A mysterious mummy that sat in a German collection for over a century was once an Incan woman who was murdered with blunt-force trauma to the head, possibly in a ritual sacrifice, new research suggests.
Dozens of skeletons might lie beneath the Uffizi Gallery in Florence, according to archaeologists who have dug up a medieval mass grave near the renowned museum. Exposed during work to build an elevator in an area designed to house an … Continue reading →
Dr. Robert A.J. Signer (left) and Dr. Sean MorrisonImage courtesy of UT Southwestern Medical CenterFor the first time, researchers have shown that an essential biological process known as protein synthesis can be studied in adult stem cells – something scientists have long struggled to accomplish. The groundbreaking findings from the Children’s Medical Center Research Institute at UT Southwestern (CRI) also demonstrate that the precise amount of protein produced by blood-forming
Signer, R., Magee, J., Salic, A. & Morrison, S. (2014). Haematopoietic stem cells require a highly regulated protein synthesis rate, Nature, DOI: 10.1038/nature13035
Kevin Kit ParkerAfter more than a decade of advances in stem cell research, almost anyone with a basic understanding of life sciences understands that stem cells are the basic form of cell from which all the other specialized cells, and eventually organs and body parts, derive.But what makes a "good" stem cell, one that can reliably be used in drug development, and for disease study? Researchers have made enormous strides in understanding the process of cellular reprogramming, and how and
Sheehy, S., Pasqualini, F., Grosberg, A., Park, S., Aratyn-Schaus, Y. & Parker, K. (2014). Quality Metrics for Stem Cell-Derived Cardiac Myocytes, Stem Cell Reports, DOI: 10.1016/j.stemcr.2014.01.015
A new study by researchers at the Karolinska Institutet,Sweden suggests that the expression of the so called MYC gene is important and necessary for neurogenesis in the spinal cord. The findings appear in the journal EMBO Reports .The MYC gene encodes the protein with the same name, and has an important role in many cellular processes such as proliferation, metabolism, cell death and the potential of differentiation from immature stem cell s to different types of specialized cells .
Zinin N, Adameyko I, Wilhelm M, Fritz N, Uhlén P, Ernfors P & Henriksson MA (2014). MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division., EMBO reports, PMID: 24599748
The bite of an infected Ixodes hard tick transmits the Lyme disease spirochete, Borrelia burgdorferi, to humans. Ticks acquire B. burgdorferi by feeding on reservoir hosts colonized with the spirochete. Reservoir hosts include small mammals such as the white-footed mouse, the main reservoir of B. burgdorferi in the northeastern United States.A study that just came out in The Yale Journal of Biology and Medicine is accompanied by videos of Borrelia burgdorferi being transmitted
Bockenstedt LK, Gonzalez D, Mao J, Li M, Belperron AA & Haberman A (2014). What ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the Lyme disease spirochete., The Yale Journal of Biology and Medicine, 87 (1) 3-13. PMID: 24600332
Anderson JF & Magnarelli LA (2008). Biology of ticks., Infectious Disease Clinics of North America, 22 (2) 195. PMID: 18452797
Nakayama Y & Spielman A (1989). Ingestion of Lyme disease spirochetes by ticks feeding on infected hosts., The Journal of infectious diseases, 160 (1) 166-7. PMID: 2732513
Tuberculosis (TB) represents a serious public health problem. The latest reports estimate an incidence of 8.7 million cases in 2001 and over 1.4 million deaths […] Read moreThe post New hope against tuberculosis: spectinamides appeared first on Mapping Ignorance.
Lee R.E., Hurdle J.G., Liu J., Bruhn D.F., Matt T., Scherman M.S., Vaddady P.K., Zheng Z., Qi J. & Akbergenov R. & (2014). Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux, Nature Medicine, 20 (2) 152-158. DOI: 10.1038/nm.3458