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Posts

March 26, 2014

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9:20 AM | Stem cell-derived pancreatic cells treat diabetes in mice
Microscopic view of Islet of Langerhans in the pancreas. Beta cells in the Islets are responsible for insulin production.Sanford-Burnham Medical Research Institute (Sanford-Burnham) and UC San Diego School of Medicine researchers have shown that by encapsulating immature pancreatic cells derived from human embryonic stem cells (hESCs), and implanting them under the skin in animal models of diabetes, sufficient insulin is produced to maintain glucose levels without unwanted potential trade-offs […]

Kirk, K., Hao, E., Lahmy, R. & Itkin-Ansari, P. (2014). Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape, Stem Cell Research, DOI:

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5:59 AM | Eat More, Die Young
A new evolutionary theory in BioEssays claims that consuming a diet very low in nutrients can extend lifespan in laboratory animals, a finding which could hold clues to promoting healthier ageing in humans. Scientists have known for decades that severely restricted food intake reduces the incidence of diseases of old age, such as cancer, and increases lifespan. […]The post Eat More, Die Young appeared first on Wiley Asia Blog.

March 25, 2014

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4:30 PM | Don’t let your feelings become infected!
We’ve all heard the message that it’s better to hold your feelings in that to show it. It’s often so subtle that we don’t even know the message is being sent. You could even say that it’s often adaptive. This... Read More ›
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1:00 PM | How to help girls with Rett syndrome, and strike a blow against extremism!
Today we have a guest post by Dr Nicoletta Landsberger, Associate Professor at the University of Insubria and Principle Investigator at the San Raffaele Rett Research Center. The San Raffaele Rett Research Center is supported by the Pro Rett Ricerce … Continue reading →
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12:55 PM | The Mini-Sentinel Healthcare Surveillance Database Enhances Drug Safety
In 2008, the U.S. Food and Drug Administration (FDA) created the Mini-Sentinel healthcare surveillance system in order to satisfy Congress’ drug safety legislation. The Mini-Sentinel structure is essentially a nationwide database that traces medical products after FDA approval, according to the Regulatory Focus publication. The Food and Drug Administration Amendments Act (FDAAA) emphasized the importance ... continue reading
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9:54 AM | Challenges Facing the Pharmaceutical Industry
Date & Time: 27 March 2014 Thursday 11am EDT / 3pm UK / 11pm SGT / 4am CET Check your timezone here Registration: Sign up here About Webinar: John LaMattina, former President, Pfizer Global R&D, discusses how and why the pharma industry is devalued and distrusted. Those that attend the webinar will be entitled to […]The post Challenges Facing the Pharmaceutical Industry appeared first on Wiley Asia Blog.
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9:22 AM | New method to generate mesenchymal stem cellls from human embryonic stem cells
Advanced Cell Technology (ACT), reported today that it has discovered a new method to generate a potent and replenishable population of mesenchymal stem cells (MSCs) from human embryonic stem cells. This new and proprietary population of embryonic stem cell-derived MSCs displays potent immunomodulatory and therapeutic properties and has a greater than 30,000 fold proliferative capacity, relative to ordinary bone marrow-derived MSCs, the most commonly used source for MSCs in clinical trials.Read

Kimbrel EA, Kouris NA, Yavanian G, Chu J, Qin Y, Chan A, Singh RP, McCurdy D, Gordon L, Levinson RD & Lanza R (2014). Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties., Stem cells and development, PMID:

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9:08 AM | Adjustable scaffolds promote stem cell growth
A new scaffold material based on a biocompatible silk-alginate hydrogel, which can be made soft or stiff, could provide the just right environment to culture stem cells for regenerative medicine, say researchers at the Stanford University and Queen’s University in Canada.Widespread clinical application of stem cells  requires a robust and reliable culture system that mimics the natural microenvironment of the cell. This microenvironment provides crucial direction to the function and […]

Ziv K, Nuhn H, Ben-Haim Y, Sasportas LS, Kempen PJ, Niedringhaus TP, Hrynyk M, Sinclair R, Barron AE & Gambhir SS & (2014). A tunable silk-alginate hydrogel scaffold for stem cell culture and transplantation., Biomaterials, 35 (12) 3736-43. PMID:

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8:52 AM | Stem cell tourism takes advantage of desperate patients
Desperate patients are easy prey for clinics offering untested and possibly risky stem cell therapies, said UW-Madison law and bioethics Professor Alta Charo, who is currently studying stem cell tourism, a trend that has been on the rise in recent years.Stem cell tourism" refers to people traveling in the U.S. or other countries, in pursuit of receiving advertised stem cell therapies which purportedly treat a variety of medical conditions."The evidence for therapeutic use of stem cells is very […]

March 24, 2014

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8:03 PM | http://renalfellow.blogspot.com/2014/03/national-course-for-renal-fellows_24.html
NATIONAL COURSE FOR RENAL FELLOWS: ORIGINS OF RENAL PHYSIOLOGYPlaces are still open for the 10th running of this one week course, held annually at the Mount Desert Island Biological Laboratories near Acadia National Park, in Maine.  The course provides a one week research experience which will:Broaden your understanding of renal physiologyMake you a better renal investigatorMake you a far stronger bedside teacherMake you a better teacher of renal physiologyEnhance your clinical […]
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5:07 PM | NephMadness 2014 Part 8 - Biologics Bracket
This is a really exciting bracket and is full of new agents that will hopefully lead to major advances in our field. Acthar is the outlier here as, even though it is a peptide, it is not and antibody. For all the other agents I find it helpful to visualize what the antibody is targeting and on which cell type. Hopefully these cartoons will help. I think Rituximab and bortezomib should always go hand in hand when treating and auto- or alloimmune process as rituximab eliminates immature and […]
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5:00 PM | Quote Therapy – by Brian Tracy
“Top people have very clear goals. They know who they are and they know what they want. They write it down and they make plans for its accomplishment.” Brian Tracy
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10:54 AM | BrainStorm receives US Patent for its autologous stem cell technology
BrainStorm Cell Therapeutics announced this Monday that the U.S. Patent and Trademark Office has granted the company a key patent for its autologous stem cell technology.The patent covers BrainStorm's stem cells induced to secrete elevated levels of neurotrophic factors for the treatment of neurodegenerative diseases.Pending approval from the U.S. FDA, Brainstorm is preparing for its upcoming mid-stage Phase II trial in the United States with its NurOwn adult stem cell therapy.BrainStorm is […]
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1:13 AM | NephMadness 2014 Part 7 - Electrolyte Bracket
The electrolyte bracket contains a mixture of the old staples of nephrology mixed with some new kids on the block trying to muscle in on established territory, Vaptans vs hypertonic saline and ZS-9 vs Kayexalate. Hypertonic saline is well established and works when used correctly. In my experience inadequate monitoring and insufficient lab testing always complicates the correction of severe and acute hyponatremia. Severe hyponatremia has potentially devastating consequences and so should be […]

March 23, 2014

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5:23 PM | NephMadness 2014 Part 6 - Kidney Stone Braket
In the kidney stone bracket I think the most disappointed team must be XO inhibitors. Allopurinol has been around for a long time and is one of the mainstays of treatment for gout. More recently, febuxostat hit the scene and can also lower uric acid. The most interesting issue relating to uric acid (for me) is the evidence linking elevated uric acid with risk of developing CKD. This idea is backed by experiments in rats. Raising the uric acid level in rats can induce glomerular hypertension and […]
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6:05 AM | Charge Your Phone Battery while Walking
Let’s admit it. We always forget to recharge our mobile phones. Or we have to take the hassle of having multiple chargers at home, at work, at school and you name it. Those who would be more diligent would bring a portable battery. We always daydream if there would be any scientific approach that we […]The post Charge Your Phone Battery while Walking appeared first on Wiley Asia Blog.

March 22, 2014

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9:10 PM | Live Kidney Donation: What’s the risk?
As ESRD prevalence continues to increase, the kidney transplant list continues to grow meaning longer waiting times for deceased donor transplantation. Living donation (LD) provides the best outcomes for patients with ESRD and is considered safe for the donor when they are screened effectively. However, although we have data demonstrating low morbidity and mortality associated with living donor nephrectomy, our longer term data has traditionally been flawed. This is primarily because previous […]
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1:22 PM | NephMadness 2014 Part 5 - Renal Replacement Bracket
In the Renal Replacement bracket we see all the usual players, except for convective clearance, which is not in mainstream use in chronic dialysis units in the US. It is relatively unknown this side of the Atlantic (west of!) but online hemodiafiltration (olHDF) is used in many parts of Europe. olHDF utilizes diffusive clearance and convective clearance during a regular dialysis session. To use convective clearance or hemofiltration a different machine is required and also a large volume of […]
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10:55 AM | Stem cell memories influences their fate
Kristi S. AnsethCreditNew research suggests that human stem cells have memories. Specifically, they can remember whether they were grown on a soft bed of polyethylene glycol or on a stiff floor of polystyrene.This mechanical memory influences their fate, such as whether they will differentiate into fat or bone cells.That’s one take-home message of a presentation given last week by University of Colorado, Boulder, materials scientist Kristi S. Anseth at the American Chemical Society […]

Yang, C., Tibbitt, M., Basta, L. & Anseth, K. (2014). Mechanical memory and dosing influence stem cell fate, Nature Materials, DOI:

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10:44 AM | Induction of human embryonic and induced pluripotent stem cells into bladder cells
Eric KurzrockCreditFor the first time, researchers have managed to coax laboratory cultures of human stem cells to develop into the specialized, unique bladder cells requred to fix a patient's defective or diseased bladder.This breakthrough, developed at the UC Davis Institute for Regenerative Cures and published today in the scientific journal Stem Cells Translational Medicine, is of great importance as it provides a pathway to regenerate replacement bladder tissue for patients whose bladders […]

Osborn, S., Thangappan, R., Luria, A., Lee, J., Nolta, J. & Kurzrock, E. (2014). Induction of Human Embryonic and Induced Pluripotent Stem Cells Into Urothelium, Stem Cells Translational Medicine, DOI:

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10:13 AM | Research identifies source of hematopoietic stem cells
Matthew InlayHematopoietic stem cells (HSCs) are routinely used to treat patients with cancers and other disorders of the blood and immune system, but researchers know little about the progenitor cells that give rise to them during embryonic development.In a study appearing in Stem Cell Reports, Matthew Inlay of the Sue & Bill Gross Stem Cell Research Center, and faculty member of the Department of Molecular Biology and Biochemistry, and Stanford University colleagues created novel cell […]

Inlay, M., Serwold, T., Mosley, A., Fathman, J., Dimov, I., Seita, J. & Weissman, I. (2014). Identification of Multipotent Progenitors that Emerge Prior to Hematopoietic Stem Cells in Embryonic Development, Stem Cell Reports, DOI:

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March 21, 2014

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5:10 PM | NephMadness 2014 Part 4 - AKI Bracket
In the AKI bracket one team caught my eye, RIPC, Remote Ischemic Preconditioning. This is a procedure of inducing transient ischemia in the arm by inflating a BP cuff for 5 minutes x2 with an interim deflation for 5 minutes. This procedure was done before coronary angiography, aneurysm repair and was shown to reduce myocardial ischemia, renal injury and contrast-induced nephropathy. These procedures have a high prevalence and there are no other therapies to reduce CNI other than fluids (see ACT […]
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4:30 PM | What is the cost of your behavior?
Nothing in life comes free. Every behavior has a consequence and every penny has a price. It’s easy to go through life making decisions thinking that we’re doing what is best for us. However, in making these fleeting decisions, we... Read More ›
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1:52 PM | Understanding addiction: NIDA article highlights contribution of animal research
Professor David Jentsch is a highly respected UCLA neuroscientist who specialises in the study of addiction, one of the most widespread and serious medical problems in our society today. Sadly, by devoting his career to finding out how to better … Continue reading →
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1:35 PM | Irvine Stem Cell Treatment Center to host public seminar on stem cells
The Irvine Stem Cell Treatment Center,  located in Irvine, CA, will hold a free public seminar on the use of adult stem cells for various degenerative and inflammatory diseases. The seminar will be led by Dr. Thomas A. Gionis, Surgeon-in-Chief.The seminar will take place on March 23, 2014 at 2:00pm PSTat 3500 Barranca Parkway, Suite 315, Irvine, CA 92606.References- http://www.StemCellsUSA.net.
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1:19 PM | RSCI to begin patient-sponsored stem cell trial for Diabetes type 2
The Repair Stem Cells Institute (RSCI) announced yesterday that it will soon begin a patient-sponsored clinical trial based in the United States for the treatment of Diabetes type using adipose stem cells. The study, which meets current FDA guidelines, will be conducted during April 2014.The study is being conducted by the U.S. based company Bioheart which has assembled teams of doctors and specialists specially trained in stem cell therapies. Based on previous treatment of Type 2 diabetes […]
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12:13 PM | NephMadness 2014 part 3 - Kidney Regeneration Bracket
No summary available for this post.
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2:07 AM | Geology : 10 Reasons to Publish in Journal of Metamorphic Geology
If your research is based on Geology and you are spending enormous amount of time wondering which Geology journal would fit to your articles, we’ve got your back! Journal of Metamorphic Geology, which is published nine times a year, encompasses the entire range of metamorphic studies, from the scale of the individual crystal to that […]The post Geology : 10 Reasons to Publish in Journal of Metamorphic Geology appeared first on Wiley Asia Blog.

March 20, 2014

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11:23 PM | NephMadness 2014 Part 2 - Poisons and Toxins Bracket
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8:53 PM | Proteins that break down glucose important for iPSCs development
Hannele Ruohola-Baker, Julie Mathieu, Amy Ferreccio, Zsuzsa Agoston, Henrik Sperber, Yalan Xing.(left to right)Credit: Michael McCarthyNew research by scientists at the University of Washington shows that two proteins that control how cells break down glucose play a key role in human stem cell formation. Their findings have implications for future work in both regenerative medicine and cancer therapy.The study was led by Julie Mathieu, a postdoctoral fellow at the UW, and Wenyu […]

Mathieu et al. (2014). Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency., Cell Stem Cell, Other: 10.1016/j.stem.2014.02.012

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