October 10, 2014

9:07 AM | Images of Guatemala (1) – Volcan de Fuego
Volcan de Fuego, Guatemala. Taken from the adjacent peak of Acatenango, this photograph captures ones of the many small eruptions of the volcano named Fuego (the Spanish word for fire!). Fuego, formed by the subduction of the Cocos plate beneath the Caribbean plate, is an active basaltic stratovolcano. You can read more about Fuego and […]

October 09, 2014

2:05 PM | Risk of seizure recurrence after achieving freedom on the ketogenic diet
My most recent post on the ketogenic diet was meant to convey one possible treatment approach for those cases where seizures had not been controlled by medication. Although the ketogenic […]
1:55 PM | A timeline of a baby’s first hour
A study carefully documents newborns’ instinctual behaviors in the first hour outside the womb, observations that paint a picture of what babies might need in the moments after birth.

October 08, 2014

2:48 PM | Flies with colon cancer help to unravel the genetic keys to disease in humans
Researchers generate for the first time Drosophila melanogaster with intestinal cancer and reveal key genetic factors behind human colon cancer. The scientists identify a human gene that favours the proliferation of tumour cells in early stages of colon cancer. Furthermore, the flies are useful for faster and more economic drug screening. Researchers at the Institute […]
12:08 PM | Autismo: la utilidad del ejercicio
Estar sano no es sólo una cuestión de lo que se come, sino del nivel de actividad que se mantiene durante el día. La dieta y el ejercicio van mano […]
11:43 AM | Crossing fields- EMBO conference on interdisciplinary plant development
There is something exciting about biologists joining forces with physicists and/or mathematicians, and finding a common language to solve biological problems that are just too complex to understand without stepping outside the realm of ‘traditional’ biology. At the recent EMBO conference on plant development, interdisciplinary studies were the main focus. And as the organiser of […]
9:00 AM | Landscapes of Ladakh (1)
  Recently we undertook some work in Ladakh (India), amongst some beautiful landscapes. To see and learn more – why not come to this event at The Geological Society. Photos: Geology for Global Development (2014)

October 07, 2014

11:58 AM | In Development this week (Vol. 141, Issue 20)
Here are the highlights from the current issue of Development:   Small (molecule) steps to making bone The repair of cartilage and bone following damage remains a clinical challenge. Current cell-based therapies rely mostly on adult mesenchymal stromal cells, but the expansion of these into correctly differentiated and functionally competent chondrocytes, which give rise to […]

October 06, 2014

Shortly after my grandson was born it became evident that he was suffering from relentless seizures. Although something was definitely wrong to us his primary physicians believed that we were […]
8:56 AM | Event: The Lost World of Ladakh: Reclaiming the Past, Sustaining the Future
THE LOST WORLD OF LADAKH: RECLAIMING THE PAST, SUSTAINING THE FUTURE Venue: The Geological Society, Burlington House, Piccadilly, London W1J 0BG. 24 October 2014, 5.30pm – 8.30pm The Geological Society recently co-organised an international conference in Leh, the capital of the historic Himalayan kingdom of Ladakh. Sustainable Resource Development in the Himalayas brought together scientists from […]

October 03, 2014

10:46 PM | Tough decisions for the developing brain
To form complex organs, somatic stem cells proliferate and then differentiate during development. In this process, intrinsic factors, i.e. the sequential expression of transcriptional genes, and extrinsic factors, i.e. extracellular microenvironment, are intimately involved. Recent in vitro studies have revealed that the physical properties of the extracellular niche, possibly tissue stiffness, may play an important […]
5:21 PM | Pregnant women’s immune systems overreact to the flu
A new study offers an exception to the assumption that a pregnant woman’s immune system fades to keep from attacking the growing fetus.
2:03 PM | ‘From Stem Cells to Human Development’ – A Company of Biologists’ Workshop
Last week, several of the Company of Biologists’ team de-camped to Surrey for our latest Workshop ‘From Stem Cells to Human Development’. Unlike previous events, this was a larger meeting, with 112 participants from all over the world. Organised by the editors of Development, the theme of the meeting (as implied by the title!) was […]
12:26 PM | A Graphic on Vaccines and Autism
I recently received a request to post a graphic on vaccines and autism on my blog. The same came from Healthcare Management Degree Guide ( The request was made by […]

October 02, 2014

10:37 AM | What do sperm have to do with brain tumors?
  This post was originally published in the Knoepfler Lab Stem Cell Blog.      Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including […]

Yuen, B., Bush, K., Barrilleaux, B., Cotterman, R. & Knoepfler, P. (2014). Histone H3.3 regulates dynamic chromatin states during spermatogenesis, Development, 141 (18) 3483-3494. DOI: 10.1242/dev.106450


October 01, 2014

1:24 PM | This month on the Node- September 2014
Here are some of the highlights for September:   Research: - Sylvain discussed his recent Development paper on the tristable regulatory network behind cell fate decisions in the early embryo. - Aryeh wrote about his research on spontaneous patterning of human ES cells, recently published in Nature Methods (he is also hiring a postdoc!). - and Christelle highlighted a recent […]
12:27 PM | Cómo seguir la creciente tasa de prevalencia del autismo?
Desde el 1988 la Organización Mundial de la Salud en colaboración con el Centro para la Investigación sobre la Epidemiología de Desastres ha mantenido una base de datos (EM-DAT) sobre […]
2:07 AM | The Future of Research Symposium:The Funding of Research
This is the last of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]

September 30, 2014

8:57 PM | “Smells Like Development” – The 73rd Society for Developmental Biology Meeting
Hosted in beautiful Seattle, the Society for Developmental Biology (SDB) held its 73rd Annual Meeting on the University of Washington campus in (mostly) sunny July. Here researchers from around the world working on different developmental processes and models come together to share their results and learn about advances in the field. SDB is quite generous […]
12:47 AM | USA Tenure Track Faculty Position, University of Chicago, Department of Neurobiology
The University of Chicago’s Department of Neurobiology seeks to recruit tenure-track faculty. Appointments can be made at any rank from Assistant Professor to Professor, and in any area of neurobiology. Candidates must have a doctoral degree and at least two years of postdoctoral training. Researchers in molecular/cellular neurobiology or neural development/plasticity are particularly encouraged to apply. […]

September 29, 2014

11:54 AM | The National Database for Autism Research (NDAR): Playing Favorites in Autism Research
According to their web site ( “The National Database for Autism Research (NDAR) is an NIH-funded research data repository that aims to accelerate progress in autism spectrum disorders (ASD) research […]

September 28, 2014

11:37 PM | The Future of Research Symposium:Metrics: The Folly of Hoping for X whilst Rewarding Y
This is the third of four posts relating to the Future of Research symposium which was announced in a previous blog post. Each of these posts will discuss a topic that is the focus of a workshop at the Symposium. Even if you can’t attend, please tweet @FORsymp with suggestions, or follow us to respond […]

September 26, 2014

9:30 AM | Friday Photo (129) – Annual Conference
  GfGD Annual Conference 2014 A selection of photographs taken from the GfGD Annual Conference, hosted and supported by the Geological Society of London. The event focused on the skills required to make a long-term, effective contribution to international development. (Credit: Geology for Global Development, 2014)
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