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Posts

May 15, 2013

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11:30 AM | The Worst Day of My Life
It required a year to get this post written for a variety of reasons. I felt strongly about getting this story out there, as difficult as it was to tell.   Cattle, Chickens, Hogs During the 2012 election season, a Georgia politician spoke in favor of a bill, that would outlaw pregnancy termination after 20 [...]
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11:00 AM | The quack view of preventing breast cancer versus reality and Angelina Jolie
I should have known it. I should have known that the reaction wouldn’t take very long. I should have known it based on prior history. The news story to which I am referring is, of course, the revelation yesterday in the New York Times editorial page by Angelina Jolie that she had decided to undergo…
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8:00 AM | Exposure to stress hormones in the womb linked to mood disorders
Stress hormones released by a pregnant mother can cause the placenta to shrink and can directly affect the developing brain of the foetus. Now, researchers have identified the mechanism through which stress may damage an unborn child in the womb. An enzyme in the placenta of the mother and the brain of the foetus acts […]
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8:00 AM | What can neuroscience teach education?
Do we really only use 10 per cent of our brain at any one time? And do we use one half of our brain more than the other? The answers are no and no, but that doesn’t seem to stop these claims circulating. The Wellcome Trust’s new education and neuroscience project seeks to banish these […]
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1:27 AM | The kibosh
Over the past several days I have spent a lot of time talking to patients, trying to explain why I've had to cancel their upcoming fecal transplant. The FDA has ruled that stool is an investigational new drug (IND), which now imposes a huge bureaucratic hurdle to getting a much needed therapy for patients with recurrent or intractable C. difficile infection. Today's Omaha World-Herald covers the new ruling and features our fellow blogger Dan Diekema.  Even before the FDA did this, there […]
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1:23 AM | Patients to DHHS: Fix the Broken ME/CFS Case Definitions NOW!
On May 12 – International Awareness Day for ME/CFS/FM/MCS/etc – Phoenix Rising joined with 8 other US ME/CFS patient organizations and 26 independent patient advocates to call on the Department of Health and Human Services (DHHS) to finally fix the problem of the many and diverse case definitions associated with our disease. In a letter to Secretary Sebelius, Dr Howard Koh, Dr Thomas Frieden and Dr Francis Collins, we explained our concerns about the current definition activities of […]

May 14, 2013

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11:31 PM | This Week in PLOS Medicine: Neonatal Mortality, M. pneumonia in Children, Childhood Diarrhoea, & Integrating Mental Health
This week PLOS Medicine spotlights infant and child health with new articles on neonatal mortality in rural Vietnam, M. pneumonia in asymptomatic children, and research priorities for childhood diarrhoea. The journal also continues with the ongoing Integrating Mental Health Series.…
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10:58 PM | Small Things Considered: Fecal Transplants in the “Good Old Days”
Small Things Considered: Fecal Transplants in the “Good Old Days”: This is an amazing anecdote from the 1950s about re-inoculating the gut microbiome of a patient post-surgery and post-antibiotic treatment. Not sure you could even get me to take those pills though… by Stanley Falkow: I had a conversation with some colleagues last week about “personalized medicine,” which has been transformed now into the term “precision medicine.” The conversation revolved around what to do […]
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9:35 PM | Ed Yong writes up the latest on “The Mucus-Lover that...
Ed Yong writes up the latest on “The Mucus-Lover that Stops Mice from Getting Fat” in his NatGeo blog. He talks about a potential “keystone” species of microbe in the human gut and the role it could play in keeping us slim. Check out the PNAS paper in discussion.
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8:45 PM | Cannabis and Chromosomal Damage
Once again a failure of knowledge translation.  I was s [...]
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7:58 PM | KSA: Two Health Care Workers Infected With nCoV
    # 7275   Providing more evidence that the novel coronavirus can be transmitted – at least in a limited fashion – from one person to another, we’ve news this afternoon from the Saudi MOH that two health care workers have been infected and are now hospitalized.   FluTrackers has been following this story for nearly two hours, in machine translated Arabic (see thread), but we now have an English language report from the Ministry of Health’s Website. […]
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7:29 PM | Genetic Risk for Breast Cancer and the Case for Prophylactic Mastectomies
Angelina Jolie's decision to have a double mastectomy sheds light on the difficult choice facing women at genetic risk for breast cancer.
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6:38 PM | WHO Novel Coronavirus Update – May 14th
  # 7274   The World Health Organization has issued a fresh update with details on the 4 new Saudi NCoV cases I mentioned earlier today (see Saudi MOH Reports 4 More nCoV Cases).   Perhaps the most expected aspect of this update is the onset date and outcome for patient #4, which is listed as just a week ago - May 7th – yet the patient is said to have recovered and been released from the hospital.   Unfortunately, beyond their ages, sex and onset dates, […]
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6:26 PM | 2013 Philadelphia Science Festival Recap
Penn Medicine faculty, staff, and students shared their love and knowledge of biomedical science with families, students, and the general public at a dozen events during the 2013 Philadelphia Science Festival.
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5:37 PM | Union of Concerned Scientists Failing on Farming
Ok, this is a little different, but it’s annoying, so I’m going to talk about it. Let me begin by saying I love the Union of Concerned Scientists. They’ve been wonderful advocates on climate change for decades; they are media savvy, they train scientists to be media savvy, and they push the media and policy makers alike to…
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4:43 PM | Rethinking treatment goals improves results for those with persistent anorexia
A clinical trial for patients with anorexia nervosa shows that patients are three times more likely to stick with treatment when they are involved in setting its goals.

Touyz S, Le Grange D, Lacey H, Hay P, Smith R, Maguire S, Bamford B, Pike KM & Crosby RD (2013). Treating severe and enduring anorexia nervosa: a randomized controlled trial., Psychological medicine, 1-11. PMID:

Citation
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4:35 PM | DVBID: 2012 Record Number Of West Nile Fatalities
  # 7273     Last December in DVBID: Final West Nile Report For 2012, we saw a preliminary accounting of last year’s West Nile virus impact across the country.  From all appearances, 2012 appeared on track to be a record year.   Total cases                5,387 cases Neuroinvasive cases   2,734 (51%)    Mild […]
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3:36 PM | Angelina Jolie, inherited breast cancer and the BRCA1 gene
The news today is full of reaction to US actress Angelina Jolie’s decision to have surgery to reduce her chances of breast cancer. She made this difficult decision because, having lost her mother to ovarian cancer, she discovered she carries … Continue reading →
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3:35 PM | Autism Community Awaits DSM 5 Changes
These days, my morning routine includes the following: after brushing my teeth, waking my kids for school and making their lunches, I check the website of the American Psychiatric Association to see if the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM 5) has been released. It is due out this month and I [...]
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2:25 PM | Declan Butler On The Lull In H7N9 Cases
  # 7272     Declan Butler, writing for Nature News, has an update (and Google Earth Maps) on China’s H7N9 outbreak, and the apparent lull in cases over the past couple of weeks.   Follow the link to read:   Avian flu update: lull in new H7N9 cases Epidemic has spread to three more Chinese provinces, but no new cases reported since 7 May. Declan Butler Nature  doi:10.1038/nature.2013.12910 14 May 2013   An update to […]
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1:01 PM | Welcome to our new program director, László Nagy, M.D., Ph.D.
Sanford-Burnham welcomes the internationally renowned genomic scientist László Nagy, M.D., Ph.D., to our Lake Nona campus. Nagy will serve as professor and program director in our Diabetes and Obesity Research Center. He will join us in October to lead a new cross-platform research program that will help accelerate discoveries at our Orlando campus.
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1:00 PM | Challenges To Developing A Coronavirus Vaccine
  # 7271   In what one hopes is not a case of art accurately anticipating the future, Steven Soderbergh’s  2011 pandemic thriller `Contagion’ showed what might happen if a bat-borne virus (dubbed MEV-1 in the movie) jumped species and sparked a human pandemic.   In my review of the movie (see Why You Should Catch `Contagion’) I praised it for a realistic portrayal (with some dramatic license) of how the CDC would tackle an outbreak of a novel zoonotic […]
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12:14 PM | May 13 2013 An Interview with Don McLeroy, Part II
In part I of my analysis of a recent interview with Don McLeroy on the SGU I discussed his assertion that those of faith are more free to accept or reject the evidence for evolution, while strict materialists can only accept it as it is the only materialist option. I mentioned in that post that [...]
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12:14 PM | An Interview with Don McLeroy, Part II
In part I of my analysis of a recent interview with Don McLeroy on the SGU I discussed his assertion that those of faith are more free to accept or reject the evidence for evolution, while strict materialists can only accept it as it is the only materialist option. I mentioned in that post that [...]
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11:16 AM | France: Both Coronavirus Patients Remain In `Poor’ Condition
  Extracorporeal membrane oxygenation (ECMO) machine in a ICU patient in Santa Cruz Hospital, Lisbon, Portugalj - Wikipedia # 7270     An update from the Centre Hospitalier Regionale et Universitaire de Lille, in France where two nCoV patients remain in their ICU; the index case who traveled to the UAE during the middle of April, and a second patient who shared a hospital room with him before he was diagnosed.     Checkup of the two patients […]
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11:07 AM | A Collaboration of Friends: Getting to Know Cochrane
Karen Daniels from the South African MRC reports back from the African Cochrane Indaba 2013.  Once in the not too distant past, one of my co-authors on a paper suggested that we ask for comments on the paper from a …
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11:00 AM | Psychopharmacological Drug Development in A Depression?
“If you are a mouse and suffer from depression, we can cure you!”. You may have heard similar statements for other diseases, which is a general reflection on the current state of drug development. After spending billions of dollars in pharmaceutical drug development only about 30 new drugs reached the market last year — a [...]
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10:20 AM | Saudi MOH Reports 4 More nCoV Cases
  # 7269   Early last evening (EDT) FluTrackers picked up a KSA MOH report indicating they had confirmed four more cases of nCoV (novel coronavirus or MERS) infection – although details were sparse.   Overnight Crof picked up a Reuters report - Saudi Arabia confirms four new MERS cases - confirming the story. Below you’ll find AFP’s version – which only tells us that one case has recovered, while three others remain hospitalized.     4 more cases […]
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7:06 AM | NCCAM and “pragmatic trials.” Again.
I’m not alone in pointing this out, but if there’s one thing about research and clinical trials into “complementary and alternative medicine” (CAM) that has become very apparent to me over the years, it’s that the more rigorous the study the less likely it is to show an effect. In normal research, the usual progression…
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7:00 AM | Antibiotics for Low Back Pain
Low back pain is a particularly frustrating condition that is common, poorly understood, and difficult to treat. Could a long course of antibiotics be the answer for some patients? A recent study from Denmark suggests that it might be:  “Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 [...]
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