September 17, 2014

4:08 PM | PTH for stroke: stem cells lite
Spur the body's regenerative agents to emerge from the bone marrow The post PTH for stroke: stem cells lite appeared first on Lab Land.
1:28 PM | Builders and Blocks – Engineering Blood Vessels with Stem Cells
Back in 2001, when we first began studying how regenerative cells (stem cells or more mature progenitor cells) enhance blood vessel growth, our group as well as many of our colleagues focused on one specific type of blood vessel: arteries. Arteries are responsible for supplying oxygen to all organs and tissues of the body and arteries are more likely to develop gradual plaque build-up (atherosclerosis) than veins or networks of smaller blood vessels (capillaries). Once the amount of plaque […]

September 16, 2014

4:15 PM | Divide and conquer vs lung cancer
Biomarkers that can predict whether doctors will see a response with common chemotherapy drugs vs lung cancer The post Divide and conquer vs lung cancer appeared first on Lab Land.
1:15 PM | Life, death and regulation
. With contributions from James Smith, a recent Oxford University graduate and current SENS Research Foundation Summer Scholar working at the Harvard Stem Cell Institute.   Consider this question: if I gave you the option to take a drug offering a 100 percent chance of survival to average life expectancy at which time you would...Read more
4:00 AM | Nontraditional Careers: Science Policy
A doctorate in biology is preparation to do more than just bench work, said Lyric Jorgenson, a PhD who now works as Science Policy Advisor and Analyst at the National Institutes of Health (NIH). "It's a degree in logic," she contends. Logic and problem solving, an interest in politics, combined with the ability to write for different audiences are essential skills for PhDs looking to make the leap into science policy. A doctorate in biology is preparation to do more than just bench work, […]

September 15, 2014

4:00 AM | Celldance 2014 Announces Microscopic Blockbuster Commissions
It will be a triple feature, short but powerful, says Duane Compton. The three "Tell Your Own Cell Story" videos just commissioned by ASCB's Celldance Studios will feature eye-popping live cell imaging and scientific storytelling, according to Compton, who chaired the Celldance selection panel. The panel today announced the names of the ASCB members from whom videos have been commissioned and the cell stories they plan to tell. Illustration by Johnny Chang, ASCBIt will be a triple feature, […]

September 13, 2014

1:12 PM | Back to the Basics- The (Not So) Simple Cell
With Freshers week upon us for many students across the country, we thought it might be a nice idea to recap some of the basics of “the cell” for those […]

September 12, 2014

12:33 PM | Right Turn: Super Cells takes flight
> Those of you who’ve been following this blog regularly will know that we were in the process of building a science exhibit — we’ve published a few teasers, here and here. This week, Super Cells: The power of stem cells was unveiled in the small, historic city of Sherbrooke, Québec (well worth a visit,...Read more

September 11, 2014

1:15 PM | Regenerative Medicine Deal Review: August
. Welcome to your deal review for the month of August. As would be expected at the end of the summer news flow was modest, but Northwest Biotherapeutics kept things alive with a $17.5 million financing via convertible debt, while Gamida Cell announced a game-changing deal with a large Pharma partner that is placing its...Read more

September 10, 2014

3:49 PM | Apple Does 3D Cell Culture
Andrew Pelling has a new application for the apple, but it is not the latest i-gizmo from Cupertino, CA. Pelling and colleagues at the University of Ottawa have come up with a possible solution to the limitations of traditional, two-dimensional (2D) cell culture, which does not reproduce the microenvironment and tissue architecture that surrounds cells in a living organism—the apple, the one-a-day fruit that keeps the doctor away and is an essential ingredient to the All-American […]

Modulevsky DJ, Lefebvre C, Haase K, Al-Rekabi Z & Pelling AE (2014). Apple derived cellulose scaffolds for 3D mammalian cell culture., PloS one, 9 (5) PMID:


September 09, 2014

1:57 PM | What are exosomes?
Tiny virus-like bubbles containing micro RNA, potentially carrying heart-healing factors The post What are exosomes? appeared first on Lab Land.
1:30 PM | CRISPR and Rejuvenation Biotechnology: have you been hiding under a rock?
. With contributions from James Smith, a recent Oxford University graduate and current SENS Research Foundation Summer Scholar working at the Harvard Stem Cell Institute.   ‘Bay Area biotechnology’ is a description that conjures images of the proud Hoover Tower at Stanford, and the iconic Genentech sign marking “Birthplace of Biotechnology,” set against the backdrop...Read more

September 08, 2014

6:10 PM | ASCB President-Elect Walter Wins Lasker
The UPR has unfolded into the 2014 Albert Lasker Basic Medical Research Award for ASCB President-Elect Peter Walter. A Howard Hughes Medical Institute investigator and Professor of Biochemistry and Biophysics at the University of California, San Francisco (UCSF), Walter was named co-winner winner today along with Kazutoshi Mori of Kyoto University for their independent but closely related work on untangling the unfolded protein response or UPR, a signaling pathway that protects cells by […]
1:02 PM | Dr. Botstein Buys a Book
It was the one of the very few moments in his life when he was truly speechless, says Malcolm Campbell. He was at the 2013 ASCB spring Council meeting in Washington, DC, seated next to fellow ASCB councilor David Botstein who had just won one of the new $3 million Breakthrough Awards in Life Sciences. Waiting for the meeting to come to order, Campbell, a professor at Davidson College in North Carolina and a leading proponent of research-driven reform in undergraduate biology education, […]
11:27 AM | Granulocyte Colony-Stimulating Factor G-CSF Stimulation
G-CSF Stimulation use in Stem Cell Therapies Granulocyte-colony stimulating factor is also known as colony-stimulating factor 3,G-CSF, GCSF, GM-CSF or Rm-GSF.  Granulocyte Colony-Stimulating Factors are a special kind of protein or “growth factor” that the body naturally manufactures in the bone marrow that is often used in cancer treatments such as chemotherapy and NK Cell Therapy. Creating […] The post Granulocyte Colony-Stimulating Factor G-CSF Stimulation […]

September 05, 2014

1:40 PM | Right Turn: Like a kid’s science show, but for grownups
. Jordan Green, a biomedical engineer from Johns Hopkins, has a way with words. And toys. He’s like a Mister Rogers (American) or Mr. Dressup (Canadian) for adults. He has a complicated idea to convey, so borrowing from the best children’s entertainers around, he uses colourful props that perfectly suit his friendly demeanor. Dr. Green’s...Read more

September 03, 2014

3:35 PM | Active Learning Halves Black-White Achievement Gap in Bio Classes, Say STEM Ed Researchers in LSE Paper
"Active-learning interventions," in which passive lectures are replaced with interactive activities, moving lecture materials to homework and outside readings, have been shown by STEM education researchers in recent years to be strikingly effective, but a new study published on September 2 in CBE—Life Sciences Education, published by ASCB, reveals that this strategy is especially powerful for black and first-generation college students. An active-learning strategy in an introductory […]
12:00 PM | Generalised Anxiety Disorder: Something on your Mind?
We can all get a little het-up about things, whether it’s something big like moving cities or something smaller like getting ready for a first date! It’s inevitable that people […]
10:13 AM | Discovery of Neuro-Mesodermal Progenitors Cinderella Cells
The human spinal cord,skeleton cells and muscle cells are all created from cells known as NMP’s or neuro-mesodermal progenitors. The formation of these vital cells has remained a mystery until now. These cells are created in a complex yet carefully timed signal by a growing embryo which instructs the neuro-mesodermal progenitor cells to differentiate into […] The post Discovery of Neuro-Mesodermal Progenitors Cinderella Cells appeared first on Regeneration Center of Thailand.

September 02, 2014

5:00 PM | Holding institutions responsible for research misconduct: The recent case of a death of stem cell scientist
Written by Dr. Zubin Master, Assistant Professor at the Alden March Bioethics Institute, Albany Medical College and Research Associate at the University of Alberta’s Health Law Institute. This article is being published simultaneously on the Alden March Bioethics Institute blog, the Knoepfler Lab Stem Cell blog and Signals Blog.  Scientist Yoshiki Sasai, age 52, committed suicide and was found dead...Read more

September 01, 2014

12:28 PM | Tracking the Daily Microbiome
Humans are essentially 90% bacteria. These bacteria pepper our skin and hang out in our digestive tracts, helping to break down complex carbohydrates and keeping bad bugs in check. We know how the human microbiome (our collection of bacteria) gets … Continue reading →

David LA, Materna AC, Friedman J, Campos-Baptista MI, Blackburn MC, Perrotta A, Erdman SE & Alm EJ (2014). Host lifestyle affects human microbiota on daily timescales., Genome biology, 15 (7) PMID:


August 30, 2014

5:51 PM | Children with 3 Parents?
  When we think about our genes, we most commonly think of the nuclear genome, the 23 pairs of chromosomes that determine our characteristics but the nuclear genome is not […]

August 29, 2014

6:40 PM | Right Turn: Lego Academics bring you into their world
> Earlier this summer, building toy makers Lego released the Research Institute: A new set that featured female minifigures in science professions, including a paleontologist, astronomer and chemist. The set may have been a response to a young girl’s plea for Lego to “make more Lego girl people and let them go on adventures and have fun,” and the Research...Read more

August 28, 2014

12:57 PM | Women In Science: The Untold Downside to Achievement
Throughout my PhD years, I have worked passionately on the issue of "Women in Science." Becoming the president of the Graduate Women in Science Organization (GWIS) at Florida State University gave me an opportunity to work on building connections between young professional women and those who were already well advanced in their careers. During GWIS meetings, we discuss the challenges faced by women in science and talk about personal experiences. As women in science finally move up to […]

August 27, 2014

5:46 PM | Key to universal flu vaccine: embrace the unfamiliar
Vaccination against H5N1 induced antibodies against the stem region of the viral hemagglutinin protein The post Key to universal flu vaccine: embrace the unfamiliar appeared first on Lab Land.
1:18 PM | Co-Chaperone Keeps Close Watch on Mice Sperm Production
Chaperones aren't just for high-school homecoming dances. Cells have chaperones as well, chaperone proteins that ensure newly made proteins are properly folded. If protein folding goes awry, diseases associated with misfolded proteins such as Alzheimer's and Parkinson's can arise. But if one set of chaperones can throw a wet blanket on a school dance, imagine a second set of co-chaperones just to keep the chaperones in check. That's the growing picture in cellular chaperoning as folding […]

Rogon, C., Ulbricht, A., Hesse, M., Alberti, S., Vijayaraj, P., Best, D., Adams, I., Magin, T., Fleischmann, B. & Hohfeld, J. & (2014). HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis, Molecular Biology of the Cell, 25 (15) 2260-2271. DOI: 10.1091/mbc.E14-02-0742

Alberti S, Böhse K, Arndt V, Schmitz A, Höhfeld J. (2004). The Cochaperone HspBP1 Inhibits the CHIP Ubiquitin Ligase and Stimulates the Maturation of the Cystic Fibrosis Transmembrane Conductance Regulator, Molecular Biology of the Cell, 15 (9) 4003-4010. DOI: 10.1091/mbc.E04-04-0293

12:40 PM | Is the academy worse than the fashion industry for “following the leader”?
This post originally appeared on The Black Hole blog and is reprinted with permission from the author and University Affairs. I hate to admit this, but I find an incredible number of scientific papers really boring. It seems that more and more, research papers are using the same sets of sexy and expensive tools without actually...Read more
9:32 AM | Copper Clothes to stop the Spread of Infection
Copper is an essential metal for human biological functions and is highly regulated within the body, however copper is starting to be exploited to now protect us from the threat […]
2:00 AM | The Cold Spot is not particularly cold
(and it probably isn't explained by a supervoid; although it is still anomalous)In the cosmic microwave background (CMB) there is a thing that cosmologists call "The Cold Spot". However, I'm going to try to argue that its name is perhaps a little, well, wrong. This is because it isn't actually very cold. Although, it is definitely notably spotty.That's the cold spot. It even has its own Wikipedia page (which really does need updated).Why care about a cold spot? This spot has become a thing to […]

August 24, 2014

11:59 AM | Could Lizards Teach Us The Secret of Regeneration?
A recent paper published in PLoS ONE imaginatively titled “Transcriptomic Analysis of Tail Regeneration in the Lizard Anolis carolinensis Reveals Activation of Conserved Vertebrate Developmental and Repair Mechanisms” has genuinely […]

Hutchins ED, Markov GJ, Eckalbar WL, George RM, King JM, Tokuyama MA, Geiger LA, Emmert N, Ammar MJ, Allen AN & Siniard AL (2014). Transcriptomic Analysis of Tail Regeneration in the Lizard Anolis carolinensis Reveals Activation of Conserved Vertebrate Developmental and Repair Mechanisms., PloS one, 9 (8) PMID:

Zhu, S., Rezvani, M., Harbell, J., Mattis, A., Wolfe, A., Benet, L., Willenbring, H. & Ding, S. (2014). Mouse liver repopulation with hepatocytes generated from human fibroblasts, Nature, 508 (7494) 93-97. DOI: 10.1038/nature13020

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