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Posts

May 14, 2013

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7:00 AM | Antibiotics for Low Back Pain
Low back pain is a particularly frustrating condition that is common, poorly understood, and difficult to treat. Could a long course of antibiotics be the answer for some patients? A recent study from Denmark suggests that it might be:  “Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 [...]
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4:31 AM | Best technician
 
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4:16 AM | Cannabinoids and Seizures – Is now the time?
…the antiseizure properties of (THC) have been de [...]

May 13, 2013

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10:29 PM | Hand Hygiene Causes Obesity
One of my favorite epidemiological study designs is the temporal association "ecological" study that attempts to imply causation by showing one exposure increasing and one outcome increasing and implying that the exposure is causing the outcome. You know, "Hey, they are both going up so one thing causes another." Vaccine use and autism rates anyone?  So, just for fun I've produced the graph above and as you can see, through the efforts of CDC, WHO, VA and many individually hard-working IPs […]
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8:44 PM | Needle-less diabetes care on the horizon
Recent breakthroughs in monitoring and treating diabetes suggest that needle-less diabetes care is on the horizon.
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8:43 PM | Poison for pain, the homeopathic way
At my local mega-grocery store last weekend, I happened to stroll down the aisle dedicated to homeopathic treatments.  I saw shelf after shelf of brightly colored packages, all claiming health benefits.  Most of these "medicines" were not cheap. Amazing.  To an average shopper, all of these products look like real medicine.  The packaging is similar, the claims are similar, and it's all on display at a respectable grocery store.  The difference, though, is that none […]
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8:22 PM | Toxic Shock Syndrome – The story of an unlikely culprit in the 1980s
This post combines two subjects that absolutely fascinate me, and hopefully you; the history of a disease, and its pathophysiology (medical observations + mechanism acting within the organism). Toxic Shock Syndrome, or TSS, is an illness...
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7:44 PM | Penn Medicine Graduation: What’s Next for the Class of 2013?
Yesterday was the Perelman School of Medicine’s graduation at the Kimmel Center for Performing Arts, and for most of the students that means goodbye medical school and hello residency. So where will the 84 men and 76 women be heading as they embark on the next phase of their lives?...
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7:10 PM | Pulmonary Hypertension Often Misdiagnosed
A study by Dr. Mardi Gomberg-Maitland found that pulmonary hypertension is often misdiagnosed.
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5:45 PM | Cerebrovascular physiology – article alert #31
Exercise training and the brain 129- Relationship between aerobic endurance training and dynamic cerebral blood flow regulation in humans – Ichikawa et al. Acute exercise and the brain 130- Dynamic exercise improves cognitive function in association with increased prefrontal oxygenation – Endo et al. Aging, cognitive load and the brain 131-Very-low-frequency oscillations of cerebral hemodynamics […]
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4:29 PM | Dog DNA may hold clues to eczema for humans
Dr. Kerstin Lindblad-Toh at Uppsala University (Sweden) who specializes in comparative genomics and Dr. Åke Hedhammar, SLU (Sweden) recently identified a novel gene in German shepherd dogs, PKP-2, that encodes a protein (plakophilin-2) important for regulating proper skin structure and function. This protein was found to be associated with canine atopic dermatitis (i.e. doggy eczema), a…
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4:22 PM | Saudi Arabia: nCoV Concerns Drive `Scores’ To The Hospital
    # 7268   Not surprisingly, people in Saudi Arabia living near where an outbreak of nCoV infections have recently been reported are viewing any signs of fever, or respiratory illness, with a heightened degree of suspicion.   Today, AFP is reporting that `scores’ of people have shown up at local emergency rooms in the city of Al Asha – many with minor complaints - fearing that they might have contracted this emerging virus.   Follow the link […]
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2:30 PM | Hong Kong: Doctors Asked To Look For `Atypical’ Signs Of nCoV
  # 7267 A pair of reports out of Hong Kong this morning in the aftermath of this weekend’s revelations about the novel coronavirus in Saudi Arabia (see Saudi Arabia: MOH Coronavirus Twitter Updates) and France (see France: Second Coronavirus Case Confirmed).   While Hong Kong has tested a number of travelers returning from the Middle East for the novel coronavirus – so far – none have tested positive.   Hong Kong’s hyper-vigilance over infectious […]
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2:09 PM | Hemoglobin Targets in CKD
For anyone who would like to read a thorough review of the current evidence with regard to Hb targets and the use of ESAs in  patients with CKD and those on dialysis, I strongly recommend the review published in Nature Reviews Nephrology this month. The field of anemia treatment if CKD has changed completely in the last 10 years. Hb targets have gotten considerably lower and the "one size fits all" model is changing into a model based on individualized Hb targets.Two questions remain to be […]
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1:00 PM | Identification of genomic regions shared between distant relatives
This is a guest post by Graham Coop and Peter Ralph, cross-posted from the Coop Lab website. We’ve been addressing some of the FAQs on topics arising from our paper on the geography of recent genetic genealogy in Europe (PLOS Biology). We wanted to write one on shared genetic material in personal genomics data but [...]
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12:21 PM | An Interview with Don McLeroy, Part I
On the SGU this week we did an interview with Don McLeroy, the former chairman of the Texas School Board of Education, famous for his (successful) attempts to insert wording into the science textbook standards that would open the door for creationist arguments. The interview was very enlightening. In my opinion it was an excellent [...]
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9:48 AM | Funding the very best science – how does it work?
Our research is funded by the public – around 80p in every pound donated to us is spent on this vital work – so we have a responsibility to make sure our supporters’ cash gets spent on the very best science … Continue reading →
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9:00 AM | The end of a seven-year itch
It started about seven years ago. I thought it was just a fleeting fascination but the seeds had been sown for a lifelong affair – I was hooked. I would tell anyone who would listen. Always something of a chatterbox, I would wax lyrical about their variety, ingenuity and rapid ability to adapt. It was […]
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8:03 AM | FDA Drug Development Workshop: Part Two
Gabby (Nielk) continues our summary of the FDA Workshop with a look at the second half of Day One – a discussion entitled “Patients’ Perspective on Treatment Approaches” The FDA Drug Development Workshop for chronic fatigue syndrome (CFS) and myalgic encephalomyelitis (ME) took place on the 25th and 26th of April 2013. It was well attended by patients, advocates, doctors, representatives of the CDC and even a few pharmaceutical reps. The workshop was also broadcast live […]
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8:00 AM | Alternative cancer “cures”: Nothing’s changed in 34 years
Sometimes blogging topics arise from the strangest places. It’s true. For instance, although references to how tobacco causes cancer and the decades long denialist campaign by tobacco companies are not infrequently referenced in my blogging (particularly from supporters of highly dubious studies alleging a link between cell phone radiation and cancer and the ham-handed misuse…
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7:48 AM | The deceptive rebranding of aspects of science-based medicine as “alternative” by naturopaths continues apace
That naturopathy is a veritable cornucopia of quackery mixed with the odd sensible, science-based suggestion here and there is not in doubt, at least not to supporters of science-based medicine (SBM). However, what naturopaths are very good at doing is representing their pseudoscience as somehow being scientific and thus on par with conventional SBM. So [...]

May 12, 2013

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9:34 PM | Page Kidney
Patient with a history of kidney transplant s/p biopsy 2 weeks prior now undergoing chemotherapy treatment for leukemia develops acute abdominal pain, worsening renal function and hypertension. Renal US followed by CT are shown below:Renal US with dopplersRenal US longitudinal viewAbdominal CT with renal tx on right lower quadrant  Abdominal CT with red-marked kidney parenchymaDiagnosis: Page kidney is a condition where extrinsic renal compression from a haematoma or mass results in […]
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7:32 PM | Sneak Peek: Elucidating the Effects of the Deep Water Horizon Oil Spill on the Atlantic Oyster Using RNA-Sequencing Data Analysis Methods
Join us this Tuesday, May 21st at 10 AM Pacific Time / 1:00 PM Eastern Time, for an interesting webinar on the effects of the Deep Water Horizon oil spill.Speakers: Natalia G. Reyero, PhD. – Mississippi State University N. Eric Olson, PhD. – PerkinElmer Sr Leader Product DevelopmentThe Deep Water Horizon oil spill exposed the commercially important Atlantic oyster to over 200 million gallons of
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4:50 PM | More On The New Coronavirus: Cases in France, The WHO In Saudi Arabia
My last two posts looked at the problems that might be caused by hospital spread of the new coronavirus, based on what happened during the early days of SARS 10 years ago. Hospital spread of this new virus is a ...
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4:47 PM | When Viral Threats Collide
A CDC scientist uses a pipette to transfer H7N9 virus into vials for sharing with partner laboratories for public health research purposes.     # 7266   While it may sound like the working title to a George Pal 1950’s Sci-Fi movie, this spring we find ourselves in the decidedly uncomfortable position of watching two novel viruses – each believed to have some degree of pandemic potential – emerge in two different and hard-to-monitor regions of the world.   […]
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3:39 PM | Vaccines work: By the numbers
It bears repeating that vaccines are one of the greatest of all the medical innovations ever invented. This infographic illustrates their success. Here’s the source: Why vaccinate from vaccines.com using CDC data. h/t @a_picazo Filed under: updates
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2:37 PM | WHO Press Statement On nCoV – May 12th
    # 7265   And no sooner had I posted a roundup of this morning’s twitter messaging by the World Health Organization on the novel coronavirus (see WHO: Messaging On nCoV – May 12th), I found the following press release being tweeted.       WHO Press Statement Related to the Novel Coronavirus Situation 12 May 2013 The emergence of this new coronavirus is globally recognized as an important and major challenge for all of the countries which […]
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2:30 PM | WHO: Messaging On nCoV – May 12th
# 7264   The World Health Organization continues to publish what information they have on the emerging novel coronavirus situation via a variety of online venues, including their twitter feed (@WHO).    This morning, in light of developments overnight both in France (see France: Second Coronavirus Case Confirmed) and Saudi Arabia (see Saudi Arabia: MOH Coronavirus Twitter Updates), WHO has posted a stream of new messages.   The information this morning from […]
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12:53 PM | Saudi Arabia: MOH Coronavirus Twitter Updates
      #7263     The Kingdom of Saudi Arabia Ministry of Health’s twitter feed (@ksahealth) this morning (7am-8am EDT) carried the following messages regarding today’s MOH briefing on the novel coronavirus.   While the total number of cases they are reporting remains steady at 24 and now show a total of 15 fatalities. Furthermore, while lacking in details, the 8th tweet down suggests there are 3 suspected cases in Dammam.   Caveat: What […]
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11:34 AM | France: Second Coronavirus Case Confirmed
  # 7262   Overnight the Health Ministry in France confirmed that country’s second novel coronavirus (nCoV) infection – that of a patient who shared a hospital room with their index case – a traveler recently returned from the UAE.   This confirmation marks the third known hospital-linked transmission of the virus. Although nCoV is not SARS, this is a  scenario similar to what we saw with the SARS virus a decade ago.   While several other close […]
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