Posts

March 28, 2013

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3:48 PM | Bardoxolone - The Final Chapter - Part 2

One of the issues surrounding the study of bardoxolone in animal models was that, because of the way that it is metabolized in rats and mice, it is highly toxic when given for long periods. This specific toxicity is not present in humans. As a result, it was not possible to study the drug directly. An alternative was to study analogues of the drug. A group from Italy have just published the results of a study of an analogue of bardoxolone, RTA 405, in rats with type 2 diabetes. This study was […]

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2:32 PM | Gut bacteria - obesity and coeliac disease - stem cells

Another very quick post to bring to your attention two very interesting papers which caught my attention recently.The first is by Ciccocioppo and colleagues* and how, quote: "allogeneic HSCT may lead to induction of gluten tolerance in patients with CD [coeliac disease]." HSCT = hematopoietic stem cell transplantation, which is indeed as controversial as it sounds. Two patients, both with CD and β-thalassemia major who at 5 year follow-up after HSCT did not appear to show a […]

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10:37 AM | Read China’s First International Psychology Journal

PsyCh Journal, China’s first international psychology journal, publishes peer-reviewed research articles, research reports and integrated research reviews spanning the entire spectrum of scientific psychology and its applications. PsyCh Journal is the flagship journal of the Institute of Psychology, Chinese Academy of Sciences – the only national psychology research institute in China – and reflects the … Continue reading »

March 27, 2013

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11:56 PM | York researchers unveil the driving force behind prostate cancer

In a new study, researchers from the University of York have made a major discovery, finding that the presence of specific gene, in cancer stem cells, is the main driving force behind most types of prostate cancer. The researchers, led by Norman Maitland, believe that their study may open the way for developing new drugs that will target and destroy cancer stem cells, thus leading to more effective treatments.Full Story

Polson, E., Lewis, J., Celik, H., Mann, V., Stower, M., Simms, M., Rodrigues, G., Collins, A. & Maitland, N. (2013). Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells, Nature Communications, 4 1623. DOI: 10.1038/ncomms2627

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10:21 AM | 10 years of IFRS: Reflections and Expectations

The adoption of international financial reporting standards (IFRS) has been described as a ‘watershed’ and the ‘greatest ever change in financial reporting’. This two-part forum marks the 10th anniversary of the International Accounting Standards Board (IASB), with the papers exploring the impact of IFRS on standard setting, financial reporting practice and accounting education from the … Continue reading »

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9:05 AM | Clinical trial focusing on cancer stem cells to begin in Japan

A clinical trial focusing on cancer stem cells is set to begin sometime next April at the National Cancer Center Hospital East in Chiba Prefecture. Purpose of the study is to assess the safety and efficacy of sulfasalazine in terminal stomach cancer patients.Full Story

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1:20 AM | Hematology News: The Top-Cited Research Articles

We are highlighting the most cited Hematology articles from our list of leading journals in the subject. Don’t forget to subscribe to our Hematology Updates via Email so you don’t miss out on important research in your field. American Journal of Hematology Edited by: Carlo Brugnara Impact Factor: 4.671 A Phase … Continue reading »

March 26, 2013

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7:39 PM | New JAMA Reader

JAMA has a new platform called the JAMA Network Reader that you can use to get access to content from any of the JAMA journals (includes what were formerly called Archives of ...). All the content (which includes the ability to download pdfs as well as viewing things through the reader) is free for a limited time. Pretty slick.

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7:09 PM | Classification based cognitive functional therapy for back pain

This story of a 28 year old man with disabling low back pain illustrates the CB-CFT intervention trialled in the RCT in Bergen, Norway.

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5:30 PM | ReNeuron to begin Phase I stem cell trial on patients with critical limb ischaemia

Reneuron just announced that it has received approval to begin Phase 1 clinical trials with its "ReN009" stem cell-based therapy on people with critical limb ischaemia. The trial will be conducted at the Ninewells Hospital and Medical School in Dundee, Scotland.Full Story

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10:57 AM | The Rise of Innovative China

Although it has long been regarded as the ‘factory of the world’, there is a growing consensus that China is going to need to move up the value-added chain in the future. In other words, it is going to have to become more innovative if it is going to continue its economic rise. The Intellectual … Continue reading »

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1:20 AM | Materials Science Update: Research in the Spotlight

In this issue, we’re highlighting more Materials Science research articles as well as special and virtual issues for you to access. Don’t forget to subscribe to our Materials Science Updates via Email. You don’t want to miss out on important research in your field, right? Special & Virtual Issues Macromolecular Journals The Macromolecular Journals features … Continue reading »

March 25, 2013

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6:48 PM | Every move you make....Are you watching you?

Monitoring....There's something about getting something into numbers and targets that just makes it seem to be so controllable, isn't there? And many people - including many doctors - just love gadgets and measuring things. No wonder there is so much monitoring in health and fitness.Actually, there's too much monitoring in some health matters. Some monitoring could cause anxiety without benefit, or lead to actions that do more harm than good.Professor Paul Glasziou, author […]

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6:25 PM | Researchers rejuvenate the blood of old mice

Researchers at Lund University in Sweden published a few days ago a study in which they successfully rejuvenated the blood of old mice, by reprogramming their blood-forming stem cells using iPSCs technology.Full Story

Wahlestedt, M., Norddahl, G., Sten, G., Ugale, A., Micha Frisk, M., Mattsson, R., Deierborg, T., Sigvardsson, M. & Bryder, D. (2013). An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state, Blood, DOI: 10.1182/blood-2012-11-469080

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5:02 PM | UK Regulations: How do you get a licence to carry out animal research?

There are three levels of licensing required before a procedure can take place in the UK. The project, the individual and the institution must all have licenses from the Home Office. This post aims to discuss the process of getting … Continue reading →

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1:12 PM | Skin Lesions in Dialysis - Part 2

Phototoxic skin disorders in renal failure:Patients with renal failure or ESRD secondary SLE can have a photosensitive skin rash. For example:Discoid Lupus Erythematosus (DLE); these lesions are thick and scaly, plug the hair follicles, appear usually on surfaces of the skin exposed to sun (but can occur in non-exposed areas), tend to scar, and usually do not itch. Acute Cutaneous Lupus Erythematosus (ACLE); Confluent erythema and edema, erythematous macules and papules that eventually become […]

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10:33 AM | Chewing Gum Impacts Vigilance and Short Term Memory

Cops chewing gum may be a stereotype from a thousand crime shows, but new research shows that the act of chewing may actually decrease vigilance and short term memory. The study, published in the British Journal of Psychology, examines the impact of chewing gum on a task that required the continual updating of short-term memory. … Continue reading »

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9:16 AM | Amniotic stem cells treat rats with necrotising enterocolitis

In a new study funded by the Great Ormond Street Hospital Children's Charity researchers from the UCL Institute of Child Health have successfully used stem cells derived from amniotic fluid to treat necrotizing enterocolitis in a rodent model. The researchers believe that their study paves the way for new, cell-based therapies for treating this, many times lethal, condition.Full Story

Zani, A., Cananzi, M., Fascetti-Leon, F., Lauriti, G., Smith, V., Bollini, S., Ghionzoli, M., D'Arrigo, A., Pozzobon, M., Piccoli, M. & Hicks, A. (2013). Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism, Gut, DOI: 10.1136/gutjnl-2012-303735

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1:38 AM | Common MS Drugs Taken Together Do Not Reduce Relapse Risk

A recent clinical trial found that interferonβ-1a (INF) and glatiramer acetate (GA), two of the most commonly prescribed drugs for multiple sclerosis (MS), provide no additional clinical benefit when taken together. While findings published in Annals of Neurology, a journal of the American Neurological Association and Child Neurology Society, suggest that taking both INF and … Continue reading »

March 24, 2013

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10:28 AM | Sleep High, Sleep Safely: How Chimpanzee Nests Are Built With Predators in Mind

Sleeping is a dangerous business for animals threatened by nocturnal predators, but chimpanzees have been found to respond to this danger by building nests in high and inaccessible tree branches. New research, published in the American Journal of Primatology, explores how great apes face the risky trade-off between sleep and predator risk. A chimp community … Continue reading »

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1:05 AM | Chemistry – An Asian Journal: More Research Articles in the Spotlight

Published on behalf of the Asian Chemical Editorial Society (ACES), Chemistry — An Asian Journal is an international high-impact journal for chemistry in its broadest sense (2011 journal impact factor: 4.500). The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Here are more research … Continue reading »

March 23, 2013

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9:56 PM | Detection and Attribution of Anthropogenic Climate Change Impacts

Human-influenced climate change is an observed phenomenon affecting physical and biological systems across the globe. The majority of observed impacts are related to temperature changes and are located in the northern high- and mid-latitudes. However, new evidence is emerging that demonstrates that impacts are related to precipitation changes as well as temperature, and that climate … Continue reading »

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4:38 PM | Shinya Yamanaka interview

The Asahi Shimbun published a few hours ago a very interesting interview with Shinya Yamanaka. Yamanaka is a pioneer in the field of induced pluripotent stem cells (iPSCs), as he was the first man to develop iPSCs both from animal and human somatic cells.Full Story

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10:44 AM | Heavy Moms-to-Be at Greater Risk of C-Section

Researchers from Norway found that women with a pre-pregnancy body mass index (BMI) of 40 had an increased risk of vacuum extraction delivery or Cesarean section (C-section). Findings that appear in Acta Obstetricia et Gynecologica Scandinavica, a journal published by Wiley on behalf of the Nordic Federation of Societies of Obstetrics and Gynecology, indicate that … Continue reading »

March 22, 2013

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8:15 PM | Concept Map of Hypokalemia

No summary available for this post.

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5:16 PM | Researchers use menstrual blood stem cells to treat heart failure

Medistem, announced today via a press release that it has updated the paper regarding its Phase II clinical trial on patients with heart failure. Purpose of the trial is to assess the safety and efficacy of Medistem's proprietary type of stem cell called "Endometrial Regenerative Cell" (ERC).Full Story

Bockeria, L., Bogin, V., Bockeria, O., Le, T., Alekyan, B., Woods, E., Brown, A., Ichim, T. & Patel, A. (2013). Endometrial regenerative cells for treatment of heart failure: a new stem cell enters the clinic, Journal of Translational Medicine, 11 (1) 56. DOI: 10.1186/1479-5876-11-56

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3:25 PM | Cellular Dynamics receives $16 million fund

According to an announcement made yesterday, Cellular Dynamics International (CDI) will be receiving a $16 million fund from the California Institute for Regenerative Medicine (CIRM). The awarded money will be used by CDI to create 3 induced pluripotent stem cell (iPSC) lines for each of the 3000 healthy and diseased participating donors.Full Story

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2:05 PM | New technique allows researchers to grow hematopoietic stem cells "on an industrial scale"

A team of researchers from the Weill Medical College of Cornell University and the Memorial-Sloan Kettering Cancer Center has developed a new method to greatly expand, in the laboratory, the numbers of hematopoietic stem cells (HSCs) after they have been extracted from bone marrow tissue. The researchers say that their method is of great importance as it allows, like no other previously described, the mass production of MSCs for clinical use.Full Story

Lee, J., Shieh, J., Zhang, J., Liu, L., Zhang, Y., Eom, J., Morrone, G., Moore, M. & Zhou, P. (2013). Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4, Blood, DOI: 10.1182/blood-2012-09-455204

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10:11 AM | How do Successful Chinese Women Avoid Becoming Marriage ‘Leftovers’

The rise of successful, career-minded young women is one of the results of China’s continued economic growth, but when it comes to marriage how does this new type of woman chime with traditional Chinese values? New research in Symbolic Interaction explores the strategies these women adopt to avoid becoming ‘leftover women’ in China’s marriage market. … Continue reading »

March 21, 2013

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10:51 PM | Special 100th Anniversary Supplement The International Labour Review and the ILO: Milestones in a shared history

Access the Special 100th Anniversary Supplement — The International Labour Review and the ILO: Milestones in a shared history Filed under: Economics, Social Sciences & Humanities Tagged: aside, Economics, Humanities, International Labour Review, Labor & Demographic Economics, Social Sciences, Social Sciences & Humanities

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