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Posts

April 05, 2013

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3:56 PM | Right Turn: Research at the bleeding edge. Literally.
How many university students can say they invented a product that people around the world will want to use? For that matter, how many people have ever invented a product that made it to the market?! Joe Landolina is CEO and Co-Founder of Suneris, Inc. and a student at the Polytechnic Institute of New York...Read more
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3:22 PM | Comment on In which I dream of going viral by cromercrox
<i>a mammoth serial dilution session that took three hours</i> Have you actually seen a mammoth? Close up? I reckon that if it took only three hours you had a very small mammoth.
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11:34 AM | Premio de Investigación CEI UAM+CSIC en Biología Molecular Física y Sintética
El Campus de Excelencia Internacional UAM+CSIC (CEI UAM+CSIC) tiene como una de sus líneas de actuación esenciales la captación de talento tanto a nivel nacional como internacional. Y con la intención de atraer científicos y profesores de primer nivel, acaba de convocar el Premio de Investigación CEI UAM+CSIC en el área de la Biología Molecular Física y Sintética. El premio tiene una dotación económica de 30.000 € anuales de libre disposición durante tres años, prorrogables a […]

April 04, 2013

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6:51 PM | Our People: In Memoriam: Adolphus “Tol” Toliver
Adolphus "Tol" Toliver Adolphus "Tol" Toliver, a prominent voice at the National Institutes of Health (NIH) for active measures to support minority students and faculty pursuing careers in biology, died March 26, exactly two weeks short of his 82nd birthday. Toliver was appointed in 1994 as Chief of the MARC (Minority Access to Research Careers) Branch in the National Institute of General Medical Sciences (NIGMS), where he served until his retirement at the first of this year. Toliver […]
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6:44 PM | Our People: In Memoriam: Ruth G. Doell
Ruth G. Doell Ruth G. Doell, an ASCB member from 1964 until her retirement from the Biology Department at San Francisco State University in 1992, died February 22 at her home in El Granada, CA. She was 86. Born in Vancouver, British Columbia, Doell earned her PhD in biochemistry from the University of California, Berkeley, in 1956 and worked as a research associate at Tufts University and then Stanford University. In 1967, she began a 25-year teaching career at San Francisco State […]
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5:10 PM | The universe as seen by Planck - Day Three (two rumours)
The conference diner here is about to start (has already started), so I don't have time for a proper post. However, the were some very interesting rumours/revelations today so I'll write them down super-quickly. In increasing order of potential interest (note this post might be a bit technical, I'll explain all of this before the end of the weekend): The feature at l=1700 A senior Planck figure gave a talk today on the features in the Planck angular power spectrum. Much of his talk was […]
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3:26 PM | Neurons and New Newt Legs
Salamanders are amazing and mystical creatures. Salamanders and their amazing leg-growing superpower (source)Not because they can survive in fire (they can't), but because they can regrow amputated limbs.A paper in 2007 investigates exactly what neural signals are required for this amazing superpower. Newt Amputee (Kumar et al., 2007)This paper brings together two interesting things about salamander (newt) leg growth.1. The salamander arm 'knows' where it was cut. If it is cut at the wrist it […]

Kumar A, Godwin JW, Gates PB, Garza-Garcia AA & Brockes JP (2007). Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate., Science (New York, N.Y.), 318 (5851) 772-7. PMID:

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12:28 PM | Eating too much salt sends immune system haywire
When it comes to knowing whether eating too much salt is a bad thing, there is a surprising lack of “verified-by-science” information available*. A certain level of salt, or sodium chloride, is a biological necessity that keeps muscles pumping and … Continue reading →

Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN & Hafler DA (2013). Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells., Nature, PMID:

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April 03, 2013

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9:22 PM | The universe as seen by Planck - Day Two
The cosmic microwave background (CMB) is the best probe we've yet found to study the early universe. The CMB's temperature is very nearly uniform. However this temperature does have very small anisotropies that can be used to study sound waves that existed in the primordial universe. The Planck satellite (an ESA funded experiment) has mapped these temperature anisotropies over the entire sky with the best resolution to date. Last month, Planck released its data and it immediately became the new […]
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3:20 PM | Social media and stem cells: Time to start tweeting
Why should stem cell researchers use Twitter? Powerful news aggregator/information filter Able to engage/converse with other attendees at conferences & meetings Increase traffic, discussion and citations of your papers Create professional networks and opportunities for collaboration  Aid the longevity of stem cell research and pace by which it progresses Research is about discovery. The words...Read more

April 02, 2013

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10:37 PM | The universe as seen by Planck - Day one
 I am currently attending the ESA run conference "The Universe as seen by Planck". I will be trying to write a summary each day of what I found interesting. To read about my motivation for this, please read yesterday's post. Below is the summary of the first day's talks. I apologise if the posts this week are overly technical. I don't have much time for writing these and this is the best I can do given the constraints. As always, if you don't understand, just ask questions in the […]
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6:28 PM | CellTweets #9: A Look Inside the Nuclear Actin Black Box
CellTweets #9   A Look Inside the Nuclear Actin Black Box Belin BJ, Cimini BA, Blackburn EH, Mullins RD. (2013). Visualization of actin filaments and monomers in somatic cell nuclei. Mol Biol Cell 24(7), 982-994 Actin's role in the nucleus comes packed in its very own black box. The cell nucleus is a very small and complex place but given how much is known about actin in the cytoplasm, it can be startling to hear how little agreement there is about actin in the […]
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5:28 PM | Reviewers and Citations: an update
A few weeks ago, I asked whether reviewers should be required to cite sources in their summary statements for submitted journal articles. I heart citations (source)I was frustrated about my paper reviews (not an uncommon sentiment) because one reviewer made some serious claims against my basic assumptions, but did not include any citations to back these claims up. A few people in the comments suggested that I write to the editor.So I did. I wrote a nice polite letter saying that citations from […]

April 01, 2013

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9:55 PM | The universe as seen by Planck (conference)
The 47th ESLAB symposium. All the cool kids will either be there, or watching it live on the webcast. Are you one of the cool kids? This week I will be at a scientific conference, organised by ESA. In ESA's words, this conference is "An international conference dedicated to an in-depth look at the initial scientific results from the Planck mission". The conference is taking place in the small Dutch down of Noordwijk. At this conference there will be many people from within the Planck […]
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9:43 PM | The Tenure Games
A little over a year ago, I dashed what seemed at the time a throwaway tweet that captured the malaise...

March 29, 2013

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10:07 AM | Right Turn: stem cell comic relief
Last week we launched a new feature — Right Turn — to showcase the “lighter” side of regenerative medicine. Every Friday, we will be bringing you cartoons, photos, videos and other content that may be just as thought provoking as the written submissions that you are used to finding here, but they definitely won’t be...Read more

March 27, 2013

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7:27 PM | Master debaters have bone (marrow) to pick at StemCellTalks Toronto
I’ve always had an interest in the science of bone marrow transplants, ever since my nephew, Simon, was diagnosed with aplastic anemia at the age of two.  Although it was a traumatic time for his parents and extended family, the story has a happy ending. His four-year-old brother was a bone marrow match and the...Read more
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3:06 PM | Newly Named NIGMS Director Jon Lorsch Talks About His Science and His New Job
Newly appointed NIGMS Director Jon R. Lorsch. Jon R. Lorsch knew it was coming but he still wasn’t prepared for the email explosion at his Johns Hopkins lab when the National Institutes of Health (NIH) announced on Monday that Lorsch would become the new Director of the National Institute of General Medical Sciences (NIGMS), starting this summer. “You can’t imagine how many emails I’ve gotten in the last few hours,” Lorsch reported by early afternoon. “It’s […]
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12:28 PM | The Evolution of the Impenetrable American Bedbug
Most of us are quite content to share our beds with a partner or a kitty, but are less inclined to extend the same warm welcome to the common bedbug, Cimex lectularius. These parasitic insects, which feed exclusively on blood, … Continue reading →

Zhu F, Gujar H, Gordon JR, Haynes KF, Potter MF & Palli SR (2013). Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides., Scientific reports, 3 1456. PMID:

Kilpinen, O., Vagn Jensen, K.-M. & Kristensen, M. (2008). Bed Bug Problems in Denmark, with a European Perspective, Proceedings of the Sixth International Conference on Urban Pests,

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March 26, 2013

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11:58 PM | CellTweets #8 Enzymes Cross Membrane Bridge to Assemble Synthesis Machinery on Lipid Droplets
CellTweets #8   Enzymes Cross Membrane Bridge to Assemble Synthesis Machinery on Lipid Droplets Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV Jr, Walther TC. (2013). Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets. Dev Cell Feb 13. Lipid droplets have suffered from an image problem, […]
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11:56 PM | Our People: In Memoriam: Frank Ruddle, Pioneer in Human Gene Mapping and Former ASCB President
Francis Hugh Ruddle, 1929-2013, Courtesy of Yale University, photo by Michael Marsland Francis Hugh Ruddle, a former ASCB President and a pioneer at Yale University in mapping the human genome and creating the first transgenic mouse, died March 10 in New Haven. He was 83. Ruddle coined the word “transgenic” in 1981, after startling the world the year before with a mouse born with heritable viral genetic material that had been inserted into newly fertilized mouse eggs. Working with […]
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10:42 PM | Advice vs Victim-blaming: a proposed study on #safetytipsforladies
So there has been a lot of noise about whether giving women 'safety tips' to avoid being raped is a form of 'victim blaming'.Don't get Raped (source)This culminated in a great hashtag (as many things do). Follow #safetytipsforladies to see some lovely tips for avoiding rape.For example:Don't be anywhere. 100% of rapes happen in places and locations. #safetytipsforladies— Conna Stevenson (@1000DaysOfRain) March 25, 2013Others suggest simply not being a woman, not ever drinking anything, not […]

Bieneck S & Krahé B (2011). Blaming the victim and exonerating the perpetrator in cases of rape and robbery: is there a double standard?, Journal of interpersonal violence, 26 (9) 1785-97. PMID:

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7:35 PM | NIH Names Jon Lorsch from Johns Hopkins as New NIGMS Director
Jon R. Lorsch will be the new Director of the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH). Lorsch, currently a professor in the Department of Biophysics and Biophysical Chemistry at Johns Hopkins University and an expert on RNA’s role in translation initiation, will start his new post sometime this summer. Lorsch earned his Bachelor’s in chemistry from Swarthmore College in 1990 and his PhD from Harvard University in 1995 where […]
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7:35 PM | Making Sausage—NIH Style
Budget-making is like sausage-making: The product is hopefully tastier than the process. Photo by John Fleischman Watching Congress craft legislation has often been compared to watching sausage being made. The product is more appetizing than the process. Such was the case during the U.S. Senate’s debate on the FY14 Budget Resolution, a document that serves as an internal framework for the construction of the individual appropriations bills that fund the government. On […]
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3:50 PM | Palifosfamide – a predictable miss in soft tissue sarcoma?
Soft tissue sarcomas (STS) are relatively rare and represent about 1% of all solid tumours. There are more than 50…
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1:53 PM | Lego® and biomaterials: the building blocks of life
When I was a child, I would sit on my living room floor playing with my Lego set for hours on end. I recall building police cars, giant spaceships and all kinds of other amazing structures. My weekend mornings always began the same way: I would dump my box of Legos onto the floor and...Read more
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11:03 AM | CellTweets #8 Enzymes Cross Membrane Bridge to Assemble Synthesis Machinery on Lipid Droplets
CellTweets #8   Enzymes Cross Membrane Bridge to Assemble Synthesis Machinery on Lipid Droplets Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV Jr, Walther TC. (2013). Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets. Dev Cell Feb 13. Lipid droplets have suffered from an image problem, […]

March 25, 2013

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5:42 PM | NIH Names Jon Lorsch from Johns Hopkins as New NGIMS Director
Newly appointed NIGMS Director Jon R. Lorsch. Jon E. Lorsch will be the new Director of the National Institute of General Medical Sciences (NGIMS) at the National Institutes of Health (NIH). Lorsch, currently a professor in the Department of Biophysics and Biophysical Chemistry at Johns Hopkins University and an expert on RNA’s role in translation initiation, will start his new post sometime this summer. Lorsch earned his Bachelor’s in chemistry from Swarthmore College in […]
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5:42 PM | NIH Names Jon Lorsch from Johns Hopkins as New NIGMS Director
Newly appointed NIGMS Director Jon R. Lorsch. Jon E. Lorsch will be the new Director of the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH). Lorsch, currently a professor in the Department of Biophysics and Biophysical Chemistry at Johns Hopkins University and an expert on RNA’s role in translation initiation, will start his new post sometime this summer. Lorsch earned his Bachelor’s in chemistry from Swarthmore College in […]
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12:38 PM | Guest Post: AMPA Receptors are not Necessary for long term potentiation
Today's post is brought to you by @BabyAttachMode, who is an electrophysiologist and blogger. Today we are blog swapping! I have a post over at her blog and her post about AMPA receptors and LTP is here. So enjoy, and when you're done reading about the newest advances in synaptic plasticity here, you can head over to InBabyAttachMode and read about my personal life. AMPA Receptors are not Necessary for long term potentiationScience is most interesting to me when you’re testing a […]

Granger AJ, Shi Y, Lu W, Cerpas M & Nicoll RA (2013). LTP requires a reserve pool of glutamate receptors independent of subunit type., Nature, 493 (7433) 495-500. PMID:

Sheng M, Malinow R & Huganir R (2013). Neuroscience: Strength in numbers., Nature, 493 (7433) 482-3. PMID:

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