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Posts

April 24, 2014

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9:01 AM | Autologous stem cell therapy improves motor function in stroke victims
CT scan slice of the brain showing a right-hemispheric ischemic stroke.People who have had a stroke, often suffer motor deficits with little potential to restore neurological function. However, a new study conducted in Taiwan, has found that when one group of stroke victims had their own peripheral blood stem cells (PBSCs) injected directly into the brain and a similar group did not, those who received the PBSCs experienced some "improvement in stroke scales and functional […]

Chen DC, Lin SZ, Fan JR, Lin CH, Lee W, Lin CC, Liu YJ, Tsai CH, Chen JC, Cho DY & Lee CC (2014). Intracerebral Implantation of Autologous Peripheral Blood Stem Cells in Stroke Patients: a Randomized Phase II Study., Cell transplantation, PMID:

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8:44 AM | Stem cells in circulating blood affect cardiovascular health
Heart DiagramA new study suggests that attempts to isolate an elusive adult stem cell from blood to understand and potentially improve cardiovascular health – a task considered possible but very difficult – might not be necessary.Instead, scientists have found that multiple types of cells with primitive characteristics circulating in the blood appear to provide the same benefits expected from a stem cell, including the endothelial progenitor cell that is the subject of hot […]

Moldovan, L., Anghelina, M., Kantor, T., Jones, D., Ramadan, E., Xiang, Y., Huang, K., Kolipaka, A., Malarkey, W., Ghasemzadeh, N. & Mohler, P. (2014). A Module of Human Peripheral Blood Mononuclear Cell Transcriptional Network Containing Primitive and Differentiation Markers Is Related to Specific Cardiovascular Health Variables, PLoS ONE, 9 (4) DOI:

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8:34 AM | Study finds long-term survival of human neural stem cells transplanted into primates
A team of researchers in Korea who transplanted human neural stem cells (hNSCs) into the brains of nonhuman primates and assessed cell survival and differentiation after 22 and 24 months found that the hNSCs had differentiated into neurons at 24 months and did not cause tumors.The hNSCs were labeled with magnetic nanoparticles to enable them to be followed by magnetic resonance imaging (MRI). They did not use immunosuppressants. According to the researchers, their study is the first to evaluate […]

Lee, S-R.; Lee, H. J.; Cha, S-H.; Jeong, K-J.; Lee, Y. J.; Jeon, C-Y.; Yi, K. S.; Lim, I.; Cho, Z-H.; Chang, K-T.; Kim, S. U. (2014). Long-term survival and differentiation of human neural stem cells in nonhuman primate brain with no immunosuppression, Cell Transplantation, Other: Link

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5:26 AM | Speak Out. Create Change.
Because hemophilia, a bleeding disorder, is affecting approximately 1 in 10,000 people and some 6.9 million people are living with a bleeding disorder. More importantly, only 25% of those suffering ့emophilia are diagnosed and the rest do not receive adequate care. That is why slogan for this year World Hemophilia Day 2014 is “Speak Out. […] The post Speak Out. Create Change. appeared first on Wiley Asia Blog.

April 23, 2014

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5:04 PM | Speaking on Reddit
Reddit is an increasingly important social network, and it is another place where you can discuss and share information about animal research. Continue reading →
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3:59 PM | The NIH Provides Assistance to New and Early Stage Investigators
If you are a researcher planning for your first clinical drug trial and do not have years of experience, you may be interested to know that the National Institutes of Health (NIH) is committed to helping new and early stage investigators succeed. The NIH recognizes that such individuals tend to be innovative and bring new ... continue reading
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3:26 AM | China and Brazil in African Agriculture
The questions of how Africa can feed itself, and how the agricultural sector can be a more effective engine for growth and development, have long been a target of international development efforts from western donors. But the emergence of the BRICS (Brazil, Russia, India, China and South Africa) countries as major players has raised hopes […] The post China and Brazil in African Agriculture appeared first on Wiley Asia Blog.

April 22, 2014

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5:00 PM | Quote Therapy – by Joel Osteen
“You’ve got to see yourself the way you want to be.” Joel Osteen
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4:20 PM | BHSC receives Wright State University IRB approval for retrospective chart review
Blue Horizon Stem Cells (BHSC), a division of Blue Horizon International, in cooperation with Wright State University Boonshoft School of Medicine (WSU BSOM), recently received Institutional Review Board (IRB) approval for a retrospective study entitled Spinal Cord Injury Stem Cell Therapy. The study has been determined to meet Federal exemption criteria 45 CFR 46.101 (b).The approval enables the study team to complete a retrospective chart review of data collected from June to September 2013.A […]
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4:04 PM | ISCO to provide up date on Its Parkinson's Disease Program at the 66th American Academy of Neurology Annual Meeting
International Stem Cell Corporation (ISCO) just announced that Dr. Ruslan Semechkin, ISCO's Chief Scientific Officer, will present data from its pre-clinical primate studies of Parkinson's disease (PD) at the 66th American Academy of Neurology Annual Meeting in Philadelphia.Date and time: Tuesday, April 29, 2014, 1:00 p.m. ETTopic: Movement DisordersSession title: Parkinson's Disease: Preclinical and Clinical TherapeuticsRead More
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12:55 PM | Video Podcast: Future Trends in the Medical Device Space in 2014
The medical device industry is constantly evolving. New product enhancements and innovations must be aligned with changing regulatory requirements. In this fast-paced environment, successful device developers need to stay on top of industry trends and understand the global regulatory implications, to ensure they deliver the most effective and efficient product development strategies. In this podcast, ... continue reading
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1:51 AM | Virtual Issue for Earth Day : Human Impact on Climate Change
That Earth Day is celebrated speaks to people’s recognition of the intrinsic value of the natural world. In recognition of Earth Day, therefore, we have compiled four articles that help us understand why people are or are not good stewards of the planet. These works explore the psychological processes that affect environmental intentions and behaviors, […] The post Virtual Issue for Earth Day : Human Impact on Climate Change appeared first on Wiley Asia Blog.

April 21, 2014

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5:12 PM | The ongoing debate about the definition of CKD in the elderly
In NDT this month, there is a nice series of articles outlining the ongoing debate about whether or not an eGFR<60 should be considered a disease, particularly in the elderly. The pro side was argued by Giuseppe Conte and the anti by Richard Glassock. Finally, there was a moderator's opinion written by Stein Hallan and Ron Gansevoort.Dr. Glassock makes the familiar argument that age-related decline in GFR is ubiquitous and should not be considered a disease (with the associated anxiety and […]
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4:01 PM | SIRT1 protein equired for integrity of induced pluripotent stem cells
This image shows chromosome abnormalities in reprogrammed cells in which SIRT1 protein has been removed (in red).Credit: Centro Nacional de Investigaciones OncologicasCell reprogramming converts specialised cells such as nerve cells or skin cells towards an embryonic stem cell state. This reversal in the evolutionary development of cells also requires a reversal in the biology of telomeres, the structures that protect the ends of chromosomes; whilst under normal conditions telomeres […]

De Bonis, M., Ortega, S. & Blasco, M. (2014). SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells, Stem Cell Reports, DOI:

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3:53 PM | Developing bulletproof vests using stem cells?
Stem cells demonstrate a bizarre property never before seen at a cellular level, according to a new study published today by researchers at the University of Cambridge. The property -- known as auxeticity -- is one which may have application as wide-ranging as soundproofing, super-absorbent sponges and bulletproof vests.Most materials when stretched will contract. For example, if one pulls on an elastic band, the elastic itself will get thinner. The opposite is also true: squeeze a material and […]

Pagliara, S., Franze, K., McClain, C., Wylde, G., Fisher, C., Franklin, R., Kabla, A., Keyser, U. & Chalut, K. (2014). Auxetic nuclei in embryonic stem cells exiting pluripotency, Nature Materials, DOI:

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3:43 PM | Researchers pinpoint the role of cancer stem cells in drug resistance
Credit: UC San Diego School of MedicineMost drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered a molecule, or biomarker, called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing the stem cell-like properties of cancer cells.The findings, published in the April 20, 2014 online […]

Seguin, L., Kato, S., Franovic, A., Camargo, M., Lesperance, J., Elliott, K., Yebra, M., Mielgo, A., Lowy, A., Husain, H. & Cascone, T. (2014). An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition, Nature Cell Biology, DOI:

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April 17, 2014

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7:29 PM | Research on flies suggests that lost stem cells are naturally replaced by non-stem cells
Erika MatunisCreditJohns Hopkins researchers have discovered an unexpected phenomenon in the organs that produce sperm in fruit flies, when a certain kind of stem cell is killed off experimentally, another group of non-stem cells can come out of retirement to replace them.The discovery sheds light on the tiny "environments" that stem cells occupy in animal bodies and may help explain how stem cells in tumors replenish themselves, the researchers report in the May 8 issue of the journal Cell […]

Phylis Hétié, Margaret de Cuevas, Erika Matunis (2014). Conversion of Quiescent Niche Cells to Somatic Stem Cells Causes Ectopic Niche Formation in the Drosophila Testis, Cell Reports, Other: http://dx.doi.org/10.1016/j.celrep.2014.03.058

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7:17 PM | Mesenchymal stem cells require hydrogen sulfide to function properly
Professor Songtao ShiMesenchymal stem cells need to produce hydrogen sulfide in order to properly multiply and form bone tissue, according to a new study from the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry.Professor Songtao Shi, principal investigator on the project, said the presence of hydrogen sulfide produced by the cells governs the flow of calcium ions. The essential ions activate a chain of cellular signals that results in osteogenesis, or the creation of […]

Liu, Y., Yang, R., Liu, X., Zhou, Y., Qu, C., Kikuiri, T., Wang, S., Zandi, E., Du, J., Ambudkar, I. & Shi, S. (2014). Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2+ Channel Sulfhydration, Cell Stem Cell, DOI:

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5:00 PM | Quote Therapy – by Iyanla Vanzant
“So many of us are clear about what we have to do, but not clear about who we have to be while we’re doing it.” Iyanla Vanzant
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1:58 PM | Voice Your Support for Animal Transport
Air France are one of the few airlines willing to transport animals for medical research. Please support them by signing the petition. Continue reading →
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10:38 AM | Neuralstem stem cell therapy for spinal cord injuries approved to begin at University Of California
Neuralstem LogoNeuralstem announced yesterday that the Institutional Review Board of the University of California, San Diego, School of Medicine has approved the Phase I safety trial to treat chronic spinal cord injury (cSCI) with its NSI-566 neural stem cells. The NSI-566/cSCI Phase I trial will enroll patients with thoracic spinal cord injuries (T2-T12) who have an American Spinal Injury Association (AIS) A level of impairment, between one and two years after injury. AIS A impairment, which […]
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10:29 AM | Modified stem cells may offer treatment for Alzheimer's disease
Mathew Blurton-JonesUC Irvine neurobiologists have found that genetically modified neural stem cells show positive results when transplanted into the brains of mice with the symptoms and pathology of Alzheimer's disease. The pre-clinical trial is published in the journal Stem Cells Research and Therapy, and the approach has been shown to work in two different mouse models.Alzheimer's disease, one of the most common forms of dementia, is associated with accumulation of the protein amyloid-beta […]

Blurton-Jones, M., Spencer, B., Michael, S., Castello, N., Agazaryan, A., Davis, J., Müller, F., Loring, J., Masliah, E. & LaFerla, F. & (2014). Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models, Stem Cell Research & Therapy, 5 (2) 46. DOI:

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6:36 AM | Discover Nursing : What’s new in Wiley Nursing?
We have some news to share with you who have great interest on nursing and midwifery practice. Let’s start with a new journal. Nursing Open, a new open access journal from Wiley, is available soon! It is a peer reviewed open access journal that welcomes articles on all aspects of nursing and midwifery practice, research, […] The post Discover Nursing : What’s new in Wiley Nursing? appeared first on Wiley Asia Blog.

April 16, 2014

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5:00 PM | The science behind the benefits of mindfulness
“I feel like I should try meditating with everyone talking about it.” These were the words that came out of my classmate’s mouth as we discussed the science behind mindfulness. What he went on to express is the sentiment that I’ve... Read More ›
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2:45 PM | How Molecular Profiling Has Transformed Modern Targeted Cancer Therapies
Advances in genomic analysis technologies have brought us to an important phase in clinical trial design and targeted cancer therapies. Today, leading academic cancer research centers around the globe are continuing to break new ground as oncologists go beyond empirical testing measures to target specific oncogenic pathways tailored to a narrow group of patients with ... continue reading
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12:59 PM | STEM Fair: Why Talking to Children about Research is Important
Outreach is important in improving the public's understanding of animal research. A school STEM fair offers the perfect opportunity. Continue reading →

April 15, 2014

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5:00 PM | Quote Therapy – by Shawn Achor
“The absence of disease is not health.” Shawn Achor
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1:30 PM | Speaking of Addiction Research
Addiction in animals involves very similar physiological changes in the brain as it does in humans. Prof Jentsch explains. Continue reading →

April 14, 2014

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4:56 PM | Center for Joint Regeneration in Arizona now offers stem cell procedures for arthritis, tendonitis and ligament injuries
The orthopedic stem cell clinic in Arizona, Center for Joint Regeneration, is now offering stem cell procedures for arthritis, tendonitis and ligament injuries. The procedures have the ability to provide pain relief and help patients avoid the need for joint replacement or soft tissue surgery.There are two Board Certified, Fellowship Trained Orthopedic Doctors at the Center for Joint Regeneration. Drs. Adam Farber and Sumit Dewanjee offer stem cell procedures for all types of joint arthritis […]
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4:50 PM | Silly Putty ingredient promotes stem cell growth
Researchers cultured stem cells on ultrafine carpets made of  microscopic posts of a key ingredient in Silly Putty. Credit: Ye Tao, Rose Anderson, Yubing Sun, Jianping FuThe sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become, a new study shows.The researchers coaxed human embryonic stem cells to turn into working spinal cord cells more efficiently by growing the cells on a soft, ultrafine carpet made of a […]

Sun, Y., Yong, K., Villa-Diaz, L., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P. & Fu, J. & (2014). Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells, Nature Materials, DOI:

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