Posts

March 16, 2015

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10:05 AM | Merck faces another Bridion knockback
It is seven years since the FDA initially rejected it
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7:50 AM | knittinggothgirl:huffingtonpost:This Is What Happens When You...
knittinggothgirl:huffingtonpost:This Is What Happens When You Mix Coca-Cola And MilkIn this fascinating YouTube video, watch what happens when milk is added to a bottle of Coke. After an hour, the liquid in the bottle appears to become clear, as brown sediment sinks to the bottom.Find out the scientific explanation behind this chemical reaction here. \/ OR READ BELOW!! \/ :0To my followers and future rebloggers, I know how much I hate to move my thumb while scrolling so the reaction […]
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7:15 AM | Marcy Rockwell’s Writing Advice
During SDSU’s 2015 Writers’ Conference, I was lucky enough to attend some of the workshops run by the lovely Marcy Rockwell and Gini Koch. Marcy has an uncanny way of summing up important advice in neat little phrases. Here are some highlights: 1. Your first idea probably isn’t your best, set it aside then come […]
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12:21 AM | Nelsons appoints new leadership team to US office
Pat Schneider, John Ende and Brad Baker join the firm
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12:20 AM | Stelara gets NICE thumbs up for psoriatic arthritis
Recommended alone and in combination with methotrexate
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12:19 AM | NICE system ‘slowing market access to cancer meds’
Two new reports show that UK access to new treatments and survival rates among lowest in Europe

March 15, 2015

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6:20 PM | Probability of finding fitter promiscuous mutants (Evolvability) as a function of purifying selection
Recently, in an opinion article, Dr. Shelley Copley, had an interesting view on evolvability.. ".. promiscuity may exist simply because it is impossible to exclude all potential substrates .." Copley SD An evolutionary biochemist’s perspective on promiscuity Trends in Biochemical Sciences.Feb … Continue reading →
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4:30 PM | futurescope: Telescopic contact lenses and wink-control...
futurescope: Telescopic contact lenses and wink-control glasses …The first iteration of the telescopic contact lens—which magnifies 2.8 times—was announced in 2013. Since then the scientists behind the DARPA-funded project have been fine-tuning the lens membranes and developing accessories to make the eyewear smarter and more comfortable for longer periods of time, and thus more usable in every day life. [read more] [Photo Credit: Eric Tremblay and Joe Ford. Courtesy of […]
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4:00 AM | CRISPR Meets iPS: Technologies Converge to Tackle Sickle Cell Disease
Researchers from Johns Hopkins University have teamed two powerful technologies to correct sickle cell disease in a lab dish. Linzhao Cheng and colleagues have deployed CRISPR/Cas-9 on iPS cells to replace the mutant beta globin gene, published in Stem Cells. ACRONYMS AND ABBREVIATIONS CRISPR conjures up images of fried chicken, but it stands for “clustered regularly interspaced short palindromic repeats” – short repeated DNA sequences interspersed with areas called spacers, […]
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1:24 AM | thebermudalocket:a-heart-of-calcifer Doing it right. (Though...
thebermudalocket:a-heart-of-calcifer Doing it right. (Though maybe figure that out before the wedding.)

March 14, 2015

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11:08 PM | The Redskins suck and so do GMOs
Empty seats at FedEx Field by Ron Cogswell via Flickr I grew up in the Washington, D.C. area watching Redskins football with my family. I haven’t seen a Redskins game since I moved away from the area in the early 2000’s, and now I couldn’t name more than 1 player currently on the team. But I have a strong opinion about them: I think they suck. They are terrible and their incompetent owner has destroyed the team. Why do I have a strong opinion on […]
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9:09 PM | Website housekeeping note–Google Feedburner
The Skeptical Raptor, stalking pseudoscience in the internet jungle. Some of you use Google’s Feedburner system to get notified of posts here and other blogs. Unfortunately, Google has deprecated Feedburner and no long supports it (and hasn’t since 2012). I’ve begun to notice a lot of errors crop up (not just here but from other blogs) from Feedburner emails. As a result, I’ve removed … Continue reading Website housekeeping note–Google Feedburner […]
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8:49 PM | A Crowd-sourced BiotechDueDiligence Journal Watch
What happens when you combine two of the most popular features here at BiotechDueDiligence - Tweets of the Week and Journal Watch? You get a Twitter-sourced collection of intriguing and noteworthy articles from scientific and medical journals. I've been meaning to try this for awhile, so let me know what you think! Our survey of P hacking (eg overanalysis to get p<0.05) led by Megan Head is out http://t.co/z5WSNHBkBz @LukeHolman_Evo @RobLanfear— Michael Jennions […]
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5:07 PM | Pi to ten thousand digits:
Pi to ten thousand digits:: kidsneedscience:3.1415926535 8979323846 2643383279 5028841971 6939937510 5820974944 5923078164 0628620899 8628034825 3421170679 8214808651 3282306647 0938446095 5058223172 5359408128 4811174502 8410270193 8521105559 6446229489 5493038196 4428810975 6659334461 2847564823 3786783165 2712019091 4564856692… In case you need to slice a pie […]
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4:49 PM | A Brief History of π (day)
exploratorium:Pi has been known for almost 4000 years—but even if we calculated the number of seconds in those 4000 years and calculated pi to that number of places, we would still only be approximating its actual value. Here’s a brief history of finding pi:The ancient Babylonians calculated the area of a circle by taking 3 times the square of its radius, which gave a value of pi = 3. One Babylonian tablet (ca. 1900–1680 BC) indicates a value of 3.125 for pi, which is a closer […]
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4:30 PM | futurescope: Future of Sports: Segway Polo is a thing The...
futurescope: Future of Sports: Segway Polo is a thing The Segway Polo world championship is the Woz Challenge Cup. Nuff said. [via wired] [wikipedia: segway polo] This is ridiculous, but also might be the best use of a Segway that I’ve ever seen.
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4:00 PM | Evidence that you’re anti-vaccine–Bob Sears’ personal attacks on Paul Offit
The Skeptical Raptor, stalking pseudoscience in the internet jungle. This article is by Dorit Rubinstein Reiss, Professor of Law at the University of California Hastings College of the Law (San Francisco, CA). She is a frequent contributor to this and many other blogs, providing in-depth, and intellectually-stimulating, articles about vaccines (generally, but sometimes moving to other areas of medicine), social policy and the law. Her articles unwind the … Continue […]
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1:00 PM | Fancy working in my lab?
I've currently got three positions open in my lab and thought I'd use this blog as another way to get the message out to prospective candidates. Two people recently moved onto new jobs; one in Inivata (the first spin-out from CRUK-CI) and one at AbCam, and another person was recently promoted. We're also busy so we're also recruiting for a six-month temporary contract to help out with the sequencing services.If you want to see what the lab does please take a look at our lab website and […]

March 13, 2015

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8:14 PM | Biotech Tweets of the Week (March 9-13, 2015)
This week's edition of the Biotech Tweets of the Week is captained by ACAD - simply the large peak to trough move in sentiment in a one day period that I can ever recall. Enjoy the compilation about this and many other story lines, c/o @23aloha.Top tickers: $ACAD $ACRX $CTIC $ZGNX $BLUE $SLXP $AMRN $TTPH $CUR $XBI $IBB [...]
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7:37 PM | sixth-impact:did-you-kno: So… go somewhere with fewer people?...
sixth-impact:did-you-kno: So… go somewhere with fewer people? Got it. {plans haven’t changed}Simulation of the spread pattern:Source Haaaahahaaahah ha aha hhhhhhaaaaaaaa uh oh I love science.
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4:30 PM | micdotcom:NASA: The U.S. is headed for a disaster not seen in...
micdotcom:NASA: The U.S. is headed for a disaster not seen in 1,000 years A new study, compiled by scientists from the space agency, Cornell University and Columbia University, predicts an 80% chance that the Great Plains and the American Southwest will endure a major weather shift beginning in 2050. "We really need to start thinking in longer-term horizons about how we’re going to manage it." But we’ll see some strong sustainability policies put into place to help […]
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3:00 PM | Organic, specialty growers reap pay day
Not all crops are created equal when it comes to the science love they receive. A lot of fruit and vegetables are lagging far behind in terms of basic genetic resources compared to their major grain counterparts (think corn, soybean, wheat, rice). However, the USDA is making $66.5 million available to the specialty crop and … Continue reading Organic, specialty growers reap pay day The post Organic, specialty growers reap pay day appeared first on Plant DNA Science.
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2:12 PM | Get Ready to Celebrate Pi!
What will you be doing on 3/14/15 at precisely 9:26:53? Twice the clocks will align with the first few digits of my favorite irrational and transcendental number (3.141592653…) or π. Over 1 trillion digits to the right of the decimal point have been calculated, and they still go on, never making a pattern, never repeating. […]
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1:15 PM | Right Turn: Super Cells in Newcastle
> Super Cells has grown wings and flown over to Newcastle. Yes, I know, you’re struck dumb at the improbability of this terrible metaphor, but far less than I am: having reviewed every word, every animation, every image, every concept of this exhibit, I’m completely baffled at how the feather follicle stem cells snuck in there...Read more
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1:03 PM | Friday SNPpets
This week’s SNPpets include new nomenclature guidelines from the American College of Medical Genetics and Genomics (ACMG) on what to call a variant in medical situations; a HapMap for wheat; and a spanking for vendor sites that over-promise in personal cancer testing. Oh–and an undergrad genome class that teaches sequencing. Welcome to our Friday feature […]
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12:37 PM | GSK and Novartis asset swap: a tale of two companies
Firms complete multi-billion dollar exchange of oncology, vaccines and consumer health interests
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12:01 PM | A better way to sequence exomes?
I caught up with a new company on the target capture scene, Directed Genomics, at AGBT. Their approach is based on a simple idea: if you want to sequence exomes, why not capture only exons? Most exome-seq methods (Illumina, Agilent, Nimblegen) use oligo-baits to pull-down adapter-ligated fragment libraries, with fragments of 200-300bp. As exons are only 170bp long (80–85% Human exons less than 200bp Zhu et al & Sakharkar et al) we sequence lots of near- or off-target bases. These can […]
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11:39 AM | Axon Communications boosts London team with five hires
Lucie Burns, Denis Bilotta, Samantha Treadwell, Karley Ura, Kate Peregrin all new-comers
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11:37 AM | Industry pays £310m to underwrite medicines bills
Latest fourth quarter rebate revealed as pharma looks to ‘underwrite’ the NHS drugs bill
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11:14 AM | Cancer Drugs Fund a ‘missed opportunity’, says MP
Chair of the Liberal Democrat health committee Paul Burstow says the CDF should have gone further
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