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April 25, 2013

4:08 PM | Human Genome Project at 10: Q&A with Eric Greene

For DNADay, you can listen to an interview that puts the last 10 years in perspective. There are other details and links available from the NHGRI’s page about HGP 10. The Genomics Landscape a Decade After the Human Genome Project

3:48 PM | Ovejas fluorecentes.uy

Ovejas transgénicas abren nueva era de investigación en salud - SubrayadoVerde flúo - La DiariaCientíficos uruguayos produjeron nueve ovejas transgénicas - Prensa LatinaNacen las primeras nueve ovejas transgénicas uruguayas - El Espectador

3:35 PM | Why Do We Have Brains?

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1:53 PM | Choosy moms choose…

On Twitter the other day, I was told that “moms choose organic” for their kids. I’m a mom (almost) and I don’t choose organic. Personally, I dislike the implication that I am doing wrong by not buying organic and I think it causes harm to spread such an idea because it might discourage people from eating healthy foods that don’t have that label (or encourage people to eat junk food just because it’s labeled organic). Also, organic is a small percentage […]

1:07 PM | ADN

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12:35 PM | What’s the Answer? (enzyme dictionary)

BioStar is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at BioStar that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here [...]

12:32 PM | DNA Day and World Malaria Day: The Sickle Cell/Malaria Link Revisited

9:12 AM | Inflammatory Bowel Disease (IBD): Key Advances in Medicine

Advances made in medicinal sciences are conventionally accepted as inevitably constant – as ongoing processes – in modern society, if you are not playing a part in forwarding human endeavour you might as well go back to digging up dirt with your ancestors. 2012 was no different a year insofar as such advances being made in [...]The post Inflammatory Bowel Disease (IBD): Key Advances in Medicine appeared first on Oxbridge Biotech.

4:00 AM | The Sickle Cell/Malaria Link Revisited

Today is both DNA Day and World Malaria Day. As I was pondering how to connect the topics, e-mail arrived from my “son,” a medical student in Liberia. He had malaria, again, and this time it had gone to his brain. I “met” Emmanuel in 2007, when he e-mailed me after finding my contact info at the end of my human genetics textbook, which he was using in his senior year of high school. He is my personal link between DNA Day and World Malaria Day. But the dual commemoration also reminds me […]

April 24, 2013

10:54 PM | Interview with Ron Stotish at BIO

Recently, we announced that we were going to interview Ron Stotish, the President and CEO of AquaBounty, the company that has made a fast-growing genetically engineered salmon. If approved for sale in the United States, it would be the first genetically engineered animal approved for human consumption. Consequently, there have been a lot of questions about this fish, so we asked our readers to submit questions of their own to have them answered in the interview. The original plan was to do an […]

7:35 PM | Is in vitro meat the future of food production?

The concept of growing meat separately from a living animal was documented as far back as 1932 when Winston Churchill wrote that “fifty years hence, we shall escape the absurdity of growing a whole chicken in order to eat the breast or wing by growing these parts separately under a suitable medium” (1). It’s 30 [...]The post Is in vitro meat the future of food production? appeared first on Oxbridge Biotech.

5:38 PM | Stem cell tourism, safe, effective & routine? Not so much.

Co-authored with Geoff Lomax, CIRM’s Senior Officer to the Standards Working Group from the “Understanding Stem Cell Controversies” Workshop organized by the Stem Cell Network in Montreal. This article is cross-posted on the CIRM blog. Dr. Harry Atkins speaking at Understanding Stem Cell Controversies in Montreal. “Stem cell tourism” “medical tourism” “unproven cell therapies” –...Read more

5:20 PM | ISIS: Quick Notes from Roche Huntington's Disease Webcast

On April 8, 2013, Isis Pharma and Roche announced a new alliance around treating Huntington's Disease with an antisense approach to target huntingtin (HTT). Here are the quick highlights from the webcast (no slide deck):• $30m upfront and typical Isis option deal with total of $362m milestones• Royalties are tiered and double digit but stay below 20%• Initial approach to target wild-type and mutant HTT but could also try to target [...]

1:46 PM | Ancient DNA reveals Europe’s dynamic genetic history

Ancient DNA recovered from a series of skeletons in central Germany up to 7500 years old has been used to reconstruct the first detailed genetic history of modern Europe. The study, published today in Nature Communications, reveals a dramatic series of events including major migrations from both Western Europe and Eurasia, and signs of an [...]

1:32 PM | Video Tip of the Week: Cancer Atlas roadmap

I’ve talked a lot about how much I am interested in seeing new visualization strategies for working with the volumes of data was have today–which are certainly not going to stop flowing in. But a more basic level of this is even just locating and navigating to find the data sets you might want to [...]

Robbins, D., Gruneberg, A., Deus, H., Tanik, M. & Almeida, J. (2013). A self-updating road map of The Cancer Genome Atlas, Bioinformatics, DOI: 10.1093/bioinformatics/btt141

The Cancer Genome Atlas (TCGA) Research Network (2008). Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature, 455 (7216) 1061-1068. DOI: 10.1038/nature07385

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1:10 PM | Deanna Church on the Reference Genome Past, Present and Future - Bio-IT World

Deanna Church on the Reference Genome Past, Present and Future - Bio-IT World

12:52 PM | A Sea Lion in Boogie Wonderland

Back in June of 2010, my colleague and fellow blogger, Isobel, wrote a post on “Snowball the Dancing Cockatoo, YouTube and Scientific Discovery.” It featured a popular YouTube video of Snowball the sulfur-crested cockatoo (Cacatua galerita) dancing to the Backstreet Boys. Besides being adorable, and the kind of video you can’t watch without getting a [...]

12:19 PM | The 5th EMBO meeting

21 Sep 2013 - 24 Sep 2013 Amsterdam, Netherlands Visit: EMBO 2013

8:30 AM | Stratified medicine: enabling the translation of cancer therapies – Oxford, May 1st

On Wednesday the 1st of May at the Wellcome Trust Centre for Human Genetics, OBR and the University of Oxford Medical Sciences Division will hold an event discussing the Stratified Medicine in Oncology among a variety of attendees and panelists. For cancer patients, a “one size-fits all” approach to drug and therapeutic treatments, is unpredictable [...]The post Stratified medicine: enabling the translation of cancer therapies – Oxford, May 1st appeared first on Oxbridge Biotech.

8:00 AM | Nanomedicine and Nanotechnology: Promising Directions for Translation

This article continues an examination of the relatively young field that applies nanotechnology to medicine. Part 1 defined nanomedicine and covered nano-based therapeutics already being translated into the clinic. New directions in Nanomedicine — clinical translation Nanomedicine research focusing on other administration routes could be much closer to clinical translation. For example, nanoparticles designed to cross [...]The post Nanomedicine and Nanotechnology: Promising Directions […]

5:34 AM | Cell Isolation: Two Worlds of Separation

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April 23, 2013

8:08 PM | Background Data in a Blue Light Model of Retinal Degeneration in the Albino Mouse – ARVO 2013

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6:25 PM | Reduction: It Sounds like a Great Idea, but how do we Apply “Reduction” to Toxicology Studies?

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5:37 PM | Stem cells in Drug Discovery

14 May 2013 - 14 May 2013 Tokyo, Japan Meeting taking place at the Swedish embassy in Tokyo. Stem-cells-in-drug-discovery.pdf Stem-cells-in-drug-discovery-Jap.pdf

4:46 PM | The “Simple” Capillary Finds Its Niche

Today we feature guest writer, Kim Smuga-Otto, stem cell biologist and assistant researcher in the Regenerative Biology Laboratory at the Morgridge Institute for Research at the Wisconsin Institutes for Discovery. ***** When I was a child, I was taught that arteries were red, veins were blue, and in between them spread a net of tiny [...]

3:43 PM | Creating the reference genome

In our workshops around the world on the UCSC Genome Browser, we talk at the very beginning about the framework for the organization of the data in the graphical representation. We describe that the reference genome–the official released genome–for a species provides the genome coordinates, or positions, that allows the rest of the data to [...]

Zody, M., Jiang, Z., Fung, H., Antonacci, F., Hillier, L., Cardone, M., Graves, T., Kidd, J., Cheng, Z., Abouelleil, A. & Chen, L. (2008). Evolutionary toggling of the MAPT 17q21.31 inversion region, Nature Genetics, 40 (9) 1076-1083. DOI: 10.1038/ng.193

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2:55 PM | HUGO Part 2 – What is it all for?

Genomics is an indecisive teenager that is scared to move out of the research lab and get a real job. His parents that have been funding him for a long time, and now they want him to start paying his own way in the world. He will, but it’s a big step- and he’s going to need some guidance because, well, he’s different. HUGO 2013 seemed to be wrestling with this topic. Many of the talks were in part dedicated to how the discoveries may be or are being applied, and if this wasn’t […]

1:48 PM | “I got into the clinical trial… I was lucky”. A story about luck, drugs, and cancer treatments.

I had tears in my eyes searching through my emails from three years ago. One of my close friends (and brother of my cartoonist bff) had emailed my sister asking for medical advice. What my friend Junior was after, was … Continue reading →

1:37 PM | How does the U.S. public rate the FDA’s performance?

. The U.S. Food and Drug Administration’s (FDA) ongoing efforts to assert its authority to regulate U.S.-based companies that offer unlicensed stem cell therapies (Regenerative Sciences or Celltex, for example) has prompted a mixed response from the regenerative medicine community. On the one hand, getting an unlicensed treatment has many potential downsides, so the FDA’s...Read more

12:32 PM | Experimental therapy saves child born 'without bones'

Experimental therapy saves child born 'without bones'Artículo original: Whyte MP et al, Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia, N Engl J Med 2012;366:904-13.

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