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Posts

April 04, 2014

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11:55 AM | Video Podcast on Streamlining Endpoint Adjudication
Centralized endpoint adjudication is becoming increasingly important from a regulatory perspective, with both the FDA and the EMA providing commentary and guidelines in recent years. Understanding the advantages of centralized endpoint adjudication in a clinical trial, as well as the potential offered by software such as Aptiv Solutions AptivEndpointTM in combination with a central Endpoint ... continue reading
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2:21 AM | Quiz : How much do you know about Wiley Open Access?
“The open access landscape is continuing to expand: at the time of writing, the Directory of Open Access Journals contains 7,200 journals and 626,000 articles. 1,310 journals have been added in the first ten months of 2011, an average of 131 per month – an 11% growth rate on 2010.”, reported by our Wiley Exchange […]The post Quiz : How much do you know about Wiley Open Access? appeared first on Wiley Asia Blog.

April 03, 2014

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1:45 PM | What do Aliens, ADRs and Animal Tests have in common?
Many activists believe climate change scientists but not animal researchers. What is behind support and mistrust of science? Continue reading →
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12:55 PM | FDA Releases Draft Guidance Concerning Distribution of Off-Label Medical Device Data
Unapproved or off-label use of medical devices is an issue that manufacturers must face with a carefully-planned strategy in order to avoid running afoul of FDA regulations. In an effort to make sure that companies don’t stray too far when discussing off-label use with physicians and other healthcare professionals, the FDA has released a new draft guidance ... continue reading

April 02, 2014

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10:02 AM | The ICECReam Guruview: Lorimer Moseley
We haven’t done one of these for a while. Here we ask an established researcher for their thoughts on the biz.   Lorimer Moseley will be name familiar to many of you in the pain and/or physiotherapy research field. His research is all about understanding the role of the brain and mind complex and chronic […]
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8:28 AM | Wiley celebrates World Autism Awareness Day
The seventh annual World Autism Awareness Day (WAAD) is April 2, 2014. The goal of WAAD is to raise awareness of an “invisible” disability, and thankfully, awareness of Autism and related disorders has increased dramatically over the last 25 years. To celebrate World Autism Awareness Day, Wiley published a virtual issue containing some of the […]The post Wiley celebrates World Autism Awareness Day appeared first on Wiley Asia Blog.
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2:51 AM | Shunichi Fukuzami’s Secret to Publishing Many High-Quality Papers
Professor Shunichi Fukuzumi of Osaka University, who has published more than 25 articles since 2000 in Angewandte Chemie, was presented in Angewandte Author Profile. He addressed some questions on his career and high-quality papers. When he was asked to elaborate the differences of current chemistry research and that of at the beginning of his career, […]The post Shunichi Fukuzami’s Secret to Publishing Many High-Quality Papers appeared first on Wiley Asia Blog.

April 01, 2014

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4:22 PM | Researchers find a better way to grow motor neurons from stem cells
Prof Fei Wang (left), scholar Qiuhao Qu (center)  andengineering professor Jianjun ChengResearchers reported today that they can generate human motor neurons from stem cells much more quickly and efficiently than previous methods allowed.The finding, described in Nature Communications, will aid efforts to model human motor neuron development, and to understand and treat spinal cord injuries and motor neuron diseases such as amyotrophic lateral sclerosis (ALS).The new method involves adding […]

Qu Q, Li D, Louis KR, Li X, Yang H, Sun Q, Crandall SR, Tsang S, Zhou J, Cox CL & Cheng J (2014). High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1., Nature communications, 5 3449. PMID:

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4:00 PM | Quote Therapy – by Darren Hardy
“If you want to sail your life in a new direction, you have to first pick up the anchors of bad habits that have been weighing you down.” Darren Hardy, author of The Compound Effect
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3:54 PM | Lifeline Skin Care expands into Mexico
International Stem Cell Corporation announced today that Lifeline Skin Care, its operating subsidiary, has signed a distribution agreement with Grupo Venta Internacional (GVI), Mexico's largest distributor of aesthetic and reconstructive products.Effective immediately, Grupo Venta Internacional will offer Lifeline's stem cell skin care products to health care professionals throughout Mexico, the second largest market for aesthetic skin care in Central and South America.Read More
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3:21 PM | SR Outreach at OAVT Conference
Last month Speaking of Research (SR) committee member Michael Brunt took part in an outreach lecture at the annual Ontario Association of Veterinary Technicians (OAVT) 2014 conference. The OAVT is the largest association for veterinary technicians in Canada. Over the … Continue reading →
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12:55 PM | The Impact of Immunotherapy Trials on the Pharmaceutical Industry
Cancer treatments have often revolved around chemotherapy, surgery, and radiation regimens. However, in recent years, immunotherapy has been revolutionizing the oncology field. There are several important areas of research for immunotherapies including; cancer vaccines, monoclonal antibodies for differentiating cancer cells, and lymphokine-activated killer cell therapy. Cancer immunotherapy studies have really made headway within the healthcare ... continue reading
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8:44 AM | Cochrane Library : Electronic Mosquito Repellents have No Effect
Have you ever used electronic mosquito repellents? Are they effective? Think again. The Cochrane Collaboration reported that KLM, a major airline, withdrew selling such electronic mosquito repellents in flight. Electronic mosquito repellents neither works nor provide protection from mosquito bites that could cause malaria, according to a Cochrane Systematic Review that was produced by the […]The post Cochrane Library : Electronic Mosquito Repellents have No Effect appeared first on Wiley […]
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6:35 AM | Welcome
Welcome to MedIntellect. This will be a forum to explore and discuss new angles on old aspects of science and medicine. Every day new and exciting discoveries and technologies are being revealed that propel us further into brave new future, yet there is still so much we've not noticed from our past and present. There is a beauty in nature that you can see in the microscopic intricacies of cellular architecture and the macroscopic b [...]

March 31, 2014

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7:50 PM | Major breakthrough in stem cell manufacturing technology
Kevin ShakesheffCreditCell therapy is an exciting and rapidly developing area of medicine in which stem cells have the potential to repair human tissue and maintain organ function in chronic disease and age-related illnesses. But a major problem with translating current successful research into actual products and treatments is how to mass-produce such a complex living material.There are two distinct phases in the production of stem cell products; proliferation (making enough cells to form […]

Dixon, J., Shah, D., Rogers, C., Hall, S., Weston, N., Parmenter, C., McNally, D., Denning, C. & Shakesheff, K. (2014). Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation, Proceedings of the National Academy of Sciences, DOI:

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7:37 PM | Clinical trial shows mesenchymal stem cells are effective for treating failing hearts
Patients with severe ischemic heart disease and heart failure can benefit from a new treatment in which stem cells found in bone marrow are injected directly into the heart muscle, according to new findings presented at the American College of Cardiology's 63rd Annual Scientific Session."Our results show that this stem cell treatment is safe and it improves heart function when compared to placebo. This represents an exciting development that has the potential to benefit many […]
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7:23 PM | Preserving fertility in boys with cancer
Hooman Sadri-ArdekaniResearchers have moved a step closer to being able to preserve fertility in young boys who undergo chemotherapy and radiation treatments for cancer. The new research, published in Fertility and Sterility, the journal of the American Society for Reproductive Medicine, addresses the safety of an option scientists are developing for boys who aren't sexually mature and cannot bank sperm.Scientists aim to freeze a sample of the boys' testicular tissue so that when they reach […]

Sadri-Ardekani H, Homburg CH, van Capel TM, van den Berg H, van der Veen F, van der Schoot CE, van Pelt AM & Repping S (2014). Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study., Fertility and sterility, PMID:

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1:17 PM | Aptiv Solutions to be Acquired by ICON
Combined companies provide unrivalled capabilities for adaptive and medical device trials worldwide Reston, Virginia, 31st March, 2014 – Aptiv Solutions, a global biopharmaceutical and medical device development services company leading the design and implementation of innovative approaches that improve data quality, efficiency, and productivity of product development today announced that it has agreed, subject to ... continue reading

March 28, 2014

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5:00 PM | Dear Abby, Let’s Talk about Teen Depression
It’s been estimated that approximately 15% of adolescents experience Major Depression with an additional 10% experiencing Minor Depression (Kessler & Walters, 1998). One-third of young women and one-fifth of young men have been depressed at some time in their lives.... Read More ›
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4:08 PM | Santa Cruz Biotechnology: Dealing with Bad Behavior
The vast majority of scientists and technicians who work in animal labs have a deep regard for animal welfare. However, there remains some bad practice - Santa Cruz Biotechnology appears to be one such example. Continue reading →
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11:32 AM | 'Mini heart' organ may help return venous blood
George Washington University (GW) researcher Narine Sarvazyan, Ph.D., has invented a new organ to help return blood flow from veins lacking functional valves. A rhythmically contracting cuff made of cardiac muscle cells surrounds the vein acting as a 'mini heart' to aid blood flow through venous segments. The cuff can be made using cardiomyocytes derived from the patient's own adult stem cells, eliminating the chance of implant rejection."We are suggesting, for the first time, to use stem cells […]

Sarvazyan N (2014). Thinking Outside the Heart: Use of Engineered Cardiac Tissue for the Treatment of Chronic Deep Venous Insufficiency., Journal of cardiovascular pharmacology and therapeutics, PMID:

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March 27, 2014

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4:00 PM | Quote Therapy – by Dr. Pat Allen
“Beware of your thoughts for they become your words. Beware of your words for they become your actions. Beware of your actions for they become your habits. Beware of your habits for they become your character. Beware of your character,... Read More ›
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8:54 AM | Osteoarthritis may be treatable in five years
Professor Frank BarryResearchers in Galway predict that stem cells may be used to treat osteoarthritis withing the next five years, if the current stem cell clinical trials prove to be successful.The trials involve injecting adult stem cells derived from adipose tissue or fat into cartilage to stimulate its regeneration.Successful trialNUI Galway (NUIG) scientists, who are part of a €9 million EU-funded project, have just finished the successful phase one clinical […]
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8:40 AM | Tumor suppressor gene linked to stem cells
Just like archeologists try to decipher ancient tablets to discern their meaning, UT Southwestern Medical Center cancer biologists are working hard to decode the purpose of an ancient gene considered one of the most important in cancer research.The p53 gene appears to be involved in signaling other cells instrumental in stopping tumor development. But the p53 gene predates cancer, so researchers are uncertain what its original function is.In trying to unravel the mystery, Dr. John Abrams, […]

Wylie A, Lu WJ, D'Brot A, Buszczak M & Abrams JM (2014). p53 activity is selectively licensed in the Drosophila stem cell compartment., eLife, 3 PMID:

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March 26, 2014

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10:33 PM | NICE does faecal microbiota transplants
OK, so just for the record I'm not actually saying that NICE (the National Institute for Health and Care Excellence) actually provide faecal microbiota transplants (FMTs) as some sort of in-house service; that's not their job. But as the BBC reported (see here) they have published guidance on the use of FMT specifically with recurrent Clostridium difficile infection in mind (see here for the full guidance). And that guidance is, as was expected, positive on the use of FMTs where and […]
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9:47 AM | Verastem to present data on product candidates targeting cancer stem cells
Verastem, a company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced today that it will present data at the upcoming American Association of Cancer Research (AACR) meeting to be held April 5-9, 2014 at the San Diego Convention Center in San Diego, CA.Read More
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9:36 AM | Stem cell study on bipolar disorder offers hope for better treatments
Cells, made from the skin of people with bipolar disorderWhat makes a bipolar person, prone to manic highs and deep, depressed lows? Why does bipolar disorder run so strongly in families, even though no single gene is to blame? And why is it so hard to find new treatments for a condition that affects more than 200 million people worldwide?A new study by a research team at the University of Michigan Medical School, and fueled by the Heinz C. Prechter Bipolar Research Fund, may help scientists […]

Chen, H., DeLong, C., Bame, M., Rajapakse, I., Herron, T., McInnis, M. & O’Shea, K. (2014). Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients, Translational Psychiatry, 4 (3) DOI:

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9:20 AM | Stem cell-derived pancreatic cells treat diabetes in mice
Microscopic view of Islet of Langerhans in the pancreas. Beta cells in the Islets are responsible for insulin production.Sanford-Burnham Medical Research Institute (Sanford-Burnham) and UC San Diego School of Medicine researchers have shown that by encapsulating immature pancreatic cells derived from human embryonic stem cells (hESCs), and implanting them under the skin in animal models of diabetes, sufficient insulin is produced to maintain glucose levels without unwanted potential trade-offs […]

Kirk, K., Hao, E., Lahmy, R. & Itkin-Ansari, P. (2014). Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape, Stem Cell Research, DOI:

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5:59 AM | Eat More, Die Young
A new evolutionary theory in BioEssays claims that consuming a diet very low in nutrients can extend lifespan in laboratory animals, a finding which could hold clues to promoting healthier ageing in humans. Scientists have known for decades that severely restricted food intake reduces the incidence of diseases of old age, such as cancer, and increases lifespan. […]The post Eat More, Die Young appeared first on Wiley Asia Blog.

March 25, 2014

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4:30 PM | Don’t let your feelings become infected!
We’ve all heard the message that it’s better to hold your feelings in that to show it. It’s often so subtle that we don’t even know the message is being sent. You could even say that it’s often adaptive. This... Read More ›
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