Posts

October 02, 2014

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11:30 PM | INC Research appoints Claire Grace
She joins from PPD as VP site and patient access
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11:30 PM | Young diabetes patients in England and Wales receive fewer vital checks
Less than a third with type 1 diabetes receive eight of nine recommended care processes
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11:15 PM | Astellas names president of US technologies business
Promotion for Brian McLellan
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7:58 PM | Dog’s Epigenome Gives Clues to Human Cancer
The bond between humans and dogs is strong and ancient. From being the protector of the first herds in a faithful pet, dogs and people share many aspects of life. The relationship between the two species has been studied by psychologists, anthropologists, ethnologists and also by genetic and molecular biologists. In this sense, dogs are […]
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7:34 PM | As Ebola Arrived, the Texas Public Health Lab was Ready
Editor's Note: This is a guest blog post by Michelle M. Forman. Michelle is the senior media specialist for the Association of Public Health Laboratories (APHL), a nonprofit membership organization representing the laboratories that protect the health and safety of the public. Often referred to as the “unsung heroes of public health,” the public health laboratories protect the public against diseases and other health hazards, ranging from testing of water, food, dairy and […]
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5:26 PM | Whole exomes from single cells: Fludigm C1 update
This was not a planned post but it follows on nicely from today's other one about exomes. This time I'm writing about Fluidigm's new single-cell exome-seq protocol. Yup that's right, whole exomes from 96 single cells! The C1 is an amazing piece of kit (wish I had one) and we've used it a little bit for mRNA-seq. The ability to sequence single-cell genomes and exomes means you can pretty much do whatever you want with a single-cell now. So how do the exomes look?C1 on YouTube: Fluidigm have a […]
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4:06 PM | No Ice Buckets or Pink Ribbons for Very Rare Genetic Diseases
As enthusiasm for dumping ice on one another fades with autumn and October brings pervasive pink, I wish that attention would turn to families confronting diseases not as well known as ALS and breast cancer. HOW RARE IS RARE? According … Continue reading »The post No Ice Buckets or Pink Ribbons for Very Rare Genetic Diseases appeared first on DNA Science Blog.
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1:32 PM | What’s the Answer? (Reddit bioinformatics AMA)
Usually, we do a highlighted item from Biostar in our “What’s the Answer?” threads to focus on some issues in bioinformatics. But there was an interesting question & answer thread on Reddit Bioinformatics recently that I thought some folks might like to see. For those of you not hip to the reddit lexicon, AMA means […]
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11:47 AM | More on exomes
I've been finding out more about exomes: specifically QC analysis using HS Metrics in Picard. There's loads of useful metrics and I'm hoping to get to a point that I can explain these to users here and also look at the results to try and troubleshoot an experiment. I'm also trying to understand what sort of read length we should be using for exome analysis. An earlier post discussed my thoughts around moving to PE125 or switching to SE125 and running more lanes. In a follow up post (watch this […]
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11:15 AM | Pfizer targets women in Viagra campaign
Hope a female voice will encourage men to seek treatment for erectile dysfunction
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10:50 AM | NICE recommends Lundbeck’s alcohol dependency drug
NHS patients to have access to Selincro to help control drinking
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10:49 AM | Novartis' Bexsero triumphs at UK Prix Galien
The Awards also saw Janssen's Sirturo pick up the Orphan Drug prize
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9:53 AM | Biosimilars could make EU big cost savings after slow start
Report says biological copies could cut health spending in region by $11bn
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8:55 AM | Patent changes 'could boost UK as research location'
Removes the risk of patient infringement claims during clinical trials
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7:52 AM | Make your own invisibility cloak
Joseph Choi and John Howell from the University of Rochester have published a paper showing how to create an invisibility cloak using four standard optical lenses which can be purchased for a hundred dollars. The invisibility cloak is a staple in science fiction and fantasy. Scientists have taken stabs at making this fiction become reality, […]
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1:53 AM | Goodbye
I started this blog for no reason other than thinking the title would be hilarious. A couple of years (and not all that many posts) later, I managed to do so much with it. I love it, but it's time to let it go. I'm now a full time science writer, and this blog, well, would basically be work.I'm not taking anything down, so feel free to wander around, read at your leisure, anything you like. I'm still around on email, Google+, Facebook, and so forth.So--thanks for listening for the past few […]

October 01, 2014

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11:31 PM | Chemia appoints network manager
Ellie Duncanson-Hunter joins from PMGroup where she was events director
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11:30 PM | M3 Europe appoints new business director
Paul Townley-Jones joins the group of online physician networks
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11:15 PM | Valeant adds Jeffrey Ubben to board
CEO of ValueAct supports takeover of Allergan
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11:01 PM | Investing in the future of R&D
Roch Doliveux on UCB’s research plans and paying for innovation
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8:57 PM | Using acupuncture to treat knee pain–no evidence
Let’s start right from the beginning–there is no evidence that acupuncture has any significant clinical benefit for any condition. And because there is a small, but significant, risk associated with the acupuncture, the risk to benefit ratio is huge (if not infinity, since there is no benefit). There is simply no reason to accept, even a […]Continue reading «Using acupuncture to treat knee pain–no evidence»
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5:21 PM | Transforming World Health With Cuban Medicine
Tweet This Post
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4:18 PM | I’ve Never Been On a Top Twitter Science List
I've never been on a 'top scientists to follow on Twitter' list. (I might now be on a #WomenTweetScienceToo list on Twitter somewhere, but not any published articles featuring a 'list' of science people to follow on Twitter, that I know of). When I was a 'younger Tweeter', I would quickly look over new lists I saw popping up in published articles and science blogs, just to see if, in some crazy alternate reality, I might be included. But of course I... Read more
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3:46 PM | 3D Chromatin Organization, Transcription, and Behavior
The chromosomes of differentiated cells contain heterochromatic and euchromatic compartments. Heterochromatin is highly condensed and associated with repressed transcription, whereas in euchromatin  transcription is generally active. Spatial organization of heterochromatin can vary vastly among different differentiated cell types1. In contrast to differentiated cells, embryonic stem cells contain only sparse heterochromatic ... The post 3D Chromatin Organization, Transcription, and […]
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2:49 PM | Opportunities for High School Students to Learn at the BTC Institute
Paul Simon famously sang about what it was like to engage as a learner in a high school environment—though his lack of education certainly hasn’t hurt him any, I do wonder about reading the “writing on the wall”. Frequently, in Education, we talk about the challenges of preparing students for careers that have yet to […]
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1:58 PM | Nimbus looks to Merck for CEO
Donald Nicholson spent 26 years at US pharma giant
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1:46 PM | Video Tip of the Week: MEGA, Molecular Evolutionary Genetics Analysis
This week’s tip of the week highlights the MEGA tools–MEGA is a collection of tools that perform Molecular Evolutionary Genetics Analysis. MEGA tools are not new–they’ve been developed and supported over many years. In fact, on their landing page you can see the first reference to MEGA was in 1994. How much computing were you […]

Tamura K., G. Peterson, N. Peterson, G. Stecher, M. Nei & S. Kumar (2011). MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods, Molecular Biology and Evolution, 28 (10) 2731-2739. DOI: http://dx.doi.org/10.1093/molbev/msr121

Tamura K., G. Stecher, D. Peterson, A. Filipski & S. Kumar (2013). MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0, Molecular Biology and Evolution, 30 (12) 2725-2729. DOI: http://dx.doi.org/10.1093/molbev/mst197

Citation
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12:55 PM | Adaptive Trials Offer Potent Weapon Against Phase 3 Failures
A failed phase 3 drug trial is one of the worst possible outcomes for a pharmaceutical company and for patients, both in terms of financial resources spent as well as time sunk into an unproductive research path. A recent article published by Roche describes how that company had to deal with several recent Phase 3 ... continue reading
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12:10 PM | Of seismic waves and closing days: take home messages
. With contributions from James Smith, a recent Oxford University graduate and current SENS Research Foundation Summer Scholar working at the Harvard Stem Cell Institute. There were two momentous events on the night of August 23, 2014. First, the inaugural Rejuvenation Biotechnology conference drew to a close. Second, the largest earthquake in nearly 25 years...Read more
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11:46 AM | Janssen backs NHS diabetes challenge
Will provide £200,000 to spread innovation across UK
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