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Posts

June 08, 2013

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2:35 AM | The Gift of Surviving Cancer and Giving Back
She’s a striking blond. Attractive, warm, funny, caring, and always smiling. He’s also a striking blond – and warm and caring and funny – and seems to always be smiling as well. “She” is Ginny Fineberg, a youthful looking 64 year old cancer survivor. And “he” is her self-proclaimed “Momma’s...
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12:43 AM | Back from break!
I was in Winnipeg, Manitoba for the last three days attending the 26th Annual Canadian Student Health Research Forum. It was a lovely multi-disciplinary symposium, complete with: Poster session/competition: Graduate students trying to dance: Lectures on “Big Science” from great speakers with a sense of humour: I have several things I want to blog about […]
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12:37 AM | LGND: Recent comments from Merck on BACE Alzheimer's program MK-8931
A key asset to watch in Ligand Pharma $LGND's portfolio is their royalty rights for a BACE inhibitor MK-8931 in development for Alzheimer's disease by Merck $MRK. You can find more of BiotechDueDiligence's  [...]

June 07, 2013

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10:46 PM | The incredible penis-shrinking gene identified in birds
Find out why most species of birds do not have a penis in this video abstract of new research published yesterday in Current Biology: Source Herrera AM, Shuster SG, Perriton CL, Cohn MJ. Developmental basis of phallus reduction during bird evolution. Current Biology Published online June 6, 2013. doi: 10.1016/j.cub.2013.04.062
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10:43 PM | Back to the Future: U.S. Department of Energy to re-emphasize hydrogen fuel cell vehicles
In the Pulitzer-prize winning book The Making of the Atomic Bomb, Richard Rhodes re-tells an early meeting between scientists investigating nuclear fission chain reactions and officials from the U.S. military.  The year was 1939, and although WWII raged in Europe, the U.S. had not yet fully entered the War nor started the Manhattan Project.  Present at the meeting was a “civilian” and physicist who worked with the navy in developing submarines- Robert Gunn.  Gunn was […]
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7:32 PM | Photo of the Week: Eye See You
This week I was lucky enough to take pictures inside North Carolina Museum of Natural Science's Living Conservatory - a room full of butterflies, and one the the most peaceful and beautiful rooms I've even been in! Using my Canon Rebel T3i, 100mm Macro lens and external flash with Honl light modifier, I captured up-close shots of many of the butterflies in the conservatory. The shot above shows the 'eye' on the wing of an Owl Butterfly, of the species Caligo
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6:17 PM | CDC: Updated H7N9 Guidance Docs
  # 7374   Although the United States has yet to see a confirmed case of H7N9 virus – and China has only reported one new case in the past several weeks - public health officials continue to watch this virus, and prudently prepare in case this virus reawakens this fall.   Today the CDC has released some updated guidance documents, which will primarily be of interest to public health officials, clinicians, and lab workers. The links are below.   Following […]
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5:30 PM | Cerebrovascular physiology – article alert #35
Brain autoregulation 150- Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges – Tzeng and Ainslie Mental work and the brain 151- Cortical oxygen consumption in mental arithmetic as a function of task difficulty: a near-infrared spectroscopy approach – Verner et al. Brain monitoring 152- Pro: cerebral oximetry should be a routine monitor during […]
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5:04 PM | On science blogs: All about sex
The contraception debate gets legally weirder. Judges and the FDA don't agree on how the morning-after pill should be sold. The two-pill version is really one-step too. The health care system is a dumping ground for all our sexual anxieties. Michael Douglas, the poster child for HPV vaccination. An etymological aside on Latinate dirty words. A NASA video assures young gays that things will get better. […]
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2:01 PM | WHO: MERS-CoV Update – June 7th
      # 7373   The latest update from the World Health Organization  provides limited details on the Saudi’s 40th reported MERS-CoV case; an 83 year old man from the Al Asha region.     Middle East respiratory syndrome coronavirus (MERS-CoV) - update 7 June 2013 - The Ministry of Health in Saudi Arabia has notified WHO of an additional laboratory-confirmed case with Middle East respiratory syndrome coronavirus (MERS-CoV).   […]
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1:00 PM | I want my ANP! [NOTE ADDENDUM]
[NOTE ADDENDUM.] It’s been a (mostly) all Stanislaw Burzynski week. I had been thinking of finishing up with a post about something completely unrelated; that is, until people started sending me a link. Also, because I was out last night with my wife in celebration of our wedding anniversary, I didn’t have time for anything…
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12:35 PM | The Francis Crick Institute – three steps closer to reality
In a little over two years, the Francis Crick Institute will open its doors to researchers from across the globe, giving them a state-of-the-art environment in which to answer the fundamental questions of human biology. The Institute, based in London, … Continue reading →
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12:24 PM | MMWR: Heat-Related Deaths During an Extreme Heat Event
Severe weather reports from 2012 Derecho   # 7372     In late June of 2012 an unusually strong storm front, known as a Derecho, swept across parts of the Eastern United States – killing 15 people – and leaving millions without electrical power for more than a week (see Picking Up The Pieces)   Adding to the misery – and danger – the region remained under an EHE (Extreme Heat Event) advisory for two weeks.   Not surprisingly, given these […]
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12:13 PM | Error in the Development of Brain Circuits
One thing you learn going through medical school and studying all sorts of diseases and pathology is a powerful medical corollary to Murphy’s Law – anything that can go biological wrong with the body, does. Every single function in the human body is associated with a disease or disorder in which that function is impaired [...]
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11:00 AM | The Neurobiology behind a Sense of Place
I remember clearly one of the first times I was aware of the concept that can be characterized as a “sense of place.” Several months into a year-long backpacking trip, I was mesmerized by my experiences in East Africa. Then, once it became what would have been summer back home, I experienced a sudden and [...]
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10:41 AM | Italy: MERS `Index’ Case Released From Hospital
  Distribution of MERS-CoV Cases – Credit VDU MERS-CoV   # 7371     The last of Italy’s confirmed MERS cases – a 46 year old man with recent travel to Jordan – was released from the hospital last night after his tests no longer showed positive for the virus.   The unnamed patient was hospitalized on May 28th - and in stark contrast to many of the other cases we’ve seen - his condition has always been described as `good’.   Two […]
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9:36 AM | ASCO 2013 – personalised medicine: potential and challenges
In our third instalment from the ASCO cancer conference, Debbie Coates writes about a major theme of modern cancer research – the concept of personalised medicine. It’s an exciting time in the world of cancer treatment. We know more than … Continue reading →
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7:35 AM | $4,600 Up for Grabs for UK ME/CFS Charities – Vote Once from Anywhere!
by Sasha You know what to do…Image from the Kheel Center, Cornell University I’m writing this the morning after an unprecedented win for our community in an online voting competition. On 1 June, one of our charities, MEandYou, pulled in an astonishing 8,000 votes in only four days in the Stormberg contest. The highest previous level I can remember was less than half that and took several weeks to achieve. MEandYou won that contest by 1,000 votes at midnight but earlier that afternoon, […]
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7:00 AM | DMAA: Efficacious but is it Safe?
by Igor I. Bussel & Andrey A. Pavlov Jr. Jann Bellamy has recently authored an excellent piece on the limitations of the FDA and how the DSHEA actually protects the profits of supplement manufacturers rather than the health and well-being of consumers. Bellamy used the very poignant and currently “controversial” example of DMAA (methylhexanamine or [...]
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3:05 AM | Kombucha: A symbiotic mix of yeast, bacteria and the naturalistic fallacy
If you grew up in the seventies, you may remember the same food fads as I do. There was the oat bran buzz that was replaced by the wheat germ movement, the family fondue set and the homemade yogurt maker. And for a while I remember my father making what I called “aquarium water” – […]

June 06, 2013

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11:38 PM | City birds are early to rise
A recent study has provided some evidence supporting the hypothesis that light and noise pollution alters the biological clocks of birds living in cities (compared to birds living in rural areas).   Dr. Dominoni (Max Planck Institute for Ornithology, Germany) and colleagues used radio-pulse transmitters attached to European blackbirds (Turdus merula) living in Munich, Germany…
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10:06 PM | This Week in PLOS NTDs and PLOS Pathogens: Fungal Spore Diversity; a Novel HAT Treatment; the Circadian Clock and Plant Immunity; and More
The following new articles are publishing in PLOS NTDs this week: In this study, Dr. John Thuita and colleagues investigate the potential of a novel diamidine prodrug, DB868 (CPD-007-10), as an oral treatment for first stage human African trypanosomiasis (HAT). …
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9:27 PM | Absence Makes the Heart Grow Fonder
I’ve been away from work for almost a week, spending time with my father and doing those things that make people say, “Oh, you are such a good daughter,” despite the fact that I wasn’t feeling like one. Watching your parents age, as well as helping with things that come along with the aging process, […]
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8:14 PM | What I Am Reading: MDs Online
Right now, you are reading a blog. You obviously know something about the online world. You probably think of Web 2.0 as a generally friendly and useful place. Your doctor probably thinks of it like those historic maps: "Here be monsters." Enter this book by Kevin Pho, of KevinMD fame. His recent book provides a [...]
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7:04 PM | MIT: Two Avian Flu Receptor Cell Binding Studies
    # 7370   We’ve a pair of avian flu studies, published today in the online journal Cell, that look at the current ability of both the H7N9 and H5N1 viruses to bind to human receptor cells.   While there may be other factors at play, the primary barrier that prevents these viruses from sparking a pandemic appears to be their preferential binding to avian receptor cells.   We’ve discussed receptor binding often in the past (see Study: Dual Receptor […]
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5:25 PM | A Genetic Variant That Could Improve Warfarin Dosing in African-Americans
Research teams, including UChicago's Minoli Perera, find a genetic variant that could improve warfarin dosing in African-Americans.

Perera, M., Cavallari, L., Limdi, N., Gamazon, E., Konkashbaev, A., Daneshjou, R., Pluzhnikov, A., Crawford, D., Wang, J., Liu, N. & Tatonetti, N. (2013). Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study, The Lancet, DOI:

Citation
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2:52 PM | Rebuttal: Folic Acid Exposure a Fair Price to Pay for Healthy Babies
  Editors’ Note: Last week, The Doctor’s Tablet published a post by Paul Marantz, M.D., M.P.H., in which he asserted that adding folic acid to the food supply may be helping babies at the expense of harming adults. The widely accepted practice of adding this B vitamin to our food supply is credited with preventing [...]
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2:20 PM | Star Trek – Into Bad Science
On the SGU this week, the episode that will be released on Saturday June 8th, we do an extended review of the new Star Trek movie, Into Darkness (STID). so – this is a warning to SGU listeners, if you want to hear the episode without spoilers, see the movie before Saturday (or whenever you [...]
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2:04 PM | Orexin Antagonist Drugs for Insomnia Treatment
Current drug treatment approaches for insomnia have significant limitations.  Benzodiazepine receptor drugs have clinical effectiveness but may contribute to morning sedation and cognitive impairment.One promising drug development target is the orexin receptor.  The effect of orexin-A on arousal and sleep has been extensively studied in rat models.  Injection of orexin-A into the brain in rats results in increased firing of the locus coeruleus, increased physical activity, […]
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12:44 PM | A MERS Vaccine Candidate
    # 7369   I don’t usually give `forward looking’, promotional, press releases from pharmaceutical companies any space in this blog because they are generally to medical science what P.T. Barnum was to the study of Zoology.   But today I’ll make an exception, as the press release from Novavax this morning – announcing their creation of a MERS vaccine candidate – is likely to generate a fair amount of media hoopla today.     […]
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