December 18, 2014

6:40 PM | Connections between starvation and immunological memory
Focus on autophagy's functions in memory T cells The post Connections between starvation and immunological memory appeared first on Lab Land.
1:00 PM | An “orchard” of cell production systems
. With contributions from David Brindley Manufacturing may not be the first thing that springs to mind when regenerative medicine is mentioned. Most will think of the enormous potential for cell therapies or transplantation or editing of faulty genes. However, having attended the fifth annual Informa Life Sciences Cell Therapy Manufacturing conference, it is clear...Read more

December 17, 2014

3:25 PM | Effects of cocaine exposure in adolescent rodents
The effects on neurons are like losing entire branches from a tree, neuroscientists are finding The post Effects of cocaine exposure in adolescent rodents appeared first on Lab Land.

December 16, 2014

2:36 AM | The story of Acheta domesticus Densovirus in the US: an outbreak which resulted in the illegal import of invasive species.
I’m trying to to get back into the tarantula breeding hobby, and decided to set up a cricket colony to help me feed the animals for cheap. I’m not thrilled about using crickets, because they’re not the best feeders for reasons I’m about to discuss in this post. Cockroaches are considered to be the best […]Read Post ›

December 15, 2014

9:20 PM | ‘Tis the season to be jolly…
Five days ago, a new article was published in Nature in which scientists tried to combine reliable sources to take “stock of how much life exists today and how quickly it will vanish in the future”. Of all the species that have populated the Earth during the last 3.5 billion years, more than 95% have […]
3:02 PM | Frailty: we know it when we can measure it
Look beyond the cane. Emory researchers are seeking to define and measure frailty, to aid in surgery-related decision-making. The post Frailty: we know it when we can measure it appeared first on Lab Land.
1:00 PM | Making sure amazing things happen
Joe Sornberger is Director of Communications Programs for the Canadian Stem Cell Foundation and author of the book “Dreams & Due Diligence: Till and McCulloch’s Stem Cell Discovery and Legacy.”   Amazing things can happen in 10 years. Consider the world, circa 2004. The United States had yet to elect an African American president, Steve...Read more

December 14, 2014

5:27 PM | Treat ‘em mean, keep ‘em keen.
Female black widow spiders (Latrodectus mactans) are notorious for killing and eating males before, during or after sex. This cannibalism is also observed in preying mantis, wolf spiders (Hogna helluo) and Australian redback spiders (Latrodectus hasselti). But why? Surely this activity, especially before copulation, reduces a female’s chances of reproduction, especially in species with very […]

December 12, 2014

1:28 PM | Where should I send this darned manuscript, anyway?
As an academic scientist, this question usually hits you right after you’ve written your results section, but haven’t had a chance to square up to the pit of seething hell that is the discussion. It’s a blissful point where you … Continue reading →
1:13 PM | Right Turn: Video primer on stem cells better than a “Ruff” cut
. The Institute of Human Development, Child and Youth Health (IHDCYH), part of the Canadian Institutes of Health Research, is holding its IHDCYH Talks competition to feature research that falls within its mandate of improving knowledge translation and demonstrating the value of reproductive, child and youth health research in Canada. For this competition, participants were...Read more
2:42 AM | Out on my own.
I’ve had a pretty good blogging career, one which has spanned 7 years and four separate blogs. My first blog was done anonymously, and I moved to Biofortified after gaining an audience from that blog which I will not name. I also occasionally write stuff for Entomology Today. I’ve built up an audience at Biofortified, […]Read Post ›

December 11, 2014

4:07 PM | “I’m Dreaming of a White Christmas” – The Scientific Solution
There is nothing more frustrating than living in a place where it is cold enough to snow, but it just refuses to. Worry not. Now you can show Mother Nature up and make your own snow! Ingredients Water A pressure nozzle A cold day (below 0˚C) Pressure nozzle? There are a few options… A pressure […]
1:10 PM | The value of a cure
. With contributions from David Brindley. We recently discussed the role that consortia could play in accelerating the timeline of discovering and implementing new treatments, covering the ‘partnering’ aspect of the ‘Partnering for Cures’ conference held in New York City that was referenced. It, therefore, seems appropriate to devote some time to the ‘other half:’...Read more

December 09, 2014

6:26 PM | The other “cho-” cardiovascular disease biomarker
Jo and Jones team up to examine metabolic signs of atherosclerosis and run into choline The post The other “cho-” cardiovascular disease biomarker appeared first on Lab Land.
1:00 PM | Surprising applications of economic thinking to scientific collaboration
. With contributions from David Brindley. Suppose you are a talented fisherman and an outstanding shoe-maker. You have abandoned your dreams of a career in the regenerative medicine industry because, in one day, you can catch 100 fish or make one complete pair of shoes. That’s a very satisfying outcome for a day’s work. Your...Read more

December 08, 2014

7:00 PM | Getting Started with Pathomx
This is quick start-up guide for new users of Pathomx. Following it should give you everything that you need to know to start using Pathomx right away. Once you’ve been through the basics you might like to see some of the demos to see what Pathomx is capable of. Pathomx aims to offer a powerful, extensible analysis and processing platform while being as simple to use as possible to the casual user. It should be possible to pick up Pathomx, use the built-in - or bioinformatician […]
2:14 PM | Inside a cancer stem cell researcher’s toolbox: CSC markers & flow cytometry
> In my previous toolbox articles (sphere formation and xenotransplantation), I’ve talked about assays that are pretty useful in determining the existence of cancer stem cell (CSC) populations based on function. What these assays cannot do is provide us with a way to identify the specific cells. Well, guess what? There’s a tool for that...Read more
2:02 PM | Climate Change: Heatwaves and Poverty in Pakistan
In the summer of 2010, over 20 million people were affected by the summer floods in Pakistan. Millions lost access to shelter and clean water, and became dependent on aid in the form of food, drinking water, tents, clothes and medical supplies in order to survive this humanitarian disaster. It is estimated that at least $1.5 billion to $2 billion were provided as aid by governments, NGOs, charity organizations and private individuals from all around the world, and helped contain the […]

December 07, 2014

10:08 PM | Human Metamorphosis
met·a·mor·pho·sis [met-uh-mawr-fuh-sis] noun, plural –  A profound change in form from one stage to the next in the life history of an organism, as from the caterpillar to the pupa and from the pupa to the adult butterfly. The human race has come a long way since 1830, when a German naturalist named Renous was arrested in […]

December 05, 2014

1:15 PM | Right Turn: Stem cells for conservation
According to the International Union for Conservation of Nature’s (IUCN) Red List, nearly 12,000 animal species are threatened with extinction today. There are many reasons for the precarious state of these species, and nearly as many plans to attempt restoration of their populations, but Japanese scientists are looking at one rarely considered option: Stem cells. Dr....Read more

December 04, 2014

7:04 PM | Going meta
A growing body of evidence suggests that linguistic metaphors reflect how we actually use our brains The post Going meta appeared first on Lab Land.
2:41 PM | Strategy to defend vs double hit at beginning of life
Inflammation and hypoxia can combine to increase of fetal brain damage. Researchers test a strategy to halt immune cells that drive the damage. The post Strategy to defend vs double hit at beginning of life appeared first on Lab Land.
1:00 PM | Beta cell transplant, hype or hope?
. The Edmonton Protocol for the transplantation of insulin producing cells into individuals with type 1 diabetes (T1DM) has a cost per quality-adjusted life year (QALY) of ~$165,000. This is more than three times the willingness-to-pay (WTP) in Canada, and comfortably twice the WTP in the United States for many health care insurance plans. Even...Read more

December 02, 2014

11:05 PM | Sugary Sweet Days
You may have heard of sunflowers facing their heads towards the light, or of seedlings orientating themselves so that their roots always grow into the ground. Now there’s evidence that plants can not respond to the light source, but can also anticipate sunrise and adjust their biological functions accordingly. Plants, just like animals, have a […]

December 01, 2014

6:43 PM | TED-Ed: An attempt at translating sciences to society
By Sarthak Sinha In the two weeks following their release, over 250,000 individuals worldwide have watched and shared these two TED-Ed lessons (see below); a project we worked on for three months. As a reflection on this work, I wanted to share where it all started, what it means in the context of sciences beyond...Read more

November 28, 2014

10:59 PM | Insects Impersonating Insects
Animals often mimic the appearance of other, usually more toxic or aggressive, species in order to avoid predation. One example of this type of natural selection, wing pattern mimicry, has been studied throughout history. Butterflies belonging to some swallowtail species, for example the Common Mormon (Papilio polytes), have been noted to mimic the wing patterns, […]
4:25 PM | Right Turn: Bands and bandages
. If you’ve never heard of epidermolysis bullosa (EB), you’re not alone. This rare genetic disease, which occurs in one of 20,000 births, creates fragile skin that tears at the slightest touch and results in blisters, sores and scar tissue. There is no cure. EB sufferers who are fortunate enough to survive into adulthood often...Read more

November 27, 2014

2:44 PM | Update from the Clinic: October
. Welcome to your Update from the Clinic for the month of October. Northwest Biotherapeutics continues to receive support for its cancer vaccine platform in Europe. Neuralstem and StemCells provided updates on their respective clinical programs for spinal cord injury. Pluristem continues to advance its second product, PLX-RAD, into large-scale manufacturing. Read on to find...Read more

November 24, 2014

11:24 PM | Glow in the dark
Why do cats’ eyes glow in the dark? When a light shines into a cat’s eyes in the dark, it causes them to “glow”. In fact, while driving at night, you might have noticed that effect is not unique to cats; headlights will cause the eyes of any nocturnal animal to shine brightly. The secret […]
6:31 PM | How the 5:2 Diet Reduces More Than Just Your Waistline
Intermittent fasting is the seemingly miraculous new weight loss method, popularised by the 5:2 diet followed by Benedict Cumberbatch, George Osborne, and Philip Schofield. Adherents to the 5:2 diet practise […]
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