Posts

July 14, 2014

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11:16 PM | Emotive hires junior planner
Georgie Burrows strengthens strategic planning team
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11:15 PM | Mylan buys Abbott’s non-US generics in $5.3bn
Lower tax rate drives bid to create new firm based in Netherlands
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11:15 PM | Merck Serono names R&D head
Luciano Rossetti replaces Annalisa Jenkins
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10:07 PM | Prices of vaccines–an uncomfortable discussion
Suddenly, there has been a lot of noise about the price of vaccines. Well, there’s always been over-exaggerations and outright misinformation about vaccine prices and profits from the antivaccination gang, and they must be embarrassed by the quality of their arguments. OK, I doubt that. But there is noise out there. But when the criticism comes […]Continue reading «Prices of vaccines–an uncomfortable discussion»
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7:16 PM | The Transformation from Personalized to Precision Medicine
Precision medicine is an advancement of personalized medicine that focuses on the health of individuals. With the aid of molecular biology-based methods, the ideal treatment is found for the individual patient. A recent study in Vienna showed just how useful precision medicine can be. The type of therapy a cancer patient receives, largely depends on […]
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3:20 PM | Purifying HIS-Tagged Proteins from Insect and Mammalian Cells
Many different polypeptide fusion partners or affinity tags have been developed to facilitate purification of target proteins. The most commonly used tag for the purification and detection of recombinant expressed proteins is the His tag. Cloning vectors designed to generate His-tagged proteins contain 5–10 histidine residues at either the C- or N terminus of the expressed […]
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3:00 PM | Ageing and sex
Sexual frustration increases stress, hastens ageing and shortens life span in flies. When male flies sense female fly pheromones, they lose fat stores, are less able to cope with starvation and don’t live as long as unexposed males. Allowing the males to actually mate with females reverses these negative metabolic and ageing effects. Since the […]
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2:22 PM | Sequencing exomes: what sort of read to use?
What's the right way to sequence an exome? We've been looking at Illumina's v4 chemistry for HiSeq 2500 and wondering whether we should jump to PE125bp or not, or should we try to reconfigure our exome capture for shorter or longer fragments.Exome-seq: Exomes have been a big hit, there are currently over 3000 publications in PubMed with the search term "exome". Given that the first in-solution exome paper was only published in 2009 that's pretty amazing, but then again the exome is an amazing […]
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1:13 PM | Old tissue, new purpose: DISCUSSing consent and iPSC derivation
Written with contributions from Geoff Lomax, CIRM’s Senior Officer for Medical and Ethical Standards and Rosario Isasi, Research Associate at McGill University and Academic Secretary for the International Stem Cell Forum Ethics Working Party. Portions of this post were previously published on the CIRM Research Blog and are included here with consent. It’s not unusual...Read more
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10:23 AM | AbbVie coaxes Shire into discussions with sweetened offer
Raises takeover bid to $53bn
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10:12 AM | NICE green light for Biogen’s oral MS drug
Overturns previous negative guidance for Tecfidera
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9:45 AM | US senators seeks answers on Sovaldi pricing
Gilead asked to justify pricing of hepatitis drug

July 13, 2014

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11:01 PM | The seven letter debate that is Sovaldi
Reimbursement of high cost hepatitis C drugs raise difficult issues
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11:01 PM | Eisai’s Bose to join Boehringer
He becomes head of global marketing for oncology
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11:00 PM | Sun Pharma recalls antidepressant in US
Withdraws more than 40,000 bottles of venlafaxine hydrochloride
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8:57 PM | Why we vaccinate–so mom will protect her newborn baby
One of the important hypotheses of vaccination is to make sure that all family members or others who may encounter a newborn child be vaccinated, especially since many vaccinations are not indicated for infants for a couple of months after birth–those newborns are very susceptible to vaccine preventable diseases until they themselves are vaccinated with the DTaP vaccine (which […]Continue reading «Why we vaccinate–so mom will protect her newborn […]

July 11, 2014

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4:00 PM | How Environment Shapes Our Epigenome
Global mapping of the human epigenome has revealed that normal somatic cells exhibit their own unique DNA methylation patterns1. This tissue-specific methylome is established during development and faithfully maintained through subsequent cell divisions, in a process mediated by the enzymes DNMT1 and DNMT3A6. In recent years, there has been a growing interest in the influence […] The post How Environment Shapes Our Epigenome appeared first on EpiBeat.
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3:43 PM | Researchers sequence sheep genome
The sheep industry is no stranger to genomics. Scientists recently weaved together the sheep genome, an accomplishment that should speed the discovery of important production traits. DNA includes four different bases, labelled A’s, C’s, G’s and T’s. “The order determines whether it’s bacteria or a strawberry or a pine tree or a human or a sheep,” Noelle Cockett, provost and executive vice president of Utah State University told the Cache Valley […]
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1:58 PM | How a Magazine Ad Helped Convict a Rapist
In May of 1986, a woman in Orange County, Florida, was surprised by a man who entered her apartment and raped her at knifepoint. Despite the fact that she got a glimpse of his face, the chances of identifying and convicting her rapist were slim. Although law enforcement officers did their best to identify the […]
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1:35 PM | Friday SNPpets
Welcome to our Friday feature link collection: SNPpets. During the week we come across a lot of links and reads that we think are interesting, but don’t make it to a blog post. Here they are for your enjoyment… RT @Haldanessieve: Single haplotype assembly of the human genome from a hydatidiform mole http://t.co/OK3eMD4uNW RT @sciencegoddess: Size […]
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1:32 PM | Right Turn: Return of Cells I See contest
. Stem cells as art is becoming a recurring theme on Signals. If you want to admire some beautiful stem cell art, there’s Klair Reis’ petri projects, Radha Chaddah’s beautiful photography here, and stem cell images are featured every week on Signals near the bottom of the screen. The images in the Photo of the...Read more
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9:12 AM | Sanofi's dengue vaccine could debut in 2015
End in sight after 20-year wait for first effective vaccine
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8:55 AM | EMA transparency policy delayed over 'wording'
Regulation on access to trial data postponed until October
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5:51 AM | Samsung incentivises African mHealth project with music
Will also offer discounted handsets and tablets to consumers and health workers
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4:43 AM | Cipla invests £100m in UK
Indian pharma company to fund both commercial and R&D activities
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12:55 AM | Pharma’s shrinking waterhole
A natural metaphor makes us think about our strategy

July 10, 2014

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11:15 PM | UDG buys Galliard and Nyxeon
Will add UK comms firms to Ashfield Healthcare Communications division
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11:00 PM | Baxter reshuffles financial heads
Names CFOs for biotech spin-off and 'new' Baxter
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11:00 PM | Illumina to provide sequencing for UK gene project
Genomics England wants company to sequence genomes of 100,000 NHS patients
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7:37 PM | Why Should We Trust Scientists?
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