Posts

August 13, 2014

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3:19 AM | Current Protocols: A tool for consistency and reliability in your research
A major concern of researchers is the reproducibility of experimental results. Earlier this year, Francis Collins and Lawrence Tabak discussed the steps the NIH was considering to address consistency and reproducibility in biomedical research.  They noted that many factors have contributed to this problem, including poor training of researchers in experimental design and limitations in […] The post Current Protocols: A tool for consistency and reliability in your research appeared […]

August 12, 2014

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8:24 PM | Epigenetics Has Large Say in the Fate of Blood Stem Cells
Epigenetics: Environmental effects influence how genes are turned on or off.Credit: Image courtesy of Weizmann Institute of ScienceEvery day trillions of blood cells are being formed in our body: from the oxygen-carrying red blood cells to the many types of white blood cells that fight pathogens and infection. All of these highly specialized cells originate from hematopoietic (blood) stem cells -- unique cells that have the potential to mature into all blood types. How exactly is the fate […]

Lara-Astiaso D, Weiner A, Lorenzo-Vivas E, Zaretsky I, Jaitin DA, David E, Keren-Shaul H, Mildner A, Winter D, Jung S & Friedman N (2014). Chromatin state dynamics during blood formation., Science (New York, N.Y.), PMID: http://www.ncbi.nlm.nih.gov/pubmed/25103404

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8:09 PM | How Breast Cancer Uses the Power of Mammary Stem Cells
Dr. David ChereshDuring pregnancy, certain hormones trigger specialized mammary stem cells to create milk-producing cells essential to lactation. Researchers at the University of California, San Diego School of Medicine and Moores Cancer Center have found that mammary stem cells associated with the pregnant mammary gland are related to stem cells found in breast cancer.Writing in the August 11, 2014 issue of Developmental Cell, David A. Cheresh, PhD, Distinguished Professor of Pathology and […]
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4:59 PM | FDA Published In Vitro Companion Diagnostic Device Guidance
The FDA has released a final guidance document on August 6, 2014 on In Vitro Companion Diagnostic Devices. The guidance defines IVD companion diagnostic device as an “in vitro diagnostic device that provides information that is essential for the safe and effective use of a corresponding therapeutic product”. FDA advises that in “most circumstances, an ... continue reading
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3:28 AM | Tips for Your Poster: Planning
Presenting posters and leading the conversation in a poster session can be intimidating. However, there are some very simple things that you can do to help yourself get through what can be a challenging experience. Richard Threlfall, Managing Editor, Asian Journal of Organic Chemistry, gives you some tips on how to plan and design an outstanding poster […] The post Tips for Your Poster: Planning appeared first on Wiley Asia Blog.

August 11, 2014

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1:38 PM | Lithium For Aging Brain
Recent studies investigating Lithium, a drug commonly used for the treatment of mood disorders in humans, found its robust neurotrophic and neuroprotective effects which can help us exploring new novel, exciting, and promising targets. The molecular mechanism underlying lithium’s mood stabilizing effect is not yet unraveled. Suggested hypotheses include inositol-depletion via inhibition of inositol- monophosphatase and neuroprotection, via inhibition of GSK-3. Chronic lithium treatment […]
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12:12 PM | Animal rights fanatics offer stunts, not real solutions
This post is simulposted with the Unlikely Activist blog, run by this post’s author, David Jentsch. Fanatical animal rights groups in the US love attention-getting stunts. PeTA creates video games extolling violence and propagates advertisements that exude adolescent sexuality. White Coat Waste uses … Continue reading →

August 09, 2014

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1:42 AM | Perspectives on Climate Change
As part of a global effort to mobilise action from governments, business, finance and society, countries will meet in 2015 to determine a global climate agreement through the United Nations Framework Convention on Climate Change. Climate change and climate policy have become political fodder for elections worldwide, with partisan views dividing nations. The burgeoning research […] The post Perspectives on Climate Change appeared first on Wiley Asia Blog.

August 08, 2014

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5:00 PM | Quote Therapy – by Elon Musk
“If something is important enough, you should try even if the probable outcome is failure.” Elon Musk
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2:44 PM | Responsible Antibody Production
Antibodies Part 2 (read Part 1 here) As noted in our previous post, there are many promising uses for antibodies. Therefore, it is no wonder that antibody production is big business. The Scientist reported that revenues from antibody sales were … Continue reading →
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1:29 PM | Medical Device Industry News Video Roundup – July 2014
Welcome to the Aptiv Solutions medical device news roundup for July 2014! We’ve gathered ten news stories offering information that may just help your company prosper. Coming up in this roundup: the medical device sector continues to evolve across the globe and over a variety of medical conditions. Outsourcing specific aspects of medical device trials ... continue reading
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12:10 PM | Dramatic Growth of Grafted Induced Pluripotent Stem Cells in Rat Spinal Cord Injuries
Building upon previous research, researchers at the University of California, San Diego School of Medicine and Veteran's Affairs San Diego Healthcare System report that neurons derived from human induced pluripotent stem cells (iPSCs) and grafted into rats after a spinal cord injury produced cells with tens of thousands of axons extending virtually the entire length of the animals' central nervous system.Leading author Paul Lu, PhD, of the UC San Diego Department of Neurosciences said the human […]
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12:00 PM | Researchers Uncover Stem Cell Behaviour of Human Bowel
For the first time, researchers say they have uncovered new information on how stem cells in the human bowel behave, revealing vital clues about the earliest stages in bowel cancer development and how we may begin to prevent it.The research, led by Queen May University of London (QMUL) and published yesterday the journal Cell Reports, discovered how many stem cells exist within the human bowel and how they behave and evolve over time.Read More

Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon (2014). Ann-Marie Baker, Biancastella Cereser, Samuel Melton, Alexander G. Fletcher, Manuel Rodriguez-Justo, Paul J. Tadrous, Adam Humphries, George Elia, Stuart A.C. McDonald, Nicholas A. Wright, Benjamin D. Simons, Marnix Jansen, Trevor A. Graham., Cell Reports, Other:

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August 07, 2014

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5:04 PM | Researchers Grow Human Gastrointestinal Cells Using Epithelial Stem Cells
Kelli L. VanDussen, PhD, and Matthew A. CiorbaA method of growing human cells from tissue removed from a patient's gastrointestinal (GI) tract may one day help scientists develop tailor-made therapies for inflammatory bowel disease and other GI-related conditions.Reporting online recently in the journal Gut, researchers from the Washington University School of Medicine in St. Louis said they have made cell lines from individual patients in as little as two weeks.They have created more than 65 […]

VanDussen, K., Marinshaw, J., Shaikh, N., Miyoshi, H., Moon, C., Tarr, P., Ciorba, M. & Stappenbeck, T. (2014). Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays, Gut, DOI: 10.1136/gutjnl-2013-306651

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4:52 PM | Harvard Researchers Identify New Potential Treatment for Amyotrophic Lateral Sclerosis
This image depicts graduate student Sophie De Boer, (left), and Prof. Kevin Eggan (right) discussing their latest work.Credit: B. D. Colen/Harvard UniversityAbout eight years ago, researchers at the Harvard Stem Cell Institute (HSCI) begun a series of studies that led to a report published today which may be a major step forward in thequest to developing real treatments for amyotrophic lateral sclerosis (ALS).The findings by Harvard professor of Stem Cell and Regenerative Biology (HSCRB) Kevin […]

de Boer, A., Koszka, K., Kiskinis, E., Suzuki, N., Davis-Dusenbery, B. & Eggan, K. (2014). Genetic validation of a therapeutic target in a mouse model of ALS, Science Translational Medicine, 6 (248) 248-248. DOI: 10.1126/scitranslmed.3009351

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4:47 PM | Pregnancy Kits to Ebola Treatment: Medical Tests & Disease Treatments Depend on Animal Products
Antibodies Part 1 There has been considerable discussion on this website about the use of animal studies to develop new medical treatments. But some animal-derived products such as antibodies also play a crucial role in diagnostic tests for some diseases … Continue reading →
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3:30 AM | How to Re-wire Your Brain to Become More Creative
There are a few things that you could start doing right now to instantly improve your brain’s performance and get you off to a flying start. Let’s  call  them  Brain  Optimization Tips,  or  BOPs for short. You  can follow these  simple suggestions to get  your brain firing on all cylinders each and every day. Here […] The post How to Re-wire Your Brain to Become More Creative appeared first on Wiley Asia Blog.

August 06, 2014

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8:05 PM | Cytori Halts Stem Cell Trials Due to Adverse Effects
Cytori Therapeutics announced yesterday that it has halted trials of its experimental stem cell therapy for heart failure after three patients developed blood flow problems. The San Diego-based company said it placed the hold on two studies after the patients developed problems with blood flow to the brain. Two of the patients' symptoms resolved in a short period of time and a third was still recovering, the company said in a statement.Cytori said it is working with the Food and Drug […]
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7:57 PM | Researchers Correct Beta-Thalassemia Mutations Using Induced Pluripotent Stem Cells
This image depicts blood cells with corrected HBB mutationsderived from induced pluripotent stem cells.Credit: courtesy of Fei Xie, University of California, San Francisco.A major hurdle in gene therapy is the efficient integration of a corrected gene into a patient's genome without mutating off-target sites. In a new study published by Genome Research, researchers have used CRISPR/Cas genome editing technology to seamlessly and efficiently correct disease-causing mutations in cells from […]
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7:45 PM | Molecular Competition Drives Adult Stem Cells to Specialize
All adult organisms ranging from fruit flies to humans harbor adult stem cells, some of which renew themselves through cell division while others differentiate into the specialized cells needed to replace worn-out or damaged organs and tissues.Understanding the molecular mechanisms that control the balance between self-renewal and differentiation in adult stem cells is an important foundation for developing therapies to regenerate diseased, injured or aged tissue.Now, in the latest issue of the […]

August 05, 2014

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4:36 PM | ISCO Launches Stroke Program With Tulane University
International Stem Cell Corporation (ISCO), a California-based biotechnology company developing stem cell based therapies, announced today that it has launched a new Stroke Program. Together with Tulane University, ISCO will study the impact of human parthenogenetic neural stem cells (hpNSC) transplantation in a pre-clinical rodent model of ischemic stroke as a first step toward the clinical development of a potential stroke treatment. The proof-of-concept study will be done in the laboratory […]
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4:30 PM | Quote Therapy – by Confucius
“It does not matter how slowly you go as long as you do not stop.” Confucius
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4:27 PM | Implanted Neurons Derived from Skin Become Part of the Brain
Researchers at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have grafted neurons reprogrammed from skin cells into the brains of mice for the first time with long-term stability. Six months after implantation, the neurons had become fully functionally integrated into the brain.This successful, lastingly stable, implantation of neurons raises hope for future therapies that will replace sick neurons with healthy ones in the brains of Parkinson's disease […]
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4:17 PM | Frankfurt-Based Researchers Discover Weakness of Leukemic Stem Cells
Despite improvements in therapy, only one out of every two adult patients survive acute myeloid leukaemia (AML). The mean survival time for this disease, which predominantly occurs in the elderly, is less than a year for patients over 65 years. It is assumed that leukaemic stem cells, which cannot be completely eliminated during treatment, are the origin of relapse. However, as has been discovered by a team of Frankfurt-based researchers, these cells do have a weakness: In the current […]
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2:27 PM | Behaviourists Defend Basic Science
Basic science is the foundation of all applied science. Because we cannot predict which basic science projects will turn into an application, we must cast a wide net Continue reading →
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2:17 AM | Celebrating World Class Research from Japan
To celebrate the contribution of Japanese research in the field of molecular biology, EMBO Press has gathered a collection of world-class papers from Japanese authors submitted to its four journals: The EMBO Journal, EMBO Reports, Molecular Systems Biology and EMBO Molecular Medicine. The papers in the new collection ‘Spotlight on Japan’ have been specially selected […] The post Celebrating World Class Research from Japan appeared first on Wiley Asia Blog.

August 04, 2014

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1:44 PM | The FDA to Hold a Public Workshop on Next Generation Sequencing Standards
The FDA has announced it will hold a public workshop for Next Generation Sequencing Standards on September 24 and 25. The workshop organizer, FDA’s Genomic Working Group, consists of experts in high throughput sequencing technology application and bioinformatics relevance. The group’s goal is to develop the IT infrastructure, material and data standards, and analytic approaches ... continue reading
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1:16 PM | Knowing what to keep and what to trash: How the Dis3l2 protein distinguishes cellular messages
Every once in a while, we are forced to sort that stack of papers on the kitchen counter. Interspersed between the expired coupons and dozens of takeout menus are important documents like your car insurance or electric bill. So it isn't an option to simply drop it all in the trash at once – you need to read through the messages to be sure that you don't lose vital information.In the cell, proteins similarly read through messages to distinguish what needs to be saved and what needs to be […]
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1:07 PM | Coxsackie Virus Depletes Cardiac Stem Cells
There is epidemiological evidence that links type B coxsackie virus (CVB) infection with heart disease, and research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress at later stages of life.CVB infection is very common and affects mostly children. The symptoms range widely: over half of the infections are thought to be asymptomatic, the majority of children who get sick have only a mild fever, and a very […]

Sin, J., Puccini, J., Huang, C., Konstandin, M., Gilbert, P., Sussman, M., Gottlieb, R. & Feuer, R. (2014). The Impact of Juvenile Coxsackievirus Infection on Cardiac Progenitor Cells and Postnatal Heart Development, PLoS Pathogens, 10 (7) DOI: 10.1371/journal.ppat.1004249

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10:09 AM | Antibiotic Overuse : How can It Affect Us?
We have learnt the term antibiotic since 1942. We might not have thought that there would be time to seriously discuss about overuse of antibiotic as some resources suggest that antibiotic overuse could be lethal. We like to shed some light on this topic by compiling some interesting research on antibiotic overuse. High Antibiotic Consumption […] The post Antibiotic Overuse : How can It Affect Us? appeared first on Wiley Asia Blog.
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