Posts

May 03, 2013

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Today’s very special guest post is from Luke Parkitny. Luke is an PhD student at NeuRA (Neuroscience Research Australia) who is just starting to see the light at the end of the tunnel – in a good way as he will submit his thesis in August! The average scientist isn’t just a white-coat who [...]

May 02, 2013

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4:14 PM | Riding for pain with a Viking Spirit

On what looks like a very fresh Danish weekend, some fearsome warriors put on their Ride for Pain jerseys and took on the elements. Watch the day unfold in the latest Danish entry for the Cannes short-film awards, in the 'Raising awareness of the world's most burdensome health issue' category.

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3:31 PM | A new drug to treat type II diabetes: Thank the…Gila monster?

Earlier this week Lyxumia (generic name Lixisenatide), a new drug that helps to control type II diabetes, was launched in the UK. In addition to being an effective and saft therapy for type II diabeted, including in some patients that do not respond … Continue reading →

May 01, 2013

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7:03 PM | Researchers decode the molecular signals used by tumours to recruit mesenchymal stem cells

Its been known for years that tumours have the ability to recruit mesenchymal stem cells (MSCs), which is why they are sometimes so persistent and difficult to deal with. Unfortunately, this process is poorly understood on the molecular level. Today, a research team from the University of Michigan, led by Professor Russell Taichman, announced that it has successfully decoded "the molecular chatter" between cancer cells and MSCs.Read More

Jung, Y., Kim, J., Shiozawa, Y., Wang, J., Mishra, A., Joseph, J., Berry, J., McGee, S., Lee, E., Sun, H. & Wang, J. (2013). Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis, Nature Communications, 4 1795. DOI: 10.1038/ncomms2766

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4:29 PM | Pericytes can be used for muscle regeneration

Researchers from the Wake Forest Baptist Medical Center (WFBMC) announced today that they have unveiled some of the mechanisms involved in obesity, diabetes mellitus type 2, muscular dystrophy and other diseases associated with fat replacing muscle tissue, causing it to weaken and degenerate. Their findings have the potential to lead to new therapies for the aforementioned diseases, say the researchers.Read More

Birbrair, A., Zhang, T., Wang, Z., Messi, M., Enikolopov, G., Mintz, A. & Delbono, O. (2013). Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation, Stem Cells and Development, 2147483647. DOI: 10.1089/scd.2012.0647

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1:54 PM | Bad Odor

Cystinosis is an autosomal recessive disease caused by a mutation in CTNS, which encodes the lysosomal transporter of cystine. This leads to intracellular cystine accumulation which leads to renal, neurological and cardiac damage. The treatment for this condition is life-long cysteamine. Back in 2011, we reported on a new formulation of cysteamine that is given just twice daily (rather than q6 hours) and is associated with a lower incidence of side effects including halitosis and body odor. […]

April 30, 2013

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5:23 PM | Trachea made of stem cells saves a girl's life

A 2-year-old girl, named Hannah Warren, now has a new chance at life thanks to stem cell technology. The girl was born without a windpipe in South Korea in 2010 and up until now had spent her whole life at the hospital, being unable to breathe, eat or drink by her own. Hannah was operated at the central Illinois hospital, where she received a new windpipe (trachea) made out of her own stem cells. Read More

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9:58 AM | Stemedica receives patent for ectodermal stem cells

Stemedica Cell Technologies (SCT) announced today that it has received a patent from the United States Patent and Trademark Office named “Culturing Ectodermal Cells Under Reduced Oxygen Tension”. The patent covers SCT's proprietary manufacturing process for enhancing the proliferation and differentiation potential of ectodermal cells of any origin.You can read the official press release here

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7:43 AM | Researchers derive human microglia from induced pluripotent stem cells

Yesterday, researchers presented the findings of a new study in which they have developed a method to turn mouse and human induced pluripotent stem cells (iPSC) into microglia, small non neural cells forming part of the supporting structure of the central nervous system. The researchers say their study has implications in studying and possibly treating various diseases of the central nervous system (CNS). Read More

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6:54 AM | Adult females lack oocyte-forming stem cells

Many researchers have claimed in the past that some of the eggs (oocytes) formed by mammals may actually originate from stem cells. In turn, this gave hope for a new possible source of stem cells that could be used to treat infertility and perhaps other diseases. Unfortunately, a new study by two researchers reveals that mice and probably humans don't use stem cells to produce eggs. Read More

Lei, L. & Spradling, A. (2013). Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.1306189110

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April 29, 2013

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7:30 PM | Lives on hold

Low back pain can be a scary experience. When pain is perceived as being harmful or dangerous to the individual, it becomes something feared and avoided.But little is known in the literature about what people with chronic low back pain are fearful of and why.

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12:08 PM | Basel Declaration Calls for Solidarity with Researchers at University of Milan

The Basel Declaration have called for a show of solidarity with researchers at the University of Milan who had years of work destroyed when animal rights activists broke into the facility. See previous two links for more background information. Please … Continue reading →

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6:24 AM | Mesenchymal stem cells against cancer

Generally, the results from studies examining the effects of stem cells in treating cancer are mixed. Other studies indicate that stem cells promote tumour growth by forming new blood vessels while others suggest that stem cells halt tumour growth. Now, a new study on mice indicates that its all about "timing". The study was conducted by a collaborative team of researchers from the Université Joseph Fourier and the CHU de Grenoble hospital, both located in France.Read More

Michelle Kéramidas, Florence de Fraipont, Anastassia Karageorgis, Anaïck Moisan, Virginie Persoons, Marie-Jeanne Richard & Jean-Luc Coll and Claire Rome (2013). The dual effect of MSCs on tumour growth and tumour angiogenesis, Stem Cell Research & Therapy,

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April 27, 2013

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12:28 AM | HSP90 Inhibitors Data at ASCO 2013

We now have our first look at the upcoming data at the 2013 ASCO Annual Meeting related to HSP90 inhibitors in development in various cancers. Full abstracts with data will be released May 15th.The key focus will be on ganetespib (Synta Pharma SNTA), with data also to come on AUY922 (Novartis) and [...]

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12:26 AM | ASCO 2013: Data on ALK Inhibitors (ARIA PFE NVS)

It is that time again.... the annual meeting of the American Society of Clinical Oncology (ASCO) is just around the corner in early June. Abstracts will be released May 15th, so we will begin to feature key presentations both here at HSP90 Central and at BiotechDueDiligence.First up? The ALK inhibitors. This post features presentations related t [...]

April 26, 2013

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10:12 AM | Feathers stem cells provide new insight into the morphogenesis process

A new study by researchers at the University of Southern California (USC), led by Professor Chuong Cheng Ming, reveals how stem cells contribute to the unique and complex patterns bird feathers have. Surprisingly, the study has implications in the field of regenerative medicine, say the researchers.Read More

Lin, S., Foley, J., Jiang, T., Yeh, C., Wu, P., Foley, A., Yen, C., Huang, Y., Cheng, H., Chen, C. & Reeder, B. (2013). Topology of Feather Melanocyte Progenitor Niche Allows Complex Pigment Patterns to Emerge, Science, DOI: 10.1126/science.1230374

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April 25, 2013

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8:46 PM | A new direction for the fear avoidance model

Almost everyone suffers acute pain. Why do most recover, but an unfortunate few descend a downward spiral of social, personal and economic disadvantage? One hypothesis that has been interrogated for two decades is the fear avoidance model. Nonetheless, the case is not settled and some might argue that the fear avoidance model has not lived up to its considerable expectations.

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5:55 PM | The Journal of Animal Breeding and Genetics Virtual Issue on Genomic Selection

In this issue of the Journal of Animal Breeding and Genetics, we flag a range of papers examining the development and use of Genomic Selection. The method was introduced in the seminal paper by Theo Meuwissen, Ben Hayes and Mike Goddard in 2001 (Genetics 157, 1819-1829). The Journal of Animal Breeding and Genetics has published ... Continue reading »The post The Journal of Animal Breeding and Genetics Virtual Issue on Genomic Selection appeared first on The Wiley Asia Blog.

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3:28 PM | Statement on Harvard’s Decision to Close the New England Primate Research Center

Speaking of Research is saddened to learn about Harvard’s decision to wind down operations at the New England Primate Research Center (NEPRC) within the next two years. Over the years the Primate Center has contributed important discoveries in the fields … Continue reading →

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2:31 PM | Developmental Delays in Children Following Prolonged Seizures

Researchers from the UK determined that developmental delays are present in children within six weeks following convulsive status epilepticus (CSE)—a seizure lasting longer than thirty minutes. The study appearing in Epilepsia, a journal published by Wiley on behalf of the International League Against Epilepsy (ILAE), suggests that neurodevelopmental impairments continue to be present one year after ... Continue reading »The post Developmental Delays in Children Following Prolonged […]

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2:09 PM | Stemedica reaches agreement with Kalbe Farma for clinical trials in Asia

Stemedica Cell Technologies announced today that it has reached an agreement with the Stem Cell and Cancer Institute, a division of PT Kalbe Farma (Kalbe) that makes Kalbe the exclusive licensor of Stemedica’s patented mesenchymal and neural stem cells for use in clinical trials in Indonesia, Philippines and Thailand.Read More

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9:22 AM | Neuroblastoma regimen employed in Europe and Egypt less toxic than the one used in U.S.

Yesterday, we reported on a study by researchers at the Dana-Farber Children's Hospital Cancer Centre, Boston (DF/CHCC) which revealed that the majority of children readmit to hospital after receiving a stem cell transplant. At the same time, DF/CHCC researchers presented another study which shows that the stem cell transplant regimen used in the U.S. for advanced neuroblastoma in children is more toxic, although equally effective, than the busulfan-based regimen used in Egypt and many […]

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3:28 AM | Falling Over At Home A Concern For Older People

Older people who fall over at home and require ambulance assistance are at higher risk of future falls and associated injuries. This is the finding of a study published in the Australian and New Zealand Journal of Public Health. Dr Anne Tiedemann from the University of Sydney led the study, which surveyed people aged 70 ... Continue reading »The post Falling Over At Home A Concern For Older People appeared first on The Wiley Asia Blog.

April 24, 2013

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5:05 PM | Most of the children readmit to hospital after receiving a hematopoietic stem cell transplant

A new study by researchers at the Dana-Farber Children's Hospital Cancer Centre, Boston reveals that about 60 % of all children receiving a hematopoietic stem cell transplant will readmit to the hospital within the first 6 months. Furthermore, the study showed children receiving an allogeneic stem cell transplant are twice as likely to readmit compared to children receiving autologous stem cells.Read More

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5:01 PM | Plants and Extracts Rich in Secondary Metabolites: Their Utility in Ruminant Nutrition – A Journal of Animal Physiology and Animal Nutrition Virtual Issue

After the ban of the use of feed antibiotics in many countries, and owing to consumers’ concerns, the search for diet supplementation with natural bioactive compounds is in the focus of research. In ruminant nutrition, such compounds are either supplemented in purified form or via entire plants, plant parts or crude extracts thereof. There is ... Continue reading »The post Plants and Extracts Rich in Secondary Metabolites: Their Utility in Ruminant Nutrition – A Journal of Animal […]

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2:40 PM | ‘Mobility Shoes’ Take a Load Off for Knee Osteoarthritis Sufferers

New research suggests that patients with knee osteoarthritis (OA) who wear flat, flexible footwear (mobility shoes) had significant reduction in knee loading—the force placed upon the joint during daily activities. Results published in Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR), show that long term use of the mobility shoes helped ... Continue reading »The post ‘Mobility Shoes’ Take a Load Off for Knee Osteoarthritis Sufferers appeared first […]

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12:01 PM | European Storm Clouds gather over Italy

There has been a rise in animal rights extremism across much of Europe for some time. Movements have increasingly focused on the breeding and transporting of Beagles used in animal experiments, however some seem to be broadening to all research. … Continue reading →

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9:24 AM | Stem Cell Institute to host free seminar on umbilical cord stem cells

The Stem Cell Institute will be hosting a seminar on umbilical cord stem cells and their potential therapeutic uses on Saturday, May 11, in Miami, Florida at the Conrad Hotel from 1:00 pm to 4:00 pm. Participation tickets are free but limited.For more information on the speakers and the topics that will be presented please visit the event's official page.

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2:52 AM | Rising Black Bear Population is Reconquering Nevada after 80 Years

A long term study into the rise of human-bear conflicts in the U.S state of Nevada has found that Black bears (Ursus americanus) are re-populating their historic range after an 80 year absence. The study was launched in 1997 following a sharp rise in the amount of reported bear attacks and incidents of car collisions. The ... Continue reading »The post Rising Black Bear Population is Reconquering Nevada after 80 Years appeared first on The Wiley Asia Blog.

April 23, 2013

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6:48 PM | Dr. Chiu to offer stem cell harvest option during cosmetic surgery

Plastic surgeon Dr. Gabriel Chiu just issued a press release announcing that from now on, any of his patients having liposuction, tummy tuck, breast reduction or other cosmetic surgery will also have the option to have their fat stem cells harvested and cryopreserved for future use.Read More

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