X

Posts

March 16, 2013

+
10:46 AM | Helping Dementia Patients Remember to Eat Well Improves Physical and Mental Health
A new analysis has found that a combination of methods that help patients with dementia remember proper eating habits can improve their physical health and lessen symptoms of depression. Published early online in the Journal of Advanced Nursing, the study indicates that clinicians should consider using this intervention in individuals with dementia who also have … Continue reading »
+
10:20 AM | Stem cells generate long standing human mandibles
A collaborative team of researchers, led by Gianpaolo Papaccio, just released a follow-up study on human patients, showing that mesenchymal stem cells have the capacity to partially regenerate the mandible (lower jaw) following a molar extraction.Full Story

ALESSANDRAGIULIANI, ADRIAN MANESCU, MAX LANGER, FRANCO RUSTICHELLI, VINCENZO DESIDERIO, FRANCESCA PAINO, ALFREDO DE ROSA, LUIGI LAINO, RICCARDO D’AQUINO, VIRGINIA TIRINO & GIANPAOLO PAPACCIO (2013). Three Years After Transplants in Human Mandibles, Histological and In-Line Holotomography Revealed That Stem Cells Regenerated a Compact Rather Than a Spongy Bone: Biological and Clinical Implications, STEM CELLS Translational Medicine,

Citation
Editor's Pick
+
2:24 AM | HSP90 at the 2013 AACR Conference: part 1
The Annual Meeting of the American Association for Cancer Research (AACR) will be held in Washington, DC from April 6-10, 2013. As usual HSP90 Central will feature key data presentations of interest. This part 1 will focus on the "high-profile" drug candidates currently in clinical trials from publicly traded biotech/pharma companies including Synta Pharma $SNTA, Novartis $NVS, Infinity Pharma $INFI, and Astex Pharma $ASTX. Part 2 wil [...]
+
1:01 AM | Design and Analytic Approaches in Sequencing Studies
A Genetic Epidemiology Virtual Issue Design and Analytic Approaches in Sequencing Studies Editor: Sanjay Shete In the post-GWAS era, investigators have shifted their focus on identifying rare causal variants through sequencing. Although the cost of whole genome sequencing has dropped significantly, it is still expensive to perform the whole genome sequencing for thousands of individuals … Continue reading »

March 15, 2013

+
8:31 PM | Selenium supplementation for the primary prevention of cardiovascular disease
Cochrane Journal Club: Selenium supplementation for the primary prevention of cardiovascular disease Filed under: Health Sciences, The Cochrane Library Tagged: aside, Cochrane Journal Club, health sciences, Selenium, Selenium supplementation, The Cochrane Library
+
1:31 PM | Nine individuals accused of selling stem cells from aborted fetuses
The Hungarian General Court is currently hearing a case in which nine defendants are accused of selling tissue material from aborted babies to a clinic offering stem cell based cosmetic procedures.Full Story
+
12:17 PM | Stem cells in the treatment of erectile dysfunction resulting from prostatectomy
A new study by a Korean research team, led by Y.S. Song, reveals that mesenchymal stem cells cultured on the surface of nanofibrous meshes may be the key for treating erectile dysfunction (ED) resulting from radical prostatectomy. The study will be presented at the 28th Annual Congress of the European Association of Urology which will be held from 15 to 19 March.Full Story

Y.S. Song et al. (2013). Repair of erectile dysfunction using transplantation of human mesenchymal stem cells cultivated on the surface of nanofibrous meshes in rats with cavernous nerve injury., 28th Annual EAU Congress,

Citation
+
12:30 AM | Neural cells derived from skin cells mature into brain cells in a Parkinson's monkey model
In a new study, researchers from the University of Wisconsin-Madison have successfully transplanted, for the first time, stem cell derived neural cells into three monkeys with artificially induced brain damage. The cells were derived from induced pluripotent stem cells, which in turn were created by autologous skin cells. According to the researchers, the neural cells integrated perfectly into the lesions and were only visible because they were previously marked with a fluorescent protein. The […]

Marina E. Emborg, Yan Liu, Jiajie Xi, Xiaoqing Zhang, Yingnan Yin, Jianfeng Lu, Valerie Joers, Christine Swanson, James E. Holden, Su-Chun Zhang. (2013). Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain, Cell Reports, Other: 10.1016/j.celrep.2013.02.016

Citation

March 14, 2013

+
9:30 PM | Brain Awareness Week: The Role of Animals in Neuroscience
If you’re a regular reader of the Speaking of Research science blog you will know that we are very interested in neuroscience – in fact several of us are neuroscientists – so you won’t be surprised to learn that we have … Continue reading →
+
6:58 PM | A stress model of chronic pain
People suffering from chronic pain know how stressful spontaneous pain can be. The reciprocal influence of stress over the neural activity contributing to chronic pain has recently received growing interest from the pain community. In our study, we tested the hypothesized maladaptive stress response and its impact on the hippocampal formation of patients suffering from idiopathic chronic low back pain.
+
4:53 PM | NSAIDs mobilize hematopoietic stem cells into the blood stream
A recent study on mice, baboons and few volunteering patients revealed that a non-steroidal anti-inflammatory drug (NSAID) called meloxicam increases significantly the number of hematopoietic stem cells entering the blood stream. The study can potentially help patients requiring a hematopoietic stem cell (HSC), most notably leukemia victims. The study was carried out by researchers, led by Louis Pelus, at Indiana University's School of MedicineFull Story

Hoggatt, J., Mohammad, K., Singh, P., Hoggatt, A., Chitteti, B., Speth, J., Hu, P., Poteat, B., Stilger, K., Ferraro, F. & Silberstein, L. (2013). Differential stem- and progenitor-cell trafficking by prostaglandin E2, Nature, DOI:

Citation
+
10:58 AM | Double-Jointed Adolescents at Risk for Joint Pain
A prospective study by U.K. researchers found that adolescents who are double-jointed—medically termed joint hypermobility—are at greater risk for developing musculoskeletal pain as they get older, particularly in the shoulders, knees, ankles and feet. Findings published in Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR), indicate that children with joint hypermobility … Continue reading »

March 13, 2013

+
8:30 PM | A Special Issue on Topological Insulators: From Materials Design to Reality
physica status solidi (RRL) – Rapid Research Letters — A Special Issue on Topological Insulators Filed under: Materials & Polymer Science, Physical Sciences Tagged: aside, Materials & Polymer Science, Materials Science, physica status solidi (RRL), Physical Sciences, Rapid Research Letters, Solid State Physics
+
6:38 PM | High Salt-Intake and Autoimmunity
The incidence of auto-immune diseases has dramatically increased in the past 50 years and the concern that environmental exposures have contributed to this increase is broadly suspected. However, it is very hard to pin-point to an individual factor. Very intriguing observations were just published at Nature linking a high-salt intake to increased auto-immunity. The authors demonstrate that a high-salt diet increased the severity of experimental autoimmune encephalomyelitis (*EAE) - a […]
+
11:17 AM | Spinal Cancer: Guidelines for Diagnosis Unsupported In Patients with Lower Back Pain
A new systematic review published in The Cochrane Library has raised doubts as to the effectiveness of “red flag” indicators at both identifying and excluding cancer in patients with lower back pain. The authors of the review concluded that most individual red flags were poor at diagnosing spinal malignancies and call for further studies focused … Continue reading »
+
9:10 AM | Mesenchymal stem cells against brain cancer
Researchers from the Johns Hopkins University released yesterday a study showing that mesenchymal stem cells may one day be an important ingredient in an effective treatment against Glioblastoma (brain cancer). The researchers, led by Alfredo Quinones-Hinojosa compared two types of mesenchymal stem cells, MSCs derived from fat and MSCs derived from bone marrow.Full Story

Pendleton, C., Li, Q., Chesler, D., Yuan, K., Guerrero-Cazares, H. & Quinones-Hinojosa, A. (2013). Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas, PLoS ONE, 8 (3) DOI:

Citation
+
8:57 AM | Insert sensationalist headline here...
A recent BMJ Minerva column alerted me to an interesting paper in the journal Transplantation. The authors used collaborative databases to compare overall and age-specific graft survival in first deceased donor transplants carried out in the US & Europe. They found that although there was broad similarity in 1-year graft survival, 5 and 10 year graft survival was considerably higher in Europe than in the US. The tendency towards worse graft survival in the US persisted across all ethnic […]

March 12, 2013

+
10:32 PM | Great news for spinal cord injury victims
The recent findings of a placebo-controlled human clinical trial give new hope to spinal cord injury victims, as they clearly show that a combination of stem cells and physical therapy can partially restore both sensory and motor functions. The study was conducted by a team of researchers, led by Hatem E. Sabaawy, at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School.Full Story

El-Kheir WA, Gabr H, Awad MR, Ghannam O, Barakat Y, Farghali HA, Maadawi ZM, Ewes I & Sabaawy HE (2013). Autologous bone marrow-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients., Cell transplantation, PMID:

Citation
+
9:00 PM | Mesenchymal stem cells may aid in Diabetic foot ulcers
In a recent preclinical study on rabbits, researchers from the National University of Ireland Galway showed that administering allogeneic mesenchymal stem cells (MSCs) has the potential to speed up wound recovery in diabetic patients. The study may help one day help treat wounds of diabetic patients, especially the ones presenting with diabetic foot ulcers, which often lead to debilitating leg amputations.Full Story

O'Loughlin, A., Kulkarni, M., Creane, M., Vaughan, E., Mooney, E., Shaw, G., Murphy, M., Dockery, P., Pandit, A. & O'Brien, T. & (2013). Topical Administration of Allogeneic Mesenchymal Stem Cells Seeded in a Collagen Scaffold Augments Wound Healing and Increases Angiogenesis in the Diabetic Rabbit Ulcer, Diabetes, DOI:

Citation
+
8:21 PM | Biointeractomics: A Mini-Theme Issue
Read IUMB Life‘s Special Issue on Biointeractomics Filed under: Cell & Molecular Biology, Life Sciences Tagged: aside, Biointeractomics, Cell & Molecular Biology, Life Sciences
+
7:47 PM | Scientists decode the first embryonic cell movements
Biologists from the University of Freiburg, Germany just made an announcement saying that they have identified, in a zebrafish model, a signalling molecule that activates the first cell movements in the embryo, explaining the deeper molecular mechanisms which transform the initially tightly connected embryonic stem cells so that their very first cell migration takes place.Full Story

Song, S., Eckerle, S., Onichtchouk, D., Marrs, J., Nitschke, R. & Driever, W. (2013). Pou5f1-Dependent EGF Expression Controls E-Cadherin Endocytosis, Cell Adhesion, and Zebrafish Epiboly Movements, Developmental Cell, 24 (5) 486-501. DOI:

Citation
+
2:48 PM | Pathology Case of the Month
An elderly woman presented for evaluation to the rheumatology service with arthritis and neuropathy. She was hypertensive and had microscopic hematuria with dysmorphic red cells on microscopy. Her creatinine was 1.6 which had not changed in the previous year. She had no history of diabetes. Her serology was notable for a positive ANCA, elevated CRP and ANA 1:640. The sense was that despite the presence of the ANCA, the likelihood of a vasculitis was low due to the indolent course but she went […]
+
12:10 PM | The beauty of slacking off
…from Tasha So last week I had a completely useless week work-wise. I got lots of little things done and had some big life events (I’m an Australian citizen now!!) but I really didn’t complete what I thought I would. The ironic thing is that last week I had finally felt like I had caught [...]
+
11:13 AM | Housing Improvements Should Be Targeted At Those in Poorest Health
Improving housing can improve health, particularly when interventions are targeted at those in the poorest health, according to a systematic review published in The Cochrane Library. The authors say their review underscores the importance of targeting those most in need when devising programmes for housing improvement. Despite a wealth of research linking housing to health, … Continue reading »
+
10:59 AM | ASPET and BPS Partner With Wiley To Launch Pharmacology Research & Perspectives, an Open Access Journal
Michael J. Curtis of King’s College London, UK Appointed as Editor-in-Chief John Wiley & Sons, Inc., The American Society for Pharmacology and Experimental Therapeutics (ASPET) and the British Pharmacological Society (BPS) announced today their partnership to publish the new open access, peer-reviewed journal, Pharmacology Research & Perspectives, which will open for submissions in April 2013. … Continue reading »
+
9:53 AM | Resources for Your Physical Sciences & Engineering Library
As the world’s leading society publisher, Wiley–Blackwell has a long history of partnering with the eminent learned and professional societies, bringing you the most authoritative, and comprehensive Computer Science & IT, Engineering, Materials Science, Polymer Science, Physics and Astronomy, Statistics & Mathematics through an extensive portfolio of journals, books, reference works, databases in specialized subject … Continue reading »
+
1:01 AM | What’s New in Urban Studies?
In this Urban Studies Update, we’re featuring a collection of research related to the Urban Affairs Association Conference as well as a free online trial for Urban Studies journals for 30 days. For future Urban Studies research, don’t forget to subscribe via email so you don’t miss out on new and important research in your … Continue reading »

March 11, 2013

+
8:36 PM | Vibrational Spectroscopy in Medicine
Must-read! Vibrational Spectroscopy in Medicine – A Journal of Biophotonics Special Issue Filed under: Electrical & Electronics Engineering, Engineering, Physical Sciences Tagged: aside, Electrical & Electronics Engineering, Journal of Biophotonics, Optics & Photonics, Physical Sciences, Special Issue, Vibrational Spectroscopy
+
7:14 PM | ReNeuron wins grands totalling £1.2 million
ReNeuron was recently awarded with two grants totalling 1.2 million pounds to further develop their stem cell-based treatments.Full Story
+
6:44 PM | Structural changes in chronic pain. The innocent bystander?
Most BiM readers will be familiar with a body of research indicating that chronic pain is associated with apparent structural changes in the brain such as reductions in grey matter density. But maybe they are simply unimportant epiphenomena; innocent bystanders who were in the wrong place at the wrong time and now stand falsely accused.
5678910111213
1,375 Results