Posts

December 18, 2014

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9:43 PM | BiotechDueDiligence Journal Watch
Maybe you were in search of some light reading for the holidays?Edits to ethics code rankle: Clinical-trial obligations introduced into the Helsinki declaration called too onerous by some.Heidi Ledford. Nature News.Web Collection: Clinical applications of next-generation sequencingNature Biotechnology. $FMINature Outlook: Hemophilia (collection of open-access articles)Data Sharing, Year 1 — Access to Data from Industry-Sponsored Clinical TrialsStrom et al. New England Journal of […]
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9:16 PM | Mutations prevent programmed cell death
ByThe Toombst New research uncovers previously signal path used to make cells commit suicide. Changing a protein in this pathway a.k.a. mutations prevent programmed cell death, attacking this process might lead to a new way of treating cancer. Apoptosis is the body’s own defense mechanism from rampaging cells creating tumors in the body. This system means that a damaged cell can be told to commit suicide for the good of the body as a whole. This system is not perfect and can be stopped by […]
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7:49 PM | RNA measurements may yield less insight about gene expression than assumed
A new study from the lab of Yoav Gilad, PhD, suggests that RNA levels often have no effect on protein abundance. The findings point to yet-unidentified gene regulation mechanisms.
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6:22 PM | What Eleanor Roosevelt’s final days can teach us about end-of-life care
Bioethicist Daniel Sulmasy revisits the prolonged death of Eleanor Roosevelt in a new case study, and talks about how the field of clinical medical ethics has changed the way physicians honor their patients' wishes.
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4:22 PM | Cannabis Drugs Reduce Intestinal Inflammation
ByThe Toombst Continuing the role of the cannabinoid receptors from yesterday, research show that cannabis drugs reduce intestinal inflammation in mice given colitis, inflammation of the large intestine. Ulcerative colitis and Crohn’s disease are two major bowel diseases characterized by chronic inflammation to parts of the intestines. The diseases can be somewhat tricky to distinguish in diagnoses but both are charachterized by inflammation in the gut. Using mice as a disease model […]
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3:24 PM | Canada: CFIA Statement On Genetic Sequencing Of H5N2
Credit CFIA   # 9459 The Canadian Food Inspection Agency (CFIA), has posted the follow statement characterizing the HPAI H5N2 virus that was first detected on a Fraser Valley poultry farm 18 days ago.   It is confirmed to be a reassortant between the Eurasian H5N8  virus and a North American avian flu virus.   The number of farms affected in Canada remains steady at 10 (see Infected Premises Chart), affecting nearly 240,000 birds.     […]
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2:50 PM | View from an M.D./Ph.D.: The Winding Road to Research Success
Graduate school is, for many, the first big dose of “failure is the mother of success.” After my first grant application came back with a substantially worse score on the revision submission than on the initial submission (how is that possible?), and the paper I was working on was rejected for the third time, my [...]
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1:46 PM | Egnor Doubles Down on Incoherent Nonsense
Egnor continues his dualist neuroscience denial in two follow up posts, mostly responding to PZ Myers’ take down of his original post. Egnor has also been writing separately about computers, arguing that they have no memory and will never be intelligent (have agency). In all of these posts Egnor is following the same basic intellectual [...]
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1:45 PM | Congress polishes the turd that was NCCAM
With the way our dysfunctional federal government works, it’s not uncommon for the end of a fiscal year to come and go without there being a budget for the next fiscal year in place. This phenomenon is particularly common during election years, and this year was no different. September 30 came and went, followed by…
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12:58 PM | Using Collaboration and Innovation to Counteract Flat Federal Research Funding
With such astounding shortfalls in funding for biomedical research, Penn Medicine, a key stakeholder of the new Penn Center for Innovation (PCI), is looking for fresh ways to fund research and partner with the private sector. The PCI consolidates and unifies the enterprise previously known as the Penn Center for Technology Transfer with other campus entities charged with commercializing Penn research and Development into license agreements, sponsored research agreements, startup companies and […]
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12:56 PM | How to Use the Genetic Code for Passwords
  Need a password for a new device or service? Try the genetic code. Messenger RNA triplets and the amino acids they specify provide nearly endless password possibilities. And it’s timely — the People’s Choice for Science magazine’s Breakthrough of … Continue reading »The post How to Use the Genetic Code for Passwords appeared first on DNA Science Blog.
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12:42 PM | H5N1 In Northern India’s Sukhna Lake
Source Wikipedia   # 9458   Sukhna Lake is a man-made recreational area and wild bird preserve located at the foothills of the Himalayas, and since its construction more than 50 years ago has become a favorite overwintering ground for a variety of migratory waterfowl.    In recent days local authorities have reported an unusual die off of birds, and today it has been announced that the India’s NIHSAD Lab in Bhopal had detected the H5N1 virus in a dead duck. […]
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12:00 PM | Does High IQ Increase the Risk of Depression and Mental Disorders?
Blame it on movies or books, but we have fallen into the habit of stereotyping. Popular culture portrays highly intelligent men and women as moody, secretive people who have so much going on in their minds that they are mentally always on the edge. There is probably a point here because psychiatrists are tinkering with […]
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12:00 PM | No, the HPV vaccine does not cause promiscuity
Today’s post isn’t about the flu vaccine, but that vaccine played a part in bringing you today’s topic. It seems that this year’s vaccine is a mediocre match for the circulating strains of influenza, and I was one of the unlucky ones in whom it didn’t appear to provide much protection. After spending several days […]
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11:58 AM | H5N6 Resurfaces In Vietnam
   Credit Wikipedia    # 9457   While H5N8 popping up in Germany, the Netherlands, the UK, Japan, and now Italy has garnered most of the avian flu headlines over the past six weeks, H5N6 – the other newly emerged HPAI H5 virus of 2014 (see Sichuan China: 1st Known Human Infection With H5N6 Avian Flu) – hasn’t gone away.    Unlike H5N8, which to date has not been reported to have infected humans - H5N6 has a track record of […]
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11:13 AM | Six Citizen Science milestones from 2014 – number four is out of this world
From vast lengths of DNA to years of collective teamwork, we look back on the achievements of our 300,000 Citizen Scientists in 2014.
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10:46 AM | Wellcome Trust Science Writing Prize 2014: The Complete Shortlist
Are you travelling over Christmas? Looking for something to read while you digest your Christmas dinner? Or perhaps just wanting to expand your knowledge to impress your friends… Well we’ve got the answer – twenty brilliant articles about science, nicely packaged into a downloadable pdf for you to savour.. it’s the Science Writing Prize 2014 […]
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7:01 AM | Correcting Metabolic Abnormalities May Help Lessen Urinary Problems
Metabolic syndrome is linked with an increased frequency and severity of lower urinary tract symptoms, but weight loss surgery may lessen these symptoms. The findings, which come from two studies published in BJU International, indicate that urinary problems may be added to the list of issues that can improve with efforts that address altered metabolism. […] The post Correcting Metabolic Abnormalities May Help Lessen Urinary Problems appeared first on Wiley Asia Blog.

Pashootan, P., Ploussard, G., Cocaul, A., de Gouvello, A. & Desgrandchamps, F. (2014). Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort, BJU International, DOI: 10.1111/bju.12931

Citation

December 17, 2014

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10:58 PM | Smoking Marijuana Lowers Inflammation
ByThe Toombst Smoking marijuana lowers inflammation in the body. Researchers found lower levels of the inflammatory marker CRP in people smoking marijuana in the last 30 days. Marijuana is the drug creating the most headlines in the research community at the moment. Every week a new press release warns about the harmful effects of smoking marijuana in anything from findings based in quality research to anecdotal claims about adverse health effects. All the while a wave of legalization sweeps […]
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9:20 PM | The future of nephrology training: A fellow's perspective
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9:01 PM | Life under Arctic ice
Ever wonder what lies beneath the polar ice? Turns out several researchers did as well. This past July a team of scientists led an expedition designed to image life under sea ice. The video below was captured with the Nereid Under Ice (NUI) vehicle and shows brown algae living on the bottom of sea ice…
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8:47 PM | Why Do We See the Man in the Moon?
Take a look at the slideshow above. The photos depict, in order: tower binoculars, a tank tread, tree …
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8:15 PM | Updated Cerebrovascular Physiology Links – 17/12/2014
I have updated the Cerebrovascular Physiology Labs section. You will now see a link to the lab of Dr Hélène Girouard from Université de Montréal. Her research interests are related to cerebrovascular pharmacology, neurovascular coupling and interactions between astrocytes and blood vessels. In addition, I have added a new section entitled “Theses”, where you will […]
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7:36 PM | UChicago prostate cancer expert to use DOD grant to study racial disparities
Donald Vander Griend, PhD, and his colleagues received a three-year, $600,000 award from the Department of Defense to study health disparities between African American and Caucasian males with prostate cancer.
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7:35 PM | Criminal Charges Filed In Fungal Meningitis Case
  # 9456   In early October of 2012 we became aware of a growing medical crisis involving contaminated preservative-free MPA steroid injections distributed by the New England Compounding Center in Framingham, Massachusetts.  In all, more than 700 patients developed infections from these  tainted injections, and more than 60 died.   Among the survivors, many have suffered serious ongoing disability.  I blogged at some length in 2012 and 2013 on this […]
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5:46 PM | WHO MERS Update – Saudi Arabia
Saudi Arabia   # 9455   The World Health Organization has published details on 11 previously announced MERS cases from Saudi Arabia, and for nearly half of these cases (n=5) no known exposure to animals or confirmed cases could be established.  Three had contact with previously confirmed cases, two had animal contacts, and 1 was a Health Care Worker but with no known contact to an infected individual.   The pattern with MERS infections in Saudi Arabia appears to […]
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4:37 PM | Identifying risk genes for autism: TADA(!)
How do you sort through thousands of genomes to find a few dozen risk genes for autism? Xin He, PhD, assistant professor of human genetics, thought of the stars, and... TADA!
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3:40 PM | Chronotherapies Treating Depression
ByThe Toombst In part one we talked about the basics of your internal clock while part two covered much of the melatonin system and bright light therapy. Here we touch on other ways to reset the internal clock with a purpose, chronotherapies treating depression. All findings are from a review article, Called Manipulating melatonin in managing mood published in Acta Psychiatr Scand 2013: 128. Chronotherapies Treating Depression Melatonin holds promise treating depression and not only by making […]
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3:20 PM | Dances with Pharma: part 2 – How Cancer Research UK works with industry
In the second part of this two-part series, we look at our work with industry, why it's important, and how we try to influence the way drugs get to patients.
Editor's Pick
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3:12 PM | It’s Beginning To Look A Lot Like . . . Flu Season
Influenza Home Care Guide – Credit CDC   # 9454 While we spend a good deal of time talking about exotics in this blog, good old-fashion seasonal influenza comes knocking every winter, and this year it shows signs it may try kicking in the door. During a `bad’ year, the potential exists for seeing  tens of thousands of flu deaths, and hundreds of thousands of flu hospitalizations across North America.   If you haven’t already heard, there’s […]
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