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Posts

April 17, 2014

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8:31 AM | Mitochondrial dysfunction as a neurobiological subtype of autism
The paper by Suzanne Goh and colleagues [1] reporting on "a possible neurobiological subtype of mitochondrial dysfunction in ASD [autism spectrum disorder]" is a worthy addition to the research roll call which has graced this blog down the years. Based on the analysis of brain lactate levels - a potential marker of mitochondrial dysfunction - via the analysis of lactate doublets on brain magnetic resonance spectroscopic imaging (MRSI), authors picked up a significantly higher rate of […]

Goh, S., Dong, Z., Zhang, Y., DiMauro, S. & Peterson, B. (2014). Mitochondrial Dysfunction as a Neurobiological Subtype of Autism Spectrum Disorder, JAMA Psychiatry, DOI:

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April 16, 2014

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5:54 AM | Joined by HDAC (inhibitors)
I'm treading quite carefully with this post which came about following my [non-expert] reading of the paper abstract from Anand Venkatraman and colleagues [1] on a potential downside to the use of HDAC (histone deacetylase) inhibitors for treating spinocerebellar ataxia type 1 (SCA1), a progressive disease affecting movement and other knock-on functions. This follows other work suggesting that certain HDAC inhibitors might offer some important new lines of investigation when it […]

Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P & Opal P (2014). The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1., Human molecular genetics, PMID:

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April 14, 2014

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7:58 AM | Neurology of inflammatory bowel diseases
The paper by Ben-Or and colleagues [1] talking about a neurologic profile present in a small participant cohort of children and adolescents diagnosed with an inflammatory bowel disease (IBD) caught my eye recently. Their findings reporting that over two-thirds of their paediatric participant group diagnosed with IBD also "exhibited neurologic manifestations" provides some compelling preliminary evidence for further investigation in this area.Outside of reports of headache and dizziness, the […]

Ben-Or O, Zelnik N, Shaoul R, Pacht A & Lerner A (2014). The Neurologic Profile of Children and Adolescents With Inflammatory Bowel Disease., Journal of child neurology, PMID:

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April 11, 2014

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10:25 PM | Dad's obesity and risk of offspring autism
In this post I'm talking about the paper by Pål Surén and colleagues [1] and their suggestion that "paternal obesity is an independent risk factor for ASDs [autism spectrum disorders] in children". I do so not with the intent of stigmatising parents and specifically parents with weight issues, which tend to be present for many more reasons than just food and exercise (see here), but merely to highlight how parental physical health may show some relationship to […]

Suren, P., Gunnes, N., Roth, C., Bresnahan, M., Hornig, M., Hirtz, D., Lie, K., Lipkin, W., Magnus, P., Reichborn-Kjennerud, T. & Schjolberg, S. (2014). Parental Obesity and Risk of Autism Spectrum Disorder, PEDIATRICS, DOI:

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April 10, 2014

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7:56 AM | Gluten exposure and "feelings of depression"?
Could exposure to dietary gluten affect a person's moods or emotional state?Well, if the paper by Simone Peters and colleagues [1] (open-access here) is to be believed the answer may very well be yes, at least in some cases, as they report a link between gluten consumption and feelings of depression under [short-term] experimental conditions. If replicated, such a finding may have profound consequences for how we view our relationship between food and mental health and wellbeing.Bread […]

Peters SL, Biesiekierski JR, Yelland GW, Muir JG & Gibson PR (2014). Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity - an exploratory randomised clinical study., Alimentary pharmacology & therapeutics, PMID:

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April 08, 2014

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7:35 AM | Chronic Fatigue Syndrome and various factors
The paper by Kate Lievesley and colleagues [1] documenting various "predisposing, precipitating and perpetuating factors in Chronic Fatigue Syndrome in children and adolescents" caught my eye recently. Based on a review of the research literature around the topic of Chronic Fatigue Syndrome (CFS) [in childhood], the authors set about detailing some of the important factors linked to the condition and in doing so, highlighted how physiology and psychology might combine when […]

Lievesley, K., Rimes, K. & Chalder, T. (2014). A review of the predisposing, precipitating and perpetuating factors in Chronic Fatigue Syndrome in children and adolescents, Clinical Psychology Review, DOI:

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April 06, 2014

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6:47 AM | Vitamin D deficiency and more and risk of ADHD
"Vitamin D – could it stop 'modern’ diseases?" was one of the headlines I read quite recently as more pressure is being applied on the sunshine vitamin to perform when it comes to our health and welbeing. Indeed, not so long ago I posted an entry updating where we're at when it comes to the 'sunshine' vitamin D and the autism spectrum conditions. The conclusion buried in that post was that whilst there is some interesting work potentially linking vitamin D and autism, there is still […]

Bener A & Kamal M (2013). Predict attention deficit hyperactivity disorder? Evidence -based medicine., Global journal of health science, 6 (2) 47-57. PMID:

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April 03, 2014

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8:20 AM | New life for naltrexone and autism?
During the very earliest days of the life of this blog I posted about the opiate antagonist naltrexone (ReVia®) and some research on its history with autism in mind; in particular, the various emerging speculations on low dose naltrexone (LDN) (see here). Today I'm following up that entry based on the results of a systematic review by Ashok Roy and colleagues [1] on the value (or not) of naltrexone for "attenuating the core symptoms of autism spectrum conditions in […]

Roy A, Roy M, Deb S, Unwin G & Roy A (2014). Are opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: a systematic review., Journal of intellectual disability research : JIDR, PMID:

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April 02, 2014

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8:21 AM | World Autism Awareness Day and the CDC estimates
As designated by the United Nations General Assembly in 2007 (see here), today, Wednesday 2nd April 2014, is World Autism Awareness Day (#WAAD).If you haven't already clicked the link to the UN statement above, I'd encourage you to do so and read over the articles included in the resolution.Secretary-General Ban Ki-moon offers some wise words about the meaning of today in his annual address: "World Autism Awareness Day is about more than generating understanding; it is a call to action. I urge […]

March 31, 2014

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8:32 AM | ALV003 glutenase and more
Today's post is a bit of mash-up but hopefully containing some common threads. If you're also reading the title of this post and wondering what it might have to do with autism research, stay with me...For mash get smash... @ Wikpedia The chopping up duties of ALV003To start, we have the paper by Lähdeaho and colleagues [1] who reported results based on the "ability of ALV003, a mixture of 2 recombinant gluten-specific proteases given orally, to protect patients […]

Lähdeaho ML, Kaukinen K, Laurila K, Vuotikka P, Koivurova OP, Kärjä-Lahdensuu T, Marcantonio A, Adelman DC & Mäki M (2014). The Glutenase ALV003 Attenuates Gluten-Induced Mucosal Injury in Patients with Celiac Disease., Gastroenterology, PMID:

Ludvigsson JF, Neovius M & Hammarström L (2014). Association Between IgA Deficiency & Other Autoimmune Conditions: A Population-Based Matched Cohort Study., Journal of clinical immunology, PMID:

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March 29, 2014

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12:06 AM | Inflaming inflammation and psychiatry
The systematic review published by Mitchell & Goldstein [1] kinda says it all when it comes to our current view of the topic of inflammation and psychiatry, and in particular inflammation and neuropsychiatric conditions such as autism, schizophrenia and attention deficit hyperactivity disorder (ADHD): "There is preliminary evidence for elevated markers of inflammation in this population".All at sea (JMW Turner) @ Wikipedia I've talked quite a bit on this blog about how, […]

Mitchell RH & Goldstein BI (2014). Inflammation in Children and Adolescents With Neuropsychiatric Disorders: A Systematic Review., Journal of the American Academy of Child and Adolescent Psychiatry, 53 (3) 274-296. PMID:

Onore CE, Schwartzer JJ, Careaga M, Berman RF & Ashwood P (2014). Maternal Immune Activation Leads to Activated Inflammatory Macrophages in Offspring., Brain, behavior, and immunity, PMID:

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March 27, 2014

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4:21 PM | The new CDC autism prevalence rate
Whilst quite a lot of media space is currently being devoted to talking about the study by Rich Stoner and colleagues [1] and sweeping generalisations like the BBC headline: Autism 'begins long before birth' with seemingly only little appreciation of the small-scale nature of the study and little details linked to samples being post-mortem tissues, other important autism-related news is also out there.CDC US autism prevalence estimates @ Autism Speaks I'm […]

Autism and Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators (2014). Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2010, Morbidity & Mortality Weekly Report, 63 Other: Link

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March 26, 2014

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10:33 PM | NICE does faecal microbiota transplants
OK, so just for the record I'm not actually saying that NICE (the National Institute for Health and Care Excellence) actually provide faecal microbiota transplants (FMTs) as some sort of in-house service; that's not their job. But as the BBC reported (see here) they have published guidance on the use of FMT specifically with recurrent Clostridium difficile infection in mind (see here for the full guidance). And that guidance is, as was expected, positive on the use of FMTs where and […]
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8:54 AM | Vision impairment and ADHD?
Science often has the ability to surprise.So it was when I first read the paper by Dawn Decarlo and colleagues* (open-access here) which suggested that: "children with vision impairment may be more likely to be diagnosed with ADHD [attention deficit hyperactivity disorder] than children in the general population". I should point out that this observation should not be totally unexpected given some media for other studies by the authors (see here).Lady in a green jacket @ […]

Decarlo DK, Bowman E, Monroe C, Kline R, McGwin G Jr & Owsley C (2014). Prevalence of attention-deficit/hyperactivity disorder among children with vision impairment., Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus, 18 (1) 10-4. PMID:

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March 24, 2014

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9:30 AM | A specific female ASD phenotype is emerging...
The title of this brief post is a quote taken from the abstract of the paper by Frazier and colleagues [1] who, following an analysis of participants included in the Simons Simplex Collection, concluded that autism research and practice might well consider looking at differences in the presentation of autism spectrum disorders (ASDs) between the sexes.The Lady of Shalott @ Wikipedia Including nearly 2500 people with autism including over 2100 males and 304 females, examining […]

Frazier TW, Georgiades S, Bishop SL & Hardan AY (2014). Behavioral and cognitive characteristics of females and males with autism in the simons simplex collection., Journal of the American Academy of Child and Adolescent Psychiatry, 53 (3) 329-340000. PMID:

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March 21, 2014

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10:29 AM | Dioxin exposure and autistic traits?
As promised in a previous post, today I'm turning my attention to the paper by Muneko Nishijo and colleagues [1] and their conclusion of "a specific impact of perinatal TCDD [2,3,7,8-tetrachlorodibenzo-p-dioxin] on autistic traits in childhood, which is different from the neurotoxicity of total dioxins (PCDDs/Fs) [polychlorinated dibenzo-p-dioxins/furans]".TCDD @ Wikipedia With all the recent chatter about [surrogate] environmental markers and the numbers […]

Nishijo M, Pham TT, Nguyen AT, Tran NN, Nakagawa H, Hoang LV, Tran AH, Morikawa Y, Ho MD, Kido T & Nguyen MN (2014). 2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam., Molecular psychiatry, PMID:

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March 20, 2014

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7:39 AM | Environmental exposure and autism continued
In a post not-so-long-ago I talked about the paper by Andrey Rzhetsky and colleagues [1] and their assertion that environment (various facets of environment) might correlate with the increasing numbers of cases of autism being diagnosed. As per what was said on that post, there were lots of media headlines generated about the findings; some balanced and some a little sensational.Luc Viatour / www.Lucnix.be @ Wikipedia One of the main caveats I had with the Rzhetsky study was the […]

Braun JM, Kalkbrenner AE, Just AC, Yolton K, Calafat AM, Sjödin A, Hauser R, Webster GM, Chen A & Lanphear BP & (2014). Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Study., Environmental health perspectives, PMID:

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