July 25, 2014

1:18 PM | Right Turn: Stem Cell Diabetes Treatment Looking Sweet
. It’s nice to end the week on a happy note. For a company like CCRM that commercializes regenerative medicine products and therapies, the news that ViaCyte, a company based in San Diego, California, has applied to the FDA to start clinical trials for its Type 1 diabetes treatment is good news for the industry....Read more

July 24, 2014

2:04 PM | Potential anticancer drugs from humble sources
Orange lichens contain a pigment with anticancer activity, Jing Chen's lab has discovered The post Potential anticancer drugs from humble sources appeared first on Lab Land.
11:00 AM | Feeling the Heat: the Science of Sunburn
No matter how careful we are, at some point in all of our lives we will develop sunburn.  Despite all of the NHS campaigns and warnings that sun damage can […]

July 22, 2014

6:48 PM | Fasting Improves Recovery of Bone Marrow Stem Cells after Chemotherapy
[Note: This is a guest post by Tauseef (@CellSpell)] Fasting is defined as either completely abstaining from or minimizing food intake for a defined period time - ranging from about 12 hours to even a few weeks. Calorie restriction, on the other hand, refers to an overall reduction in the daily calorie intake by about 20%-40% without necessarily reducing the meal intake frequency. Although calorie restriction is well-suited for weight loss and thus also reduces the risk of chronic diseases... […]

Cheng, C., Adams, G., Perin, L., Wei, M., Zhou, X., Lam, B., Da Sacco, S., Mirisola, M., Quinn, D., Dorff, T. & Kopchick, J. (2014). Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression, Cell Stem Cell, 14 (6) 810-823. DOI: 10.1016/j.stem.2014.04.014

3:23 PM | Buzzword overuse alert: epigenetics
Self criticism The post Buzzword overuse alert: epigenetics appeared first on Lab Land.
1:32 PM | Nontraditional Animal Models—Beyond the Zebrafish, the Other Teleosts
Fishermen can tell you many tales of the teleosts but most cell biologists know but one—the zebrafish. That's a shame, says John Postlethwait, professor of biology at the University of Oregon, who made his scientific mark with the zebrafish but is a fan of a much wider circle of the teleosts, ray-finned fish whose ranks include nearly all of the important sport or commercial bony fish on Earth. Postlethwait thinks there are discoveries to be made amongst the lesser-known teleosts. […]

July 21, 2014

1:37 PM | Highlights from The Business of Regenerative Medicine Course
. The Centre for Commercialization of Regenerative Medicine (CCRM) just finished hosting the 7th annual Business of Regenerative Medicine course here in Toronto, which saw many notable figures in the space come to weigh-in on a number of critical issues relevant to commercialization in the world of regenerative medicine and cell therapy (RM).   The...Read more
1:08 PM | Making cardiac progenitor cells feel at home
Does this Jello dessert call up memories? We explain the connection to the Davis lab's hydrogels that help cardiac progenitor cells stay in the heart The post Making cardiac progenitor cells feel at home appeared first on Lab Land.
12:45 PM | Biological Pacemakers- A Hearty Improvement?
In 1957 the first man-made pacemaker was created by Earl Bakken to help people with heart defects live their lives without being plagued by symptoms like rapid heart beat, dizziness, […]

July 20, 2014

12:00 PM | Mycobacterium Tuberculosis- Evolving With The Enemy: How TB may have Influenced our Own Evolution
 Mycobacterium tuberculosis is an acid-fast pathogen that is a huge plague upon humanity, even within developed countries. Although this pathogen has a low rate of incidence in these countries now, […]

July 18, 2014

3:26 PM | Rare disease diagnosis, accelerated by social media
Emory geneticists' involvement in an effort to diagnose children with a rare genetic disorder. Whole exome sequencing comes up too. The post Rare disease diagnosis, accelerated by social media appeared first on Lab Land.
2:19 PM | Right Turn: Nailed it! The making of a stem cell exhibit
A few months ago, I mentioned that we were involved in the creation of a traveling science exhibit with a number of great partners, and introduced one of the fictional characters, the “Regenerator”, who will be appearing as one of our stem cell superheroes. A lot has happened in the three months, and the exhibit,...Read more
2:08 PM | DNA
DNA is also known as Deoxyribonucleic Acid. DNA is considered to the building block of the body and is found in the nuclei of all cells.  Found inside the nucleus the DNA strands are sets of chromosomes. Each set of chromosomes have a constriction point from where two arms are formed called the centromere. The […] The post DNA appeared first on Regeneration Center of Thailand.

July 17, 2014

11:29 PM | What makes a cancer a cancer? The hallmarks of cancer.
Cancer – the ‘C word’ in far too many of our lives. Wherever you are, it’s unlikely you’ll be able to avoid the news reports and personal stories about people […]

July 16, 2014

2:20 PM | LEGO Lab Proposal Has Exciting Possibilities for Cell Biologists
"ALEster" is the pseudonym of a self–described postdoc in molecular biology who wants to build a highly portable cell biology lab, including cell culture incubator, laminar flow hood, and fluorescence microscope, that you could take everywhere you go. It occupies 15 square inches (.381 square meters) of floor space. ALEster is an AFOL, that is, an Adult Fan of LEGO, so his pocket lab was designed with LEGO bricks, complete with PI, Professor Umami, and postdoctoral fellows, the red-haired […]

July 15, 2014

1:30 PM | Pathomx v3.0.0alpha4 for Mac
A development version of Pathomx v3.0.0-alpha4 is now available as a installable app for Mac. This latest version showcases the new IPython backend, with notebooks and reports. Note that this is a development version so contains a number of bugs that will be fixed before release. You can install alongside an existing Pathomx installation, simply drag to the Applications folder and select “Keep both”.
11:04 AM | The Reality of Old Age – Hutchinson-Gilford Progeria Syndrome
As kids we all want to grow up but for about 1 child in 4 million, it’s a painful reality. Hutchinson-Gilford progeria syndrome (HGPF) is a rare genetic disorder determined […]
1:50 AM | Intro to Lysosomal Storage Diseases
Lysosomes are small organelles within cells that are responsible for breaking down and recycling cellular material, such as proteins, lipids, sugars — and even entire cellular compartments — that are damaged or worn out. This essential task is carried out by a mixture of enzymes. If any one of these enzymes is non-functional due to […] The post Intro to Lysosomal Storage Diseases appeared first on Perlstein Lab.

July 14, 2014

6:08 PM | Learning the Biotech Ropes—ASCB-KGI Short Course Wraps Up
The 40 came from all over North America, Europe, and Africa, 24 grad students and 16 postdocs, chosen from the 532 applications the ASCB received from members for a special 12-day "short" course on "Managing Science in the Biotech Industry" at the Keck Graduate Institute (KGI) with funding from EMD Millipore. Besides their ASCB connection, what the participants had in common were years of academic training and a curiosity about life in biotech. Graduate students and postdocs were eager to […]
1:13 PM | Old tissue, new purpose: DISCUSSing consent and iPSC derivation
Written with contributions from Geoff Lomax, CIRM’s Senior Officer for Medical and Ethical Standards and Rosario Isasi, Research Associate at McGill University and Academic Secretary for the International Stem Cell Forum Ethics Working Party. Portions of this post were previously published on the CIRM Research Blog and are included here with consent. It’s not unusual...Read more

July 12, 2014

10:01 AM | Media and the Mind: Emotional Contagion
Social media has tremendous power to share ideas, information and emotions to almost anyone or any audience you choose to reach. In the past it was the high level of communication and trade that, […]

Kramer, A., Guillory, J. & Hancock, J. (2014). Experimental evidence of massive-scale emotional contagion through social networks, Proceedings of the National Academy of Sciences, 111 (24) 8788-8790. DOI: 10.1073/pnas.1320040111

Woolley, A., Chabris, C., Pentland, A., Hashmi, N. & Malone, T. (2010). Evidence for a Collective Intelligence Factor in the Performance of Human Groups, Science, 330 (6004) 686-688. DOI: 10.1126/science.1193147


July 11, 2014

8:56 PM | Flashback to LSD research from the 1950s
An old photo can remind us how much has changed The post Flashback to LSD research from the 1950s appeared first on Lab Land.
1:32 PM | Right Turn: Return of Cells I See contest
. Stem cells as art is becoming a recurring theme on Signals. If you want to admire some beautiful stem cell art, there’s Klair Reis’ petri projects, Radha Chaddah’s beautiful photography here, and stem cell images are featured every week on Signals near the bottom of the screen. The images in the Photo of the...Read more

July 10, 2014

4:51 PM | The Flatworm Turns (Over)—Regenerating Planaria Show Hidden Talents
Sometimes in science it pays to turn over a new leaf or an old laboratory animal. Stephen M. King at the University of Connecticut Health Center recently turned over planarian Schmidtea mediterranea, the nonparasitic flatworm justly renowned for its incredible regenerative powers, and saw on its underside a new way into a old problem. King, who is an ASCB member, believes that planaria could be an alternate model system for studying ciliary motility and its associated diseases now known as […]

July 09, 2014

7:03 PM | Hunting for potential diabetes drugs
A compound that can mimic the action of insulin, originally isolated from moldy rice The post Hunting for potential diabetes drugs appeared first on Lab Land.
2:34 PM | TCAs as Painkillers: Proof That You Can Teach an Old Dog New Tricks
The creation of a new drug that is safer, more effective, and has fewer side effects than the current treatment surely renders the current treatment obsolete, right? Well, not necessarily. […]

Sindrup, S., Otto, M., Finnerup, N. & Jensen, T. (2005). Antidepressants in the Treatment of Neuropathic Pain, Basic Clinical Pharmacology Toxicology, 96 (6) 399-409. DOI: 10.1111/j.1742-7843.2005.pto_96696601.x

Bohren Y, Tessier LH, Megat S, Petitjean H, Hugel S, Daniel D, Kremer M, Fournel S, Hein L, Schlichter R & Freund-Mercier MJ (2013). Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism., Neurobiology of disease, 60 39-50. PMID:

Micó JA, Ardid D, Berrocoso E & Eschalier A (2006). Antidepressants and pain., Trends in pharmacological sciences, 27 (7) 348-54. PMID:

1:03 PM | Update from the Clinic: June
. Welcome to your Update from the Clinic for the month of June. Neuralstem presented final data on a first-in-class drug for the treatment of major depressive disorder, which is proving to be an effective and non-invasive means to boost brain volume. OncoMed has a shaky start to its Phase I programs targeting the Wnt...Read more

July 08, 2014

9:08 PM | The Road to Bad Science Is Paved with Obedience and Secrecy
We often laud intellectual diversity of a scientific research group because we hope that the multitude of opinions can help point out flaws and improve the quality of research long before it is finalized and written up as a manuscript. The recent events surrounding the research in one of the world's most famous stem cell research laboratories at Harvard shows us the disastrous effects of suppressing diverse and dissenting opinions. The infamous "Orlic paper" was a landmark research article […]
6:47 AM | Lessons Learned from Shopping for a Startup Biotech Company
At Perlstein Lab, we want to set an example to help other scientists and startups be more prepared for their journey. Therefore we will post once a month about our experience with managing a lab with a focus on searching for and purchasing lab supplies and equipment. To do this, our Virtual Lab Manager from […] The post Lessons Learned from Shopping for a Startup Biotech Company appeared first on Perlstein Lab.

July 07, 2014

2:19 PM | Tips from the grad school trenches on launching a career
> Anyone who has, or is working on, a graduate degree (e.g. PhD, MSc) has likely encountered the “what does a PhD/MSc get you?” question. In my experience, the most frustrating thing wasn’t that I was asked this question at least three times at every family gathering, but it was that I often didn’t know...Read more
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