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Posts

April 01, 2014

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4:00 PM | Quote Therapy – by Darren Hardy
“If you want to sail your life in a new direction, you have to first pick up the anchors of bad habits that have been weighing you down.” Darren Hardy, author of The Compound Effect
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3:54 PM | Lifeline Skin Care expands into Mexico
International Stem Cell Corporation announced today that Lifeline Skin Care, its operating subsidiary, has signed a distribution agreement with Grupo Venta Internacional (GVI), Mexico's largest distributor of aesthetic and reconstructive products.Effective immediately, Grupo Venta Internacional will offer Lifeline's stem cell skin care products to health care professionals throughout Mexico, the second largest market for aesthetic skin care in Central and South America.Read More
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3:21 PM | SR Outreach at OAVT Conference
Last month Speaking of Research (SR) committee member Michael Brunt took part in an outreach lecture at the annual Ontario Association of Veterinary Technicians (OAVT) 2014 conference. The OAVT is the largest association for veterinary technicians in Canada. Over the … Continue reading →
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12:55 PM | The Impact of Immunotherapy Trials on the Pharmaceutical Industry
Cancer treatments have often revolved around chemotherapy, surgery, and radiation regimens. However, in recent years, immunotherapy has been revolutionizing the oncology field. There are several important areas of research for immunotherapies including; cancer vaccines, monoclonal antibodies for differentiating cancer cells, and lymphokine-activated killer cell therapy. Cancer immunotherapy studies have really made headway within the healthcare ... continue reading
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8:44 AM | Cochrane Library : Electronic Mosquito Repellents have No Effect
Have you ever used electronic mosquito repellents? Are they effective? Think again. The Cochrane Collaboration reported that KLM, a major airline, withdrew selling such electronic mosquito repellents in flight. Electronic mosquito repellents neither works nor provide protection from mosquito bites that could cause malaria, according to a Cochrane Systematic Review that was produced by the […]The post Cochrane Library : Electronic Mosquito Repellents have No Effect appeared first on Wiley […]
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6:35 AM | Welcome
Welcome to MedIntellect. This will be a forum to explore and discuss new angles on old aspects of science and medicine. Every day new and exciting discoveries and technologies are being revealed that propel us further into brave new future, yet there is still so much we've not noticed from our past and present. There is a beauty in nature that you can see in the microscopic intricacies of cellular architecture and the macroscopic b [...]

March 31, 2014

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7:50 PM | Major breakthrough in stem cell manufacturing technology
Kevin ShakesheffCreditCell therapy is an exciting and rapidly developing area of medicine in which stem cells have the potential to repair human tissue and maintain organ function in chronic disease and age-related illnesses. But a major problem with translating current successful research into actual products and treatments is how to mass-produce such a complex living material.There are two distinct phases in the production of stem cell products; proliferation (making enough cells to form […]

Dixon, J., Shah, D., Rogers, C., Hall, S., Weston, N., Parmenter, C., McNally, D., Denning, C. & Shakesheff, K. (2014). Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation, Proceedings of the National Academy of Sciences, DOI:

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7:37 PM | Clinical trial shows mesenchymal stem cells are effective for treating failing hearts
Patients with severe ischemic heart disease and heart failure can benefit from a new treatment in which stem cells found in bone marrow are injected directly into the heart muscle, according to new findings presented at the American College of Cardiology's 63rd Annual Scientific Session."Our results show that this stem cell treatment is safe and it improves heart function when compared to placebo. This represents an exciting development that has the potential to benefit many […]
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7:23 PM | Preserving fertility in boys with cancer
Hooman Sadri-ArdekaniResearchers have moved a step closer to being able to preserve fertility in young boys who undergo chemotherapy and radiation treatments for cancer. The new research, published in Fertility and Sterility, the journal of the American Society for Reproductive Medicine, addresses the safety of an option scientists are developing for boys who aren't sexually mature and cannot bank sperm.Scientists aim to freeze a sample of the boys' testicular tissue so that when they reach […]

Sadri-Ardekani H, Homburg CH, van Capel TM, van den Berg H, van der Veen F, van der Schoot CE, van Pelt AM & Repping S (2014). Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study., Fertility and sterility, PMID:

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1:17 PM | Aptiv Solutions to be Acquired by ICON
Combined companies provide unrivalled capabilities for adaptive and medical device trials worldwide Reston, Virginia, 31st March, 2014 – Aptiv Solutions, a global biopharmaceutical and medical device development services company leading the design and implementation of innovative approaches that improve data quality, efficiency, and productivity of product development today announced that it has agreed, subject to ... continue reading

March 28, 2014

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5:00 PM | Dear Abby, Let’s Talk about Teen Depression
It’s been estimated that approximately 15% of adolescents experience Major Depression with an additional 10% experiencing Minor Depression (Kessler & Walters, 1998). One-third of young women and one-fifth of young men have been depressed at some time in their lives.... Read More ›
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4:08 PM | Santa Cruz Biotechnology: Dealing with Bad Behavior
The vast majority of scientists and technicians who work in animal labs have a deep regard for animal welfare. However, there remains some bad practice - Santa Cruz Biotechnology appears to be one such example. Continue reading →
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11:32 AM | 'Mini heart' organ may help return venous blood
George Washington University (GW) researcher Narine Sarvazyan, Ph.D., has invented a new organ to help return blood flow from veins lacking functional valves. A rhythmically contracting cuff made of cardiac muscle cells surrounds the vein acting as a 'mini heart' to aid blood flow through venous segments. The cuff can be made using cardiomyocytes derived from the patient's own adult stem cells, eliminating the chance of implant rejection."We are suggesting, for the first time, to use stem cells […]

Sarvazyan N (2014). Thinking Outside the Heart: Use of Engineered Cardiac Tissue for the Treatment of Chronic Deep Venous Insufficiency., Journal of cardiovascular pharmacology and therapeutics, PMID:

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March 27, 2014

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4:00 PM | Quote Therapy – by Dr. Pat Allen
“Beware of your thoughts for they become your words. Beware of your words for they become your actions. Beware of your actions for they become your habits. Beware of your habits for they become your character. Beware of your character,... Read More ›
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8:54 AM | Osteoarthritis may be treatable in five years
Professor Frank BarryResearchers in Galway predict that stem cells may be used to treat osteoarthritis withing the next five years, if the current stem cell clinical trials prove to be successful.The trials involve injecting adult stem cells derived from adipose tissue or fat into cartilage to stimulate its regeneration.Successful trialNUI Galway (NUIG) scientists, who are part of a €9 million EU-funded project, have just finished the successful phase one clinical […]
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8:40 AM | Tumor suppressor gene linked to stem cells
Just like archeologists try to decipher ancient tablets to discern their meaning, UT Southwestern Medical Center cancer biologists are working hard to decode the purpose of an ancient gene considered one of the most important in cancer research.The p53 gene appears to be involved in signaling other cells instrumental in stopping tumor development. But the p53 gene predates cancer, so researchers are uncertain what its original function is.In trying to unravel the mystery, Dr. John Abrams, […]

Wylie A, Lu WJ, D'Brot A, Buszczak M & Abrams JM (2014). p53 activity is selectively licensed in the Drosophila stem cell compartment., eLife, 3 PMID:

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March 26, 2014

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10:33 PM | NICE does faecal microbiota transplants
OK, so just for the record I'm not actually saying that NICE (the National Institute for Health and Care Excellence) actually provide faecal microbiota transplants (FMTs) as some sort of in-house service; that's not their job. But as the BBC reported (see here) they have published guidance on the use of FMT specifically with recurrent Clostridium difficile infection in mind (see here for the full guidance). And that guidance is, as was expected, positive on the use of FMTs where and […]
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9:47 AM | Verastem to present data on product candidates targeting cancer stem cells
Verastem, a company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced today that it will present data at the upcoming American Association of Cancer Research (AACR) meeting to be held April 5-9, 2014 at the San Diego Convention Center in San Diego, CA.Read More
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9:36 AM | Stem cell study on bipolar disorder offers hope for better treatments
Cells, made from the skin of people with bipolar disorderWhat makes a bipolar person, prone to manic highs and deep, depressed lows? Why does bipolar disorder run so strongly in families, even though no single gene is to blame? And why is it so hard to find new treatments for a condition that affects more than 200 million people worldwide?A new study by a research team at the University of Michigan Medical School, and fueled by the Heinz C. Prechter Bipolar Research Fund, may help scientists […]

Chen, H., DeLong, C., Bame, M., Rajapakse, I., Herron, T., McInnis, M. & O’Shea, K. (2014). Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients, Translational Psychiatry, 4 (3) DOI:

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9:20 AM | Stem cell-derived pancreatic cells treat diabetes in mice
Microscopic view of Islet of Langerhans in the pancreas. Beta cells in the Islets are responsible for insulin production.Sanford-Burnham Medical Research Institute (Sanford-Burnham) and UC San Diego School of Medicine researchers have shown that by encapsulating immature pancreatic cells derived from human embryonic stem cells (hESCs), and implanting them under the skin in animal models of diabetes, sufficient insulin is produced to maintain glucose levels without unwanted potential trade-offs […]

Kirk, K., Hao, E., Lahmy, R. & Itkin-Ansari, P. (2014). Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape, Stem Cell Research, DOI:

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5:59 AM | Eat More, Die Young
A new evolutionary theory in BioEssays claims that consuming a diet very low in nutrients can extend lifespan in laboratory animals, a finding which could hold clues to promoting healthier ageing in humans. Scientists have known for decades that severely restricted food intake reduces the incidence of diseases of old age, such as cancer, and increases lifespan. […]The post Eat More, Die Young appeared first on Wiley Asia Blog.

March 25, 2014

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4:30 PM | Don’t let your feelings become infected!
We’ve all heard the message that it’s better to hold your feelings in that to show it. It’s often so subtle that we don’t even know the message is being sent. You could even say that it’s often adaptive. This... Read More ›
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1:00 PM | How to help girls with Rett syndrome, and strike a blow against extremism!
Today we have a guest post by Dr Nicoletta Landsberger, Associate Professor at the University of Insubria and Principle Investigator at the San Raffaele Rett Research Center. The San Raffaele Rett Research Center is supported by the Pro Rett Ricerce … Continue reading →
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12:55 PM | The Mini-Sentinel Healthcare Surveillance Database Enhances Drug Safety
In 2008, the U.S. Food and Drug Administration (FDA) created the Mini-Sentinel healthcare surveillance system in order to satisfy Congress’ drug safety legislation. The Mini-Sentinel structure is essentially a nationwide database that traces medical products after FDA approval, according to the Regulatory Focus publication. The Food and Drug Administration Amendments Act (FDAAA) emphasized the importance ... continue reading
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9:54 AM | Challenges Facing the Pharmaceutical Industry
Date & Time: 27 March 2014 Thursday 11am EDT / 3pm UK / 11pm SGT / 4am CET Check your timezone here Registration: Sign up here About Webinar: John LaMattina, former President, Pfizer Global R&D, discusses how and why the pharma industry is devalued and distrusted. Those that attend the webinar will be entitled to […]The post Challenges Facing the Pharmaceutical Industry appeared first on Wiley Asia Blog.
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9:22 AM | New method to generate mesenchymal stem cellls from human embryonic stem cells
Advanced Cell Technology (ACT), reported today that it has discovered a new method to generate a potent and replenishable population of mesenchymal stem cells (MSCs) from human embryonic stem cells. This new and proprietary population of embryonic stem cell-derived MSCs displays potent immunomodulatory and therapeutic properties and has a greater than 30,000 fold proliferative capacity, relative to ordinary bone marrow-derived MSCs, the most commonly used source for MSCs in clinical trials.Read

Kimbrel EA, Kouris NA, Yavanian G, Chu J, Qin Y, Chan A, Singh RP, McCurdy D, Gordon L, Levinson RD & Lanza R (2014). Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties., Stem cells and development, PMID:

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9:08 AM | Adjustable scaffolds promote stem cell growth
A new scaffold material based on a biocompatible silk-alginate hydrogel, which can be made soft or stiff, could provide the just right environment to culture stem cells for regenerative medicine, say researchers at the Stanford University and Queen’s University in Canada.Widespread clinical application of stem cells  requires a robust and reliable culture system that mimics the natural microenvironment of the cell. This microenvironment provides crucial direction to the function and […]

Ziv K, Nuhn H, Ben-Haim Y, Sasportas LS, Kempen PJ, Niedringhaus TP, Hrynyk M, Sinclair R, Barron AE & Gambhir SS & (2014). A tunable silk-alginate hydrogel scaffold for stem cell culture and transplantation., Biomaterials, 35 (12) 3736-43. PMID:

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8:52 AM | Stem cell tourism takes advantage of desperate patients
Desperate patients are easy prey for clinics offering untested and possibly risky stem cell therapies, said UW-Madison law and bioethics Professor Alta Charo, who is currently studying stem cell tourism, a trend that has been on the rise in recent years.Stem cell tourism" refers to people traveling in the U.S. or other countries, in pursuit of receiving advertised stem cell therapies which purportedly treat a variety of medical conditions."The evidence for therapeutic use of stem cells is very […]

March 24, 2014

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8:03 PM | http://renalfellow.blogspot.com/2014/03/national-course-for-renal-fellows_24.html
NATIONAL COURSE FOR RENAL FELLOWS: ORIGINS OF RENAL PHYSIOLOGYPlaces are still open for the 10th running of this one week course, held annually at the Mount Desert Island Biological Laboratories near Acadia National Park, in Maine.  The course provides a one week research experience which will:Broaden your understanding of renal physiologyMake you a better renal investigatorMake you a far stronger bedside teacherMake you a better teacher of renal physiologyEnhance your clinical […]
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5:07 PM | NephMadness 2014 Part 8 - Biologics Bracket
This is a really exciting bracket and is full of new agents that will hopefully lead to major advances in our field. Acthar is the outlier here as, even though it is a peptide, it is not and antibody. For all the other agents I find it helpful to visualize what the antibody is targeting and on which cell type. Hopefully these cartoons will help. I think Rituximab and bortezomib should always go hand in hand when treating and auto- or alloimmune process as rituximab eliminates immature and […]
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