Posts

August 24, 2014

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2:31 AM | Updated: Compilation of Biotech/Pharma R&D Pipelines
I am pleased to report that the Pipelines page has been completely updated over the past couple days. This feature highlights the latest links and files related to clinical research and development pipeline progress for major biotech and pharmaceutical companies. More and more, I am trying to host PDF files of the pipeline status rather than just a website link, in order to better preserve the historical context. I hope you find this resource useful and I welcome any feedback. […]

August 22, 2014

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8:55 PM | The evolution of sequencing technology
Un excelente poster con datos históricos y una buena visión general del tema (para los no iniciados):http://www.sciencemag.org/site/products/posters/SequencingPoster.pdf
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4:52 PM | The Impact of Environment on Epigenetics and Metal Health
Bulimia Nervosa, a well-known eating disorder is commonly characterized by recurrent binge-eating, subsequent compensatory behaviors, and body image obsession. In addition to these common symptoms, some individuals with BN also suffer from other disorders such as mood fluctuations, anxiety, substance abuse, and personality problems. However, other individuals do not. Due ... The post The Impact of Environment on Epigenetics and Metal Health appeared first on EpiBeat.
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3:41 PM | Preliminary results promising in beef genomics project
Alberta researchers are starting to get some promising results back from a five year study aiming to improve molecular breeding values and show how genomics can be used by beef producers to make better breeding decisions. University of Alberta researchers split the composite herd at the Roy Berg Kinsella Research Ranch into control and experimental groups. Cows in the control group were bred to control bulls, while the other cows were bred to feed efficient bulls. The Kinsella herd is heavily […]
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1:20 PM | Right Turn: What do stem cells, ice and ALS have in common?
. You have to be living under a rock – or perhaps spending every minute of your time culturing your cells – to be unaware of the ALS #Icebucketchallenge. Since it began on July 29 on social media, the American ALS Association has raised millions (nearly $42 million at the time of writing) in donations...Read more
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1:02 PM | Friday SNPpets
Welcome to our Friday feature link collection: SNPpets. During the week we come across a lot of links and reads that we think are interesting, but don’t make it to a blog post. Here they are for your enjoyment… RT @dgmacarthur: Great story by @edyong209 on a woman who correctly guessed the genetic cause of […]
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10:10 AM | Lilly's psoriasis candidate tops Enbrel in phase III trials
Ixekizumab on course for regulatory filing in first half of 2015
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10:07 AM | Baxter 'will file long-acting haemophilia drug by year-end'
New version of Advate clears late-stage trial
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9:51 AM | FDA approves BMS/Pfizer’s Eliquis in DVT and PE
New blood clot indication puts drug on a level with rival oral anticoagulants
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1:46 AM | Hollywood Science is Getting Better
There was a time when scientists in the movies were consistently made into villains, odd-balls or crazy-haired geeks. Think Frankenstein, Back to the Future, or even Nightmare Before Christmas. I’ve long been fascinated by science fiction and science in Hollywood. If anyone can remember back far enough, I began this very blog with a pitch to Nature Network (now SciLogs.com) to cover science in film. One of my first ever blog posts explored genetic sequencing and genetic profiling […]
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12:20 AM | Biotech Reading List
Cancer: Unpronounceable Drugs, Incomprehensible PricesPeter Bach (Forbes) $PFE Xalkori, $NVS ZykadiaIncomprehensible Drug Prices? Think AgainDerek Lowe (In the Pipeline)9 Free Tools Regulatory Professionals Can use to Monitor the Regulatory LandscapeAlec Gaffney (RAPS Regulatory Focus)Spotting Cancer in a Vial of BloodAntonio Regalado (MIT Technology Review)While Protesters Rage Against Tech Giants, Biotech Drives Quietly ByAlex Lash (Xconomy)Flatley's Law: How One Company Is Creating Medic […]

August 21, 2014

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11:16 PM | Ex GSK exec to lead Sanford-Burnham
Perry Nisen appointed CEO at research institute
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11:16 PM | Omega buys pharmacy to understand customers
Will turn Warman-Freed in North London into ‘learning pharmacy’
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10:42 PM | Natural News gets it all wrong about mandatory vaccinations–Part 2
This article was written by Dorit Rubinstein Reiss, Professor of Law at the University of California Hastings College of the Law in San Francisco, CA. Dr. Reiss writes extensively in law journals about the social and legal policies of vaccination. She is also member of the Parent Advisory Board of Voices for Vaccines, a parent-led organization that supports and advocates for on-time vaccination […]Continue reading «Natural News gets it all […]
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10:42 PM | Natural News gets it all wrong about mandatory vaccinations–Part 1
For the typical American skeptic, there is nothing surprising by a headline that says that Natural News get it’s it all wrong. Most skeptics might wonder when they’ve ever gotten it right. Just to be thorough, Natural News is a website that’s focused on anti-science delusions and pushing junk medicine, while marketing a whole boatload […]Continue reading «Natural News gets it all wrong about mandatory vaccinations–Part 1»
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5:30 PM | FFPE: the bane of next-generation sequencing? Maybe not for long...
FFPE makes DNA extraction difficult; DNA yields are generally low, quality can be affected by fixation artefacts and the number of amplifiable copies of DNA are reduced by strand-breaks and other DNA damage. Add on top of this almost no standardisation in the protocols used for fixation and widley different ages of samples and it's not suprising FFPE causes a headache for people that want to sequence genomes and exomes. In this post I'm going to look at alternative fixatives to formalin, QC […]
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1:27 PM | What’s the Answer? (new Ensembl stuff)
Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]
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10:06 AM | FDA gives green light to Genzyme’s oral Gaucher drug
Oral therapy Cerdelga is set to complement intravenous Cerezyme
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9:50 AM | Illumina partners with pharma majors on cancer diagnostic
Will work with AstraZeneca, Janssen and Sanofi to develop gene sequencing tool
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7:12 AM | CRISPR gene therapy cures liver disease
The CRISPR-Cas9 system can be used to edit out gene mutations and correct diseases. It has been used to tailor make a number of different experimental animals that express exactly the DNA sequence scientists want. This is done by injecting the cells of developing embryos with the Cas9 enzyme that cuts DNA, along with an […]

August 20, 2014

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11:16 PM | BMS and Celgene to research cancer immunotherapy combo
Companies will study combination of nivolumab and Abraxane
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11:16 PM | MHRA launches online oral anticoagulation module
Aims to help healthcare professionals understand new blood clot treatments
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11:16 PM | Have we all gone tablet daft?
We need to think of new devices simply as an aid to selling
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11:15 PM | Allergan appoints financial head
Jim Hindman named chief financial officer
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11:07 PM | Sue Ryder appoints head of PR, celebrity and communications
Susan Fiddian joins charity focused on hospice and end-of-life care needs
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7:08 PM | No Belle and No Nobel Prize
This is a fun musical rendition of one man’s quest for a girlfriend and a Nobel prize. To be appreciated by male graduate students everywhere! Tweet This Post
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2:27 PM | Chikungunya Virus and the Promise of a Virus-Like Particle Vaccine
My family and I just returned from a week-long camping trip along the North Shore of Lake Superior in Minnesota. It is beautiful country, filled with lakes, rivers, ponds—and mosquitoes, lots and lots of mosquitoes. We went prepared for the worse. We had a screen tent, head nets and tubes and tubes of insect repellent […]
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1:49 PM | Plastica commestibile? Con Ooho da oggi si può
Il suo nome sarebbe Ooho e si tratterebbe di un nuovo materiale inventato dal trio di scienziati Rodrigo Garcia Gonzalez, Pierre Paslier e Guillaume Couche, vincitori del prestigioso premio “Lexus Design Award 2014″, caratterizzato da membrane commestibili costituite da cloruro…Read more →
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1:38 PM | Video Tip of the Week: Immune Epitope DB (IEDB)
This week’s tip was inspired by the recent NHGRI workshop of the future directions for funding and resourcing of genomics-related projects. Titled “Future Opportunities for Genome Sequencing and Beyond: A Planning Workshop for the National Human Genome Research Institute” brought together a lot of influential folks on this topic, and had them noodle on the […]

Vita R., J. A. Greenbaum, H. Emami, I. Hoof, N. Salimi, R. Damle, A. Sette & B. Peters (2010). The Immune Epitope Database 2.0, Nucleic Acids Research, 38 (Database) D854-D862. DOI: http://dx.doi.org/10.1093/nar/gkp1004

Kim Y., Z. Zhu, D. Tamang, P. Wang, J. Greenbaum, C. Lundegaard, A. Sette, O. Lund, P. E. Bourne & M. Nielsen & (2012). Immune epitope database analysis resource, Nucleic Acids Research, 40 (W1) W525-W530. DOI: http://dx.doi.org/10.1093/nar/gks438

Lundegaard C. & M. Nielsen (2008). Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers, Bioinformatics, 24 (11) 1397-1398. DOI: http://dx.doi.org/10.1093/bioinformatics/btn128

Bhattacharya S., Linda Gomes, Patrick Dunn, Henry Schaefer, Joan Pontius, Patty Berger, Vince Desborough, Tom Smith, John Campbell & Elizabeth Thomson & (2014). ImmPort: disseminating data to the public for the future of immunology, Immunologic Research, 58 (2-3) 234-239. DOI: http://dx.doi.org/10.1007/s12026-014-8516-1

Citation
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10:13 AM | Novartis licenses tuberculosis R&D to TB Alliance
Includes drugs to tackle resistant forms of the disease
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