April 02, 2014

12:56 PM | Medicine goes under the Needle
Tattoo artists may soon be faced with the prospect of a career change into the world of medicine thanks to the revelation that tattooing technology can be effectively applied in […]

Bins AD, Jorritsma A, Wolkers MC, Hung CF, Wu TC, Schumacher TN & Haanen JB (2005). A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression., Nature medicine, 11 (8) 899-904. PMID:

Shio MT, Paquet M, Martel C, Bosschaerts T, Stienstra S, Olivier M & Fortin A (2014). Drug delivery by tattooing to treat cutaneous leishmaniasis., Scientific reports, 4 4156. PMID:

Editor's Pick
5:28 AM | Potyviruses: bad enough to infect but good enough not to kill
RNA viruses have evolved a whole arsenal of post-translational mechanisms to overcome the inherent limitations of their small, relatively simple genome – they must assure the spatio-temporal availability of the building blocks needed for their successful replication, assembly and amplification in the host cell. Hydrolysis of the viral polyprotein by several proteases, encoded by the viral genome, and regulated both by host factors and by viral proteins, is a common virus strategy to […]

April 01, 2014

8:47 AM | Undifferentiated Cells Definition, Sources and Purpose
Undifferentiated cells refers to a cell that has yet to develop into a particular cell variant. Undifferentiated stem cells are the very basic cells in biology that all other cells derive from. The very first few cells in an embryo are considered undifferentiated. Stem cells are basically undifferentiated cells that have the unique ability to […] The post Undifferentiated Cells Definition, Sources and Purpose appeared first on Regeneration Center of Thailand.

March 31, 2014

8:30 AM | Discovery of a small protein involved in plant tolerance to water stress
Eukaryotic cells have a system, termed the ubiquitin proteasome system (UPS), that allows protein degradation. This is not only an intracellular garbage disposal system but, by selectively degrading targeted proteins, also controls protein homeostasis, which is vital for plant processes such as embryogenesis and flowering. In a recent study published in Read more...
4:00 AM | A Big Prep and a Short Walk Pays off for ASCB Member Titia de Lange
It was an all-or-nothing moment. Titia de Lange, a newly hired assistant professor at the Rockefeller University, had months of prep work and her entire grant's supply budget in hand as she waited to cross York Avenue, the busy north-south street on Manhattan's Upper East Side that separates Rockefeller from Memorial Sloan-Kettering Cancer Center, where a collaborator was waiting to sequence de Lange's protein distillate. "We walked with all the protein we had from 1,500 liters of HeLa cells," […]

March 29, 2014

1:34 PM | Supercomputers, The Human Brain and the Advent of Computational Biology
How advanced is computational power when it comes to simulating biological systems? This year, with the planned release of “transcendence” (an absolutely awesome looking film based on the technological singularity) and the […]

Janes KA, Reinhardt HC & Yaffe MB (2008). Cytokine-induced signaling networks prioritize dynamic range over signal strength., Cell, 135 (2) 343-54. PMID:

Yoon, B. (2009). Hidden Markov Models and their Applications in Biological Sequence Analysis, Current Genomics, 10 (6) 402-415. DOI:


March 28, 2014

10:52 PM | Science in the News: Woman Receives a 3D Printed Skull
We previously wrote this article about the use of 3D printing in medicine. Who would have thought less than a year later that we’d be able to tell you that […]
2:19 PM | Right Turn: Stripping down to the muscle
> Michael Rudnicki has been studying muscle biology for a long time… all the way back to his days as a graduate student. In this time, he’s contributed greatly to our understanding about muscle formation and the molecular “switches” that guide a stem cell’s decision to develop down the pathway towards muscle or brown fat....Read more
1:49 PM | Vaccination Coverage and Herd Immunity
Originally posted on Parasite Ecology:I’ve talked about vaccination and herd immunity on this blog before, but I think it’s important for me to emphasize how INCREDIBLY IMPORTANT it is to get vaccinated.  The importance of vaccinating most of the…
12:58 PM | Can Basic Research Find Safe Shelter from the Budgetary Storms?
Consider it progress but many in Congress are coming around to the idea that the current system for funding the U.S. National Institutes of Health (NIH) and other federal science programs isn't working. Getting everyone on the Hill to agree what should be done to protect research funding is another matter. Now, one senator has come up with a daring new idea on how to shelter biomedical research funding from the budgetary hurricanes blowing through both chambers. Would a biomedical research […]

March 27, 2014

10:50 PM | A new cosmological coincidence problem?
One of the consequences of the BICEP2 data from last week, should it hold up to scrutiny, and be seen by other experiments (I hope it holds up to scrutiny and is seen by other experiments), is that there is a significant lack of "power" in the temperature anisotropies on large angular scales.What that sentence means is that when you look at the CMB in very large patches on the sky (about the size of the moon and bigger) its temperature fluctuates from patch to patch less than we would […]
7:24 PM | In which outrage finds focus: petition about the Daily Mail Peiris/Aderin-Pocock affair
Most of you have probably heard about the crass article that appeared in everyone’s favorite working mum- and immigrant-bashing rag (that’s me firmly in its sights, then, for embodying both evils simultaneously), the Daily Mail. Which one, you ask? Because … Continue reading →
2:25 PM | Breaking News: Growing Concerns Over STAP Cell Sources
“Very sad results,” said cloning pioneer Teruhiko Wakayama about the latest troubling development in the STAP (“acid bath”) stem cell investigation. “I simply feel sad,” echoed Shinichi Nishikawa, former deputy director of Riken Center for Developmental Biology.Read more about Breaking News: Growing Concerns Over STAP Cell SourcesComments
11:22 AM | Hematopoietic Growth Factors and Hematopoiesis Transplantation
Hematopoietic stem cells are variants specifically found in bone marrow or blood in the umbilical cord, which is responsible for the formation of platelets, as well as RBCs (red blood cells) and WBCs (white blood cells). Hematopoietic stem cells (HSc) are also known as Blood cells. These powerful cells are in charge of continuous bodycare and […] The post Hematopoietic Growth Factors and Hematopoiesis Transplantation appeared first on Regeneration Center of Thailand.
6:30 AM | New role of p38 MAP kinases in rheumatoid arthritis
Rheumatoid arthritis is an autoimmune disease that causes chronic systemic inflammation that may affect many tissues and organs, but principally attacks joints. It affects approximately 1% of the population. The clinical symptoms of the disease, synovial hyperplasia and joint destruction, are the consequence of continuous and deregulated release of pro-inflammatory cytokines. In a recent study published in the journal Arthritis and Rheumatism, Ana Cuenda's team, in collaboration with […]
3:22 AM | Infected with Love: A Viral Aphrodisiac in Crickets
Like many other insects, field crickets (Gryllinae) use a courtship song to attract potential mates and initiate mating. A team of researchers headed by Shelley Adamo at Dalhousie University has recently discovered a surprising trigger which speeds up this dating process - a virus. In their recent article “A viral aphrodisiac in the cricket Gryllus texensis” published in the Journal of Experimental Biology, the researchers found that a pathogenic insect virus (iridovirus) is able to […]

Adamo, S., Kovalko, I., Easy, R. & Stoltz, D. (2014). A viral aphrodisiac in the cricket Gryllus texensis, Journal of Experimental Biology, DOI:


March 26, 2014

4:55 PM | The Good Words—Bench Bloggers
Supposedly, 200 million people are out there blogging. Unsurprisingly, many of them are working scientists, some are even cell biologists. It's one of the encouraging features of the evolving science writing ecosystem that scientists can write directly about their lives and their work. Some scientists use their blogs as podiums, some as pulpits, and some as stand-up mikes for riffs on the day-to-day research world of dirty glassware, shaky funding, and bad behavior. Illustration by […]

March 25, 2014

6:27 PM | Genetically Modified (GM) Crops- Friend or Foe?
With the Council for Science and Technology advising that we need to rethink our stance on GM food, we decided to look into some of the science behind genetic engineering […]

Eamens A, Wang MB, Smith NA & Waterhouse PM (2008). RNA silencing in plants: yesterday, today, and tomorrow., Plant physiology, 147 (2) 456-68. PMID:

Funke T, Han H, Healy-Fried ML, Fischer M & Schönbrunn E (2006). Molecular basis for the herbicide resistance of Roundup Ready crops., Proceedings of the National Academy of Sciences of the United States of America, 103 (35) 13010-5. PMID:

Paine JA, Shipton CA, Chaggar S, Howells RM, Kennedy MJ, Vernon G, Wright SY, Hinchliffe E, Adams JL, Silverstone AL & Drake R (2005). Improving the nutritional value of Golden Rice through increased pro-vitamin A content., Nature biotechnology, 23 (4) 482-7. PMID:

1:14 PM | In which satellite models trump circumspection: the case of MH370
The strange disappearance of Malaysian Airlines flight MH340 has captivated the world, myself included. In an era of instant information, it’s sobering that an entire Boeing 777 could just vanish. I am sure I am not the only one who … Continue reading →
11:17 AM | Cytokine Function as Immunoregulation Agents|Interleukin Therapy
Regenerative Medicine Blog and Stem Cell News The medical term of “cytokine” is derived from a blending of two Greek words – “cyto” or cell and “kinos” which means movement. Cytokine molecules exist in peptides, proteins and glyco-proteins (sugar attached). The cytokines cells come form a sizable family of molecules that can be classified into several different categories due to them not […] The post Cytokine Function as Immunoregulation […]
10:00 AM | Discovery of a mechanism that governs cilium size
Many mammalian cells bear primary cilia on their surface, involved in a variety of physiological processes such as sensing of the environment, cell growth, and development. Several pathologies such as hydrocephalus, anosmia (loss of olfaction) or retinitis pigmentosa are caused by defects in these organelles. The published results show that not only kinase-dependent activation of HDAC6 but also its distribution determines substrate selection of the deacetylase. The Dido3 protein […]
4:00 AM | Yogurt Shows the Way for a Revolution in Genome Editing
A yogurt producer with concerns, a puzzling aspect of bacterial genomes, a discussion over coffee, and a new MIT faculty member so youthful that he was mistaken for a freshman—these are a few links in the chain of discovery that led to CRISPR, today's hottest genetic rewriting technology. It stands for Clustered Regularly Interspaced Short Palindromic Repeats, and CRISPRs are changing biological research by making it easier than ever to edit genomes, opening whole fields to new […]

March 24, 2014

5:07 PM | The human machine: finely-tuned sensors
The previous post in this series can be found here.All good machines need sensors, and we are no different. Everyone is familiar with the five classic senses of sight, smell, touch, taste, and hearing, but we often forget just how amazingly finely tuned these senses are, and many people have little appreciation of just how complex the biology behind each sense is. In this week's post, I hope to give you an understanding of how one of our senses, smell, functions and how, in light of recent […]
1:51 PM | Nature Rejects Challenge to "Acid Stem Cells"; Scientists Try New Tips
Read more about Nature Rejects Challenge to "Acid Stem Cells"; Scientists Try New TipsComments

March 22, 2014

11:00 AM | Civil War in the Body: Autoimmune Disease
Allergic to something? Many of us are. Whether it’s itchy earlobes from those not-so-expensive earrings from a not-so-missed ex-boyfriend, or wheeziness during the hayfever season, allergies can be a pain! […]

DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT & Diamond B (2001). A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus., Nature medicine, 7 (11) 1189-93. PMID:

Rook, G. (2011). Hygiene Hypothesis and Autoimmune Diseases, Clinical Reviews in Allergy & Immunology, 42 (1) 5-15. DOI:

Loma, I. & Heyman, R. (2011). Multiple Sclerosis: Pathogenesis and Treatment, Current Neuropharmacology, 9 (3) 409-416. DOI:


March 21, 2014

1:15 PM | Right Turn: Lab parodies to cell-ebrate spring
. Hopefully this is a happy Friday for you and Mother Nature has sent you a healthy dose of spring to acknowledge the date on the calendar. Regardless, whether you are rejoicing in warmer temperatures and reveling in bird song or cursing vile weather as you layer appropriately, Right Turn is feeling optimistic and has...Read more
9:34 AM | In which we feel the force
It’s amazing what you can buy off the internet these days.

March 20, 2014

2:45 PM | Far Afield—An ORCID By Any Other Name
It's not a corsage but ORCID is a way of pinning your scientific identity firmly to your scientific chest. ORCID is, of course, an acronym. It stands for Open Researcher and Contributor ID but ORCID is also the tiny organization with global reach that issues unique alphanumeric identifiers for contributors to the world's scholarly and scientific literature. ORCID, the organization, refers to the identifier as the ORCID ID, which both makes sense and sounds redundant. As children, we all believe […]
10:56 AM | A new generation of the centrosomal proteins database
The Government of Madrid (CAM) recently granted a scientific project named PROFUN II: Interactomics of the Centrosome (CS Interactomics) that studies the interactome of the centrosome, a key cellular organelle in the organization process of the cellular architecture. In this project a multidisciplinary scientific research groups from Madrid are joining their expertise and efforts to provide a qualitative push to the current body of knowledge about the centrosome, fundamental to the […]
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