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November 19, 2012

2:00 PM | Why Sanofi’s Zaltrap Deal Won’t Help Patients

I got excited when I read the New York Times story Nov. 9 (“Sanofi Halves Price of Cancer Drug Zaltrap After Sloan-Kettering Rejection)”. Zaltrap is an intravenous infusion colon cancer drug for metastatic colorectal cancer that is resistant to or has progressed with platinum-based chemotherapy. With a list price of $11,000 per patient per month, [...]

August 10, 2012

4:09 PM | Global Drug Companies Go for Gold with Aggressive Insulin Analogue Marketing

While nations and athletes compete briefly on a world stage for Olympic gold, three recent articles in the BMJ remind us that pharmaceutical companies compete across the world for real gold. For instance, the worldwide market for insulin is huge and the papers question the ethics of global pharmaceutical companies. Sanofi-Aventis, Novo-Nordisk, and Eli Lilly [...]

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Whence the Earliest Berliners? (Part 1)

This week, I'm hanging out in Chapel Hill at the Isotope Geochemistry Lab on UNC's campus. I'm here to process human dental enamel from Medieval Germans for strontium, to test the hypothesis that the earliest residents of modern Berlin migrated east from Cologne. A bit of background for this project: In the early 13th century AD, two towns were built on opposite sides of the Spree River. Called Berlin (or, sometimes, Altberlin) and Cölln, they eventually became one city in the […]

C.M. Melisch & J.P. Sewell (2011). Historische Chance – eine umfangreiche, mittelalterliche bis neuzeitliche Skelettserie vom ehemaligen St. Petri-Kirchhof in Berlin-Mitte, Mitteilungen der Berliner Gesellschaft für Anthropologie, Ethnologie und Urgeschichte, 32 107-120.

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Compost Program Could Bring Dangerous Fungus into NYC Homes

If Mayor Bloomberg's wildest decay-related fantasies are realized, New Yorkers will soon be sparing their food scraps from the garbage. A new composting program would encourage (or possibly require) people in the city to collect their food waste in a separate container. Yet Bloomberg may want to consider whether a Manhattan apartment has the square footage to fit both its residents and their potentially harmful compost fungi. The New York City recycling plan, as described in the New York […]

De Gannes, V., Eudoxie, G. & Hickey, W. (2013). Insights into fungal communities in composts revealed by 454-pyrosequencing: implications for human health and safety, Frontiers in Microbiology, 4 DOI: 10.3389/fmicb.2013.00164

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Simple fist-squeezing procedure helps athletes avoid choking under pressure

The next time you're faced with a high-pressure situation in sport, try squeezing your left fist tight for thirty seconds. According to a team of German sports psychologists, doing so will activate your right hemisphere, aiding automatic, skilled performance. This helps prevent choking under pressure, they say, which is linked with left-hemisphere activity, excess self-focus and conscious deliberation. Jurgen Beckmann and his colleagues tested their intervention across three studies. In the […]

Beckmann, J., Gröpel, P. & Ehrlenspiel, F. (2012). Preventing Motor Skill Failure Through Hemisphere-Specific Priming: Cases From Choking Under Pressure., Journal of Experimental Psychology: General, DOI: 10.1037/a0029852

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Scientists Model Biofuel Production After Ants’ Fungus Gardens

Researchers at the University of Wisconsin-Madison Department of Bacteriology are studying the colonies of leaf-cutter ants as they cultivate thriving communities of fungi and bacteria using freshly cut plant material. While these fungi provide nutrients for the ants, researchers are hoping to replicate the process and apply it for better biofuel production. Read more »

Aylward, F., Burnum-Johnson, K., Tringe, S., Teiling, C., Tremmel, D., Moeller, J., Scott, J., Barry, K., Piehowski, P., Nicora, C. & Malfatti, S. (2013). Leucoagaricus gongylophorus Produces Diverse Enzymes for the Degradation of Recalcitrant Plant Polymers in Leaf-Cutter Ant Fungus Gardens, Applied and Environmental Microbiology, 79 (12) 3770-3778. DOI: 10.1128/AEM.03833-12

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Video Tip of the Week: ENCODE ChIP-Seq Significance Tool

We’ve been doing training and workshops on the UCSC Genome Browser for 10 years now. It’s a tremendous tool that has to be a foundational item in your toolkit in genomics. But–there may be times when you want to examine some of the data that you can find there in another way, with a different [...]

Auerbach, R., Chen, B. & Butte, A. (2013). Relating Genes to Function: Identifying Enriched Transcription Factors using the ENCODE ChIP-Seq Significance Tool, Bioinformatics, DOI: 10.1093/bioinformatics/btt316

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November 19, 2012

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