Posts

July 15, 2014

+
6:50 PM | Lithium and the Kidney: Old Observations & New Insights
Lithium is indispensable as an effective treatment for bipolar affective disorder. However, it has a narrow therapeutic index with desired therapeutic levels between 0.6 and 1.2 mEq/L. Lithium is handled by the kidney (responsible for almost all its excretion) in a manner very similar to sodium. It has a molecular weight of 7 daltons, has a moderate volume of distribution, is <10% protein bound and is therefore readily dialyzable. Lithium may cause of myriad of renal related toxicities, some […]
+
5:00 PM | Quote Therapy – Bishop T.D. Jakes
“Your complications are not an indication that you cannot conquer.” Bishop T.D. Jakes
+
12:55 PM | Verifying 100% of Source Data May be Unnecessary
Source data verification, or checking the original information present in electronic media, has become a controversial topic as of late. According to the Applied Clinical Trials Online publication, 84 percent of sponsors check all of their source data against case report data. Many sponsors claim that regulations require this practice, but regulatory agencies explain that ... continue reading
+
7:20 AM | Wisconsin researchers report new genetic recipe to turn stem cells to blood
Igor SlukvinA group led by University of Wisconsin-Madison stem cell researcher Igor Slukvin reported yesterday the discovery of two genetic programs responsible for taking blank-slate stem cells and turning them into both red and the array of white cells that make up human blood.The research is important because it identifies how nature itself makes blood products at the earliest stages of development. The discovery gives scientists the tools to make the cells themselves, investigate how blood […]

Irina Elcheva, Vera Brok-Volchanskaya, Akhilesh Kumar, Patricia Liu, Jeong-Hee Lee, et al. (2014). Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators., Nature Communications, Other:

Citation

July 14, 2014

+
1:23 PM | Why is alcohol research with nonhuman animals essential?
The following guest post is from Jeff Weiner, a Professor in the Department of Physiology and Pharmacology at Wake Forest School of Medicine.  Dr. Weiner is the Director of an NIH-funded translational research grant that employs rodent, monkey and human models to study the neurobiological substrates that contribute to alcohol addiction vulnerability.  He is also … … Continue reading →
+
6:47 AM | Let’s Time-Travel to Dig Priceless Research
Keeping up-to-date with current research trend is great. It really is. Yet, once in a while, you need to time-travel to immerse yourself in great findings of past decades. But how? When you are on the verge of finalizing a new compelling research and tend to realize that something you like to cite is not […] The post Let’s Time-Travel to Dig Priceless Research appeared first on Wiley Asia Blog.

July 11, 2014

+
1:04 PM | Parvovirus B19 and the Kidney
Parvovirus B19 (PVB19) is a small, non-enveloped, single-stranded DNA virus belonging to the Erythrovirus genus, named for their tropism for erythroid precursor cells. It is the only known parvovirus to infect humans. By late adulthood, most people have IgG Anti-PVB19 serology demonstrating previous exposure, often from an asymptomatic infection. However, infection with PVB19 may cause a variety of clinical syndromes including fifth disease (‘Erythema infectiosum‘, a childhood viral […]
+
6:49 AM | Lung Institute Case Reveals Stem Cell Therapy Is Effective for Lung Disease
The Lung Institute works to help people who have received a diagnosis of debilitating lung disease get their quality of life back. The latest case study demonstrates how stem cell therapy can be used effectively to treat interstitial lung disease.After his recent stem cell treatment at the Lung Institute, Al Corter can now complete his daily tasks on his horse farm much faster, and finally attend the Silver Spur Riding Club Open Horse Show the weekend of July 12th in Fonda, NY.Twelve years ago, […]
+
6:40 AM | Induced pluripotent stem cells in the treatment of retinitis pigmentosa
Researchers at the Columbia University Medical Center (CUMC) have have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss. The approach, the first of its kind, takes advantage of induced pluripotent stem cells (iPSCs) cell technology to transform skin cells into retinal cells, which are then used as a patient-specific model for disease study and preclinical testing.Using this approach, researchers led by Stephen […]

Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV & Hua H (2014). Gene Therapy in Patient-specific Stem Cell Lines and a Preclinical Model of Retinitis Pigmentosa With Membrane Frizzled-related Protein Defects., Molecular therapy : the journal of the American Society of Gene Therapy, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24895994

Citation

July 10, 2014

+
12:30 PM | Animal Experiments in the UK: Government releases 2013 statistics
Every year the UK Home Office publishes statistics showing the number of procedures carried out on animals covered by the Animals (Scientific Procedures) Act, 1986; this covers all vertebrate species. Overall, the number of animals used in research fell slightly … Continue reading →
+
8:06 AM | No extra mutations in modified stem cells, study reports
The ability to switch out one gene for another in a line of living stem cells has only crossed from science fiction to reality within this decade. As with any new technology, it brings with it both promise--the hope of fixing disease-causing genes in humans, for example--as well as questions and safety concerns. Now, Salk scientists have put one of those concerns to rest: using gene-editing techniques on induced pluripotent stem cells doesn't increase the overall occurrence of mutations in the […]

Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E & Zhang F (2014). Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones., Cell stem cell, 15 (1) 31-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24996168

Citation

July 09, 2014

+
8:53 AM | Will Nanofiltration Bring Practical Clean Water?
Do you know that there are millions of people around the world that lack access to safe and clean water for daily consumption? As a result, waterborne illnesses claim the lives of many children and adults in the world, especially in developing nations. This water crisis has led to many scientists and researchers finding ways […] The post Will Nanofiltration Bring Practical Clean Water? appeared first on Wiley Asia Blog.
+
7:50 AM | Woman grows nose tissue in spine after stem cell treatment
A spinal mass was identified in a young woman with complete spinal cord injury 8 years after she had undergone implantation of olfactory mucosal cells in the hopes of regaining sensory and motor function.The case was presented yesterday, in the Journal of Neurosurgery. The authors say that this is the first report of a spinal cord mass arising from spinal cord cell transplantation and neural stem cell therapy, and they caution that physicians should be vigilant in their follow-up of patients […]

Dlouhy, B., Awe, O., Rao, R., Kirby, P. & Hitchon, P. (2014). Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient, Journal of Neurosurgery: Spine, 1-5. DOI: 10.3171/2014.5.SPINE13992

Citation
+
7:39 AM | International Stem Cell Corporation Signs Agreement With Rohto Pharmaceutical
International Stem Cell Corporation (ISCO), a California-based biotechnology company developing novel stem cell-based therapies, announced today that it has reached a research agreement with Rohto Pharmaceutical Co., Ltd. ("Rohto"), a global Japanese pharmaceutical company that develops new technology for the medical and cosmetics markets with approximately $1.3 billion in consolidated annual sales.Under the agreement, Rohto will evaluate stem cell-derived human cells owned and provided by ISCO […]

July 08, 2014

+
11:22 PM | Lessons from the Akita mouse
Diabetic nephropathy (DN) is a major cause of ESRD worldwide. While many attempts have been made to develop reliable animal models that mimic human disease—ob/ob, db/db obese diabetes type 2 diabetes models, NOD1 mice, streptozotocin (STZ)-induced diabetes model etc., current mouse models still do not display full spectrum of functional and pathological process of human DN (JASN 2009). In addition, it was revealed recently that genetic background has an important effect on the development […]
+
1:15 PM | Israel provides animal research statistics for 2013
Number of animals used in research in Israel from 2010 to 2013. Continue reading →
+
12:55 PM | Adaptive Trials Offer Potent Weapon Against Phase 3 Failures
A failed phase 3 drug trial is one of the worst possible outcomes for a pharmaceutical company and for patients, both in terms of financial resources spent as well as time sunk into an unproductive research path. A recent article published by Roche describes how that company had to deal with several recent Phase 3 ... continue reading
+
8:17 AM | Researchers discover important piece in the brain tumour puzzle
Researchers at the Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre have shown that a member of the protein family known as SUMO (small ubiquitin-like modifier) is a key to why tumour cells multiply uncontrollably, especially in the case of glioblastoma. The SUMO family proteins modify other proteins and the SUMOylation of proteins are critical for many cellular processes. Identifying SUMO's role in the cancer cell growth will lead to a new […]

Bellail, A., Olson, J. & Hao, C. (2014). SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression, Nature Communications, 5 DOI: 10.1038/ncomms5234

Citation

July 07, 2014

+
3:52 PM | Teeth Stem Cells Help Regenerate Retinal Ganglion Cells after Injury
Dr. Ben SchevenCreditResearchers at the University of Birmingham, UK, led by Dr. Ben Scheven, Dr. Wendy Leadbeater and Ben Mead announced today that adult stem cells isolated from the teeth , can protect retinal ganglion cells (RGCs) from death following injury and even promote regeneration of their axons along the optic nerve.RGC loss is the leading cause of blindness and can arise through traumatic injury or degenerative diseases such as glaucoma. Neurotrophic factors (NTFs), which travel […]
+
1:32 AM | Interview: How to Validate Medical Claims Using Evidence-Based Medicine Databases
Every day, we receive conflicting news reports on various medical claims and treatments.  As a layman, how can we differentiate credible sources of evidence from misguided messages, to make informed healthcare decisions? Let us hear from Dr. Lai Nai Ming, Associate Professor at Taylor’s University, School of Medicine in Malaysia and learn how he validates […] The post Interview: How to Validate Medical Claims Using Evidence-Based Medicine Databases appeared first on Wiley Asia […]

July 04, 2014

+
5:53 AM | New stem cell based strategy could uncover genes at the root of psychiatric illnesses
Guo-li Ming, M.D., Ph.D.CreditUnderstanding the basis of psychiatric disorders has been extremely challenging because there are many genetic variants that may increase risk but are insufficient to cause disease.Now investigators reporting in the July 3rd issue of the Cell Press journal Cell Stem Celldescribe a strategy that may help reveal how such "subthreshold" genetic risks interact with other risk factors or environmental exposures to affect the development of the nervous system. Their […]

July 02, 2014

+
8:11 PM | Researchers regrow corneas using limbal stem cells
Restored functional cornea following human limbal stem cells transplantation to limbal stem cell-deficient mice. Credit: Kira Lathrop, Bruce Ksander, Markus Frank, and Natasha Frank.Boston researchers have identified a way to enhance regrowth of human corneal tissue to restore vision, using a molecule known as ABCB5 that acts as a marker for hard-to-find limbal stem cells.This research, a collaboration between the Massachusetts Eye and Ear/Schepens Eye Research Institute (Mass. Eye and Ear), […]
+
7:54 PM | New method for better induced pluripotent stem cells
Scanning electron micrograph of cultured human neuron from induced pluripotent stem cell. Credit: Mark Ellisman and Thomas Deerinck, National Center for Microscopy and Imaging Research UC San DiegoA research team from the University of California, San Diego School of Medicine, Oregon Health & Science University (OHSU) and Salk Institute for Biological Studies has shown for the first time that induced pluripotent stem cells created using different methods produce differing cells.The […]
+
7:42 PM | Adipose-derived stem cells resist chemotherapy
New research reveals that adipose-derived human mesenchymal stem cells, which can become vital tissues such as bone, may be highly resistant to the common chemotherapy drug methotrexate (MTX). The preliminary finding from lab testing may prove significant because MTX causes bone tissue damage in many patients. MTX is used to treat cancers including acute lymphoblastic leukemia, the most common form of childhood cancer. A major side effect of the therapy, however, is a loss of bone mineral […]
+
6:09 PM | Infographic : 9 Ways to Make Sure Your Article Gets Read
Everyone is publishing many things almost everyday. How are you going to stand out among gigantic amount of publications? We have once blogged about easy ways to make sure your article gets read. Here, we illustrated those valuable points in this little infographic. If you find it useful, feel free to share it with your […] The post Infographic : 9 Ways to Make Sure Your Article Gets Read appeared first on Wiley Asia Blog.
+
5:00 PM | Quote Therapy – by Helen Keller
“Avoiding danger is no safer in the long run than outright exposure. Life is either a daring adventure, or nothing.” Helen Keller
+
7:57 AM | New research on the distribution, function, utility and greater potential of stem cells
With the plethora of research and published studies on stem cells over the last decade, many would say that the definition of stem cells is well established and commonly agreed upon. However, a new review article appearing in the July 2014 issue of The FASEB Journal , suggests that researchers have only scratched the surface of understanding the nature, physiology and location of these cells.Specifically, the study suggests that embryonic and induced pluripotent stem cells may not be the only […]

July 01, 2014

+
4:30 PM | Creating Change in Our Lives
Creating Change in Our Lives [Article via Psychology Today. Click above for full post] I realize more and more every time I fly that life is no different than flying. And if we think about creating change in our life... Read More ›
+
12:04 PM | Regenestem announces grand opening of stem cell clinic in Manila
Global Stem Cells Group announced the grand opening of Regenestem Asia in Manila, Philippines, adding a new clinic to the international stem cell medicine company's growing worldwide presence.With clinics in Miami, New York, Los Angeles and Dubai, Regenestem Asia now offers the same comprehensive stem cell treatments and experienced medical staff that have fueled the company's worldwide growth.The launch of Regenestem Asia is a collaborative effort between Global Stem Cells Group and Eric […]
+
11:58 AM | Researchers pursue techniques to improve mesenchymal stem cell therapy
Mesenchymal stem cellStem cell scientists had what first appeared to be an easy win for regenerative medicine when they discovered mesenchymal stem cells several decades ago. These cells, found in the bone marrow, can give rise to bone, fat, and muscle tissue, and have been used in hundreds of clinical trials for tissue repair. Unfortunately, the results of these trials have been underwhelming. One problem is that these stem cells don't stick around in the body long enough to benefit the […]
123
73 Results