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Posts

April 23, 2014

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6:32 PM | Nontraditional Animal Models—The Ground Squirrel
We still talk about guinea pigs as experimental subjects yet you'd have a hard time finding one in a modern research laboratory. Guinea pigs were first used in biomedical research in the late 19th century, playing a major role in establishing the germ theory, identifying pathogens, linking vitamin C insufficiency to scurvy, and modeling diabetes and pre-eclampsia. The guinea pig metaphor lives on but today, mice, rats, fruit flies, nematodes, and zebrafish dominate as model animals. But there […]

April 22, 2014

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1:54 PM | No link between STAP cells and acid reflux, except for paper’s authors
> If you’ve stayed current with the STAP cell fiasco you know it’s been a wild ride. STAP cells, or Stimulus-Triggered Acquisition of Pluripotency cells, caught the imagination of many in late January through their sheer simplicity: You hit cells with a shock of acidic conditions, and they become pluripotent. That’s it. No Yamanaka factors...Read more

Chen X., Qin R., Liu B., Ma Y., Su Y., Yang C., Glickman J., Odze R. & Shaheen N. Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers, BMC Gastroentereology, 8 (1) DOI:

Wang X., Yang S., Zhao X., Guo H., Ling X., Wang L., Fan C., Yu J. & Zhou S. (2014). OCT3 and SOX2 promote the transformation of Barrett's esophagus to adenocarcinoma by regulating the formation of tumor stem cells., Oncology reports, PMID:

Wang X., Ouyang H., Yamamoto Y., Kumar P.A., Wei T.S., Dagher R., Vincent M., Lu X., Bellizzi A.M. & Ho K.Y. & Residual embryonic cells as precursors of a Barrett's-like metaplasia., Cell, PMID:

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April 21, 2014

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6:56 PM | Easter Chocolate Cravings: The Power of Polyphenols
With the Easter weekend over for another year and the family festivities drawing to a close, we can sit and contemplate one thing…just how much chocolate have I eaten the […]

Katz, D., Doughty, K. & Ali, A. (2011). Cocoa and Chocolate in Human Health and Disease, Antioxidants & Redox Signaling, 15 (10) 2779-2811. DOI:

Franco R, Oñatibia-Astibia A & Martínez-Pinilla E (2013). Health benefits of methylxanthines in cacao and chocolate., Nutrients, 5 (10) 4159-73. PMID:

Selmi C, Cocchi CA, Lanfredini M, Keen CL & Gershwin ME (2008). Chocolate at heart: the anti-inflammatory impact of cocoa flavanols., Molecular nutrition & food research, 52 (11) 1340-8. PMID:

Ellam S & Williamson G (2013). Cocoa and human health., Annual review of nutrition, 33 105-28. PMID:

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2:08 PM | The Kaluza Prizes Are Back, Bigger Than Ever as ASCB and Sponsor Beckman Coulter Increase Number of 2014 Cash Awards
The Kaluza Prizes to honor the best in graduate student bioscience research are growing. In announcing the opening of the 2014 Kaluza Prize competition, the American Society for Cell Biology (ASCB), in collaboration with Beckman Coulter Life Sciences, said that the awards will increase to $5,000, $3,000, and $1,000 in ranked order for the top three winners. The Kaluza Prizes to honor the best in graduate student bioscience research are growing. In announcing the opening of the 2014 Kaluza […]
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12:28 PM | Swimming with Viruses
You can find viruses everywhere: in the soil, in the clouds and in animals. According to scientists from the University of Oldenburg in Germany, there are also a ridiculous number of viruses buried at sea, in the sediments of the … Continue reading →

April 19, 2014

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1:01 PM | Preprints: Trying Something New in Publishing
As a trainee, having my papers reviewed by experts in the field has been both a frustrating and positive experience.  It has been positive, in that in nearly every case my publications have been improved by the process.  The enhancements from little embarrassing typos to new ways of conceptualizing our data, and certainly these papers are better for it.On the other hand, some times it takes forever.  One paper went through 18 rounds of submission/resubmission, lasting over 3 […]

April 18, 2014

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2:03 PM | Glucosidase I: Could targeting N-linked glycosylation of proteins help us fight viral infection?
Viruses are sneaky.  As you probably already know from your last bout with the common cold or the flu, for most viral infections doctors will simply prescribe plenty of water and […]

Sadat, M., Moir, S., Chun, T., Lusso, P., Kaplan, G., Wolfe, L., Memoli, M., He, M., Vega, H., Kim, L. & Huang, Y. (2014). Glycosylation, Hypogammaglobulinemia, and Resistance to Viral Infections, New England Journal of Medicine, 2147483647. DOI:

Herscovics, A. (1999). Importance of glycosidases in mammalian glycoprotein biosynthesis, Biochimica et Biophysica Acta (BBA) - General Subjects, 1473 (1) 96-107. DOI:

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8:59 AM | In which the season turns
London is in the throes of springtime, and everything is in bud. Last year this time, my belly was swelling ever bigger in pregnancy. Now, my son – nearing the seven month mark – grows so fast that he seems … Continue reading →

April 17, 2014

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9:55 PM | Right Turn: Time to stop the bleeding
Recently Revmedx, a pioneer in the biomaterial wound dressing field, made some waves with the commercialization of its product XStatTM . XStatTM received a lot of press because of its FDA approval for use against gunshot wounds and shrapnel-related injuries in the battlefield. It is used to help stop the bleeding and help sustain the...Read more
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3:53 PM | Lab Grown Organs and Artistic Computers in Fifty Years?
The Pew Research Center released the 2014 survey of U.S. adults (1,001 participants, surveyed by land-line or cell phone interviews) regarding their views on technological advancements in the next 50 years. Over eighty percent of the participants said that "People in need of an organ transplant will have new organs custom made for them in a lab" and roughly half of the participants felt that "Computers will be as effective as people at creating important works of art such as... Read more
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11:32 AM | Cannabis use and structural changes in the brain
  “One or two spliffs a week could mess up your brain” – Metro, 16 April 2014 Spark your interest? This headline caught the eyes of the Antisense team, so […]

Gilman, J., Kuster, J., Lee, S., Lee, M., Kim, B., Makris, N., van der Kouwe, A., Blood, A. & Breiter, H. (2014). Cannabis Use Is Quantitatively Associated with Nucleus Accumbens and Amygdala Abnormalities in Young Adult Recreational Users, Journal of Neuroscience, 34 (16) 5529-5538. DOI:

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April 16, 2014

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2:57 PM | Our People— A Special Society, a Prestigious Medal, and a Big Promotion
ASCB Women in Cell Biology committee member Ora Weisz, of the University of Pittsburgh, was inducted last week into Johns Hopkins University's (JHU) Society of Scholars. The Society recognizes accomplished former JHU postdoctoral fellows or visiting faculty who have gained marked distinction elsewhere. Just over 600 people have been inducted into the society since 1969. Weisz joined distinguished academics from around the world for an induction ceremony at JHU's Peabody Institute on April […]
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1:36 AM | New Study Shows Surgical Checklists In Operating Rooms Are Less Effective Than Assumed
The patient has verified his or her identity, the surgical site, the type of procedure, and his or her consent. Check. The surgical site is marked on a patient if such marking is appropriate for the procedure. Check. The probe measuring blood oxygen content has been placed on the patient and is functioning. Check. All members of the surgical and anesthesia team are aware of whether the patient has a known allergy? Check. These were the first items on a... Read more

Urbach DR, Govindarajan A, Saskin R, Wilton AS & Baxter NN (2014). Introduction of surgical safety checklists in Ontario, Canada., The New England Journal of Medicine, 370 (11) 1029-38. PMID:

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April 15, 2014

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3:32 PM | How to Rescue U.S. Bioscience from its Successes and Excesses
Calling it "a recipe for long-term decline," four of the nation's most distinguished cell biologists describe the present U.S. system of biomedical research as "unsustainable" and "hypercompetitive," calling for a sweeping rebalancing of bioscience education, funding, and direction. In a "Perspective" just published in PNAS, Bruce Alberts, Marc Kirschner, Shirley Tilghman, and Harold Varmus advocate reforms in the scientific workforce with a gradual reduction in the number of students […]
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12:39 PM | Testing stem cells in the clinic – a role for publicly funded trials?
> In February this year, the biggest stem cell trial for heart attack patients was begun and will involve over 3000 patients from 11 different countries in Europe. The BAMI trial (the effect of intracoronary reinfusion of Bone marrow-derived mononuclear cells on all course mortality in Acute Myocardial Infarction) aims to demonstrate whether or not...Read more

April 14, 2014

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5:09 PM | Buckle Your Seatbelt or Grab Your Parachute? Turbulent Times Make “Something Else” the New Majority Career Choice in Bioscience
It isn't your imagination. The recent ups and downs in biomedical research funding have made for turbulent times in academic laboratories across the US. Jennifer Couzin-Frankel points out in her overview article to an imaginatively reported "News Focus" section last week in Science on the work force and funding crisis in biomedical science that the NIH budget doubled between 1998 and 2003 from around $14 billion to $27 billion but remained essentially flat for the next five years. The […]
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11:25 AM | Porn and Working Memory
“Around half of 15 to 17-year-olds have accessed porn on a smartphone or tablet” (BBC, 2014). Surprised by the quote above? Whatever the answer, your feelings on how these behaviours […]

April 13, 2014

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8:40 AM | Primordial Human Embryonic Germ Cells
Embryonic germ cells are pluripotent cells that originated from the early germ cells that are responsible for the formation of sperm and egg cells. Rethinking Germ Cells | Video Embryonic germ cells are believed to mimic the properties of embryonic stem cells. Germ cells are essentially very specialized cells that are crucial in reproduction. Cells […] The post Primordial Human Embryonic Germ Cells appeared first on Regeneration Center of Thailand.

April 11, 2014

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1:26 PM | Right Turn: Bringing stem cells to (fictional) life
> I’ve been thinking a fair bit about the “personalities” of stem cells in recent weeks — specifically, the characteristics of stem cells that might translate into a persona or a fictional character of some sort. It’s with good reason, of course: The Stem Cell Network is in the process of creating a traveling science...Read more
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12:00 PM | The Guardians In Our Gut- Using Bacteria to Sense Disease
You’re sitting there, reading this post, and your skin should be crawling. Well it practically is, along with your nostrils, lungs, gut and any of your mucus-covered surfaces. You’re crawling with […]

Kotula JW, Kerns SJ, Shaket LA, Siraj L, Collins JJ, Way JC & Silver PA (2014). Programmable bacteria detect and record an environmental signal in the mammalian gut., Proceedings of the National Academy of Sciences of the United States of America, 111 (13) 4838-43. PMID:

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April 10, 2014

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4:00 AM | Ten Click Baits We Would Never Use on Our Science News Site
There is this awesome technology site called The Verge. How awesome, we can barely tell you although we can reveal a recent The Verge top story: "'Captain America 3' to hit theaters on May 6th, 2016." Save the date. What makes The Verge so additionally awesome, according to the New York Times, is that The Verge belongs to Vox Media, the General Motors conglomerate of the New Digital Media Age. "Vox Takes the Melding of Journalism and Technology to a New Level," says the Times. (Our […]
Editor's Pick

April 09, 2014

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3:42 PM | Lusty Worms Pass Love Notes through Tiny Bubbles
Nearly every cell in your body is releasing microscopic bubbles that contain tiny messages to other cells in your body. The bubbles are so small that if a cell were the size of the Empire State Building, the vesicles would be the size of teenage couriers, running to deliver messages to neighboring buildings in the organism of Manhattan. But now there's evidence that at least in worms, these little bubbles, called extracellular vesicles (ECVs), can leave the cells of the Manhattan Island worm to […]

Wang J, Silva M, Haas LA, Morsci NS, Nguyen KC, Hall DH & Barr MM (2014). C. elegans Ciliated Sensory Neurons Release Extracellular Vesicles that Function in Animal Communication., Current biology : CB, 24 (5) 519-25. PMID:

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Editor's Pick
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11:00 AM | Omega Fatty Acids: The Science Behind Fish Oil- Guest post from Beauty by the Geeks
So we all know that old story your grandma used to tell you… ‘Make sure you eat plenty of fish so you grow up to be a brainbox’ but where […]

Simopoulos, A. (1997). Nutrition tid‐bites: Essential fatty acids in health and chronic disease, Food Reviews International, 13 (4) 623-631. DOI:

Chang CY, Ke DS & Chen JY (2009). Essential fatty acids and human brain., Acta neurologica Taiwanica, 18 (4) 231-41. PMID:

Calder PC (2013). Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?, British journal of clinical pharmacology, 75 (3) 645-62. PMID:

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10:03 AM | 2nd CNB Course on Introduction to Research
The Centro Nacional de Biotecnología (CNB-CSIC) is organising its 2nd Course on Introduction to Research for students in the final years of any university degree in science. The course is designed for qualified, highly motivated students who would like to contact the scientists at the CNB. The goal of this course is to provide an overview of the centre’s cutting-edge research facilities. For four weeks, the students will participate in the scientific activities of two […]

April 08, 2014

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5:34 PM | The Lure of the Ring—A Chloride Ion Channel Gene Makes a Surprise Appearance in Ciliogenesis
It's been nearly 14 years since the primary cilium pushed its way into cell biology's center ring with the discovery that this "irrelevant" vestigial organelle was connected to a common and fatal human disorder, polycystic kidney disease (PKD). In the years since, a long list of diseases and disorders have been classified as ciliopathies while the primary cilium currently has 2,347 citations on PubMed. One ring to rule them all—The “nimbus” ring, […]

Ruppersburg CC & Hartzell HC (2014). The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis., Molecular biology of the cell, PMID:

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1:28 PM | Cell lines, patient samples, and cultures – oh my!
> The thing that is so intriguing about cancer stem cells (CSCs), from a cancer researcher’s perspective, is their powerful potential as therapeutic targets. While CSCs can create or regenerate tumours (causing relapse in some patients despite our best efforts to prevent it – more on this in my previous post on CSCs), they also...Read more

Rosland G.V., Svendsen A., Torsvik A., Sobala E., McCormack E., Immervoll H., Mysliwietz J., Tonn J.C., Goldbrunner R. & Lonning P.E. & (2009). Long-term Cultures of Bone Marrow-Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation, Cancer Research, 69 (13) 5331-5339. DOI:

Li Y., Héroux P. & Kyrychenko I. (2012). Metabolic restriction of cancer cells in vitro causes karyotype contraction—an indicator of cancer promotion?, Tumor Biology, 33 (1) 195-205. DOI:

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11:00 AM | Coffee vs. Parkinson’s Disease – Can Caffeine Reduce the Risk of Developing the Disease?
Coffee: Black, two Sugars and hold the Parkinson’s. As the second most common neurodegenerative disease, it’s estimated that around 10 million people are living with Parkinson’s disease worldwide. Parkinson’s is […]

Costa J, Lunet N, Santos C, Santos J & Vaz-Carneiro A (2010). Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies., Journal of Alzheimer's disease : JAD, 20 Suppl 1 38. PMID:

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April 07, 2014

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12:35 PM | Usher Syndrome and Cochlear Implants – Hearing Sound for the First Time
There aren’t many of us who won’t have read the heart-warming story about Joanne Milne, an Usher syndrome sufferer who, after being profoundly deaf her whole life, was able to […]

Cosgrove, D. & Zallocchi, M. (2014). Usher protein functions in hair cells and photoreceptors, The International Journal of Biochemistry & Cell Biology, 46 80-89. DOI:

Loundon, N., Marlin, S., Busquet, D., Denoyelle, F., Roger, G., Renaud, F. & Garabedian, E. (2003). Usher Syndrome and Cochlear Implantation, Otology & Neurotology, 24 (2) 216-221. DOI:

Petit C (2001). Usher syndrome: from genetics to pathogenesis, Annu Rev Genomics Hum Genet,

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April 06, 2014

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2:37 PM | Can 7-a-day save your life?
On the 1st of April I heard over my morning cup of coffee that new research suggests that the staple 5-a-day which has been ingrained into our idea of health since […]

Oyebode O, Gordon-Dseagu V, Walker A & Mindell JS (2014). Fruit and vegetable consumption and all-cause, cancer and CVD mortality: analysis of Health Survey for England data., Journal of epidemiology and community health, PMID:

Lock K, Pomerleau J, Causer L, Altmann DR & McKee M (2005). The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet., Bulletin of the World Health Organization, 83 (2) 100-8. PMID:

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April 05, 2014

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5:01 AM | Haploid Cell Function and Formation in Humans
The human body contains two primary types of cells: Haploid cells Diploid cells Haploid Vs Diploid – VIDEO Haploid cells pertains to the number of chromosomes found in a gamete or represents half of the normal chromosome count in a particular somatic cells. The primary difference between haploid and diploid cells are the total number […] The post Haploid Cell Function and Formation in Humans appeared first on Regeneration Center of Thailand.
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