February 27, 2015

8:38 PM | Reviving drugs with anti-stroke potential, minus side effects
pH-dependent NMDA receptor antagonists -- more active in the injured areas of the brain The post Reviving drugs with anti-stroke potential, minus side effects appeared first on Lab Land.

February 23, 2015

1:00 PM | Regenerative Medicine Deal Review: January
. Welcome to your deal review for the month of January. There was a mixed bag of news last month, which included financing activity, industry partnerships and research collaborations. The cell therapy tools industry was front and centre as NeoStem and Invetech struck up a deal to develop a closed, automated cell manufacturing unit for...Read more

February 20, 2015

1:00 PM | Right Turn: Why Janet Rossant is optimistic about the future of regenerative medicine
. If you haven’t heard the name Janet Rossant, my guess is that you aren’t part of the stem cell community or you spend a little too much time in the lab. Dr. Rossant is Chief of Research at the Hospital for Sick Children in Toronto, Canada and she leads the new Ontario Institute for...Read more

February 19, 2015

1:00 PM | Update from the clinic: January
. Welcome to your Update from the Clinic for the month of January. Pluristem and OncoMed reported preliminary efficacy data from early-stage trials, while the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) granted a number of Orphan Drug Designations for various cancer indications being developed by OncoMed, Stemline Therapeutics, and Kite...Read more

February 17, 2015

10:35 PM | A structure for SorLA/LR11
First identified by Alzheimer's researchers at Emory, the structure of the SorLA protein, aka LR11, was recently determined. SorLA appears to scavenge toxic beta-amyloid in the brain. The post A structure for SorLA/LR11 appeared first on Lab Land.
3:09 PM | The dermal cup, home to the elusive dermal stem cell
> The scientific community has long sought to uncover the identity of a true dermal stem cell. While many unique cell populations have been described in the literature, some of which are predictive of a dermal stem cell, the exact location and behavior of this cell has largely eluded us. In a landmark paper published...Read more
11:37 AM | When can you have sex after a heart attack? Most doctors do not talk about it.
Each year in the United States about 720,000 people have heart attacks and about 124,000 people in the UK and 55,000 people in Australia will have them as well. Since the 1980s, survival rates from heart attacks have improved – a lot of people get them, but more and more people are surviving. A recent study of patients in Denmark showed that in 1984-1988 31.4% of patients died within a month of having a heart attack. From 2004-2008 this was... Read more

February 16, 2015

8:41 PM | Explainer: oncolytic viruses
Viruses are masters of stealth and manipulation. So cancer researchers can learn a lot from them. The post Explainer: oncolytic viruses appeared first on Lab Land.
1:21 PM | Genome Editing – The science behind ‘designer babies’.
A vote in the House of Commons last week has allowed the UK to become the first country to carry out mitochondrial DNA transfer in order to replace defective mitochondria […]

February 13, 2015

11:08 PM | “L is for the way you look at me”
Every year on Valentine’s Day, 141 million cards are exchanged worldwide. The average American is expected to spend $116.21 on this day. Approximately 150 million roses are sold between the 12th and 15th of February. All in the name of LOVE. But, what is the science behind the common symptoms of infatuation: flushed cheeks, a […]
3:28 PM | Immune ‘traffic jam’ from viral infection
Immune complexes formed during an active infection can clog the receptors needed for therapeutic antibodies to work The post Immune ‘traffic jam’ from viral infection appeared first on Lab Land.
2:36 PM | Right Turn: My bloody valentine (a new StemCellShort video)
> The blood stem cell (or hematopoietic stem cell as it’s known in scientific parlance) was the first stem cell to be identified, which makes it a bit of a celebrity, as stem cells go. Here in Canada, we like to think of Drs. James Till and Ernest McCulloch, who made that initial discovery in...Read more

February 12, 2015

7:54 PM | Nox4 inhibitor expands its reach to A-T
Ataxia telangiectasia, a multifaceted genetic disorder, is often marked by prominent blood vessels in the eyes The post Nox4 inhibitor expands its reach to A-T appeared first on Lab Land.

February 09, 2015

4:57 PM | Reflections on the Stem Cell Network Part 2: Building a broad talent base
> This article is the second in a series about the human capital created by the Network of Centre of Excellence known as the Stem Cell Network (SCN), which was created in 2001, will wind down the majority of it’s activities this year. The first article focused on the trainees turned academic group leader, but...Read more

February 06, 2015

8:28 PM | A risk worth taking–And one your immune system is prepared to take.
When was the last time you made an important decision with 100% certainty? Most, if not all, decisions in life come with risks, consequences or trade-offs. Healthcare is no different from anything else. Every surgery, pill, shot, even every new … Continue reading →
2:19 PM | Back to Basics: An Introduction to Viruses.
Stories about patients demanding antibiotics to treat cold and flu symptoms are all too common, highlighting the confusion many people have when it comes to understanding the difference between a […]
1:28 PM | Fish oil capsules probably won’t boost your brain
My mum and dad are troopers. Every morning, they down a tablespoon of fish oil in an effort to stave off old age and dry rot. And they do it without any obvious signs that swallowing a few millilitres of … Continue reading →

Albert, B., Derraik, J., Cameron-Smith, D., Hofman, P., Tumanov, S., Villas-Boas, S., Garg, M. & Cutfield, W. (2015). Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA, Scientific Reports, 5 7928. DOI: 10.1038/srep07928

1:00 PM | Right Turn: Cross my heart
. In 2012, Deborah Lieu from the University of California, Davis was granted $1.3 million by the California Institute for Regenerative Medicine (CIRM) to develop pacemaking cells from human induced pluripotent stem cells (HiPSCs) to replace electronic pacemakers. I first wrote about this in Keeping pace with stem cell technology. With Valentine’s Day just a...Read more

February 04, 2015

6:55 PM | Insecticide-ADHD link, with caveats
There's a dopamine-environment connection. Maybe. The post Insecticide-ADHD link, with caveats appeared first on Lab Land.
12:11 AM | Combined constraints from BICEP2, Keck, Planck and WMAP on primordial gravitational waves
This week, the joint analysis of BICEP2 (+ BICEP2's successor Keck) and Planck has finally arrived. The result is more or less what was expected, which is that what BICEP2 saw last year in the B-mode polarisation signal of the CMB was not actually primordial gravitational waves (as had originally been hoped and claimed), but was unfortunately actually due to dust in the Milky Way. Such is life. Though we did of course have the best part of a year to come to grips with this reality.Combined […]

February 02, 2015

8:16 PM | Threshold for long-term marijuana effects on lung function
Exposure to 20 joint-years is a threshold for marijuana's long-term effects on lung function, Emory researchers found The post Threshold for long-term marijuana effects on lung function appeared first on Lab Land.
5:26 PM | Literature and Philosophy in the Laboratory Meeting
Research institutions in the life sciences engage in two types of regular scientific meet-ups: scientific seminars and lab meetings. The structure of scientific seminars is fairly standard. Speakers give Powerpoint presentations (typically 45 to 55 minutes long) which provide the necessary scientific background, summarize their group's recent published scientific work and then (hopefully) present newer, unpublished data. Lab meetings are a rather different affair. The purpose of a lab meeting […]

Thomas Kuhn (2012). The Structure of Scientific Revolutions, University of Chicago Press, DOI: 10.7208/chicago/9780226458106.001.0001

2:37 PM | Reflections on the Stem Cell Network Part 1: Establishing the next generation of stem cell academics
> As many of our readers are aware, the Network of Centre of Excellence known as the Stem Cell Network (SCN), which was created in 2001, will wind down the majority of it’s activities this year. I have been a trainee/alumnus since the start of my PhD in 2003 and have therefore spent my entire...Read more

January 30, 2015

10:13 PM | MS HSCT
Multiple sclerosis, or MS, is an autoimmune disorder that affects the brain and spinal cord. The immune system destroys the patient’s own myelin sheath, the protective membrane that surrounds nerve cells, thus disrupting communication with the central nervous system. About 50 percent of patients are unable to walk within 25 years of their diagnosis. Most existing […]
5:17 PM | Right Turn: Multiple sclerosis clinical trial begins in Ottawa
  Click image to go to CTV News Ottawa video     We’ve written about some questionable “clinical trials” recruiting patients in Canada recently, so it only makes sense to follow-up with some hopeful news about a legitimate, regulator-approved trial that launched this past week. Dr. Mark Freedman, Senior Scientist of the Neuroscience Program at the Ottawa...Read more
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