Posts

October 22, 2014

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3:11 PM | Post-doc and research assistant positions in Drosophila planar polarity
Two Wellcome Trust-funded positions are available for candidates with a background in cell and/or developmental biology to join an interdisciplinary team investigating cell signalling and coordinated cell polarisation using Drosophila epithelial development as a model system. The Strutt lab (http://www.shef.ac.uk/bms/research/strutt) studies cell signalling and coordinated cell polarisation in animal tissues via analysis of the “core” […]
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1:00 PM | There’s no need to panic about enterovirus
The enterovirus behind this year’s outbreak, EV-D68, has been around for decades and generally causes mild symptoms.

October 21, 2014

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5:33 PM | La Base Nacional de Datos para la Investigación del Autismo (NDAR): Como el Gobierno Federal Juega con Favoritos en la Investigación del Autismo
De acuerdo con su Página web (http://ndar.nih.gov/): “La Base Nacional de Datos para la Investigación del Autismo (NDAR) es un repositorio de datos de investigación financiada por el NIH que […]
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3:42 PM | Human Stem Cell research: new ethical questions?
The Ethics Session at the Company of Biologists “From Stem Cells to Human Development” workshop Last September the Company Of Biologists organized an exciting three-day dive into the biology of human stem cells and their use to study human development and regeneration (look out for the full meeting report in Development, coming soon, and Katherine […]
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1:21 PM | In Development this week (Vol. 141, Issue 21)
Here are the highlights from the new issue of Development:   Two top tips for angiogenesis The widely accepted model of angiogenic sprouting proposes that a single cell – the tip cell – is found at the leading edge of vessel sprouts. Now, Victoria Bautch and colleagues describe an alternative blood vessel topology in which […]
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7:40 AM | Postdoctoral Researcher in Skeletal Development, Disease, and Repair
  A postdoctoral research position is available in the Hilton Laboratory within the Duke Orthopaedic Cellular, Developmental, and Genome Laboratories at Duke University School of Medicine. The primary research focus of this position will utilize novel mouse genetic and surgical models to study  skeletal development, disease, and repair/regeneration with a particular emphasis on identifying underlying […]

October 20, 2014

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1:00 PM | A new set of Node postcards!
Every year we give you a chance to choose from sets of beautiful images taken by the students at the MBL Woods Hole embryology course. The most voted image then feature in the cover of Development. The images from Woods Hole are always beautiful, and to showcase them last year we produced a set of four Node […]
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12:04 PM | Part 3: Implementing the ketogenic diet
This is the last of a series of blogs written about the ketogenic diet. The first two dealt with a historical background to the diet (http://bit.ly/11Q9HWX) as well as some […]

October 19, 2014

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4:15 PM | Autism: The Truth is (not) Out There
Parents of a child affected by autism naturally want to know the cause. Autism can dramatically disrupt the typical childhood pattern of cognitive, behavioural and social development. At the most severe end, the child may require care for the rest of their lives. Even at the milder end, it may make mainstream education impossible and exclude many opportunities available to typically developing children. Any parent would hope that knowing the cause could lead to better treatment and […]

October 18, 2014

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5:42 AM | Full-term developmet of quail chick by ICSI
The eggs of domestic birds have been used in the study of developmental biology, leading to the extensive accumulation of knowledge on embryonic development. However, the early events involved in bird development, particularly the mechanism underlying fertilization, have not been elucidated in as much detail as those of other species of animals. The ooplasm in […]

Mizushima, S., Hiyama, G., Shiba, K., Inaba, K., Dohra, H., Ono, T., Shimada, K. & Sasanami, T. (2014). The birth of quail chicks after intracytoplasmic sperm injection, Development, 141 (19) 3799-3806. DOI: 10.1242/dev.111765

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5:42 AM | Full-term development of quail chick by ICSI
The eggs of domestic birds have been used in the study of developmental biology, leading to the extensive accumulation of knowledge on embryonic development. However, the early events involved in bird development, particularly the mechanism underlying fertilization, have not been elucidated in as much detail as those of other species of animals. The ooplasm in […]

October 17, 2014

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9:00 AM | Images of Guatemala (2) – Pyroclastic Flow Deposits
Pyroclastic Flow Deposits close to Volcan de Fuego, Guatemala. The scale of these deposits, formed in 2012, can be seen against the scale of the person standing in the background [dark line, just above the red shrub]. Pyroclastic flows, alongside lahars, are two of the most significant and destructive volcanic hazards associated with Volcan de Fuego. […]
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12:04 AM | Postdoctoral Position in Developmental Genetics
Postdoctoral Research Position: This is a funded position in the Extavour lab at Harvard University (Departments of Organismic & Evolutionary Biology/Molecular and Cellular Biology). The project aims to understand how growth and patterning of distinct cell types are coordinated during organ development, using the Drosophila melanogaster ovary as a model. The successful candidate will participate […]

October 16, 2014

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6:19 PM | Is Axon Guidance by Attraction and Repulsion, or by a Roll of the Dice?
Attractants and repellants guide axons to their targets.  On its journey, a migrating axon may be confronted with multiple attractive and repulsive guidance cues.  This presents a conundrum. How does the axon avoid a tug-of-war between attractants and repellants?  Does the strongest cue win?  Can one cue negate the effects of another?  Can an axon switch its responsiveness to cues until they all match?  

Tang, X. & Wadsworth, W. (2014). SAX-3 (Robo) and UNC-40 (DCC) Regulate a Directional Bias for Axon Guidance in Response to Multiple Extracellular Cues, PLoS ONE, 9 (10) Other:

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9:00 AM | Event Reminder: The Lost World of Ladakh
EVENT REMINDER —- THE LOST WORLD OF LADAKH: RECLAIMING THE PAST, SUSTAINING THE FUTURE Venue: The Geological Society, Burlington House, Piccadilly, London W1J 0BG. 24 October 2014, 5.30pm – 8.30pm Tickets (£20) and Registration –  www.geolsoc.org.uk/Lost-world-of-Ladakh The Geological Society recently co-organised an international conference in Leh, the capital of the historic Himalayan kingdom of Ladakh. Sustainable […]

October 15, 2014

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10:33 PM | Gone Fishing. Zebrafish Meeting 2014, Madison, WI.
“In scientific thinking are always present elements of poetry. Science and music requires a thought homogeneous.” ~Albert Einstein. This year the biannual Zebrafish meeting started out in the best possible fashion, combining music with science. The exceptionally talented organist Dr. Graham Lieschke performed three pieces composed by Bach, and Overture Hall never sounded better! Having […]
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6:49 PM | A Random Walk into the Genetics of Axon Guidance
The man claimed he was a wizard and had cast the “spell of attraction” on the target.  Now the target would guide his arrow to the mark.  So we gave the man a broken arrow and watched to see if this arrow could hit the target.  The man took the arrow and flung it at the target.  Indeed, this arrow too could hit the target. Credit: Nina Matthews PhotographyPerhaps we had asked the wrong question.  Instead of looking at whether the arrow made it to […]

Wadsworth, W. (2002). Moving around in a worm: netrin UNC-6 and circumferential axon guidance in C. elegans, Trends in Neurosciences, 25 (8) 423-429. DOI: 10.1016/S0166-2236(02)02206-3

Kulkarni, G., Xu, Z., Mohamed, A., Li, H., Tang, X., Limerick, G. & Wadsworth, W. (2013). Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity, Biology Open, 2 (12) 1300-1312. DOI: 10.1242/bio.20136346

Yang, Y., Lee, W., Tang, X. & Wadsworth, W. (2014). Extracellular Matrix Regulates UNC-6 (Netrin) Axon Guidance by Controlling the Direction of Intracellular UNC-40 (DCC) Outgrowth Activity, PLoS ONE, 9 (5) DOI: 10.1371/journal.pone.0097258

Xu, Z., Li, H. & Wadsworth, W. (2009). The Roles of Multiple UNC-40 (DCC) Receptor-Mediated Signals in Determining Neuronal Asymmetry Induced by the UNC-6 (Netrin) Ligand, Genetics, 183 (3) 941-949. DOI: 10.1534/genetics.109.108654

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5:28 PM | Post-doc and research associate positions in cardiovascular development
The Wythe Lab at Baylor College of Medicine favors a cross disciplinary approach to solving key problems in cardiovascular development. Rather than wed ourselves to a singular model system or technique, we attack biological questions from multiple fronts, using gold standard genetic models-such as the mouse, cutting edge imaging techniques, genome-wide analyses, and classical biochemistry. […]
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2:23 PM | Axon Guidance Meets Statistical Physics
The proposition that the response of an axon to guidance cues is a random walk provides a different perspective of axon guidance.For the most part, Biologists like deterministic models, i.e. cause and effect.  From the deterministic point-of-view, axon guidance is caused when axon outgrowth activity occurs at the site where the neuron detects an external attractive guidance cue. But what if the direction of axon outgrowth activity were to rapidly fluctuates in different […]
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2:23 PM | Random Walks, the Brain Initiative, and the Genius of Einstein's Brain
Over a four-month period in 1905, Einstein published a series of remarkable papers that changed our conception of time and space.
Even more remarkable is the instrument that enabled Einstein to unlock the mysteries of time and space.  His brain.  Credit: internetarchivebookimages
Some100 billion neurons allowed Einstein to think.  And in order to do this, the neurons in Einstein's developing brain formed a network of neural circuits.  By sending […]
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2:17 PM | The Attraction of Axons; the Moth or the Spider?
An axon is attracted towards its target by guidance cues.  A moth flies towards the source of a pheromone.  A spider is sucked across the floor towards the nozzle of a vacuum cleaner.  Is the attraction of an axon towards its target more like the movement of the moth or the spider?credit: pmillera4External molecules direct the movement of the axon, the moth, and the spider.  In response to pheromone molecules a moth directs its movement toward the source of the […]
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11:54 AM | La investigación del autismo financiada por el gobierno federal de los Estados unidos
James Madison escribió la célebre frase: “Si los hombres fueran ángeles, no sería necesario ningún gobierno. Si los ángeles gobernaran a los hombres, ni controles externos ni internos en el […]
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11:02 AM | (Developmental) Biology around the internet- October 2014
Here is October’s round-up of some of the interesting content that we spotted around the internet:   News & Research: - Bananas, Jesus on toast and polar bear disguises- some of the 2014 IgNobel Prizes! And since then the real Nobel Prizes have also been announced, with two prizes for Biology. The prize in Physiology or […]

October 14, 2014

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8:00 AM | Landscapes of Ladakh (2)
  Further photographs showing the varied landscapes of Ladakh, India. Photographs were taken as part of our hazards education work in the region. To see and learn more – why not come to this event at The Geological Society. (Credit: Geology for Global Development)

October 13, 2014

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11:58 AM | THE ROLE OF THE KETOGENIC DIET IN AUTISM OR WHY BACON IS YOUR FRIEND? PART 2: METABOLIC CONSIDERATIONS
Low carbohydrate diets create fuel metabolism by using fatty acids and ketones while minimizing glucose utilization. In a low carbohydrate diet the body consumes the available blood glucose and then […]
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10:57 AM | What do you call your PCR machine?
Last Friday we came across the blog of the Sauka-Spengler lab in Oxford, and noticed that their PCR machines are called Kit and Kat. This made us think- who else gives pet names to their lab equipment? We asked the twittersphere for suggestions, and collated them in the storify below. How about your lab? Share […]

October 10, 2014

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3:24 PM | EuroStemCell September 2014 Newsletter: Creative stem cells
As September comes to a close, we’ve got a newsletter packed with creativity and colour! If you are anything like us, you will be wondering how you can get yourself to Sherbrooke or Barcelona to visit the amazing public stem cell exhibits that are currently open. Or failing that, perhaps you would like to drop […]
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9:07 AM | Images of Guatemala (1) – Volcan de Fuego
Volcan de Fuego, Guatemala. Taken from the adjacent peak of Acatenango, this photograph captures ones of the many small eruptions of the volcano named Fuego (the Spanish word for fire!). Fuego, formed by the subduction of the Cocos plate beneath the Caribbean plate, is an active basaltic stratovolcano. You can read more about Fuego and […]

October 09, 2014

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2:05 PM | Risk of seizure recurrence after achieving freedom on the ketogenic diet
My most recent post on the ketogenic diet was meant to convey one possible treatment approach for those cases where seizures had not been controlled by medication. Although the ketogenic […]
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1:55 PM | A timeline of a baby’s first hour
A study carefully documents newborns’ instinctual behaviors in the first hour outside the womb, observations that paint a picture of what babies might need in the moments after birth.
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