Posts

July 24, 2014

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7:00 AM | Infographic : Smartphones Apps to Support Prescribing
Are you a doctor? Have you ever prescribed any medication with some mistakes? How about seeking help from innovative mobile apps that could help you achieve your daily tasks without stressing yourself out? Junior doctors, who accidentally makes error while prescribing, tend to use more medical mobile apps. Those medical mobile apps help doctors not […] The post Infographic : Smartphones Apps to Support Prescribing appeared first on Wiley Asia Blog.
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6:13 AM | The New York Stem Cell Foundation Partners With Beyond Batten Disease Foundation to Fight Juvenile Batten Disease
The New York Stem Cell Foundation (NYSCF) and Beyond Batten Disease Foundation (BBDF) have partnered to develop stem cell resources to investigate and explore new treatments and ultimately find a cure for juvenile Batten disease, a fatal illness affecting children.NYSCF scientists will create induced pluripotent stem (iPS) cell lines from skin samples of young people affected by juvenile Batten disease as well as unaffected family members. IPS cell lines are produced by artificially […]
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6:03 AM | Stem Cell Trial by StemGenex® Offers Hope to Parkinson's Patients
StemGenex®, the leading resource for adult adipose stem cell therapy in the US aimed at improving the lives of patients dealing with degenerative diseases today announced their newest clinical study for Parkinson’s disease. StemGenex believes that a commitment to the safety and efficacy of stem cell therapy are paramount when providing care to patients with degenerative diseases.This clinical study makes stem cell therapy accessible to the millions of individuals currently living […]

July 23, 2014

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8:07 PM | Hyperammonemia - When should we start dialysis?
I would like to discuss a case that I recently saw in renal consult. He was a man in his 60s with history of end stage liver disease who received a liver transplant. His hospital course was complicated by anuric ATN and liver graft failure. As a result, he was started on dialysis on post-operative day 0.  Dialysis was stopped on post-op day 2 due to recovering renal function. On post-op day 3 he became encephalopathic. His ammonia level was elevated to 337 and did not improve with […]
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12:55 PM | Mexico And Korea Announce Medical Device Regulatory Harmonization
The medical device regulatory landscape is far more interlinked that it might first seem. For proof, look no further than the recent news from Mexico that will allow manufacturers from South Korea to benefit from expedited access to the Mexican medical device market. The products in question must have already been approved for sale within ... continue reading
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9:33 AM | Altmetric, Wiley and Buzz
Altmetric is available across all Wiley journals since last week. We have listened to buzz about it and compiled opinion on Wiley journals with Altmetric scores. View the story “Altmetric, Wiley and Buzz” on Storify The post Altmetric, Wiley and Buzz appeared first on Wiley Asia Blog.
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7:17 AM | Novel Methods May Improve Stem Cell Survival after Transplantation into Damaged Tissues
BioResearch Open Access is published online six times per year.Stem cells are a very promising solution for treating damaged organs and tissues, but with current transplantation approaches stem cell survival is poor, greatly limiting their effectiveness.New methods are being developed and tested to improve the survival and optimize their therapeutic function after transplantation, as described in a Review article in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., […]
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7:05 AM | ISCO Secures Approval for Core Technology Patents in Europe
International Stem Cell Corporation ( ISCO), a California-based biotechnology company developing novel stem cell based therapies and biomedical products, announced yesterday that it has received formal opinion from the Advocate General for the European Union Court of Justice (CJEU) in favor of the Company's pending core technology patents on parthenogenetic stem cells.Read More

July 22, 2014

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5:12 PM | Tick borne diseases for the nephrologist - Babesiosis
The following few posts are a summary of tick borne illnesses that can cause renal failure and/or electrolyte problems. BabesiosisFirst identified on Nantucket Island in 1969 and was initially know as Nantucket fever.Endemic areas.CDC map. Reported cases in 2012Cases have been reported in Europe (Croatia, France, Great Britain, Ireland, Portugal, Spain, Sweden, Switzerland)(Babesia divergens). The tick. Ixodes scapularis. The Blacklegged tick.The pathogen.Babesia […]
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4:30 PM | Quote Therapy – by Lindsay Lohan
“Be ok with just being ok.” Lindsay Lohan
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12:55 PM | Malaysia Implements New Medical Device Policies
Medical device companies interested in doing business in Malaysia now have a clearer path to market thanks to the country’s Medical Device Authority (MDA) putting into place policies associated with the Medical Device Act. The Medical Device Act was initially adopted in the first quarter of 2013, and went into effect July 1, 2013, but ... continue reading
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9:06 AM | Celladon announces In-License of Stem Cell Factor Development Program
Celladon Corporation, a clinical-stage biotechnology company applying its leadership position in the field of gene therapy and calcium dysregulation today announced an exclusive, global license from Enterprise Partners Venture Capital for gene therapy applications of the membrane-bound form of the Stem Cell Factor gene (mSCF) for treatment of cardiac ischemia. Stem Cell Factor is a critical cytokine which contributes to cell migration, proliferation, and survival of cardiac stem cells.Read More
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8:55 AM | Mesenchymal stem cells promote muscle repair and strengthening after resistance exercise
Professor Marni BoppartNew research in mice reveals that mesenchymal stem cells (MSCs) help rejuvenate skeletal muscle after resistance exercise. By injecting MSCs into mouse leg muscles prior to several bouts of eccentric exercise (similar to the lengthening contractions performed during resistance training in humans that result in mild muscle damage), researchers were able to increase the rate of repair and enhance the growth and strength of those muscles in the exercising mice.The […]

July 21, 2014

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2:21 PM | Report On Medical Device Approval Process Underlines Areas To Improve
There’s good news from the CDRH regarding its strategy to more rapidly bring medical devices to market in crucial, innovation-linked treatment areas. A third-party study of the medical device submission process, carried out by Booz Allen Hamilton, was published in June of 2014 and indicated that the FDA has been able to make progress in ... continue reading
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2:12 PM | Background Briefing on Animal Research in the UK
Background briefing on the use of animals in research in the UK. This provides facts, laws and statistics about animal testing in the UK. Continue reading →
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2:23 AM | Going Grey: Chinese Plants Evolve Alpine Camouflage to Avoid Attack
Many animal species have evolved sophisticated camouflage to avoid predators, yet research in New Phytologist has found that in the plant world a Chinese species of herb uses its grey leaves to blend into its mountainside surroundings. As a defense strategy camouflage can be costly for plants. Flowers which rely on attracting insects for pollination […] The post Going Grey: Chinese Plants Evolve Alpine Camouflage to Avoid Attack appeared first on Wiley Asia Blog.

July 20, 2014

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8:57 AM | Role of Astroglia in Down's Syndrome Revealed Thanks to iPSCs
David Pleasure, Chen Chen, Wenbin Deng and Peng Jiang(left to right)Researchers from UC Davis School of Medicine and Shriners Hospitals for Children -- Northern California have identified a group of cells in the brain that they say plays an important role in the abnormal neuron development in Down syndrome.After developing a new model for studying the syndrome using patient-derived induced pluripotent stem cells, the scientists also found that applying an inexpensive antibiotic to the cells […]

Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC & Loring JF (2014). Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells., Nature communications, 5 4430. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25034944

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July 18, 2014

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9:24 PM | The Lone Star Tick
Recently a 65-year-old female was referred to an ED in the state of Missouri complaining of fevers, chills, headache, diarrhea and vomiting occurring over the last week. 3 weeks prior she had received an orthotopic liver transplant. Her post transplant course was unremarkable and she was discharged on prograf 2mf bid, myfortic 360mg bid, prednisone tapering, Bactrim single strength daily and valcyte 450mg od. She also took thyroid replacement, Januvia, warfarin and aspirin. Past medical history […]
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4:30 PM | Quote Therapy – by Robin Roberts
“The tragedy is not so much the experience that you’re having. The tragedy is that we don’t take the time to understand the meaning and purpose behind what we’re going through.” Robin Roberts
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12:37 PM | ALF Claims Responsibility for CALAS National Office Vandalism
On Tuesday, July 15, an act of vandalism occurred near the Canadian Association for Laboratory Animal Science National Office in Toronto, ON.  There were no injuries and a police investigation is ongoing. The extremist website Bite Back published an unsigned … Continue reading →
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10:37 AM | Scientists discover gene that links stem cells, aging and cancer
Stem cells from adult mouse epidermis (green, Cytokeratin 6; blue, cell nucleus); Sox4 protein maintains tissue homeostasis in these cells.An organism is healthy thanks to a good maintenance system: the normal functioning of organs and environmental exposure cause damage to tissues, which need to be continuously repaired.This process is not yet well understood, but it is known that stem cells in the organs play a key role, and that when repair fails, the organism ages more quickly. Researchers […]

Foronda, M., Martínez, P., Schoeftner, S., Gómez-López, G., Schneider, R., Flores, J., Pisano, D. & Blasco, M. (2014). Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation, Cell Reports, DOI: 10.1016/j.celrep.2014.06.031

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10:29 AM | Discovery May Make It Easier to Develop Life-Saving Induced Pluripotent Stem Cells
Human oocyteNot unlike looking for the proverbial needle in a haystack, a team of Michigan State University researchers have found a gene that could be key to the development of induced pluripotent stem cells, cells that can potentially save millions of lives by morphing into practically any cell in the body.The gene, known as ASF1A, was not discovered by the team. However, it is at least one of the genes responsible for the mechanism of cellular reprogramming, a phenomenon that can turn one […]

Gonzalez-Munoz, E., Arboleda-Estudillo, Y., Out, H. & Cibelli, J. (2014). Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming, Science, DOI: 10.1126/science.1254745

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July 17, 2014

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9:02 PM | Courses
A bit of housekeeping here - I noticed that all of our current course announcements were out of date. These have now been updated with the most recent versions of each course including the following courses coming up shortly:ASN Board Review Course - August 2-8 2014HD University - August 15-16 2014Brigham Renal Board Review Course - August 4-8 2014Medstar Kidney and Pancreas Transplantation Course - October 11, 2014Ultrasonography for Nephrologists - October 25-26 2014 (which I recently […]
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2:44 PM | Top marks for Speaking of Research website
The industry magazine Lab Animal occasionally reviews websites applicable to it’s readers. Earlier this year, they reviewed the Speaking of Research website. The article does a good job of relaying the history behind how Speaking of Research began and some … Continue reading →
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2:02 AM | Air Quality in Pakistan : Just What You Need to Know
With more than 180 million people in the country and industrialization, Pakistan is facing some risks of air pollution. Various vehicles, power plants and industrial activities contribute to poor ambient air quality in South Asia Nation. Researchers measured and analysed air pollution in Pakistan by monitoring hourly air quality from 2007 to 2011. While carbon […] The post Air Quality in Pakistan : Just What You Need to Know appeared first on Wiley Asia Blog.

July 16, 2014

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4:30 PM | Preventing a Drug Overdose
Preventing a Drug Overdose [Article via Psychology Today. Click above for full post] Researchers from New York once found that nearly 98 percent of all accidental overdose deaths were caused by opiates,cocaine, and alcohol. Nearly 60 percent of those were... Read More ›
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2:51 PM | Baclofen in dialysis patients: Just say no!
At our hospital, we started noticing a pattern of admissions among some of our maintenance dialysis patients. In one case, an elderly woman with DM, peripheral arterial disease, and ESRD on thrice weekly hemodialysis was sent to the emergency department from her nursing facility for altered mental status. She was normal three days prior to admission, but when her nurse found her confused and difficult to arouse, they sent her to our ED. We got consulted to continue maintenance dialysis, but we […]
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12:55 PM | Medical Device Industry News Video Roundup – June 2014
Welcome to the Aptiv Solutions medical device news roundup! We’ve collected ten intriguing news articles to provide you with information you need to help your organization succeed. Coming up in this roundup: As the summer progresses, the medical device sector continues to grow and expand. New regulations and innovative tools are changing the industry every ... continue reading

July 15, 2014

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6:50 PM | Lithium and the Kidney: Old Observations & New Insights
Lithium is indispensable as an effective treatment for bipolar affective disorder. However, it has a narrow therapeutic index with desired therapeutic levels between 0.6 and 1.2 mEq/L. Lithium is handled by the kidney (responsible for almost all its excretion) in a manner very similar to sodium. It has a molecular weight of 7 daltons, has a moderate volume of distribution, is <10% protein bound and is therefore readily dialyzable. Lithium may cause of myriad of renal related toxicities, some […]
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5:00 PM | Quote Therapy – Bishop T.D. Jakes
“Your complications are not an indication that you cannot conquer.” Bishop T.D. Jakes
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