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April 17, 2014

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7:29 PM | Research on flies suggests that lost stem cells are naturally replaced by non-stem cells
Erika MatunisCreditJohns Hopkins researchers have discovered an unexpected phenomenon in the organs that produce sperm in fruit flies, when a certain kind of stem cell is killed off experimentally, another group of non-stem cells can come out of retirement to replace them.The discovery sheds light on the tiny "environments" that stem cells occupy in animal bodies and may help explain how stem cells in tumors replenish themselves, the researchers report in the May 8 issue of the journal Cell […]

Phylis Hétié, Margaret de Cuevas, Erika Matunis (2014). Conversion of Quiescent Niche Cells to Somatic Stem Cells Causes Ectopic Niche Formation in the Drosophila Testis, Cell Reports, Other: http://dx.doi.org/10.1016/j.celrep.2014.03.058

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7:17 PM | Mesenchymal stem cells require hydrogen sulfide to function properly
Professor Songtao ShiMesenchymal stem cells need to produce hydrogen sulfide in order to properly multiply and form bone tissue, according to a new study from the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry.Professor Songtao Shi, principal investigator on the project, said the presence of hydrogen sulfide produced by the cells governs the flow of calcium ions. The essential ions activate a chain of cellular signals that results in osteogenesis, or the creation of […]

Liu, Y., Yang, R., Liu, X., Zhou, Y., Qu, C., Kikuiri, T., Wang, S., Zandi, E., Du, J., Ambudkar, I. & Shi, S. (2014). Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2+ Channel Sulfhydration, Cell Stem Cell, DOI:

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5:00 PM | Quote Therapy – by Iyanla Vanzant
“So many of us are clear about what we have to do, but not clear about who we have to be while we’re doing it.” Iyanla Vanzant
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1:58 PM | Voice Your Support for Animal Transport
Air France are one of the few airlines willing to transport animals for medical research. Please support them by signing the petition. Continue reading →
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10:38 AM | Neuralstem stem cell therapy for spinal cord injuries approved to begin at University Of California
Neuralstem LogoNeuralstem announced yesterday that the Institutional Review Board of the University of California, San Diego, School of Medicine has approved the Phase I safety trial to treat chronic spinal cord injury (cSCI) with its NSI-566 neural stem cells. The NSI-566/cSCI Phase I trial will enroll patients with thoracic spinal cord injuries (T2-T12) who have an American Spinal Injury Association (AIS) A level of impairment, between one and two years after injury. AIS A impairment, which […]
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10:29 AM | Modified stem cells may offer treatment for Alzheimer's disease
Mathew Blurton-JonesUC Irvine neurobiologists have found that genetically modified neural stem cells show positive results when transplanted into the brains of mice with the symptoms and pathology of Alzheimer's disease. The pre-clinical trial is published in the journal Stem Cells Research and Therapy, and the approach has been shown to work in two different mouse models.Alzheimer's disease, one of the most common forms of dementia, is associated with accumulation of the protein amyloid-beta […]

Blurton-Jones, M., Spencer, B., Michael, S., Castello, N., Agazaryan, A., Davis, J., Müller, F., Loring, J., Masliah, E. & LaFerla, F. & (2014). Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models, Stem Cell Research & Therapy, 5 (2) 46. DOI:

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6:36 AM | Discover Nursing : What’s new in Wiley Nursing?
We have some news to share with you who have great interest on nursing and midwifery practice. Let’s start with a new journal. Nursing Open, a new open access journal from Wiley, is available soon! It is a peer reviewed open access journal that welcomes articles on all aspects of nursing and midwifery practice, research, […] The post Discover Nursing : What’s new in Wiley Nursing? appeared first on Wiley Asia Blog.

April 16, 2014

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5:00 PM | The science behind the benefits of mindfulness
“I feel like I should try meditating with everyone talking about it.” These were the words that came out of my classmate’s mouth as we discussed the science behind mindfulness. What he went on to express is the sentiment that I’ve... Read More ›
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2:45 PM | How Molecular Profiling Has Transformed Modern Targeted Cancer Therapies
Advances in genomic analysis technologies have brought us to an important phase in clinical trial design and targeted cancer therapies. Today, leading academic cancer research centers around the globe are continuing to break new ground as oncologists go beyond empirical testing measures to target specific oncogenic pathways tailored to a narrow group of patients with ... continue reading
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12:59 PM | STEM Fair: Why Talking to Children about Research is Important
Outreach is important in improving the public's understanding of animal research. A school STEM fair offers the perfect opportunity. Continue reading →

April 15, 2014

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5:00 PM | Quote Therapy – by Shawn Achor
“The absence of disease is not health.” Shawn Achor
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1:30 PM | Speaking of Addiction Research
Addiction in animals involves very similar physiological changes in the brain as it does in humans. Prof Jentsch explains. Continue reading →

April 14, 2014

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4:56 PM | Center for Joint Regeneration in Arizona now offers stem cell procedures for arthritis, tendonitis and ligament injuries
The orthopedic stem cell clinic in Arizona, Center for Joint Regeneration, is now offering stem cell procedures for arthritis, tendonitis and ligament injuries. The procedures have the ability to provide pain relief and help patients avoid the need for joint replacement or soft tissue surgery.There are two Board Certified, Fellowship Trained Orthopedic Doctors at the Center for Joint Regeneration. Drs. Adam Farber and Sumit Dewanjee offer stem cell procedures for all types of joint arthritis […]
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4:50 PM | Silly Putty ingredient promotes stem cell growth
Researchers cultured stem cells on ultrafine carpets made of  microscopic posts of a key ingredient in Silly Putty. Credit: Ye Tao, Rose Anderson, Yubing Sun, Jianping FuThe sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become, a new study shows.The researchers coaxed human embryonic stem cells to turn into working spinal cord cells more efficiently by growing the cells on a soft, ultrafine carpet made of a […]

Sun, Y., Yong, K., Villa-Diaz, L., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P. & Fu, J. & (2014). Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells, Nature Materials, DOI:

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4:37 PM | Hepatitis C cure on the Horizon: Implications for Nephrology
You have probably noticed the flurry of articles published this week in the NEJM, coinciding with the International Liver Congress meeting in London, reporting incredible results with new direct-acting antiviral agentsin Hepatitis C. This is undoubtedly one of the biggest medical stories of the year and a triumph for science, coming just 25 years after the discovery of the RNA virus. The studies were in patients with genotype 1 HCV although apparently the response is equally as good in other […]
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3:12 PM | Better Mice, Better Research, Better Results
Perrin recently discussed some difficulties of translational mouse research in Nature. He is right, there are issues, but many of them come down to human error. Continue reading →
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2:18 PM | Risk-based Monitoring of Clinical Trials Decreases Costs and Improves Results
In August 2013, the U.S. Food and Drug Administration (FDA) released an industry guidance on a risk-based approach to monitoring clinical trials. The guidance called for multiple ways to monitor research and is focused on preventing risk to data quality, human subject safety, and clinical trial purity. When interpreting risk-based monitoring, it is useful to ... continue reading

April 12, 2014

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2:39 AM | The Eventual Millionaire: How Anyone Can Be an Entrepreneur and Successfully Grow Their Startup
For many people, starting a business is one of the best ways to achieve both wealth and the personal goals that they have set for themselves. Many people want to become entrepreneurs at some point, but lack confidence in their ability to run a business. The truth is, though, that anyone can start their own […]The post The Eventual Millionaire: How Anyone Can Be an Entrepreneur and Successfully Grow Their Startup appeared first on Wiley Asia Blog.

April 11, 2014

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2:52 PM | BrainStorm granted additional patent for its autologous stem cell technology
BrainStorm Cell Therapeutics, a developer of adult stem cell technologies for neurodegenerative diseases, today announced that the U.S. Patent and Trademark Office has granted the company an additional patent for its autologous stem cell technology. The patent covers the production method of the company's proprietary stem cells induced to secrete significantly elevated levels of neurotrophic factors for the treatment of neurodegenerative diseases.Read More
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2:46 PM | Yale researchers search for earliest roots of psychiatric disorders
Credit: Michael HelfenbeinNewborns whose mothers were exposed during pregnancy to any one of a variety of environmental stressors -- such as trauma, illness, and alcohol or drug abuse -- become susceptible to various psychiatric disorders that frequently arise later in life. However, it has been unclear how these stressors affect the cells of the developing brain prenatally and give rise to conditions such as schizophrenia, post-traumatic stress disorder, and some forms of autism and bipolar […]

Hashimoto-Torii, K., Torii, M., Fujimoto, M., Nakai, A., El Fatimy, R., Mezger, V., Ju, M., Ishii, S., Chao, S., Brennand, K. & Gage, F. (2014). Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders, Neuron, DOI:

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2:36 PM | Researchers identify transcription factors distinguishing glioblastoma stem cells
The activity of four transcription factors – proteins that regulate the expression of other genes – appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor. The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics – processes […]

Suvà, M., Rheinbay, E., Gillespie, S., Patel, A., Wakimoto, H., Rabkin, S., Riggi, N., Chi, A., Cahill, D., Nahed, B. & Curry, W. (2014). Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells, Cell, DOI:

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2:28 PM | Background Briefing on Animal Research in Canada
Background briefing on the facts of animal research in Canada Continue reading →

April 10, 2014

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5:00 PM | Quote Therapy – by Robert Herjavec
“The best way to get past doubt and inexperience is simply action.” Robert Herjavec
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2:33 PM | SYR: Why I Became a Biologist
After a relative died from measles, I discovered my purpose - to become a biologist and fight disease Continue reading →
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12:54 PM | Mobile Medical Device Poll Describes Efficiency Gains By Practitioners
A recent MedData Point poll concerning mobile health adoption amongst practitioners reveals several insights of interest to medical device manufacturers – especially those operating in the software app segment of the industry. The survey, which was conducted by the MedData Group, contacted 141 physicians from a variety of different backgrounds in order to get their ... continue reading
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3:04 AM | Transplant Drugs May Help Wipe Out Persistent HIV Infections
New research suggests that drugs commonly used to prevent organ rejection after transplantation may also be helpful for combating HIV. The findings, which are published in the American Journal of Transplantation, suggest a new strategy in the fight against HIV and AIDS. Despite the effectiveness of antiviral therapies at suppressing HIV, the virus still persists indefinitely […]The post Transplant Drugs May Help Wipe Out Persistent HIV Infections appeared first on Wiley Asia Blog.

April 09, 2014

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7:13 PM | Mesenchymal stem cells show promise in stroke treatment
Neurologist Dr. Steven CramerIn an analysis of published research, neurologist Dr. Steven Cramer and biomedical engineer Weian Zhao identified 46 studies that examined the use of mesenchymal stromal cells -- a type of multipotent adult stem cells mostly processed from bone marrow -- in animal models of stroke. They found mesenchymal stem cells (MSCs) to be significantly better than control therapy in 44 of the studies.Importantly, the effects of these cells on functional recovery were robust […]

Vu Q, Xie K, Eckert M, Zhao W & Cramer SC (2014). Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke., Neurology, 82 (14) 1277-86. PMID:

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7:04 PM | Solving platelet 'puzzle' unveils blood disorder link
Dr Ashley Ng Melbourne researchers have solved a puzzle as to how an essential blood-making hormone stimulates production of the blood clotting cells known as platelets.Platelets are small, disc shaped clear cell fragments which are essential for stopping bleeding. They are produced by their ‘parent’ cells, called megakaryocytes.The discovery, made by scientists at the Walter and Eliza Hall Institute, identified how bone marrow cells could become overstimulated and produce too […]

Ng, A., Kauppi, M., Metcalf, D., Hyland, C., Josefsson, E., Lebois, M., Zhang, J., Baldwin, T., Di Rago, L., Hilton, D. & Alexander, W. (2014). Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation, Proceedings of the National Academy of Sciences, DOI:

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5:00 PM | The 5 Stages of Change: Are You Ready to Change?
Do I need to start drinking less or am I actually ok with my current amount? I need to drink less, but not sure how. Ok I definitely need to drink less, but now I just have to lay everything... Read More ›

April 08, 2014

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4:00 PM | Quote Therapy – by Thomas Szasz
“People often say that this person is or that person has not yet found himself. But the self is not something that one finds. It is something one creates.” Thomas Szasz
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