Posts

August 20, 2014

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2:27 PM | Chikungunya Virus and the Promise of a Virus-Like Particle Vaccine
My family and I just returned from a week-long camping trip along the North Shore of Lake Superior in Minnesota. It is beautiful country, filled with lakes, rivers, ponds—and mosquitoes, lots and lots of mosquitoes. We went prepared for the worse. We had a screen tent, head nets and tubes and tubes of insect repellent […]
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1:49 PM | Plastica commestibile? Con Ooho da oggi si può
Il suo nome sarebbe Ooho e si tratterebbe di un nuovo materiale inventato dal trio di scienziati Rodrigo Garcia Gonzalez, Pierre Paslier e Guillaume Couche, vincitori del prestigioso premio “Lexus Design Award 2014″, caratterizzato da membrane commestibili costituite da cloruro…Read more →
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1:38 PM | Video Tip of the Week: Immune Epitope DB (IEDB)
This week’s tip was inspired by the recent NHGRI workshop of the future directions for funding and resourcing of genomics-related projects. Titled “Future Opportunities for Genome Sequencing and Beyond: A Planning Workshop for the National Human Genome Research Institute” brought together a lot of influential folks on this topic, and had them noodle on the […]

Vita R., J. A. Greenbaum, H. Emami, I. Hoof, N. Salimi, R. Damle, A. Sette & B. Peters (2010). The Immune Epitope Database 2.0, Nucleic Acids Research, 38 (Database) D854-D862. DOI: http://dx.doi.org/10.1093/nar/gkp1004

Kim Y., Z. Zhu, D. Tamang, P. Wang, J. Greenbaum, C. Lundegaard, A. Sette, O. Lund, P. E. Bourne & M. Nielsen & (2012). Immune epitope database analysis resource, Nucleic Acids Research, 40 (W1) W525-W530. DOI: http://dx.doi.org/10.1093/nar/gks438

Lundegaard C. & M. Nielsen (2008). Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers, Bioinformatics, 24 (11) 1397-1398. DOI: http://dx.doi.org/10.1093/bioinformatics/btn128

Bhattacharya S., Linda Gomes, Patrick Dunn, Henry Schaefer, Joan Pontius, Patty Berger, Vince Desborough, Tom Smith, John Campbell & Elizabeth Thomson & (2014). ImmPort: disseminating data to the public for the future of immunology, Immunologic Research, 58 (2-3) 234-239. DOI: http://dx.doi.org/10.1007/s12026-014-8516-1

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10:13 AM | Novartis licenses tuberculosis R&D to TB Alliance
Includes drugs to tackle resistant forms of the disease
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9:28 AM | UDG sells stake in UniDrug
Alliance Boots will take over full control of supply chain specialist
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8:58 AM | Brilinta bill of health boosts AstraZeneca
US drops investigation into study data

August 19, 2014

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11:16 PM | Catalent appoints two board members
Jack Stahl and Rolf Classon to advise drug development, delivery and supply company
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11:15 PM | NICE backs Celgene’s Revlimid in bone marrow disorder
Recommends that drug can be used on NHS to treat myelodysplastic syndromes
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11:15 PM | History rhymes: modern globalisation trends mirror the past
Recent events are an echo of the late 19th century
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8:45 PM | A Call for Transparency and Objectivity in European Science Policy Making
Let’s talk politics. Politics and science. The European Commission (EC), according to its own description, “represents the interests of the EU as a whole. It proposes new legislation to the European Parliament and the Council of the European Union, and it ensures that EU law is correctly applied by member countries”. Part of its mandate […]
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2:13 PM | Inside a cancer stem cell researcher’s toolbox: Xenotransplantation
> In previous posts, I have alluded to the fact that studying cancer in a dish (in vitro) is not optimal (here and here). Today, I give you the next essential tool in a cancer stem cell (CSC) researcher’s toolbox: xenotransplantation. Xenotransplantation is an impressive mouthful that simply means the transplantation of living cells, tissues,...Read more
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12:00 PM | Salt, Cardiovascular Disease, and Death: Controversial Correlations
Just last Thursday, three papers were published in The New England Journal of Medicine that came to very different conclusions about how much table salt (sodium chloride) we should have in our diets if we want to avoid cardiovascular disease and a related death. While two of the studies suggested that most people could safely … Continue reading »
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10:43 AM | ‘Tentative’ US approval for Lilly/Boehringer’s Lantus copy
Full FDA recommendation for insulin is dependent on lawsuit filed by Sanofi
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10:01 AM | How can pharma meet the need for new diabetes drugs in cash-strapped healthcare markets?
Join the Tweet chat on September 25 using hashtag #M3insight
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9:41 AM | Chugai soars on Roche buyout rumours
Reports circulating that Swiss company is poised to make $10bn offer
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9:20 AM | Eisai ‘outraged’ by IQWIG’s failure to back epilepsy drug
German cost-effectiveness body once again says Fycompa should not be reimbursed

August 18, 2014

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11:16 PM | Basilea appoints commercial head
David Veitch spent 15 years at BMS
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11:15 PM | AstraZeneca launches diabetes portal in Germany
Zuckerkrank.de is designed to educate patients and families
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11:15 PM | Life appoints principal writer
Catriona Hampton joins from Pan
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9:14 PM | $1000 genomes = 1000x coverage for just £20,000
It strikes me that if you can now sequence a genome for $1000, then you could buy 1000x coverage for not much more than a 30x genome cost a couple of years ago! Using a PCR-free approach I can imagine that this would be the most sensitive tool to determine tumour, or population, heterogeneity. I’m sure that sampling statistics might limit the ability to detect low-prevalence alleles but I’m amazed by the possibility none-the-less. 1 X-Ten run costs $1,000 1000x requires 33 X-Ten […]
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9:07 PM | OK, why aren’t kids getting vaccinated with Gardasil?
This is my 48th article about Gardasil, following by just a few hours, my 47th. After my 50th, I get a watch made from the gold hidden in the subterranean vaults of the Big Pharma overlords who generates bundles of cash from vaccines. Oh, I keep forgetting–that’s not true. Despite the overwhelming evidence that the HPV […]Continue reading «OK, why aren't kids getting vaccinated with Gardasil?»
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7:32 PM | Because Timing Is Everything….
Timing is everything! I learned that the hard way just two weeks ago when I took my son to scout camp and thought I would try to capture the traditional American flag ceremony for posterity. I set up my camera for a panoramic shot and scanned the crowd.  Feeling very pleased with myself, I got […]
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7:01 PM | Single-Cell Western Blot
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6:27 PM | Gardasil’s safety and effectiveness-Part 47. Long-Term Study
This is my 47th article on the HPV quadrivalent vaccine, also known as Gardasil (or Silgard in Europe), which can prevent infection by human papillomavirus, substantially reducing the risk of several types of cancers.* Forty-seven** articles about Gardasil and the HPV vaccine! You’d think I would be tiring of it by now, but I think that Gardasil (or Silgard) are critically important […]Continue reading «Gardasil's safety and […]
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4:34 PM | Arte e ambiente: Change As Art
Rhinewater Purification Plant (Germania, 1972) Cheryl Gladu è un’artista e designer canadese con il pallino per l’ambiente e per i progetti che favoriscano il cambiamento del tessuto sociale locale. Con il sostegno della Concordia University di Montreal (Canada), dove è…Read more →
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4:24 PM | Risparmio energetico in casa: alcune soluzioni
2 motivi e 7 modi per risparmiare energia in casa. Perché farlo? Banalmente si potrebbe iniziare a risparmiare sull’energia anche solo per un discorso prettamente egoistico e di salvaguardia del nostro portafogli, partendo da una domanda: perché spendere 100 euro…Read more →
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4:16 PM | Scienza: scoperto M82 X-1, nuovo buco nero di taglia media
I buchi neri di ‘taglia media’ esistono eccome e sono stati svelati da lampi di luce a ritmo di bossa nova: ad accertarlo e’ stato un gruppo di astronomi dell’universita’ del Maryland. Per primo ha identificato uno di questi rari…Read more →
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4:08 PM | Pile in grafene per ricaricare gli smartphone. Merito dei ricercatori dell’IIT
L’invenzione dell’Istituto italiano di tecnologia sarà sfruttata nel settore delle auto elettriche e dei device tecnologiciRead more →
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1:58 PM | Beni culturali: boom di visite a ferragosto
E’ stato un vero successo l’afflusso di visitatori nei musei italiani nella giornata di Ferragosto. E’ stato così possibile, per migliaia di turisti e non solo, fare visita ai musei di Stato, ai castelli ed ai siti archeologici che da…Read more →
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1:15 PM | Update from the Clinic: July
. Welcome to your Update from the Clinic for the month of July. The cancer stem cell companies were back in the news last month. OncoMed initiated its ALPINE clinical trial of Tarextumab for pancreatic cancer, while Stemline Therapeutics announced an investigational new drug (IND) for SL-401 and initiation of clinical trials in two blood...Read more
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