Posts

March 29, 2015

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2:26 PM | Metformin Guidelines
Metformin is one of the most useful drugs in patients with type 2 diabetes and yet its use in patients with CKD is limited by the perceived association with lactic acidosis. These concerns are due to the association of a prior biguanide, phenformin, with a marked increase in the rate of lactic acidosis. The mechanism for this appears to be reduced peripheral glucose oxidation and increased lactic acid which occurs with even small increases in phenformin levels. The drug was eventually removed […]
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2:04 PM | BiotechDueDiligence Journal Watch
Please enjoy the latest edition of the BiotechDueDIligence Journal Watch - a round-up of articles from the scientific and medical literature that are related to, or are driving, biopharma discussion. This week's collections is a hybrid of some links I have curated plus a couple from the Twitter stream.Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomersGoyenvalle et al. Nature Medicine. $SRPT $BMRN $RNA $PTCTStatin […]
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12:55 PM | Saudi MOH: 3 MERS Cases, 2 Fatal
  # 9880   After a two-day lull, the Saudi MOH is back with three new MERS cases, two of which are already listed as deceased.  Given the recent reduction in case information being presented in these daily updates, we’ll need to wait for a WHO update to get some sense as to how they were exposed.  
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12:44 PM | More Than One Way to `Contain An Outbreak’
Credit WHO     # 9879   Until the middle of January, Egypt’s Ministry of Health got good marks in reporting this winter’s surge in H5N1 cases, publishing frequent updates that included YTD numbers for cases, deaths, hospitalizations, and recoveries.    That streak ended on January 22nd, when Egypt’s MOH Confirms their 21st H5N1 Case of 2015.   Since then, as has been noted often (see The Silence Of The Egyptian MOH &  […]
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11:00 AM | Running From Aging – Fitness And Brain Health
Evolution did not prepare us to become couch potatoes – our ancestors actually had to move around to find food, they couldn’t just order it over the phone. Running to hunt and gather food and fasting due to food scarcity are considered some of the biggest evolutionary energetic challenges our bodies and brains have faced. […]
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11:00 AM | But It's Already Been Done! #ExpBio
Despite the proliferation of journals and publications, our basic science efforts often do not pay off in new treatments. Part of this is time; it generally takes 15-20 years for a new science observation to be translated to the bedside. The uglier part of the story is lack of reproducibility of preclinical studies. In 2011 […]
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2:51 AM | http://renalfellow.blogspot.com/2015/03/precision-nephrology-one-of-our.html
Precision NephrologyOne of our attendings, Dr. Sylvia Betcher, PhD, MD gave an excellent presentation at our renal conference about genetic testing in renal diseases that she learned about at #KidneyWeek2015. There were so many good things I liked about her talk, that I want to share what I learned. On January 30th 2015, President Obama announced in his State of the Union address a Precision Medicine initiative. This will provide researchers in the biomedical field with the necessary tools to […]
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2:33 AM | To Sleep: 2015 Cannon Award #ExpBio
The American Physiological Society portion of Experimental Biology officially opened Saturday evening with the Cannon Lecture. This year's recipient of the award, Masashi Yanagisawa, addressed his work in understanding sleep. Solving the mystery of sleep: from orphan receptors to forward genetics started with studies of the orexin knock-out mouse. They thought the mouse would have […]

March 28, 2015

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6:13 PM | USDA: 3rd Minnesota Turkey Farm Hit By H5N2
  # 9878   Just 24 hours after the 2nd infected Minnesota turkey farm was announced, we learn of a facility in Stearns county that has tested positive.  The first outbreak, in neighboring Pope county, was reported 3 weeks ago.   This week Wyoming became the 11th state to report HPAI H5 viruses in either wild birds, or poultry,  which has led to repeated warnings to both commercial and backyard poultry operations on the need for enhanced biosecurity (see […]
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5:21 PM | What's wrong with Indiana?
It's been a bad couple of weeks for Indiana. First, Indiana University and Butler were knocked out of the NCAA basketball tournament while their capital city was mocked in a widely-played television ad. (above) Then Indiana Governor Mike Pence signed a law allowing businesses to refuse service to same-sex couples. The NY Times suggests that the law might be part of the Governor's plans to run for President in 2016. There's been a backlash against the state with many crying for a boycott. […]
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12:06 PM | USDA Avian Flu Biosecurity Videos
  # 9877   Although Europe, Asia, Africa, and the Middle East have had to deal with highly pathogenic avian H5 viruses for the better part of a decade, until very recently North America’s poultry industry and wild bird population have been spared.  All that changed last December when a dozen poultry farms in British Columbia’s Fraser Valley reported an outbreak of HPAI H5, which in very short order was reported in Washington, Oregon, and California.   […]
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11:00 AM | Live, Fast, Die Old – Intermittent Energy Restriction Diets
Intermittent energy restriction (IER), or intermittent fasting, is a form of calorie restriction diet. The principle is simple: periods of non-fasting are intercalated with periods of fasting. IER is not about starvation followed by binge eating: non-fasting periods have regular caloric intake, while during fasting periods, little or no food is consumed. Fasting periods can […]
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9:00 AM | News digest – Angelina Jolie, pesticides, liver cancer, and more
We've digested all the week's key cancer-related headlines. You can read them here.

March 27, 2015

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8:25 PM | APHIS: USDA Confirms 2nd H5N2 Outbreak In Minnesota Turkey Flock
# 9876   Three weeks after we first learned from APHIS: HPAI H5N2 In A Minnesota Turkey Farm in Pope County, we are informed that a second farm has been affected in Lac Qui Parle County.     Given that these counties are not immediately adjacent, and a  CIDRAP News report (see Wild birds nixed as Minnesota H5N2 source) from earlier this week quoted the Minnesota Department of Natural Resources (DNR) saying they found no evidence of the H5N2 strain in samples […]
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6:40 PM | Turning the Tables
Earlier today, a very nice first year medical student came by my office and apologetically asked me if I could tell her where the offices of our Institutional Review Board people are. I don’t work in the library anymore, you might recall, and now my office sits in a maze of other offices on the […]
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6:36 PM | ‘It’s really difficult to be a polymath’ – Sir Paul Nurse on multidisciplinary research
We talked to Sir Paul Nurse about his role spearheading one of the UK’s most exciting ventures into modern multidisciplinary research.
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6:34 PM | Media Reports: Bird Flu Detected In Romania & Italy
  # 9875   Yesterday’s bird flu report from Bulgaria, very near the Romanian border (see OIE: H5N1 Kills 21 Pelicans In Bulgaria) has been quickly followed by multiple media reports that dead pelicans found this week in Romania have now tested positive for the H5N1 virus as well.   If confirmed by the OIE, this would be the first appearance of H5N1 in Romania since 2010. Bird flu in Romania. Authorities found infected pelicans in the Danube […]
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3:53 PM | Biotech Tweets of the Week (March 23-27, 2015)
We had a bit of everything this week: data euphoria, data ridicule, blue skies, bubble talk and much more. Catch up on the action with the latest edition of the Biotech Tweets of the Week. Thanks as always to @23aloha for helping to curate this feature.Top Tickers:$BIIB $VRTX $GILD $MEIP $ESPR $PTCT $ACAD $CNAT $TRIL $KITE $JUNO $GNFT $ICPT $BMRN and many more! $XBI $IBB [...]
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2:17 PM | A Genetic Predisposition To Severe Flu Infection
Photo Credit – CDC PHIL     # 9874   Influenza can produce a wide spectrum of illness, ranging from mild or even asymptomatic presentation to severe and/or life threatening disease.     Often we talk about `high risk’ patients – where their age and/or co-morbidities (COPD, Asthma, pregnancy, etc. ) can sometimes lead to a greater chance of complications, but there may be other factors at work as well.    As we saw in […]
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2:08 PM | Stem Cell Therapy in Chronic Obstructive Pulmonary Disease
Scientists from the Xinhua Hospital in Shanghai have discovered the possibility of utilising stem cells for treatment of chronic obstructive pulmonary disease, a disease commonly associated with long-term smoking....
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1:11 PM | Separating Fact from Fiction in the Not-So-Normal Newborn Nursery: Chiropractic and Craniosynostosis
Pediatricians, particularly those who spend a significant amount of time caring for newborns, see a lot of babies with unusually-shaped heads. Although to be fair, the fact that the overwhelming majority of vaginally-delivered babies, and quite a few born via Caesarean section, will have a transient and abnormal shape to their heads makes it, well, […]
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12:05 PM | Dark Matter Collisions
The existence of dark matter is one of the coolest science stories of my lifetime. When I was growing up I was in love with pretty much every field of science, but particularly with astronomy, and at that time we had no idea that 85% of the matter in the universe even existed. We now [...]
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12:00 PM | Regulating magic: The FDA considers revamping its regulation of homeopathic products
Homeopathy is quackery. It can’t be repeated often enough. Homeopathy is The One Quackery To Rule Them All. It is based on prescientific vitalism and principles so addled that one must wonder whether Samuel Hahnemann, the guy who dreamt up this medical system, was a fan of excess alcohol use, opium, marijuana, or some unholy…
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11:16 AM | NIH: Ebola Virus More Stable Than Previous Study Suggested
Credit CDC PHIL # 9873   Last August, while Ebola was still accelerating in West Africa, we saw a study warning that the Ebola Virus Is Rapidly Evolving.  Specifically, that 99 Ebola viruses taken from 78 people from Sierra Leone during the month of June, and found that the virus is showing a marked propensity to accumulate `interhost and intrahost genetic variation’ as it passages through the population. This led to media reports such as Ebola virus mutating […]
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11:00 AM | Genes, Stress, and Behavior – Is Your Child an Orchid or a Dandelion?
Picture a group of children coming to the school for the first time in their life. In this group you will always notice that some children tend to spend the day moping and sulking in a corner of the classroom while other children clearly enjoy the new experience. Why this behavioral difference is so great? […]
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10:11 AM | Image of the Week: Structure of the dynactin complex
This image shows a model of a tiny protein machine that moves things around within our cells. A new study reveals how the motor called dynein (grey) is attached to its cargo via an adaptor protein (orange). The attachment requires the help of another protein complex called dynactin (multi-coloured). The dynein/dynactin machine drags its cargo along […]
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9:38 AM | Obesity and cancer – three things the Government should do
It's not just about lifestyle choices - the government should play a role in combating obesity - which is linked to several types of cancer
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6:14 AM | Virtual Issue – Focus on Alternative and Complementary Therapies
To celebrate our 20th years of publication, we are offering free virtual issue on Alternative and Complementary Therapies. Our Editorial Board has compiled Best Papers from the last 20 years into this virtual issue, with the aim of providing readers with interesting and thought-provoking content. Access it now. The post Virtual Issue – Focus on Alternative and Complementary Therapies appeared first on Wiley Asia Blog.
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1:42 AM | Faster Wound Healing with Silent Gene
ByThe Toombst   New study finds that a drug combining siRNA and nanoparticles promotes faster wound healing. Nanoparticles are marvelously multi-purposed. Earliers studies have used the particles to fight different forms of cancer, used them as an antiseptic, to reduce inflammation or even replace certain blood cells . Now a new study combines siRNA with nanoparticles to engineer a drug that promotes faster wound healing. Faster Wound healing with siRNA and Nanoparticles “We envision […]

March 26, 2015

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11:45 PM | 2015 Experimental Biology Meeting
I am so excited about the Experimental Biology conference this year in Boston, MA! I have packed my bags, prepared my posters and am on my way to the airport. As usual there will be several seminars and poster sessions about various comparative physiology topics sponsored by the American Physiological Society that look really exciting. Can’t wait! To…
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