Posts

August 08, 2014

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2:44 PM | Responsible Antibody Production
Antibodies Part 2 (read Part 1 here) As noted in our previous post, there are many promising uses for antibodies. Therefore, it is no wonder that antibody production is big business. The Scientist reported that revenues from antibody sales were … Continue reading →
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1:29 PM | Medical Device Industry News Video Roundup – July 2014
Welcome to the Aptiv Solutions medical device news roundup for July 2014! We’ve gathered ten news stories offering information that may just help your company prosper. Coming up in this roundup: the medical device sector continues to evolve across the globe and over a variety of medical conditions. Outsourcing specific aspects of medical device trials ... continue reading
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12:10 PM | Dramatic Growth of Grafted Induced Pluripotent Stem Cells in Rat Spinal Cord Injuries
Building upon previous research, researchers at the University of California, San Diego School of Medicine and Veteran's Affairs San Diego Healthcare System report that neurons derived from human induced pluripotent stem cells (iPSCs) and grafted into rats after a spinal cord injury produced cells with tens of thousands of axons extending virtually the entire length of the animals' central nervous system.Leading author Paul Lu, PhD, of the UC San Diego Department of Neurosciences said the human […]
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12:00 PM | Researchers Uncover Stem Cell Behaviour of Human Bowel
For the first time, researchers say they have uncovered new information on how stem cells in the human bowel behave, revealing vital clues about the earliest stages in bowel cancer development and how we may begin to prevent it.The research, led by Queen May University of London (QMUL) and published yesterday the journal Cell Reports, discovered how many stem cells exist within the human bowel and how they behave and evolve over time.Read More

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon (2014). Ann-Marie Baker, Biancastella Cereser, Samuel Melton, Alexander G. Fletcher, Manuel Rodriguez-Justo, Paul J. Tadrous, Adam Humphries, George Elia, Stuart A.C. McDonald, Nicholas A. Wright, Benjamin D. Simons, Marnix Jansen, Trevor A. Graham., Cell Reports, Other:

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August 07, 2014

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5:04 PM | Researchers Grow Human Gastrointestinal Cells Using Epithelial Stem Cells
Kelli L. VanDussen, PhD, and Matthew A. CiorbaA method of growing human cells from tissue removed from a patient's gastrointestinal (GI) tract may one day help scientists develop tailor-made therapies for inflammatory bowel disease and other GI-related conditions.Reporting online recently in the journal Gut, researchers from the Washington University School of Medicine in St. Louis said they have made cell lines from individual patients in as little as two weeks.They have created more than 65 […]

VanDussen, K., Marinshaw, J., Shaikh, N., Miyoshi, H., Moon, C., Tarr, P., Ciorba, M. & Stappenbeck, T. (2014). Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays, Gut, DOI: 10.1136/gutjnl-2013-306651

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4:52 PM | Harvard Researchers Identify New Potential Treatment for Amyotrophic Lateral Sclerosis
This image depicts graduate student Sophie De Boer, (left), and Prof. Kevin Eggan (right) discussing their latest work.Credit: B. D. Colen/Harvard UniversityAbout eight years ago, researchers at the Harvard Stem Cell Institute (HSCI) begun a series of studies that led to a report published today which may be a major step forward in thequest to developing real treatments for amyotrophic lateral sclerosis (ALS).The findings by Harvard professor of Stem Cell and Regenerative Biology (HSCRB) Kevin […]

de Boer, A., Koszka, K., Kiskinis, E., Suzuki, N., Davis-Dusenbery, B. & Eggan, K. (2014). Genetic validation of a therapeutic target in a mouse model of ALS, Science Translational Medicine, 6 (248) 248-248. DOI: 10.1126/scitranslmed.3009351

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4:47 PM | Pregnancy Kits to Ebola Treatment: Medical Tests & Disease Treatments Depend on Animal Products
Antibodies Part 1 There has been considerable discussion on this website about the use of animal studies to develop new medical treatments. But some animal-derived products such as antibodies also play a crucial role in diagnostic tests for some diseases … Continue reading →
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3:30 AM | How to Re-wire Your Brain to Become More Creative
There are a few things that you could start doing right now to instantly improve your brain’s performance and get you off to a flying start. Let’s  call  them  Brain  Optimization Tips,  or  BOPs for short. You  can follow these  simple suggestions to get  your brain firing on all cylinders each and every day. Here […] The post How to Re-wire Your Brain to Become More Creative appeared first on Wiley Asia Blog.

August 06, 2014

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8:05 PM | Cytori Halts Stem Cell Trials Due to Adverse Effects
Cytori Therapeutics announced yesterday that it has halted trials of its experimental stem cell therapy for heart failure after three patients developed blood flow problems. The San Diego-based company said it placed the hold on two studies after the patients developed problems with blood flow to the brain. Two of the patients' symptoms resolved in a short period of time and a third was still recovering, the company said in a statement.Cytori said it is working with the Food and Drug […]
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7:57 PM | Researchers Correct Beta-Thalassemia Mutations Using Induced Pluripotent Stem Cells
This image depicts blood cells with corrected HBB mutationsderived from induced pluripotent stem cells.Credit: courtesy of Fei Xie, University of California, San Francisco.A major hurdle in gene therapy is the efficient integration of a corrected gene into a patient's genome without mutating off-target sites. In a new study published by Genome Research, researchers have used CRISPR/Cas genome editing technology to seamlessly and efficiently correct disease-causing mutations in cells from […]
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7:45 PM | Molecular Competition Drives Adult Stem Cells to Specialize
All adult organisms ranging from fruit flies to humans harbor adult stem cells, some of which renew themselves through cell division while others differentiate into the specialized cells needed to replace worn-out or damaged organs and tissues.Understanding the molecular mechanisms that control the balance between self-renewal and differentiation in adult stem cells is an important foundation for developing therapies to regenerate diseased, injured or aged tissue.Now, in the latest issue of the […]

August 05, 2014

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4:36 PM | ISCO Launches Stroke Program With Tulane University
International Stem Cell Corporation (ISCO), a California-based biotechnology company developing stem cell based therapies, announced today that it has launched a new Stroke Program. Together with Tulane University, ISCO will study the impact of human parthenogenetic neural stem cells (hpNSC) transplantation in a pre-clinical rodent model of ischemic stroke as a first step toward the clinical development of a potential stroke treatment. The proof-of-concept study will be done in the laboratory […]
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4:30 PM | Quote Therapy – by Confucius
“It does not matter how slowly you go as long as you do not stop.” Confucius
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4:27 PM | Implanted Neurons Derived from Skin Become Part of the Brain
Researchers at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have grafted neurons reprogrammed from skin cells into the brains of mice for the first time with long-term stability. Six months after implantation, the neurons had become fully functionally integrated into the brain.This successful, lastingly stable, implantation of neurons raises hope for future therapies that will replace sick neurons with healthy ones in the brains of Parkinson's disease […]
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4:17 PM | Frankfurt-Based Researchers Discover Weakness of Leukemic Stem Cells
Despite improvements in therapy, only one out of every two adult patients survive acute myeloid leukaemia (AML). The mean survival time for this disease, which predominantly occurs in the elderly, is less than a year for patients over 65 years. It is assumed that leukaemic stem cells, which cannot be completely eliminated during treatment, are the origin of relapse. However, as has been discovered by a team of Frankfurt-based researchers, these cells do have a weakness: In the current […]
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2:27 PM | Behaviourists Defend Basic Science
Basic science is the foundation of all applied science. Because we cannot predict which basic science projects will turn into an application, we must cast a wide net Continue reading →
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2:17 AM | Celebrating World Class Research from Japan
To celebrate the contribution of Japanese research in the field of molecular biology, EMBO Press has gathered a collection of world-class papers from Japanese authors submitted to its four journals: The EMBO Journal, EMBO Reports, Molecular Systems Biology and EMBO Molecular Medicine. The papers in the new collection ‘Spotlight on Japan’ have been specially selected […] The post Celebrating World Class Research from Japan appeared first on Wiley Asia Blog.

August 04, 2014

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1:44 PM | The FDA to Hold a Public Workshop on Next Generation Sequencing Standards
The FDA has announced it will hold a public workshop for Next Generation Sequencing Standards on September 24 and 25. The workshop organizer, FDA’s Genomic Working Group, consists of experts in high throughput sequencing technology application and bioinformatics relevance. The group’s goal is to develop the IT infrastructure, material and data standards, and analytic approaches ... continue reading
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1:16 PM | Knowing what to keep and what to trash: How the Dis3l2 protein distinguishes cellular messages
Every once in a while, we are forced to sort that stack of papers on the kitchen counter. Interspersed between the expired coupons and dozens of takeout menus are important documents like your car insurance or electric bill. So it isn't an option to simply drop it all in the trash at once – you need to read through the messages to be sure that you don't lose vital information.In the cell, proteins similarly read through messages to distinguish what needs to be saved and what needs to be […]
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1:07 PM | Coxsackie Virus Depletes Cardiac Stem Cells
There is epidemiological evidence that links type B coxsackie virus (CVB) infection with heart disease, and research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress at later stages of life.CVB infection is very common and affects mostly children. The symptoms range widely: over half of the infections are thought to be asymptomatic, the majority of children who get sick have only a mild fever, and a very […]

Sin, J., Puccini, J., Huang, C., Konstandin, M., Gilbert, P., Sussman, M., Gottlieb, R. & Feuer, R. (2014). The Impact of Juvenile Coxsackievirus Infection on Cardiac Progenitor Cells and Postnatal Heart Development, PLoS Pathogens, 10 (7) DOI: 10.1371/journal.ppat.1004249

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10:09 AM | Antibiotic Overuse : How can It Affect Us?
We have learnt the term antibiotic since 1942. We might not have thought that there would be time to seriously discuss about overuse of antibiotic as some resources suggest that antibiotic overuse could be lethal. We like to shed some light on this topic by compiling some interesting research on antibiotic overuse. High Antibiotic Consumption […] The post Antibiotic Overuse : How can It Affect Us? appeared first on Wiley Asia Blog.
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1:11 AM | Spironolactone Revisited
As a renal fellow, I have found myself reaching for spironolactone more and more. It is very helpful when treating the patient with resistant hypertension, but it continues to be under-utilized. Aside from the renal-centric effects of aldosterone, there is evidence that mineralocorticoid receptor activation is responsible for pathogenic remodeling (both structural and electrical) after myocardial infarction. In fact, aldosterone is also produced by the heart, and cardiac expression of the […]

August 03, 2014

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2:00 PM | Harlow Dead, Bioethicists Outraged
The philosophy and bioethics community was rocked and in turmoil Friday when they learned that groundbreaking experimental psychologist Professor Harry Harlow had died over 30 years ago. Harlow’s iconic studies of mother and infant monkeys have endured for decades as … Continue reading →
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8:53 AM | Do people love Wiley’s Anywhere Article?
We have once blogged about Anywhere Article launched across Wiley Online Library. In case you have not experimented it, here a video that sums up how Anywhere Article actually looks like on various devices. What do you think people would talk about Anywhere Article after they have used it? Find out by watching the video […] The post Do people love Wiley’s Anywhere Article? appeared first on Wiley Asia Blog.

August 02, 2014

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1:47 AM | Virtual Issue: (Post-) Developmental Urbanism in Japan and Korea
This virtual issue is composed of 10 articles on urban and regional development in Japan and Korea, published in IJURR International Journal of Urban and Regional Research, over the past three decades. The processes of urbanization in Japan and Korea are distinctive in the sense that they have been deeply connected to the developmentalist efforts […] The post Virtual Issue: (Post-) Developmental Urbanism in Japan and Korea appeared first on Wiley Asia Blog.

August 01, 2014

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6:36 PM | UCSF Scientist Discovers Key to Immune System Aging
Emmanuelle Passegué, PhDThere's a good reason people over the age of sixty are not donor candidates for bone marrow transplantation. The immune system ages and weakens with time, making the elderly prone to life-threatening infection and other maladies, and a UC San Francisco research team now has discovered a reason why."We have found the cellular mechanism responsible for the inability of blood-forming cells to maintain blood production over time in an old organism, and have identified […]
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4:30 PM | Are You Happy with Your Life?
Are You Happy with Your Life? [Article via Psychology Today. Click above for full post] Have you ever created a goal, reached it, became content, and then went looking for the next best thing? It’s interesting to see how quickly... Read More ›
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1:45 PM | Tweet for Science!
We have written thousands of tweets about animal research since we opened our accounts a little over five years ago. Now we want you to help us spread our Twitter messages. We have created a list of short, tweet-able, facts … Continue reading →
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8:44 AM | Prepare the Best Answers to Tough Interview Questions
In today’s competitive job market, a stellar interview lends you an edge over the competition, which can make or break your chances at a new career. Business psychologist and interview expert Rob Yeung provides you with proven strategies to making your honest answers sound great and your best answer sound honest. Responding to Questions for […] The post Prepare the Best Answers to Tough Interview Questions appeared first on Wiley Asia Blog.

July 31, 2014

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7:16 AM | Livestock and Food Security: How to Feed 10.6 Billion People in 2050?
We have kind of heard or read somewhere that total population on earth is expected to hit 10.6 billion by 2050? But did you know that we need to increase food production by 70% to cater to a population of 9 billion people? While animal products account for about one-third of our protein consumption globally, […] The post Livestock and Food Security: How to Feed 10.6 Billion People in 2050? appeared first on Wiley Asia Blog.
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