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Posts

May 06, 2013

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4:10 PM | Clock Ticking On Colorado’s Marijuana Repeal Bill
Proposal to revote on pot legalization is losing steam. While the rest of the nation argues over Colorado’s recent decision to legalize limited amounts of marijuana, a small but determined group of legislators in that state have been promoting a bill that would allow a “conditional repeal” of the pot amendment. The proposal to resubmit the question of retail marijuana sales to Colorado voters is supported by Senate President John Morse (D-Colorado Springs) and Senate Minority […]
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3:49 PM | Statins Tied to Better Prostate Cancer Outcomes
A new study suggests that men with prostate cancer who take statins may have a lower risk of dying from the disease than those who do not.
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3:41 PM | Gene thought to only form heart tissue revealed to form blood and muscle tissues as well
A new study by researchers at the Lillehei Heart Institute, University of Minnesota reveals that the Mesp1 gene, previously thought to only be involved in the production of heart tissue, can be used to produce blood and muscle forming stem cells if manipulated properly.Read More

Chan, S., Shi, X., Toyama, A., Arpke, R., Dandapat, A., Iacovino, M., Kang, J., Le, G., Hagen, H., Garry, D. & Kyba, M. (2013). Mesp1 Patterns Mesoderm into Cardiac, Hematopoietic, or Skeletal Myogenic Progenitors in a Context-Dependent Manner, Cell Stem Cell, 12 (5) 587-601. DOI:

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1:51 PM | Researchers generate cortical interneurons from human embryonic stem cells
In a recent study, researchers from The Children's Hospital of Philadelphia and the Sloan-Kettering Institute have presented a new method to derive cortical interneurons from human embruonic stem cells. The study has implications in the treatment of  several neurodevelopmental disorders, like autism.Read More

Asif M. Maroof, Sotirios Keros, Jennifer A. Tyson, Shui-Wang Ying, Yosif M. Ganat, Florian T. Merkle, Becky Liu, Adam Goulburn, Edouard G. Stanley, Andrew G. Elefanty & Hans Ruedi Widmer (2013). Turning Human Stem Cells Into Brain Cells Sheds Light On Neural Development, Cell Stem Cell, Other: Link

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10:53 AM | Researchers announce "fundamental" discovery on how Oct-4 controls embryonic stem cell function
A few days ago, researchers at the University of Edinburgh announced that they have made a "fundamental" discovery on how embryonic stem cells replicate and differentiate.Read More

Karwacki-Neisius, V., Göke, J., Osorno, R., Halbritter, F., Ng, J., Weiße, A., Wong, F., Gagliardi, A., Mullin, N., Festuccia, N. & Colby, D. (2013). Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog, Cell Stem Cell, 12 (5) 531-545. DOI:

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7:53 AM | Stem cells can be used to investigate Dravet syndrome and other rare diseases
Dravet syndrome (DS), also known as severe myoclonic epilepsy of infancy, is a rare and catastrophic form of intractable epilepsy that affects about 1 in every 30,000 infants. Unfortunately, research on DS is severely hampered by its extreme rareness. However, the recent findings by a team of researchers at the Fukuoka University, Japan not only shed new light into the condition, but could also help increase our current understanding of other similarly rare genetic disorders.Read More

Higurashi, N., Uchida, T., Christoph, L., Misumi, Y., Okada, Y., Akamatsu, W., Imaizumi, Y., Zhang, B., Nabeshima, K., Mori, M. & Katsurabayashi, S. (2013). A human Dravet syndrome model from patient induced pluripotent stem cells, Molecular Brain, 6 (1) 19. DOI:

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7:47 AM | MEandYou and Rituximab: Dr Maria Gjerpe’s Fundraising Marathon Update
by Sasha Maria gets 300,000 krone from the Kavli Foundation(Photo: Skjalg Ekeland/BA) I call Dr Maria Gjerpe’s 90-day campaign to raise money for a crucial confirmatory Rituximab trial a ‘fundraising marathon’ but that hardly covers it. It’s more like a triathlon a day for three months. Maria, previously bedridden for years with ME/CFS, has been working 12-hour days non-stop to fund the Phase III trial on the drug that has, for now, restored her to health. As she explained in her […]
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7:00 AM | Undermining the regulation of stem cell therapies in Italy: A warning for the future?
Stem cells are magical. At least, if you listen to what docs and “practitioners” who run stem cell clinics in various parts of the world, usually where regulation is lax and money from First World clientele is much sought after, that’s what you could easily come to believe. Unfortunately, it’s not just Third World countries [...]
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5:00 AM | AREDS2 Study Results Released
Researchers found no extra benefit to adding lutein and zeaxanthin, omega 3 fatty acids EPA and DHA, or both to the Age-Related Eye Disease Study (AREDS) formulation, which already included antioxidant vitamins C and E, beta-carotene and zinc, according to a study published in the Journal of the American Medical Association (JAMA).
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5:00 AM | Associations Ask FDA for Guidance on New Dietary Ingredient Identity
The five associations representing the dietary supplement industry have requested that FDA issue revised guidance on new dietary ingredient (NDI) notifications, with a specific focus on the information to be included to identify the new dietary ingredient.
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4:01 AM | Sucking Your Child’s Pacifier Clean May Have Benefits
Children whose parents had no problems sucking their pacifiers to clean them had fewer allergies, lower rates of eczema and fewer signs of asthma than those whose parents typically rinsed or boiled them.
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4:01 AM | A Musical Message for Children on Healthy Eating
A former Rockette runs a program teaching children in New York City public schools about better nutrition through dance, music and a play.

May 05, 2013

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11:05 PM | Experimental Biology tweets #EB2013
As I’ve done for another conference, I collected tweets for this year’s Experimental Biology conference with a Python script that I wrote and played around with them in R. I could not attend but it was great to follow along through twitter. Check out David Despain’s roundup post for nutrition coverage. Here is the spreadsheet of 5,455 tweets starting on 4/18 at 4:21PM EST through 4/28 at 6:34PM EST: link. This is obviously more days than the conference, but if anyone wants to […]
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11:00 AM | Is Obesity Linked to ADHD?
As more and more children consume high-fat diets and become increasingly overweight, the incidences of diseases like type 2 diabetes and high blood pressure have steadily grown among the population. However, these may not be the only health issues linked with this surge in overeating among children. In a recent study from the University of [...]

May 04, 2013

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7:17 AM | The effects of light smoking
A new study, published on line recently in the journal Arthritis Research and Therapy  followed 34,101 women aged 54 to 89 years from the existing Swedish Mammography Cohort to look at whether smoking increased their risk of developing rheumatoid arthritis. … Continue reading →
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2:56 AM | What’s really in your supplement?
When you pick up a bottle of supplements, should you trust what the label says? While there is the perception that supplements are effective and inherently safe, there are good reasons to be skeptical. Few supplements are backed by good evidence that show they work as claimed. The risks of supplements are often not well [...]

Harel Z., Harel S., Wald R., Mamdani M. & Bell C.M. (2013). The Frequency and Characteristics of Dietary Supplement Recalls in the United States., JAMA internal medicine, PMID:

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May 03, 2013

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8:53 PM | Think Like a Doctor: An Unusual Headache Solved
Readers solve the mystery of a 23-year-old woman with a terrible headache who kept getting worse.
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7:17 PM | Overweight Patients, Overweight Doctors: Readers Weigh In
There’s been much discussion this week on Well about weight in the doctor’s office. As usual, our readers had a lot to say.
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6:35 PM | FDA Drug Development Workshop: Part One
by Joel (snowathlete) and Gabby (Nielk) The FDA Drug Development Workshop for chronic fatigue syndrome (CFS) and myalgic encephalomyelitis (ME) took place last week on the 25th and 26th of April. It was well attended by patients, advocates, doctors, representatives of the CDC and even a few pharmaceutical reps. The workshop was also broadcast live over the internet, enabling many more people to follow what happened without being there in person. This meeting was an opportunity for us to be […]
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6:23 PM | Caffeine-Laced Foods Spur F.D.A. Investigation
With caffeine now being added to jelly beans, waffles, even potato chips and gum, the Food and Drug Administration is stepping up efforts to investigate the impact on health.
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6:17 PM | Streamlining Cancer Care: Affordability and Accountability
As policymakers, patients and healthcare clinicians begin to find their way through the maze of changes outlined and endorsed under the Affordable Care Act, some providers are calling for further restructuring to address what they call missed opportunities in the legislation. While the guidelines aim to improve the quality of...
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5:54 PM | Expanding Your Kitchen Literacy: Dukkah
The Recipes for Health columnist Martha Rose Shulman suspects that dukkah, a Middle Eastern nut and spice mix, could be the next big thing.
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5:47 PM | Plan B: Meet the Cast of the Latest Emergency Contraceptive Drama
The political and legal battle over access to emergency contraceptives left the realm of common sense and empirical evidence years ago. In other words, this one's ripe for a fall pilot. Listen up, Lifetime, OWN. Plan B? Are you kidding me? With that ready-made title, how could you ignore this latest addition to the medical drama line-up or the political line-up.  Move over Scandal. Olivia Pope and Fitzy you're not the only […]
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1:41 PM | Quiet Yet Busy
Though our blog has been fairly quiet lately, our labs have been busy. In this post we discuss Dr. Heller's recent grant applications and renewals for SICHL's research core and for the Heller Lab's mouse stem cell work, as well as the need for continued funding in order to reach our exciting goal of curing major forms of hearing loss.
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1:41 PM | Quiet Yet Busy
You may have noticed that our blog has been fairly quite lately, but rest assured, our labs have been very busy. In fact we are expecting the publication of a many of papers in 2013, with several very good fundamental science papers from the Ricci lab, which we will cover …
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12:10 PM | Link Love: Pedagogy, Higher Ed, Ladies and Neat Stuff
I’ve been reading some good stuff the last few weeks, thought I’d share it here. Pedagogy Cheating to Learn. A great way to engage students is put them in charge of the conditions for their exam. These students “cheated” by working together on an animal behavior final. Math teacher explains math anxiety. Math and science anxiety [...]
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10:06 AM | Animal Therapy
Animal-assisted therapy is a huge topic: almost 1500 hits using those terms alone. There is no way I am going to cover all of them and do them justice. Instead I am going to cherry pick, er, I mean, select references of interest to illustrate issues surrounding animals in the hospital. Sometimes I get the [...]
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10:00 AM | Ask Well: Long-Term Risk of Antidepressants
Are there any studies on the long-term -- 10-plus years -- use of S.S.R.I.'s to treat depression? Dr. Richard A. Friedman responds to reader questions.
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4:01 AM | The Workout: Sofia Vergara Hates to Exercise
The star of the hit ABC television show "Modern Family" talks about life after thyroid cancer and staying fit at 40.
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12:24 AM | Who Says Cancer Researchers Can’t Dance?
I was delighted to learn today that a fundraising video that aired on You Tube almost 2 years ago has won an international journalism award. The “Medicine Goes Viral” story in the McGill Reporter... Let me take you behind today's and tomorrow's headlines and show you the kinds of research progress we are making in fighting cancers. Go to the web site for more...
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