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Posts

January 11, 2013

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11:44 AM | Epigenetics and Nuclear Signalling position at Abcam – come join us!
Abcam is a leading web based business supplying research tools to life scientists worldwide. Our head office is in Cambridge (UK), we also have offices in Bristol (UK), Cambridge, Eugene and San Francisco, (USA), Tokyo (Japan), Hong Kong and Hangzhou (China). A position has become available to develop the product portfolio in the Epigenetics and [...]
the Node
Biology | Development

January 10, 2013

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4:59 PM | François Guillemot joins the Development team
Here at Development, we’re delighted to welcome François Guillemot to the team of academic editors. François will be replacing Alexandra Joyner, who is soon to step down as our neurodevelopment expert. François heads up the Division of Molecular Neurobiology at the National Institute for Medical Research in London, and his research focuses on the regulation [...]
the Node
Biology | Development
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9:16 AM | Postdoc Position
A Postdoctoral Fellow position is available in my laboratory. The overall goal of our laboratory is to understand the cellular and molecular basis of vertebrate organogenesis. Our primary focus is on the elucidation of the mechanisms that govern fate decision and cellular plasticity within the endoderm, for example between pancreas and liver. Toward this aim [...]
the Node
Biology | Development

January 08, 2013

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5:10 PM | Overly Honest Methods
Why did you incubate that sample for 16 hours? Because you wanted to go home for the day - but that much detail is not in your paper! Last night, a few scientists on Twitter started sharing their “overly honest methods”, and today the #overlyhonestmethods hashtag exploded with lots of funny and true stories about [...]
the Node
Biology | Development
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10:36 AM | In Development this week (Vol. 140, Issue 3)
Here are the research highlights from the current issue of Development:   Directed differentiation: Nodal steps forward The directed differentiation of pluripotent stem cells into endodermal derivatives, including insulin-producing pancreatic β cells, has considerable clinical promise in cell replacement therapies. The first step in this process is the conversion of pluripotent stem cells into definitive [...]
the Node
Biology | Development

January 07, 2013

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7:55 PM | Milk: Not Just from Moms, Not Just for Mammals
I recently realized that you can't really have a milk mustache if you don't have lips. I guess that means we won't be seeing pigeons in any upcoming dairy ad campaigns- even though they make "milk," and it functions like the milk of mammals.by L. Lan Danny“Pigeon milk” was first systematically described in the 1930s and continues to intrigue […]
Mammals Suck... Milk!
Development | Evolution

January 04, 2013

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4:50 PM | Posdtoc position
A postdoctoral position is available in the laboratory of Dr. Sophie Astrof to study roles of cell-extracellular matrix interactions in cardiovascular development and disease using mouse model system. The research will involve investigation of the role of extracellular matrix in orchestrating signaling/communication between various progenitor cell populations during morphogenesis of the aortic arch arteries.  In [...]
the Node
Biology | Development
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4:50 PM | Postdoc position
A postdoctoral position is available in the laboratory of Dr. Sophie Astrof to study roles of cell-extracellular matrix interactions in cardiovascular development and disease using mouse model system. The research will involve investigation of the role of extracellular matrix in orchestrating signaling/communication between various progenitor cell populations during morphogenesis of the aortic arch arteries.  In [...]
the Node
Biology | Development

January 03, 2013

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5:52 PM | What’s the future of peer review? « the Node
embryoboy says: January 3, 2013 at 5:48 PM A small comment on a big topic, but when reviewing for Development we are given an initial tick box for accept, or reject. What’s the reasoning behind this? Do others find it helpful? It’s relatively rare that a paper is an absolute yes or no on initial [...]
the Node
Biology | Development
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1:22 PM | What’s the future of peer review?
Jordan Raff’s recent Biology Open editorial on the future of publishing, posted on the Node, sparked quite a debate in the comments section. Much of that discussion focussed on perceived problems with the peer review system in scientific publishing. Particularly with the rise of journals like PLoS One and BiO, it seems that authors are [...]
the Node
Biology | Development
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11:16 AM | Top Node posts of 2012
Happy New Year! We’ve looked at our stats for the past year to see which posts were the most popular. At the top of the list were the Woods Hole images and the two essay competition nominees, There’ll be dragons? and An Excitingly Predictable ‘Omic Future. But there were many other popular posts this past [...]
the Node
Biology | Development

December 31, 2012

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11:00 AM | This month on the Node – December 2012
And we’ve reached the end of another full calendar year on the Node. What were your favourite posts this year? As a refresher, here is a look back on some of the content of this past month. Advent calendar For most of this past month, you will have been able to find a new paper [...]
the Node
Biology | Development

December 27, 2012

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2:47 PM | Book review: Theme and variations on biology and civilisation
This book review originally appeared in Development. Alfonso Martinez Arias reviews “Cells to Civilizations: The Principles of Change that Shape Life ” by Enrico Coen. Book info: Cells to Civilizations: The Principles of Change that Shape Life. By Enrico Coen. Princeton University Press (2012) 360 pages ISBN 9780691149677 $29.95 (hardback) In 1953, Alan Turing, a [...]
the Node
Biology | Development

December 26, 2012

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12:21 AM | From sharks to mammals
My name is Idoia, I am a PhD student within the Brainshark group at the University of Santiago de Compostela (Spain). I am currently finishing a research stay at the University of Edinburgh (Scotland) funded by the travelling fellowships offered by the Company of Biologists. It is being four years since I started my predoctoral [...]
the Node
Biology | Development

December 25, 2012

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8:00 AM | Advent calendar round-up
If you have been following along with the advent calendar we’ve had in the sidebar for the past couple of weeks, you will have seen twenty-four papers - all selected by readers of the Node. We’ve seen a diverse selection of papers, all describing recent work in developmental and stem cell biology. The people who [...]

Thurman R.E., Rynes E., Humbert R., Vierstra J., Maurano M.T., Haugen E., Sheffield N.C., Stergachis A.B., Wang H. & Vernot B. & (2012). The accessible chromatin landscape of the human genome, Nature, 489 (7414) 75-82. DOI:

Unhavaithaya Y. & Orr-Weaver T.L. (2012). Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity, Genes & Development, 26 (1) 31-36. DOI:

Tschopp P., Christen A.J. & Duboule D. (2012). Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters, Development, 139 (5) 929-939. DOI:

Reynolds N., Latos P., Hynes-Allen A., Loos R., Leaford D., O'Shaughnessy A., Mosaku O., Signolet J., Brennecke P. & Kalkan T. & (2012). NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment, Cell Stem Cell, 10 (5) 583-594. DOI:

Massarwa R. & Niswander L. (2012). In toto live imaging of mouse morphogenesis and new insights into neural tube closure, Development, 140 (1) 226-236. DOI:

Salbreux G., Barthel L.K., Raymond P.A. & Lubensky D.K. (2012). Coupling mechanical deformations and planar cell polarity to create regular patterns in the zebrafish retina., PLoS computational biology, PMID:

Stone M., Rao K., Gheres K., Kim S., Tao J., La Rochelle C., Folker C., Sherwood N. & Rolls M. (2012). Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration, Cell Reports, 2 (5) 1340-1350. DOI:

Schoenebeck J.J., Hutchinson S.A., Byers A., Beale H.C., Carrington B., Faden D.L., Rimbault M., Decker B., Kidd J.M. & Sood R. & (2012). Variation of BMP3 contributes to dog breed skull diversity., PLoS genetics, PMID:

Scherptong R.W.C., Jongbloed M.R.M., Wisse L.J., Vicente-Steijn R., Bartelings M.M., Poelmann R.E., Schalij M.J. & Gittenberger-De Groot A.C. (2012). Morphogenesis of outflow tract rotation during cardiac development: The pulmonary push concept, Developmental Dynamics, 241 (9) 1413-1422. DOI:

Shi Y., Kirwan P., Smith J., MacLean G., Orkin S.H. & Livesey F.J. (2012). A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome, Science Translational Medicine, 4 (124) 124ra29-124ra29. DOI:

Zhou S., Lo W.C., Suhalim J., Digman M., Gratton E., Nie Q. & Lander A. (2012). Free Extracellular Diffusion Creates the Dpp Morphogen Gradient of the Drosophila Wing Disc, Current Biology, 22 (8) 668-675. DOI:

Weber G., Bjerke M. & DeSimone D. (2012). A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration, Developmental Cell, 22 (1) 104-115. DOI:

Hayashi K., Ogushi S., Kurimoto K., Shimamoto S., Ohta H. & Saitou M. (2012). Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice, Science, 338 (6109) 971-975. DOI:

Colas A.R., McKeithan W.L., Cunningham T.J., Bushway P.J., Garmire L.X., Duester G., Subramaniam S. & Mercola M. (2012). Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis, Genes & Development, 26 (23) 2567-2579. DOI:

Haskel-Ittah M., Ben-Zvi D., Branski-Arieli M., Schejter E., Shilo B.Z. & Barkai N. (2012). Self-Organized Shuttling: Generating Sharp Dorsoventral Polarity in the Early Drosophila Embryo, Cell, 150 (5) 1016-1028. DOI:

Kaelin C.B., Xu X., Hong L.Z., David V.A., McGowan K.A., Schmidt-Kuntzel A., Roelke M.E., Pino J., Pontius J. & Cooper G.M. & (2012). Specifying and Sustaining Pigmentation Patterns in Domestic and Wild Cats, Science, 337 (6101) 1536-1541. DOI:

Chen H., Xu Z., Mei C., Yu D. & Small S. (2012). A System of Repressor Gradients Spatially Organizes the Boundaries of Bicoid-Dependent Target Genes, Cell, 149 (3) 618-629. DOI:

Yoshiba S., Shiratori H., Kuo I.Y., Kawasumi A., Shinohara K., Nonaka S., Asai Y., Sasaki G., Belo J.A. & Sasaki H. & (2012). Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2, Science, 338 (6104) 226-231. DOI:

Hödl M. & Basler K. (2012). Transcription in the Absence of Histone H3.2 and H3K4 Methylation, Current Biology, 22 (23) 2253-2257. DOI:

Zhao T., Graham O.S., Raposo A. & St Johnston D. (2012). Growing Microtubules Push the Oocyte Nucleus to Polarize the Drosophila Dorsal-Ventral Axis, Science, 336 (6084) 999-1003. DOI:

Lefebvre J.L., Kostadinov D., Chen W.V., Maniatis T. & Sanes J.R. (2012). Protocadherins mediate dendritic self-avoidance in the mammalian nervous system, Nature, 488 (7412) 517-521. DOI:

Guichard P., Desfosses A., Maheshwari A., Hachet V., Dietrich C., Brune A., Ishikawa T., Sachse C. & Gonczy P. (2012). Cartwheel Architecture of Trichonympha Basal Body, Science, 337 (6094) 553-553. DOI:

Charrier C., Joshi K., Coutinho-Budd J., Kim J.E., Lambert N., de Marchena J., Jin W.L., Vanderhaeghen P., Ghosh A. & Sassa T. & (2012). Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation, Cell, 149 (4) 923-935. DOI:

Christen B., Rodrigues A.M.C., Monasterio M.B., Roig C.F. & Belmonte J.C.I. (2012). Transient downregulation of Bmp signalling induces extra limbs in vertebrates, Development, 139 (14) 2557-2565. DOI:

the Node
Biology | Development
Citation

December 23, 2012

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9:40 PM | A feedback from Paris UPMC/Curie International program
The UPMC/Curie Institute International Course in Developmental Biology took place in Paris during five weeks. Students coming from Master or PhD programs around the world gathered together for the three first weeks to participate to the practical part. The group was composed of approximately 20 people from France, Portugal, the Netherlands, Ireland, India, Greece, the [...]
the Node
Biology | Development

December 20, 2012

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2:32 PM | Book review: Updated interpretation of the principles of neural development
This book review originally appeared in Development. Tatsumi Hirata reviews “Neuronal Guidance: The Biology of Brain Wiring ” (Edited by Marc Tessier-Lavigne and Alex L. Kolodkin). Book info: Neuronal Guidance: The Biology of Brain Wiring. Edited by Marc Tessier-Lavigne, Alex L. Kolodkin. Cold Spring Harbor Laboratory Press (2011) 397 pages ISBN 978-0-879698-97-3 $135 (hardback) As [...]
the Node
Biology | Development

December 19, 2012

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11:05 AM | An interview with Roger Barker
An interview with Roger Barker Roger Barker is Professor of Clinical Neuroscience at the Cambridge Centre for Brain Repair, and one of the authors on a recent Development paper from Elena Cattaneo’s group in Italy, about the derivation of functional neurons from human stem cells. EuroStemCell has published a range of videos by several authors [...]

Carri A.D., Onorati M., Lelos M.J., Castiglioni V., Faedo A., Menon R., Camnasio S., Vuono R., Spaiardi P. & Talpo F. & (2012). Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons, Development, 140 (2) 301-312. DOI:

the Node
Biology | Development
Citation

December 18, 2012

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12:58 PM | In Development this week (Vol. 140, Issue 2)
Here are the highlights from the current issue of Development:   Against the segmentation clock A gene expression oscillator called the segmentation clock controls the periodic formation of somites in vertebrate embryos. In zebrafish, negative autoregulation of the transcriptional repressor genes her1 and her7 is thought to control the clock’s oscillations. Delays in this negative-feedback [...]
the Node
Biology | Development

December 17, 2012

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9:25 PM | Academic Visit to Oxford University : Thanks to Development Travelling Fellowship
I am a second year graduate student in Department of Chemical and Biological Engineering, Princeton University. I got a chance to visit Center for Mathematical Biology, Mathematical Institute, University of Oxford this November. I would like to thank Company of Biologist’s Traveling Fellowships program and people behind it for supporting me. It was an amazing and [...]
the Node
Biology | Development
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11:23 AM | Travelling Fellowships
Do you need to learn a new technique?  Are you planning a collaborative visit?  If so please have a look at The Compnay of Biologist’s Travelling Fellowships - http://www.biologists.com/fellowships.html.  The next deadline is the 31st December 2012.
the Node
Biology | Development

December 16, 2012

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5:39 AM | Counting transcripts to track cell state
Many years ago, we started to use micro-arrays to look at how gene expression changes during differentiation of lateral mesoderm. In particular we were interested in differentiation leading to the endothelial and hematopoietic lineages (derivatives of lateral mesoderm) and we performed array experiments on populations of cells sorted by surface molecules at different stages of [...]

Jakt L.M., Moriwaki S. & Nishikawa S. (2013). A continuum of transcriptional identities visualized by combinatorial fluorescent in situ hybridization, Development, 140 (1) 216-225. DOI:

the Node
Biology | Development
Citation

December 14, 2012

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3:04 PM | Take a tea break with the Node
If you got into the habit of reading the Node on your tea breaks, we’ve got just the thing for you! We now have Node tea bags, custom made for us. They’ll be at our stand at the ASCB meeting next week (stand 1303) and at several other conferences. Below are some photos of the [...]
the Node
Biology | Development

December 13, 2012

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3:36 PM | Book review: Life and the matrix
This book review originally appeared in Development. Charles Streuli reviews “Extracellular Matrix Biology ” (Edited by Richard O. Hynes and Kenneth M. Yamada). Book info: Extracellular Matrix Biology. Edited by Richard O. Hynes, Kenneth M. Yamada Cold Spring Harbor Laboratory Press (2012) 387 pages ISBN 978-1-936113-38-5 $67.50 (hardcover) To be metazoan is to have an [...]
the Node
Biology | Development
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3:17 PM | Would you like to work for the Node?
As you may have spotted, we’ve just posted a job ad for community manager for the Node. That is currently my job, but I will be leaving at the end of February, so there will be a vacancy. I’ve had this job since the Node launched, and even before then! I’ve had a great time [...]
the Node
Biology | Development
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3:11 PM | Community Manager for the Node
The Company of Biologists and its journal Development are seeking to appoint a new Community Manager to run its successful community website the Node and the journal’s social media activities. Launched in 2010, the Node is the place for the developmental biology community to share news, discuss issues relevant to the field and read about [...]
the Node
Biology | Development

December 12, 2012

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9:17 PM | Don’t get rid of the middleman
There are a lot of situations in life where the “middleman” is unnecessary and costly.  In cells, that middleman is necessary and fascinating at the same time.  The sequence of DNA to middleman mRNA to protein provides our cells with countless ways to regulate complex events, including those surrounding stem cell divisions. When stem cells [...]

Eun, S., Stoiber, P., Wright, H., McMurdie, K., Choi, C., Gan, Q., Lim, C. & Chen, X. (2012). MicroRNAs downregulate Bag of marbles to ensure proper terminal differentiation in the Drosophila male germline, Development, 140 (1) 23-30. DOI:

the Node
Biology | Development
Citation

December 11, 2012

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4:00 PM | Skate wins again
Remember the skate image by David Gold, Lynn Kee, and Meghan Morrissey of the 2011 Woods Hole embryology course? It won the cover competition in April, and appeared on the cover of Development issue 139(12). Today, at the Company of Biologists Christmas lunch, we held a small inter-journal cover competition. Over the past few weeks, [...]
the Node
Biology | Development
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9:49 AM | Nobel Laureates Warn Against Going over the Fiscal Cliff
Although I’m not a fan of simply reposting press releases, this press release from The Coalition for the Life Sciences, about a letter-campaign by Nobel Laureates to emphasize the importance of research funding, is worthy of a read. The coalition is made up of several scientific organisations that overlap with the Node’s readership (ASBMB, ASCB, [...]
the Node
Biology | Development

December 06, 2012

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3:03 PM | Book review: Everything you always wanted to know about auxin but were afraid to ask
This book review originally appeared in Development. Sabrina Sabatini reviews “Auxin Signaling: From Synthesis to Systems Biology ” (Edited by Mark Estelle, Dolf Weijers, Karin Ljung and Ottoline Leyser). Book info: Auxin Signaling: From Synthesis to Systems Biology. Edited by Mark Estelle, Dolf Weijers, Karin Ljung, Ottoline Leyser. Cold Spring Harbor Laboratory Press (2011) 253 [...]
the Node
Biology | Development
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