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Posts

May 21, 2013

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4:26 PM | Critical Science Writing: A Checklist for the Life Sciences
One major obstacle in the "infotainment versus critical science writing" debate is that there is no universal definition of what constitutes "critical analysis" in science writing. How can we decide whether or not critical science writing is adequately represented in contemporary science writing or science journalism, if we do not have a standardized way of assessing it. For this purpose, I would like to propose a following checklist of questions that one would find in a news article or […]

May 20, 2013

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9:37 PM | Stem cells 2.0
It's been a divisive issue for as long as it's existed, but the topic of human embryonic cloning has been thrust back into the spotlight this week with the news that researchers in the US have successfully produced human embryonic stem cells (hESCs) from adult cells for the first time. This is big news because hESCs have the potential, in theory, to become any type of adult cell - opening the possibility for repairing damaged tissues in previously unthinkable ways. Neatly, this was […]

May 19, 2013

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11:05 AM | ‘Infotainment’ and Critical Science Journalism
I recently wrote an op-ed piece for the Guardian in which I suggested that there is too much of an emphasis on ‘infotainment’ in contemporary science journalism and there is too little critical science journalism. The response to the article was unexpectedly strong, provoking some hostile comments on Twitter, and some of the most angry comments seem to indicate a misunderstanding of the core message. One of the themes that emerged in response to the article was the Us-vs.-Them perception... […]

May 18, 2013

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1:23 PM | Homeostatic platsicity in a thorny situation
Synapses, the connections between neurons can strengthen and weaken depending on the specific activity at that synapse. This is called synaptic plasticity, and we've talked about it a lot on this blog (here, here, here and here).the strengthening and weakening of synaptic connections corresponds to the spine growing or shrinking (Matsuzaki 2007)However, there is another kind of plasticity that can occur at synapses. This is called homeostatic plasticity. And instead of the synapse strengthening […]

Lee KJ, Queenan BN, Rozeboom AM, Bellmore R, Lim ST, Vicini S & Pak DT (2013). Mossy fiber-CA3 synapses mediate homeostatic plasticity in mature hippocampal neurons., Neuron, 77 (1) 99-114. PMID:

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8:00 AM | cx_Freeze and PySide on Mac
I’d had success using py2app for building Mac binaries for distribution but wanted to give cx_Freeze a go since it’s cross platform - allowing builds for Windows, Linux, and more. Unfortunately, attempting to build using cx_Freeze was resulting in errors: libpyside-python2.7.1.1.dylib: No such file or directory If found a tip suggesting you can do a touch libpyside-python2.7.1.1.dylib in you’re applications folder to get rid of this error by creating a dummy file. But […]

May 17, 2013

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2:20 PM | Right Turn: Everybody loves infographics (right?)!
. Inspired by the first Right Turn featuring a regenerative medicine infographic, Signals Blog is holding a contest to seek the best original (i.e. not previously published) stem cell or regenerative medicine infographics out there! We’re keeping the subject matter broad to see how creative you are. We’re looking for the following: Scientific accuracy Skill...Read more

May 16, 2013

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7:37 PM | Cultured Skin Fibroblasts in Storage Disorders
Electron microscopic studies were performed on cultured fibroblasts from patients with metachromatic leukodystrophy, Fabry’s, Gaucher’s, Niemann-Pick’s (Type A and C),...
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6:30 PM | ASCO 2013 Highlights PD-1 and PD-L1 immunotherapy
One of the hot topics at this year’s annual ASCO meeting is clearly going to be PD-1 and PD-L1 immunotherapies,…
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1:37 PM | To the stars and beyond: Assessing the impact of the $100 Genome
We live in a time of extraordinary medical advances. So far in 2013, we’ve seen the successful transplantation of a bioengineered kidney into rats, an infant reportedly cured of HIV using anti-retroviral drugs that are currently on the market, and discovered a protein that has the potential to ‘reverse aging’ in the heart. These ‘small...Read more
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5:00 AM | Scientific Insurgents Say Journal Impact Factors Distort Science
The journal impact factor insurrection, which began last December in San Francisco, is spreading through scientific institutions and organizations around the world. ASCB Urges All Researchers to Sign the DORA Pledge An ad hoc coalition of unlikely insurgents—scientists, journal editors and publishers, scholarly societies, and research funders across many scientific disciplines—today posted an international declaration calling on the world scientific community to eliminate the role of […]
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4:42 AM | “Citizen Science”: Scientific Consensus On Global Warming
I came across an interesting study about the consensus in the scientific community on anthropogenic global warming (AGW), i.e. the idea that human activity is very likely causing most of global warming. What makes this study so interesting is the fact that it involved a “citizen science” approach. Volunteers who contributed to the Skeptical Science website were asked to grade the abstracts of 11, 944 scientific papers on global climate change that were published in the years 1991-2011.  […]

May 15, 2013

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2:00 PM | Using stem cells to cure… extinction?
In last week’s Right Turn, we talked about how stem cells are responsible for the colours and patterns of bird feathers—and birds, as the graphic on the right demonstrates, are basically just tiny dinosaurs. Given that there is much promise in stem cell research (and also a great deal of hype), it makes one wonder:...Read more

Friedrich Ben-Nun I., Montague S.C., Houck M.L., Tran H.T., Garitaonandia I., Leonardo T.R., Wang Y.C., Charter S.J., Laurent L.C. & Ryder O.A. & (2011). Induced pluripotent stem cells from highly endangered species, Nature Methods, 8 (10) 829-831. DOI:

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May 14, 2013

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5:27 PM | The Stem Cell Renewal Theory: The Other Big Paper of 1953
Charles Philippe Leblond -- His stem cell renewal theory was shocking in 1953. Photo courtesy John Bergeron, McGill University The year 1953 is generally considered the year zero for molecular cell biology with the publication of Watson and Crick’s celebrated Nature paper on the structure of DNA. But there was another big paper in 1953 by Yves Clermont and Charles Leblond of McGill University that appeared in the American Journal of Anatomy. It contained a discovery nearly on the […]
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12:28 PM | How to survive the bacterial antibiotic revolution
These days, we have a pretty serious problem when it comes to our ability to kill resistant bacteria causing serious illness. People petition governments to urge action, while drug companies lament over how those pesky bacteria evolved to defeat their … Continue reading →

Johnston BC, Ma SS, Goldenberg JZ, Thorlund K, Vandvik PO, Loeb M & Guyatt GH (2012). Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis., Annals of internal medicine, 157 (12) 878-88. PMID:

Karuppiah P & Rajaram S (2012). Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens., Asian Pacific journal of tropical biomedicine, 2 (8) 597-601. PMID:

Kwakman PH, te Velde AA, de Boer L, Speijer D, Vandenbroucke-Grauls CM & Zaat SA (2010). How honey kills bacteria., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24 (7) 2576-82. PMID:

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May 13, 2013

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12:00 AM | The Inadvertent Psychological Experiment
Escape from Camp 14 is deeply disturbing, and I highly recommend it. Escape from Camp 14 by Blaine HardenEscape from Camp 14 is a chilling tale of Shin Dong-hyuk's escape from a North Korean prison camp. What is so interesting about Shin Dong-hyuk's story as written by Blaine Harden is that he was born inside this North Korean prison camp. Apparently they allow breeding between prisoners as a reward for 'good behavior.'Escape from Camp 14 reveals the obscene violations of human rights that […]

Lee YM, Shin OJ & Lim MH (2012). The psychological problems of north korean adolescent refugees living in South Korea., Psychiatry investigation, 9 (3) 217-22. PMID:

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May 11, 2013

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5:37 AM | Cellular Alchemy: Converting Fibroblasts Into Heart Cells
Medieval alchemists devoted their lives to the pursuit of the infamous Philosopher's Stone, an elusive substance that was thought to convert base metals into valuable gold. Needless to say, nobody ever discovered the Philosopher’s Stone. Well, perhaps some alchemist did get lucky but was wise enough to keep the discovery secret. Instead of publishing the discovery and receiving the Nobel Prize for Alchemy, the lucky alchemist probably just walked around in junkyards, surreptitiously collected […]

Nam, Y., Song, K., Luo, X., Daniel, E., Lambeth, K., West, K., Hill, J., DiMaio, J., Baker, L., Bassel-Duby, R. & Olson, E. (2013). Reprogramming of human fibroblasts toward a cardiac fate, Proceedings of the National Academy of Sciences, 110 (14) 5588-5593. DOI:

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May 10, 2013

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1:27 PM | Right Turn: Feathers as an example of stem cell complexity
Pea Hen Feather. Credit: Bill Gracey The arrival of summer’s songbirds to much of Canada over the past month makes this a fitting time to talk about feathers. Coincidentally, a paper was released in Science in late April that revealed how stem cells function to create an incredible array of colours and patterns in bird...Read more

Lin S.J., Foley J., Jiang T.X., Yeh C.Y., Wu P., Foley A., Yen C.M., Huang Y.C., Cheng H.C., Chen C.F. & Chuong C. M. Topology of Feather Melanocyte Progenitor Niche Allows Complex Pigment Patterns to Emerge, Science, DOI:

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May 07, 2013

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8:11 PM | Yeast de résistance
I kickstarted my now defunct academic lab 5 ½ years ago with a simple yeast genetics experiment that I now want to repeat...
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7:51 AM | Identifican un gen clave en fertilidad y en el desarrollo de testículos
El grupo del Centro Nacional de Biotecnología del CSIC dirigido por Jesús M. Salvador acaba de publicar que la expresión del gen Gadd45g es crítica durante el desarrollo embrionario para la formación de testículos. Al generar ratones deficientes en la proteína Gadd45g se dieron cuenta de que sorprendentemente todas las crías eran fenotípicamente hembras. En humanos, las anomalías de la diferenciación sexual son un grupo amplio de patologías ocasionadas por diferentes alteraciones […]

May 06, 2013

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8:37 PM | Everyone should learn everything.
Today I am getting on a bit of a soapbox about things.  Specifically about things scientists should learn. Scientists should learn everything (source)In an ideal world everyone would be good at everything, but as you have probably noticed this is NOT the case. Some people are good at lots of things and some people are really good at specific things, but terrible at others, and some unfortunate people are generally bad at a lot of things and mediocre at a few.Recently, I've been hearing […]

May 04, 2013

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5:32 AM | Characterization of behavioral and endocrine effects of LSD on zebrafish
Lysergic acid diethylamide (LSD) is a potent hallucinogenic drug that strongly affects animal and human behavior. Although adult zebrafish (Danio...

May 03, 2013

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6:37 PM | Shirley Tilghman Elected as ASCB 2015 President
Shirley M. Tilghman Shirley M. Tilghman, President of Princeton University, has been elected by the members of the American Society for Cell Biology to serve as Society President in 2015. “ASCB is very fortunate to have Shirley Tilghman as our President-Elect,” said Don Cleveland, Head of the Laboratory for Cell Biology at the Ludwig Institute for Cancer Research and current Society President. “A spectacularly accomplished scientist who is just finishing […]
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2:06 PM | Right Turn: Parents breathe sigh of relief after windpipe surgery success
. It was big news this week when doctors at Children’s Hospital of Illinois performed the first successful pediatric transplant in the U.S. of a regenerated trachea using a synthetic scaffold. The Canadian father and Korean mother of two-year-old Hannah Genevieve Warren are delighted that their daughter, born without a windpipe, now has one grown...Read more

May 02, 2013

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4:51 PM | a STORM inside a cell
We've been talking about some of the most cutting edge intracellular visualization techniques lately. Array tomography and Serial block-face electron microscopy have been featured. Today we'll talk about STORM imaging. STORM imaging (Xu et al., 2013)STORM stands for Stochastic Optical Reconstruction Microscopy. While Array tomography and Serial block-face EM are both revolutionary in that they can combine very high resolution imaging with relatively large volumes of tissue, STORM is an […]

Xu K, Zhong G & Zhuang X (2013). Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons., Science (New York, N.Y.), 339 (6118) 452-6. PMID:

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5:00 AM | Give Me Your Huddled and Talented Masses Yearning to Study Science
Give Me Your Huddled and Talented Masses Yearning to Study Science In this era of intense partisanship, Congress finally seems to agree on the need to write a comprehensive overhaul of the U.S. immigration system. Their motives may differ but everyone seems to agree that change is needed. Soon after the 2012 elections, eight Senators—four Republicans and four Democrats—joined together to try to write a bill overhauling the U.S. immigration system. Members of the House of […]

May 01, 2013

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8:22 PM | Our People: Newly Elected NAS Members
Our People: Newly Elected NAS Members The ASCB congratulates two ASCB members who were recently elected to the National Academy of Sciences: Stephen M. Beverley, Washington University in St. Louis, and Robert H. Singer, Albert Einstein College of Medicine. Robert H. Singer, Albert Einstein College of Medicine Stephen M. Beverley, Washington University in St. Louis Science National Academy of Sciences
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1:53 PM | At the forefront of biomaterial research
. The work by Joe Landolina and Suneris Inc., highlighted by Stacey Johnson in her recent post, helps bring to the forefront the industry’s motivation to utilize “smart biomaterials”. The Armed Forces Institute of Regenerative Medicine has been researching smart biomaterials that could be used to treat soldiers injured in the field. Photo: Flickr Commons...Read more

April 30, 2013

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6:12 PM | Comment on In which it all goes a bit Hitchcock by Austin Elliott
We got used to screened windows in the States, and definitely missed them when we got back to the UK. As a result, in the 70s my dad used to occasionally re-appear from trips to North America with <a href="http://www.newblinds.co.uk/content/telescopic_flyscreen_3662?gclid=CP7D44j-8rYCFXHLtAodWi0A3w" rel="nofollow">things like this</a>.
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3:54 PM | Comment on In which it all goes a bit Hitchcock by Jennifer Rohn
/double-take. I always thought they were *Morning* Doves, back when they sang outside my window in Ohio. You learn something every day. "Mourning" makes much more sense, given the plaintive nature of their call.
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3:52 PM | Comment on In which it all goes a bit Hitchcock by Jennifer Rohn
Winty, I can't tell you how much I miss screened windows - especially in one's bedroom on a hot summer's night. (See also, crickets and fireflies, also sadly lacking.) They just don't *do* screens in the UK. Our nurse has asked Estates if they could rig up some netting as per Dr HG of Cromer's suggestion, so we'll see what they say.
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