 2013

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7:26 PM | The squeaky wheel gets the grease…
…and the squeaky rat pup gets all the attention! Sci is at Neurotic Physiology today talking about rat pup squeaking, and what it means for mom’s attention. Head over and check it out.

May 14, 2013

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8:04 PM | RDoC and the cross-roads of psychiatry
The Irish poet Brendan Behan is, I think, credited with the phrase: "There's no bad publicity except an obituary". One wonders how appropriate this phrase might be to the 'diagnostic Bible' (except that it isn't) which is DSM-V which is poised to make its entrance into the World in the coming days.The real Homer @ Wikipedia Indeed, the story of DSM-V even before it hits the diagnostic shelves of all good psychiatric bookshops, has the makings of an epic piece of poetry or literature, […]

Ian B Hickie1, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier & Patrick D McGorry (2013). Clinical classification in mental health at the cross-roads: which direction next?, BMC Medicine, 11 126. Other: Link

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May 13, 2013

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1:43 PM | Bingeing and Purging: Keeping the “Positives” and Eliminating The Negatives?
I have been fascinated and perplexed by reports of the seemingly invigorating and anxiety reducing effects of bingeing and purging (purging by self-induced vomiting). Personally, I cringe at the idea of self-induced vomiting and have always wanted to avoid vomiting at all costs, including during food poisoning. The insight from recent blog entries and the subsequent comments has made an impact on me. I see that the motivation to engage in bingeing/purging (b/p-ing) behavior can […]
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12:18 PM | When should I publish with open access? A handy flow chart
Mike Taylor over at the Sauropod Vertebra Picture of the Week blog created the wonderful flowchart above to help researchers decide whether to post in an open access journal. A few months ago the British Government made the tremendous step forward of announcing that government funded research ...Read More
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9:21 AM | How NOT to spot a murderer's brain
An article by Tim Adams in yesterday's Observer (the Sunday edition of British newspaper The Guardian) is currently topping the most read list on The Guardian's science section. The piece makes a spine tingling case, the byline reads: "Do your genes, rather than upbringing, determine whether you ...Read More
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5:11 AM | Growing old with NF-kB
Aging happens. As you get older, your body slows down, eventually your brain slows down, too. Some things go gradually, and some go suddenly. To many people, this might seem like a pretty random process. We used to think of aging this way, as just…well cells get old, which means we get old, too. DNA [...]

May 12, 2013

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2:18 PM | DSM-5 Due Out and International Nurses Day News Round-Up May 2nd Edition 2013
The American Diagnostic and Statistical Manual of Mental Disorders (DSM-5) is due out this month. In the period leading up the launch of DSM-5 there has been considerable debate. Professor David Kupfer, head of the DSM-5 taskforce responds to the NIMH statement here (with a write-up here). The Observer features a debate between psychiatrist Professor […]
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10:51 AM | An interesting case report on autism and diet
Nodding syndrome.Ever heard of it? Well, up until a few days ago I hadn't. That is before coming across articles on the topic by Richard Idro and colleagues* (open-access) and Angelina Kakooza-Mwesige and colleagues** (open-access). Whilst not specifically my line of expertise or interest, I was intrigued to read about how nodding and other symptoms of the epileptic variety, at least in some cases, seemed to be precipitated by food and showed a potential nutritional angle.Curving […]

Herbert, M. & Buckley, J. (2013). Autism and Dietary Therapy: Case Report and Review of the Literature, Journal of Child Neurology, DOI:

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May 11, 2013

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11:10 AM | How the New NIMH Research Strategy Can Strengthen Future Editions of DSM
The National Institute for Mental Health (NIMH) is an American institution leading research into mental illnesses. Recently Dr Thomas Insel, Director of NIMH wrote an article on his blog about the future research direction for NIMH. Dr Insel’s wrote about the reliability and validity of diagnostic criteria in the Diagnostic and Statistical Manual of Mental […]

May 10, 2013

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4:02 PM | Friday Weird Science: Are Boobs Better Bouncing and Braless?
Sci is at Neurotic Physiology today for Friday Weird Science, talking about boobs. And bras. Do bras really help prevent sagging? Or is braless better? And what does it mean when the science saying so hasn’t been published yet? Head over and check it out.
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7:44 AM | Depression or antidepressant use linked to C.diff infection?
"There's no mystical energy field that controls my destiny". So said a very sceptical Han Solo.Regular readers might know that I'm a bit of fan of the whole gut-brain axis; indeed other kinds of axes too. I know that to some it might sound a bit daft that what goes on in our deepest, darkest bowels might actually have some important effects on the operations of the grey-pinkish matter floating around in skull central - and vice-versa -  but nonetheless it interests me. The gastrointestinal […]

Rogers, M., Greene, M., Young, V., Saint, S., Langa, K., Kao, J. & Aronoff, D. (2013). Depression, antidepressant medications, and risk of Clostridium difficile infection, BMC Medicine, 11 (1) 121. DOI:

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5:32 AM | This is water
Buffer On May 21, 2005, David Foster Wallace got up before the graduating class of Kenyon college and delivered one of history’s most memorable commencement addresses. It wasn’t until Wallace’s death in 2008 that the speech took on a life of its own under the title This Is Water, and was even adapted into a [...] No related posts.
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12:47 AM | Hear Me Talk about Social and Emotional Learning!
On Monday, May 13, at 7pm, I’ll be moderating a panel at The New York Academy of Sciences. If you are in the area, please attend! Here a description of the event: Social and Emotional Learning: Preparing Our Children to Excel Monday, May 13, 2013 | 7:00 PM – 8:30 PM The New York Academy [...]
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