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Posts

February 11, 2013

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1:58 PM | I want to break free – the microenvironment and metastasis
No man is an island, and the same can be said of tumour cells. Previous posts in our ‘microenvironment’ series have discussed how the cells and structures around a tumour – known collectively as its microenvironment – are crucial to … Continue reading →

Joyce J.A. & Pollard J.W. (2008). Microenvironmental regulation of metastasis, Nature Reviews Cancer, 9 (4) 239-252. DOI:

Cancer Research UK - Science Update
Medicine | Biology
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February 01, 2013

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1:58 PM | Feeling the heat – the link between inflammation and cancer
Regular readers will know that the infrastructure supporting a tumour – its ‘microenvironment’ – is a hot topic in cancer research at the moment. In our previous post in this series, we looked at how otherwise healthy cells collude to … Continue reading →
Cancer Research UK - Science Update
Medicine | Biology

August 03, 2012

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3:20 PM | The queen in the hive – scientists find more evidence for cancer stem cells
Biology has its share of contentious issues, and the existence of cancer ‘stem cells’ – treatment-resistant cells at the heart of a tumour – is certainly controversial. We’ve written before about these enigmatic cells, but they’ve made the headlines again this … Continue reading →

Driessens, G., Beck, B., Caauwe, A., Simons, B.D. & Blanpain, C. (2012). Defining the mode of tumour growth by clonal analysis, Nature, DOI:

Chen, J., Li, Y., Yu, T.S., McKay, R.M., Burns, D.K., Kernie, S.G. & Parada, L.F. (2012). A restricted cell population propagates glioblastoma growth after chemotherapy, Nature, DOI:

Schepers, A.G., Snippert, H.J., Stange, D.E., van den Born, M., van Es, J.H., van de Wetering, M. & Clevers, H. Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas, Science, DOI:

Cancer Research UK - Science Update
Medicine | Biology
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Editor's Pick

June 07, 2012

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2:30 PM | High-impact science: Hedgehogs, flies and skin cancer – the story of vismodegib
The course of drug development never did run smooth. Drug development pipelines – like the X-Factor – are littered with thousands of ‘hopefuls’ who fail to make the cut. Very few drugs survive the arduous journey from bench to bedside, … Continue reading →

Aleksandar Sekulic, M.D., Ph.D.,, Michael R. Migden, M.D.,, Anthony E. Oro, M.D., Ph.D.,, Luc Dirix, M.D., Ph.D.,, Karl D. Lewis, M.D.,, John D. Hainsworth, M.D.,, James A. Solomon, M.D., Ph.D.,, Simon Yoo, M.D.,, Sarah T. Arron, M.D., Ph.D.,, Philip A. Friedlander, M.D., Ph.D., & Ellen Marmur, M.D., (2012). Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma, New England Journal of Medicine, 366 2171-2179. Other:

Jean Y. Tang, Julian M. Mackay-Wiggan, Michelle Aszterbaum, Robert L. Yauch, Joselyn Lindgren, Kris Chang, Carol Coppola, Anita M. Chanana, Jackleen Marji, David R. Bickers & Ervin H. Epstein (2012). Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome, N Engl J Med, 366 2180-2188. Other:

Cancer Research UK - Science Update
Medicine | Biology
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