Posts

October 29, 2014

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2:07 PM | A mechanism that allows a differentiated cell to reactivate as a stem cell revealed
The study, performed with fruit flies, describes a gene that determines whether a specialized cell conserves the capacity to become a stem cell again. Unveiling the genetic traits that favour the retention of stem cell properties is crucial for regenerative medicine. Published in Cell Reports, the article is the fruit of collaboration between researchers at […]
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11:28 AM | Barcelona BioMed Conference: Drosophila as a model in cancer (15 Jun 2015 to 17 Jun 2015)
Barcelona BioMed Conference: Drosophila as a model in cancer 15 - 17 Jun 2015 Cancer is a multi-hit process involving mutations in oncogenes and tumour suppressors, as well as interactions between the tumour cells and the surrounding normal tissue. The fruit fly, Drosophila, is an excellent, genetically-tractable system for modelling the development of cancer, due to the […]
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11:20 AM | La historia de la dieta cetogénica
Poco después del nacimiento de mi nieto se hizo evidente que él sufría de ataques convulsivos implacables. A pesar de que algo andaba definitivamente mal sus médicos de atención primaria […]

October 27, 2014

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12:03 PM | The Waisman Center and its Autism-Related Efforts
This path month I had the opportunity to visit the Waisman Center in Madison, Wisconsin in order to provide the John D. Wiley Seminar Series. I was hosted by my […]
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8:52 AM | 4 Yr PhD Programme in Developmental Mechanisms
Applications are open for the Wellcome Trust funded four year PhD programme in Developmental Mechanisms at Cambridge. We are looking for talented, motivated graduates or final year undergraduates, and are keen to attract outstanding applicants in the biological sciences, who are committed to doing a PhD. We are able to fund both EU and non-EU […]
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8:00 AM | Missing Maps – A London Event
Information about an external event that may be of interest to some of our readers: “You are warmly invited to attend the launch of the Missing Maps Project, a collaboration between the Humanitarian OpenStreetMap Team (HOT) , the British Red Cross, the American Red Cross, and Médecins Sans Frontières / Doctors Without Borders (MSF) . […]

October 26, 2014

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11:26 AM | Biology and maths partner to understand life decisions
Starting with the one fertilized egg that we all once were, embryonic development is made of cell divisions and most importantly of cell decisions. These first life decisions are the first steps of the development of various cell types, which will further divide, decide, specialize, organize, form specialized organs and ultimately an entire very complex […]

Bessonnard, S., De Mot, L., Gonze, D., Barriol, M., Dennis, C., Goldbeter, A., Dupont, G. & Chazaud, C. (2014). Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network, Development, 141 (19) 3637-3648. DOI: 10.1242/dev.109678

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October 24, 2014

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11:58 AM | Early- and late-onset complications of the ketogenic diet for intractable epilepsy
The following is an abstract of a publication dealing with the side-effects of the ketogenic diet. The reference to the article is: Kang HC, Chung DE, Kim DW, Kim HD.Early- […]
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9:20 AM | Public Engagement Officer
Department/Location: Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute Salary: £28,695-£37,394 Reference: PS03788 Closing date: 16 November 2014 Fixed-term: The funds for this post are available until 30 June 2017 in the first instance. The Stem Cell Institute is a world-leading centre of excellence in stem cell biology and regenerative medicine, supported by […]
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9:00 AM | Images of Guatemala (3) – Lahar Deposits at Fuego
Lahars at Volcan de Fuego, Guatemala. This image captures a lahar [mudflow] deposit close to Volcan de Fuego. These deposits are formed when rain mobilises ash and pyroclastic material on the volcano to form a fast moving, powerful mudflow with the ability to transport material including large boulders. As the energy dissipates, the sediment is deposited as […]

October 22, 2014

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3:11 PM | Post-doc and research assistant positions in Drosophila planar polarity
Two Wellcome Trust-funded positions are available for candidates with a background in cell and/or developmental biology to join an interdisciplinary team investigating cell signalling and coordinated cell polarisation using Drosophila epithelial development as a model system. The Strutt lab (http://www.shef.ac.uk/bms/research/strutt) studies cell signalling and coordinated cell polarisation in animal tissues via analysis of the “core” […]
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1:00 PM | There’s no need to panic about enterovirus
The enterovirus behind this year’s outbreak, EV-D68, has been around for decades and generally causes mild symptoms.

October 21, 2014

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5:33 PM | La Base Nacional de Datos para la Investigación del Autismo (NDAR): Como el Gobierno Federal Juega con Favoritos en la Investigación del Autismo
De acuerdo con su Página web (http://ndar.nih.gov/): “La Base Nacional de Datos para la Investigación del Autismo (NDAR) es un repositorio de datos de investigación financiada por el NIH que […]
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3:42 PM | Human Stem Cell research: new ethical questions?
The Ethics Session at the Company of Biologists “From Stem Cells to Human Development” workshop Last September the Company Of Biologists organized an exciting three-day dive into the biology of human stem cells and their use to study human development and regeneration (look out for the full meeting report in Development, coming soon, and Katherine […]
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1:21 PM | In Development this week (Vol. 141, Issue 21)
Here are the highlights from the new issue of Development:   Two top tips for angiogenesis The widely accepted model of angiogenic sprouting proposes that a single cell – the tip cell – is found at the leading edge of vessel sprouts. Now, Victoria Bautch and colleagues describe an alternative blood vessel topology in which […]
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7:40 AM | Postdoctoral Researcher in Skeletal Development, Disease, and Repair
  A postdoctoral research position is available in the Hilton Laboratory within the Duke Orthopaedic Cellular, Developmental, and Genome Laboratories at Duke University School of Medicine. The primary research focus of this position will utilize novel mouse genetic and surgical models to study  skeletal development, disease, and repair/regeneration with a particular emphasis on identifying underlying […]

October 20, 2014

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1:00 PM | A new set of Node postcards!
Every year we give you a chance to choose from sets of beautiful images taken by the students at the MBL Woods Hole embryology course. The most voted image then feature in the cover of Development. The images from Woods Hole are always beautiful, and to showcase them last year we produced a set of four Node […]
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12:04 PM | Part 3: Implementing the ketogenic diet
This is the last of a series of blogs written about the ketogenic diet. The first two dealt with a historical background to the diet (http://bit.ly/11Q9HWX) as well as some […]

October 19, 2014

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4:15 PM | Autism: The Truth is (not) Out There
Parents of a child affected by autism naturally want to know the cause. Autism can dramatically disrupt the typical childhood pattern of cognitive, behavioural and social development. At the most severe end, the child may require care for the rest of their lives. Even at the milder end, it may make mainstream education impossible and exclude many opportunities available to typically developing children. Any parent would hope that knowing the cause could lead to better treatment and […]

October 18, 2014

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5:42 AM | Full-term developmet of quail chick by ICSI
The eggs of domestic birds have been used in the study of developmental biology, leading to the extensive accumulation of knowledge on embryonic development. However, the early events involved in bird development, particularly the mechanism underlying fertilization, have not been elucidated in as much detail as those of other species of animals. The ooplasm in […]

Mizushima, S., Hiyama, G., Shiba, K., Inaba, K., Dohra, H., Ono, T., Shimada, K. & Sasanami, T. (2014). The birth of quail chicks after intracytoplasmic sperm injection, Development, 141 (19) 3799-3806. DOI: 10.1242/dev.111765

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5:42 AM | Full-term development of quail chick by ICSI
The eggs of domestic birds have been used in the study of developmental biology, leading to the extensive accumulation of knowledge on embryonic development. However, the early events involved in bird development, particularly the mechanism underlying fertilization, have not been elucidated in as much detail as those of other species of animals. The ooplasm in […]

October 17, 2014

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9:00 AM | Images of Guatemala (2) – Pyroclastic Flow Deposits
Pyroclastic Flow Deposits close to Volcan de Fuego, Guatemala. The scale of these deposits, formed in 2012, can be seen against the scale of the person standing in the background [dark line, just above the red shrub]. Pyroclastic flows, alongside lahars, are two of the most significant and destructive volcanic hazards associated with Volcan de Fuego. […]
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12:04 AM | Postdoctoral Position in Developmental Genetics
Postdoctoral Research Position: This is a funded position in the Extavour lab at Harvard University (Departments of Organismic & Evolutionary Biology/Molecular and Cellular Biology). The project aims to understand how growth and patterning of distinct cell types are coordinated during organ development, using the Drosophila melanogaster ovary as a model. The successful candidate will participate […]

October 16, 2014

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6:19 PM | Is Axon Guidance by Attraction and Repulsion, or by a Roll of the Dice?
Attractants and repellants guide axons to their targets.  On its journey, a migrating axon may be confronted with multiple attractive and repulsive guidance cues.  This presents a conundrum. How does the axon avoid a tug-of-war between attractants and repellants?  Does the strongest cue win?  Can one cue negate the effects of another?  Can an axon switch its responsiveness to cues until they all match?  

Tang, X. & Wadsworth, W. (2014). SAX-3 (Robo) and UNC-40 (DCC) Regulate a Directional Bias for Axon Guidance in Response to Multiple Extracellular Cues, PLoS ONE, 9 (10) Other:

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9:00 AM | Event Reminder: The Lost World of Ladakh
EVENT REMINDER —- THE LOST WORLD OF LADAKH: RECLAIMING THE PAST, SUSTAINING THE FUTURE Venue: The Geological Society, Burlington House, Piccadilly, London W1J 0BG. 24 October 2014, 5.30pm – 8.30pm Tickets (£20) and Registration –  www.geolsoc.org.uk/Lost-world-of-Ladakh The Geological Society recently co-organised an international conference in Leh, the capital of the historic Himalayan kingdom of Ladakh. Sustainable […]

October 15, 2014

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10:33 PM | Gone Fishing. Zebrafish Meeting 2014, Madison, WI.
“In scientific thinking are always present elements of poetry. Science and music requires a thought homogeneous.” ~Albert Einstein. This year the biannual Zebrafish meeting started out in the best possible fashion, combining music with science. The exceptionally talented organist Dr. Graham Lieschke performed three pieces composed by Bach, and Overture Hall never sounded better! Having […]
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6:49 PM | A Random Walk into the Genetics of Axon Guidance
The man claimed he was a wizard and had cast the “spell of attraction” on the target.  Now the target would guide his arrow to the mark.  So we gave the man a broken arrow and watched to see if this arrow could hit the target.  The man took the arrow and flung it at the target.  Indeed, this arrow too could hit the target. Credit: Nina Matthews PhotographyPerhaps we had asked the wrong question.  Instead of looking at whether the arrow made it to […]

Wadsworth, W. (2002). Moving around in a worm: netrin UNC-6 and circumferential axon guidance in C. elegans, Trends in Neurosciences, 25 (8) 423-429. DOI: 10.1016/S0166-2236(02)02206-3

Kulkarni, G., Xu, Z., Mohamed, A., Li, H., Tang, X., Limerick, G. & Wadsworth, W. (2013). Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity, Biology Open, 2 (12) 1300-1312. DOI: 10.1242/bio.20136346

Yang, Y., Lee, W., Tang, X. & Wadsworth, W. (2014). Extracellular Matrix Regulates UNC-6 (Netrin) Axon Guidance by Controlling the Direction of Intracellular UNC-40 (DCC) Outgrowth Activity, PLoS ONE, 9 (5) DOI: 10.1371/journal.pone.0097258

Xu, Z., Li, H. & Wadsworth, W. (2009). The Roles of Multiple UNC-40 (DCC) Receptor-Mediated Signals in Determining Neuronal Asymmetry Induced by the UNC-6 (Netrin) Ligand, Genetics, 183 (3) 941-949. DOI: 10.1534/genetics.109.108654

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5:28 PM | Post-doc and research associate positions in cardiovascular development
The Wythe Lab at Baylor College of Medicine favors a cross disciplinary approach to solving key problems in cardiovascular development. Rather than wed ourselves to a singular model system or technique, we attack biological questions from multiple fronts, using gold standard genetic models-such as the mouse, cutting edge imaging techniques, genome-wide analyses, and classical biochemistry. […]
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2:23 PM | Axon Guidance Meets Statistical Physics
The proposition that the response of an axon to guidance cues is a random walk provides a different perspective of axon guidance.For the most part, Biologists like deterministic models, i.e. cause and effect.  From the deterministic point-of-view, axon guidance is caused when axon outgrowth activity occurs at the site where the neuron detects an external attractive guidance cue. But what if the direction of axon outgrowth activity were to rapidly fluctuates in different […]
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2:23 PM | Random Walks, the Brain Initiative, and the Genius of Einstein's Brain
Over a four-month period in 1905, Einstein published a series of remarkable papers that changed our conception of time and space.
Even more remarkable is the instrument that enabled Einstein to unlock the mysteries of time and space.  His brain.  Credit: internetarchivebookimages
Some100 billion neurons allowed Einstein to think.  And in order to do this, the neurons in Einstein's developing brain formed a network of neural circuits.  By sending […]
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