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April 12, 2014

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2:39 AM | The Eventual Millionaire: How Anyone Can Be an Entrepreneur and Successfully Grow Their Startup
For many people, starting a business is one of the best ways to achieve both wealth and the personal goals that they have set for themselves. Many people want to become entrepreneurs at some point, but lack confidence in their ability to run a business. The truth is, though, that anyone can start their own […]The post The Eventual Millionaire: How Anyone Can Be an Entrepreneur and Successfully Grow Their Startup appeared first on Wiley Asia Blog.

April 11, 2014

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2:52 PM | BrainStorm granted additional patent for its autologous stem cell technology
BrainStorm Cell Therapeutics, a developer of adult stem cell technologies for neurodegenerative diseases, today announced that the U.S. Patent and Trademark Office has granted the company an additional patent for its autologous stem cell technology. The patent covers the production method of the company's proprietary stem cells induced to secrete significantly elevated levels of neurotrophic factors for the treatment of neurodegenerative diseases.Read More
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2:46 PM | Yale researchers search for earliest roots of psychiatric disorders
Credit: Michael HelfenbeinNewborns whose mothers were exposed during pregnancy to any one of a variety of environmental stressors -- such as trauma, illness, and alcohol or drug abuse -- become susceptible to various psychiatric disorders that frequently arise later in life. However, it has been unclear how these stressors affect the cells of the developing brain prenatally and give rise to conditions such as schizophrenia, post-traumatic stress disorder, and some forms of autism and bipolar […]

Hashimoto-Torii, K., Torii, M., Fujimoto, M., Nakai, A., El Fatimy, R., Mezger, V., Ju, M., Ishii, S., Chao, S., Brennand, K. & Gage, F. (2014). Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders, Neuron, DOI:

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2:36 PM | Researchers identify transcription factors distinguishing glioblastoma stem cells
The activity of four transcription factors – proteins that regulate the expression of other genes – appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics – processes […]

Suvà, M., Rheinbay, E., Gillespie, S., Patel, A., Wakimoto, H., Rabkin, S., Riggi, N., Chi, A., Cahill, D., Nahed, B. & Curry, W. (2014). Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells, Cell, DOI:

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2:28 PM | Background Briefing on Animal Research in Canada
Background briefing on the facts of animal research in Canada Continue reading →

April 10, 2014

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5:00 PM | Quote Therapy – by Robert Herjavec
“The best way to get past doubt and inexperience is simply action.” Robert Herjavec
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2:33 PM | SYR: Why I Became a Biologist
After a relative died from measles, I discovered my purpose - to become a biologist and fight disease Continue reading →
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12:54 PM | Mobile Medical Device Poll Describes Efficiency Gains By Practitioners
A recent MedData Point poll concerning mobile health adoption amongst practitioners reveals several insights of interest to medical device manufacturers – especially those operating in the software app segment of the industry. The survey, which was conducted by the MedData Group, contacted 141 physicians from a variety of different backgrounds in order to get their ... continue reading
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3:04 AM | Transplant Drugs May Help Wipe Out Persistent HIV Infections
New research suggests that drugs commonly used to prevent organ rejection after transplantation may also be helpful for combating HIV. The findings, which are published in the American Journal of Transplantation, suggest a new strategy in the fight against HIV and AIDS. Despite the effectiveness of antiviral therapies at suppressing HIV, the virus still persists indefinitely […]The post Transplant Drugs May Help Wipe Out Persistent HIV Infections appeared first on Wiley Asia Blog.

April 09, 2014

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7:13 PM | Mesenchymal stem cells show promise in stroke treatment
Neurologist Dr. Steven CramerIn an analysis of published research, neurologist Dr. Steven Cramer and biomedical engineer Weian Zhao identified 46 studies that examined the use of mesenchymal stromal cells -- a type of multipotent adult stem cells mostly processed from bone marrow -- in animal models of stroke. They found mesenchymal stem cells (MSCs) to be significantly better than control therapy in 44 of the studies.Importantly, the effects of these cells on functional recovery were robust […]

Vu Q, Xie K, Eckert M, Zhao W & Cramer SC (2014). Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke., Neurology, 82 (14) 1277-86. PMID:

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7:04 PM | Solving platelet 'puzzle' unveils blood disorder link
Dr Ashley Ng Melbourne researchers have solved a puzzle as to how an essential blood-making hormone stimulates production of the blood clotting cells known as platelets.Platelets are small, disc shaped clear cell fragments which are essential for stopping bleeding. They are produced by their ‘parent’ cells, called megakaryocytes.The discovery, made by scientists at the Walter and Eliza Hall Institute, identified how bone marrow cells could become overstimulated and produce too […]

Ng, A., Kauppi, M., Metcalf, D., Hyland, C., Josefsson, E., Lebois, M., Zhang, J., Baldwin, T., Di Rago, L., Hilton, D. & Alexander, W. (2014). Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation, Proceedings of the National Academy of Sciences, DOI:

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5:00 PM | The 5 Stages of Change: Are You Ready to Change?
Do I need to start drinking less or am I actually ok with my current amount? I need to drink less, but not sure how. Ok I definitely need to drink less, but now I just have to lay everything... Read More ›

April 08, 2014

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4:00 PM | Quote Therapy – by Thomas Szasz
“People often say that this person is or that person has not yet found himself. But the self is not something that one finds. It is something one creates.” Thomas Szasz
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12:55 PM | FDA Advises Manufacturers on Off-label Use within Scientific and Medical Literature
In February 2014, the U.S. Food and Drug Administration (FDA) published a new guidance advising drug and medical device manufacturers on best practices of distributing product information to healthcare professionals. The “Distributing Scientific and Medical Publications on Unapproved New Uses – Recommended Practices” guidance discusses the FDA’s position on disseminating scientific and medical reference texts ... continue reading
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12:00 PM | Pictures in need of accurate words: University of Florida animal photos
Pictures from labs are often used out of context to criticise animal research - make you sure your pictures keep their context Continue reading →
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1:25 AM | Special Issue: Ecology of Freshwater Fish
Freshwater habitats play an important role in fundamental ecosystem functions and services, besides sustaining an overwhelming diversity of species. Ecology of Freshwater Fish  publishes original articles on all aspects of fish ecology and fishery sciences in lakes, rivers and estuaries. The journal also includes ecologically oriented studies of behaviour, genetics and physiology, as well as […]The post Special Issue: Ecology of Freshwater Fish appeared first on Wiley Asia Blog.

April 07, 2014

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10:19 PM | The use of Rituximab in Kidney Disease
Rituximab, the monoclonal chimeric anti-CD20 antibody, is an effective B-Cell depleting agent and continues to gather data for its use in a wide range of conditions relevant for the Nephrologist. It was also a pre-season favourite in the recent NephMadness event run by our friends at eAJKD, so I figured a quick recap was timely. As the literature is vast and grows by the week, I will only give a brief review on the current data, much of which is weak consisting of small observational reports. […]

April 05, 2014

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4:10 PM | U.Va. researchers turn embryonic stem cells into a fish embryo
The U.Va. researchers have created a zebrafish embryo using stem cells.Researchers at the University of Virginia School of Medicine have overcome one of the greatest challenges in biology and taken a major step toward being able to grow whole organs and tissues from stem cells.By manipulating the appropriate signaling, the U.Va. researchers have turned embryonic stem cells into a fish embryo, essentially controlling embryonic development.The research will have dramatic impact on the future use […]

Xu, P., Houssin, N., Ferri-Lagneau, K., Thisse, B. & Thisse, C. (2014). Construction of a Vertebrate Embryo from Two Opposing Morphogen Gradients, Science, 344 (6179) 87-89. DOI:

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3:50 PM | Light-activated neurons from stem cells restore function in paralyzed mice
A new method to artificially control muscles using light, with the potential to restore function to muscles paralyzed by conditions such as motor neuron disease and spinal cord injury, has been developed by scientists at UCL and King's College London.The technique involves transplanting specially-designed motor neurons created from stem cells into injured nerve branches. These motor neurons are designed to react to pulses of blue light, allowing scientists to fine-tune muscle control by […]

Bryson, J., Machado, C., Crossley, M., Stevenson, D., Bros-Facer, V., Burrone, J., Greensmith, L. & Lieberam, I. (2014). Optical Control of Muscle Function by Transplantation of Stem Cell-Derived Motor Neurons in Mice, Science, 344 (6179) 94-97. DOI:

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April 04, 2014

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10:10 PM | Perils of Estimating GFR in Patients with Cirrhosis
In my attempt to highlight nephrology content in non-renal journals I will this month focus on a series of articles in Hepatologyconcerning eGFR in cirrhotic patients. We are all aware of the concerns using creatinine-based tools for estimating GFR in this patient cohort given their malnourished, low muscle-mass state. The use of Cystatin-C based equations may theoretically be more informative as this protein is not influenced to the same degree by non-renal factors. However, Cystatin-C is far […]
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12:36 PM | Evidence indicates that VSELs from human adult tissues are multipotent
Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two new papers published in Stem Cells and Development, a peer-reviewed […]

Havens A.M., Sun H., Shiozawa Y., Jung Y., Wang J., Mishra A., Jiang Y., O'Neill D.W., Krebsbach P.H. & Rodgerson D.O. & (2014). Human and Murine Very Small Embryonic-Like Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo, Stem Cells and Development, 23 (7) 689-701. DOI:

Suszynska M., Zuba-Surma E.K., Maj M., Mierzejewska K., Ratajczak J., Kucia M. & Ratajczak M.Z. (2014). The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells, and Some Nomenclature Issues, Stem Cells and Development, 23 (7) 702-713. DOI:

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12:22 PM | New hope for the treatment of Amyotrophic lateral sclerosis
Kevin EgganHarvard stem cell researchers have discovered that a recently approved medication for epilepsy might be a meaningful treatment for patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital (MGH) to design an initial clinical trial testing the safety of the treatment in ALS patients.The investigators all caution that a great […]

Wainger B., Kiskinis E., Mellin C., Wiskow O., Han S.W., Sandoe J., Perez N., Williams L., Lee S. & Boulting G. & (2014). Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons, Cell Reports, DOI:

Kiskinis E., Sandoe J., Williams L., Boulting G., Moccia R., Wainger B., Han S., Peng T., Thams S. & Mikkilineni S. & (2014). Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1, Cell Stem Cell, DOI:

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12:09 PM | Cell-surface receptor offers promising breakthrough for patients with pancreatic cancer
Liang XuCreditPancreatic cancer rates in the U.S. have been on the rise over the past decade, and the disease takes a very heavy toll. The American Cancer Society estimates that in the last year alone about 45,220 people were diagnosed with pancreatic cancer, while 38,460 died of the illness.Numbers like this are of course discouraging. However, a researcher at the University of Kansas is striving to develop new hope for pancreatic cancer patients.Liang Xu, Ph.D. member of the KU Cancer […]

Li L., Hao X., Qin J., Tang W., He F., Smith A., Zhang M., Simeone D.M., Qiao X.T. & Chen Z.N. & (2014). Antibody Against CD44s Inhibits Pancreatic Tumor Initiation and Postradiation Recurrence in Mice, Gastroenterology, 146 (4) 1108-1118.e12. DOI:

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11:55 AM | Video Podcast on Streamlining Endpoint Adjudication
Centralized endpoint adjudication is becoming increasingly important from a regulatory perspective, with both the FDA and the EMA providing commentary and guidelines in recent years. Understanding the advantages of centralized endpoint adjudication in a clinical trial, as well as the potential offered by software such as Aptiv Solutions AptivEndpointTM in combination with a central Endpoint ... continue reading
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2:21 AM | Quiz : How much do you know about Wiley Open Access?
“The open access landscape is continuing to expand: at the time of writing, the Directory of Open Access Journals contains 7,200 journals and 626,000 articles. 1,310 journals have been added in the first ten months of 2011, an average of 131 per month – an 11% growth rate on 2010.”, reported by our Wiley Exchange […]The post Quiz : How much do you know about Wiley Open Access? appeared first on Wiley Asia Blog.

April 03, 2014

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1:45 PM | What do Aliens, ADRs and Animal Tests have in common?
Many activists believe climate change scientists but not animal researchers. What is behind support and mistrust of science? Continue reading →
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12:55 PM | FDA Releases Draft Guidance Concerning Distribution of Off-Label Medical Device Data
Unapproved or off-label use of medical devices is an issue that manufacturers must face with a carefully-planned strategy in order to avoid running afoul of FDA regulations. In an effort to make sure that companies don’t stray too far when discussing off-label use with physicians and other healthcare professionals, the FDA has released a new draft guidance ... continue reading

April 02, 2014

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10:02 AM | The ICECReam Guruview: Lorimer Moseley
We haven’t done one of these for a while. Here we ask an established researcher for their thoughts on the biz.   Lorimer Moseley will be name familiar to many of you in the pain and/or physiotherapy research field. His research is all about understanding the role of the brain and mind complex and chronic […]
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8:28 AM | Wiley celebrates World Autism Awareness Day
The seventh annual World Autism Awareness Day (WAAD) is April 2, 2014. The goal of WAAD is to raise awareness of an “invisible” disability, and thankfully, awareness of Autism and related disorders has increased dramatically over the last 25 years. To celebrate World Autism Awareness Day, Wiley published a virtual issue containing some of the […]The post Wiley celebrates World Autism Awareness Day appeared first on Wiley Asia Blog.
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2:51 AM | Shunichi Fukuzami’s Secret to Publishing Many High-Quality Papers
Professor Shunichi Fukuzumi of Osaka University, who has published more than 25 articles since 2000 in Angewandte Chemie, was presented in Angewandte Author Profile. He addressed some questions on his career and high-quality papers. When he was asked to elaborate the differences of current chemistry research and that of at the beginning of his career, […]The post Shunichi Fukuzami’s Secret to Publishing Many High-Quality Papers appeared first on Wiley Asia Blog.
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