October 31, 2014

3:44 PM | Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9
Researchers have always been interested in tissue-specific loss of function to probe the role of specific genes in embryonic development, cell physiology and disease conditions. Migration of lateral plate primordial germ cells in zebrafish, border cell migration during oogenesis in drosophila, interaction of T-cells with their target, and numerous other cases have continued to give […]

Stolfi, A., Gandhi, S., Salek, F. & Christiaen, L. (2014). Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9, Development, 141 (21) 4115-4120. DOI: 10.1242/dev.114488

12:34 PM | A day in the life of a shark lab
Hi! I am Nuria, a PhD student. I work in the Department of Cell Biology at the University of Santiago de Compostela (Spain). Our group, the BRAINSHARK group, has been working in the evolutionary changes occurring during the development of the nervous system of a small shark (Scyliorhinus canicula) for many years. Our work mostly […]
9:00 AM | Images of Guatemala (4) – Fiesta at Lake Atitlan
Fiesta at Lake Atitlan, Guatemala. Guatemala is a country with many volcanic hazards, as shown in some of the previous images in this series, but also a country rich in culture and traditions. The image above was taken at the annual fiesta in San Pablo, a small town on the edge of Lake Atitlan. During the […]

October 29, 2014

2:07 PM | A mechanism that allows a differentiated cell to reactivate as a stem cell revealed
The study, performed with fruit flies, describes a gene that determines whether a specialized cell conserves the capacity to become a stem cell again. Unveiling the genetic traits that favour the retention of stem cell properties is crucial for regenerative medicine. Published in Cell Reports, the article is the fruit of collaboration between researchers at […]
11:28 AM | Barcelona BioMed Conference: Drosophila as a model in cancer (15 Jun 2015 to 17 Jun 2015)
Barcelona BioMed Conference: Drosophila as a model in cancer 15 - 17 Jun 2015 Cancer is a multi-hit process involving mutations in oncogenes and tumour suppressors, as well as interactions between the tumour cells and the surrounding normal tissue. The fruit fly, Drosophila, is an excellent, genetically-tractable system for modelling the development of cancer, due to the […]
11:20 AM | La historia de la dieta cetogénica
Poco después del nacimiento de mi nieto se hizo evidente que él sufría de ataques convulsivos implacables. A pesar de que algo andaba definitivamente mal sus médicos de atención primaria […]

October 27, 2014

12:03 PM | The Waisman Center and its Autism-Related Efforts
This path month I had the opportunity to visit the Waisman Center in Madison, Wisconsin in order to provide the John D. Wiley Seminar Series. I was hosted by my […]
8:52 AM | 4 Yr PhD Programme in Developmental Mechanisms
Applications are open for the Wellcome Trust funded four year PhD programme in Developmental Mechanisms at Cambridge. We are looking for talented, motivated graduates or final year undergraduates, and are keen to attract outstanding applicants in the biological sciences, who are committed to doing a PhD. We are able to fund both EU and non-EU […]
8:00 AM | Missing Maps – A London Event
Information about an external event that may be of interest to some of our readers: “You are warmly invited to attend the launch of the Missing Maps Project, a collaboration between the Humanitarian OpenStreetMap Team (HOT) , the British Red Cross, the American Red Cross, and Médecins Sans Frontières / Doctors Without Borders (MSF) . […]

October 26, 2014

11:26 AM | Biology and maths partner to understand life decisions
Starting with the one fertilized egg that we all once were, embryonic development is made of cell divisions and most importantly of cell decisions. These first life decisions are the first steps of the development of various cell types, which will further divide, decide, specialize, organize, form specialized organs and ultimately an entire very complex […]

Bessonnard, S., De Mot, L., Gonze, D., Barriol, M., Dennis, C., Goldbeter, A., Dupont, G. & Chazaud, C. (2014). Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network, Development, 141 (19) 3637-3648. DOI: 10.1242/dev.109678


October 24, 2014

11:58 AM | Early- and late-onset complications of the ketogenic diet for intractable epilepsy
The following is an abstract of a publication dealing with the side-effects of the ketogenic diet. The reference to the article is: Kang HC, Chung DE, Kim DW, Kim HD.Early- […]
9:20 AM | Public Engagement Officer
Department/Location: Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute Salary: £28,695-£37,394 Reference: PS03788 Closing date: 16 November 2014 Fixed-term: The funds for this post are available until 30 June 2017 in the first instance. The Stem Cell Institute is a world-leading centre of excellence in stem cell biology and regenerative medicine, supported by […]
9:00 AM | Images of Guatemala (3) – Lahar Deposits at Fuego
Lahars at Volcan de Fuego, Guatemala. This image captures a lahar [mudflow] deposit close to Volcan de Fuego. These deposits are formed when rain mobilises ash and pyroclastic material on the volcano to form a fast moving, powerful mudflow with the ability to transport material including large boulders. As the energy dissipates, the sediment is deposited as […]
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