Posts

July 22, 2014

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12:55 PM | Malaysia Implements New Medical Device Policies
Medical device companies interested in doing business in Malaysia now have a clearer path to market thanks to the country’s Medical Device Authority (MDA) putting into place policies associated with the Medical Device Act. The Medical Device Act was initially adopted in the first quarter of 2013, and went into effect July 1, 2013, but ... continue reading
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9:06 AM | Celladon announces In-License of Stem Cell Factor Development Program
Celladon Corporation, a clinical-stage biotechnology company applying its leadership position in the field of gene therapy and calcium dysregulation today announced an exclusive, global license from Enterprise Partners Venture Capital for gene therapy applications of the membrane-bound form of the Stem Cell Factor gene (mSCF) for treatment of cardiac ischemia. Stem Cell Factor is a critical cytokine which contributes to cell migration, proliferation, and survival of cardiac stem cells.Read More
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8:55 AM | Mesenchymal stem cells promote muscle repair and strengthening after resistance exercise
Professor Marni BoppartNew research in mice reveals that mesenchymal stem cells (MSCs) help rejuvenate skeletal muscle after resistance exercise. By injecting MSCs into mouse leg muscles prior to several bouts of eccentric exercise (similar to the lengthening contractions performed during resistance training in humans that result in mild muscle damage), researchers were able to increase the rate of repair and enhance the growth and strength of those muscles in the exercising mice.The […]

July 21, 2014

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2:21 PM | Report On Medical Device Approval Process Underlines Areas To Improve
There’s good news from the CDRH regarding its strategy to more rapidly bring medical devices to market in crucial, innovation-linked treatment areas. A third-party study of the medical device submission process, carried out by Booz Allen Hamilton, was published in June of 2014 and indicated that the FDA has been able to make progress in ... continue reading
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2:12 PM | Background Briefing on Animal Research in the UK
Background briefing on the use of animals in research in the UK. This provides facts, laws and statistics about animal testing in the UK. Continue reading →
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2:23 AM | Going Grey: Chinese Plants Evolve Alpine Camouflage to Avoid Attack
Many animal species have evolved sophisticated camouflage to avoid predators, yet research in New Phytologist has found that in the plant world a Chinese species of herb uses its grey leaves to blend into its mountainside surroundings. As a defense strategy camouflage can be costly for plants. Flowers which rely on attracting insects for pollination […] The post Going Grey: Chinese Plants Evolve Alpine Camouflage to Avoid Attack appeared first on Wiley Asia Blog.

July 20, 2014

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8:57 AM | Role of Astroglia in Down's Syndrome Revealed Thanks to iPSCs
David Pleasure, Chen Chen, Wenbin Deng and Peng Jiang(left to right)Researchers from UC Davis School of Medicine and Shriners Hospitals for Children -- Northern California have identified a group of cells in the brain that they say plays an important role in the abnormal neuron development in Down syndrome.After developing a new model for studying the syndrome using patient-derived induced pluripotent stem cells, the scientists also found that applying an inexpensive antibiotic to the cells […]

Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC & Loring JF (2014). Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells., Nature communications, 5 4430. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25034944

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July 18, 2014

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9:24 PM | The Lone Star Tick
Recently a 65-year-old female was referred to an ED in the state of Missouri complaining of fevers, chills, headache, diarrhea and vomiting occurring over the last week. 3 weeks prior she had received an orthotopic liver transplant. Her post transplant course was unremarkable and she was discharged on prograf 2mf bid, myfortic 360mg bid, prednisone tapering, Bactrim single strength daily and valcyte 450mg od. She also took thyroid replacement, Januvia, warfarin and aspirin. Past medical history […]
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4:30 PM | Quote Therapy – by Robin Roberts
“The tragedy is not so much the experience that you’re having. The tragedy is that we don’t take the time to understand the meaning and purpose behind what we’re going through.” Robin Roberts
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12:37 PM | ALF Claims Responsibility for CALAS National Office Vandalism
On Tuesday, July 15, an act of vandalism occurred near the Canadian Association for Laboratory Animal Science National Office in Toronto, ON.  There were no injuries and a police investigation is ongoing. The extremist website Bite Back published an unsigned … Continue reading →
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10:37 AM | Scientists discover gene that links stem cells, aging and cancer
Stem cells from adult mouse epidermis (green, Cytokeratin 6; blue, cell nucleus); Sox4 protein maintains tissue homeostasis in these cells.An organism is healthy thanks to a good maintenance system: the normal functioning of organs and environmental exposure cause damage to tissues, which need to be continuously repaired.This process is not yet well understood, but it is known that stem cells in the organs play a key role, and that when repair fails, the organism ages more quickly. Researchers […]

Foronda, M., Martínez, P., Schoeftner, S., Gómez-López, G., Schneider, R., Flores, J., Pisano, D. & Blasco, M. (2014). Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation, Cell Reports, DOI: 10.1016/j.celrep.2014.06.031

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10:29 AM | Discovery May Make It Easier to Develop Life-Saving Induced Pluripotent Stem Cells
Human oocyteNot unlike looking for the proverbial needle in a haystack, a team of Michigan State University researchers have found a gene that could be key to the development of induced pluripotent stem cells, cells that can potentially save millions of lives by morphing into practically any cell in the body.The gene, known as ASF1A, was not discovered by the team. However, it is at least one of the genes responsible for the mechanism of cellular reprogramming, a phenomenon that can turn one […]

Gonzalez-Munoz, E., Arboleda-Estudillo, Y., Out, H. & Cibelli, J. (2014). Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming, Science, DOI: 10.1126/science.1254745

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July 17, 2014

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9:02 PM | Courses
A bit of housekeeping here - I noticed that all of our current course announcements were out of date. These have now been updated with the most recent versions of each course including the following courses coming up shortly:ASN Board Review Course - August 2-8 2014HD University - August 15-16 2014Brigham Renal Board Review Course - August 4-8 2014Medstar Kidney and Pancreas Transplantation Course - October 11, 2014Ultrasonography for Nephrologists - October 25-26 2014 (which I recently […]
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2:44 PM | Top marks for Speaking of Research website
The industry magazine Lab Animal occasionally reviews websites applicable to it’s readers. Earlier this year, they reviewed the Speaking of Research website. The article does a good job of relaying the history behind how Speaking of Research began and some … Continue reading →
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2:02 AM | Air Quality in Pakistan : Just What You Need to Know
With more than 180 million people in the country and industrialization, Pakistan is facing some risks of air pollution. Various vehicles, power plants and industrial activities contribute to poor ambient air quality in South Asia Nation. Researchers measured and analysed air pollution in Pakistan by monitoring hourly air quality from 2007 to 2011. While carbon […] The post Air Quality in Pakistan : Just What You Need to Know appeared first on Wiley Asia Blog.

July 16, 2014

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4:30 PM | Preventing a Drug Overdose
Preventing a Drug Overdose [Article via Psychology Today. Click above for full post] Researchers from New York once found that nearly 98 percent of all accidental overdose deaths were caused by opiates,cocaine, and alcohol. Nearly 60 percent of those were... Read More ›
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2:51 PM | Baclofen in dialysis patients: Just say no!
At our hospital, we started noticing a pattern of admissions among some of our maintenance dialysis patients. In one case, an elderly woman with DM, peripheral arterial disease, and ESRD on thrice weekly hemodialysis was sent to the emergency department from her nursing facility for altered mental status. She was normal three days prior to admission, but when her nurse found her confused and difficult to arouse, they sent her to our ED. We got consulted to continue maintenance dialysis, but we […]
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12:55 PM | Medical Device Industry News Video Roundup – June 2014
Welcome to the Aptiv Solutions medical device news roundup! We’ve collected ten intriguing news articles to provide you with information you need to help your organization succeed. Coming up in this roundup: As the summer progresses, the medical device sector continues to grow and expand. New regulations and innovative tools are changing the industry every ... continue reading

July 15, 2014

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6:50 PM | Lithium and the Kidney: Old Observations & New Insights
Lithium is indispensable as an effective treatment for bipolar affective disorder. However, it has a narrow therapeutic index with desired therapeutic levels between 0.6 and 1.2 mEq/L. Lithium is handled by the kidney (responsible for almost all its excretion) in a manner very similar to sodium. It has a molecular weight of 7 daltons, has a moderate volume of distribution, is <10% protein bound and is therefore readily dialyzable. Lithium may cause of myriad of renal related toxicities, some […]
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5:00 PM | Quote Therapy – Bishop T.D. Jakes
“Your complications are not an indication that you cannot conquer.” Bishop T.D. Jakes
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12:55 PM | Verifying 100% of Source Data May be Unnecessary
Source data verification, or checking the original information present in electronic media, has become a controversial topic as of late. According to the Applied Clinical Trials Online publication, 84 percent of sponsors check all of their source data against case report data. Many sponsors claim that regulations require this practice, but regulatory agencies explain that ... continue reading
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7:20 AM | Wisconsin researchers report new genetic recipe to turn stem cells to blood
Igor SlukvinA group led by University of Wisconsin-Madison stem cell researcher Igor Slukvin reported yesterday the discovery of two genetic programs responsible for taking blank-slate stem cells and turning them into both red and the array of white cells that make up human blood.The research is important because it identifies how nature itself makes blood products at the earliest stages of development. The discovery gives scientists the tools to make the cells themselves, investigate how blood […]

Irina Elcheva, Vera Brok-Volchanskaya, Akhilesh Kumar, Patricia Liu, Jeong-Hee Lee, et al. (2014). Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators., Nature Communications, Other:

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July 14, 2014

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1:23 PM | Why is alcohol research with nonhuman animals essential?
The following guest post is from Jeff Weiner, a Professor in the Department of Physiology and Pharmacology at Wake Forest School of Medicine.  Dr. Weiner is the Director of an NIH-funded translational research grant that employs rodent, monkey and human models to study the neurobiological substrates that contribute to alcohol addiction vulnerability.  He is also … … Continue reading →
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6:47 AM | Let’s Time-Travel to Dig Priceless Research
Keeping up-to-date with current research trend is great. It really is. Yet, once in a while, you need to time-travel to immerse yourself in great findings of past decades. But how? When you are on the verge of finalizing a new compelling research and tend to realize that something you like to cite is not […] The post Let’s Time-Travel to Dig Priceless Research appeared first on Wiley Asia Blog.

July 11, 2014

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1:04 PM | Parvovirus B19 and the Kidney
Parvovirus B19 (PVB19) is a small, non-enveloped, single-stranded DNA virus belonging to the Erythrovirus genus, named for their tropism for erythroid precursor cells. It is the only known parvovirus to infect humans. By late adulthood, most people have IgG Anti-PVB19 serology demonstrating previous exposure, often from an asymptomatic infection. However, infection with PVB19 may cause a variety of clinical syndromes including fifth disease (‘Erythema infectiosum‘, a childhood viral […]
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6:49 AM | Lung Institute Case Reveals Stem Cell Therapy Is Effective for Lung Disease
The Lung Institute works to help people who have received a diagnosis of debilitating lung disease get their quality of life back. The latest case study demonstrates how stem cell therapy can be used effectively to treat interstitial lung disease.After his recent stem cell treatment at the Lung Institute, Al Corter can now complete his daily tasks on his horse farm much faster, and finally attend the Silver Spur Riding Club Open Horse Show the weekend of July 12th in Fonda, NY.Twelve years ago, […]
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6:40 AM | Induced pluripotent stem cells in the treatment of retinitis pigmentosa
Researchers at the Columbia University Medical Center (CUMC) have have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss. The approach, the first of its kind, takes advantage of induced pluripotent stem cells (iPSCs) cell technology to transform skin cells into retinal cells, which are then used as a patient-specific model for disease study and preclinical testing.Using this approach, researchers led by Stephen […]

Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV & Hua H (2014). Gene Therapy in Patient-specific Stem Cell Lines and a Preclinical Model of Retinitis Pigmentosa With Membrane Frizzled-related Protein Defects., Molecular therapy : the journal of the American Society of Gene Therapy, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24895994

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July 10, 2014

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12:30 PM | Animal Experiments in the UK: Government releases 2013 statistics
Every year the UK Home Office publishes statistics showing the number of procedures carried out on animals covered by the Animals (Scientific Procedures) Act, 1986; this covers all vertebrate species. Overall, the number of animals used in research fell slightly … Continue reading →
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8:06 AM | No extra mutations in modified stem cells, study reports
The ability to switch out one gene for another in a line of living stem cells has only crossed from science fiction to reality within this decade. As with any new technology, it brings with it both promise--the hope of fixing disease-causing genes in humans, for example--as well as questions and safety concerns. Now, Salk scientists have put one of those concerns to rest: using gene-editing techniques on induced pluripotent stem cells doesn't increase the overall occurrence of mutations in the […]

Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E & Zhang F (2014). Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones., Cell stem cell, 15 (1) 31-6. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24996168

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July 09, 2014

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8:53 AM | Will Nanofiltration Bring Practical Clean Water?
Do you know that there are millions of people around the world that lack access to safe and clean water for daily consumption? As a result, waterborne illnesses claim the lives of many children and adults in the world, especially in developing nations. This water crisis has led to many scientists and researchers finding ways […] The post Will Nanofiltration Bring Practical Clean Water? appeared first on Wiley Asia Blog.
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