Posts

February 26, 2015

+
7:43 AM | Carnitine and autism continued
The paper from everyone's favourite Saudi - Egyptian autism research tag-team that is Gehan Mostafa and Laila AL-Ayadhi [1] (open-access) on plasma polyunsaturated fatty acids and serum carnitine levels in a cohort of children diagnosed with autism / autism spectrum disorder (ASD) is served up for your reading delight today.Regular readers of this blog might have heard me talk before about the pretty interesting research findings to come from this research partnership (see here and see […]

Mostafa, G. & AL-Ayadhi, L. (2015). Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: relation to gastrointestinal manifestations, Behavioral and Brain Functions, 11 (1) DOI: 10.1186/s12993-014-0048-2

Citation

February 25, 2015

+
10:31 AM | Analysing the salivary proteome in autism
The paper from Armand Ngounou Wetie and colleagues [1] (open-access here) reporting pilot results from a mass spectrometry based proteomic analysis of saliva in cases of autism or autism spectrum disorder (ASD) compared with asymptomatic controls is served up for your reading delight today. There has already been some media attention about this paper (see here).It's an interesting paper for quite a few reasons; not least the continuing voyage of the analytical technique known as mass […]

Ngounou Wetie AG, Wormwood KL, Russell S, Ryan JP, Darie CC & Woods AG (2015). A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder., Autism research : official journal of the International Society for Autism Research, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25626423

Citation

February 24, 2015

+
9:38 AM | Maternal recall vs. medical records: implications for autism research
I don't want to dwell too much on the findings reported by Paula Krakowiak and colleagues [1] talking about the accuracy of "maternally-reported diabetes and hypertensive disorders, and reliability of BMI [body mass index] measurements during periconception and pregnancy compared with medical records when mothers are interviewed 2-5 years after delivery" but they are potentially important.With authors such as Krakowiak and Irva Hertz-Picciotto on the paper in question, those who […]

February 23, 2015

+
9:34 AM | Late, delayed and mis-diagnosis of autism
It's inevitable that with all the mountains of autism research published on a daily basis, certain themes will occur at certain times. My post today is reflective of one of those themes and how, on occasion, the autism diagnostic process does not run as smoothly as we would all like to think.I start this post with a link to an article discussing some forthcoming research to be published titled: 'The autistic pupils ‘traumatised’ by delayed diagnosis'. Describing the results of a […]

Davidovitch M, Levit-Binnun N, Golan D & Manning-Courtney P (2015). Late Diagnosis of Autism Spectrum Disorder After Initial Negative Assessment by a Multidisciplinary Team., Journal of developmental and behavioral pediatrics : JDBP, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25651066

Aggarwal S & Angus B (2015). Misdiagnosis versus missed diagnosis: diagnosing autism spectrum disorder in adolescents., Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25653302

Citation

February 21, 2015

+
10:39 AM | Coeliac disease: genes, autoimmunity, gut bacteria and bafflement?
Some things in life really do baffle me. When it comes to this blog, nothing seems to baffle me more than some of the talk about the triad that is autoimmunity, coeliac disease and gluten (see here for an example).My bafflement continued upon reading the papers by Emilsson and colleagues [1] and by Olivares and colleagues [2]. Respectively suggesting that: "spouses of individuals with celiac disease are at increased risk of non-celiac autoimmune disease" and "a specific disease-biased host […]

Emilsson L, Wijmenga C, Murray JA & Ludvigsson JF (2015). Autoimmune Disease in First-degree Relatives and Spouses of Individuals with Celiac Disease., Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25645875

Olivares M, Neef A, Castillejo G, Palma GD, Varea V, Capilla A, Palau F, Nova E, Marcos A, Polanco I & Ribes-Koninckx C (2014). The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease., Gut, PMID: http://www.ncbi.nlm.nih.gov/pubmed/24939571

Citation

February 20, 2015

+
8:43 AM | Behavioural sleep intervention for ADHD?
I was really quite interested to read about the study from Harriet Hiscock and colleagues [1] (open-access) suggesting that: "A brief behavioural sleep intervention modestly improves the severity of ADHD [attention deficit hyperactivity disorder] symptoms in a community sample of children with ADHD." I had heard that these results would be forthcoming based on the publication of the study trial protocol [2] a few years back, alongside the trial entry listed in the ISRCTN registry […]

Hiscock H, Sciberras E, Mensah F, Gerner B, Efron D, Khano S & Oberklaid F (2015). Impact of a behavioural sleep intervention on symptoms and sleep in children with attention deficit hyperactivity disorder, and parental mental health: randomised controlled trial., BMJ (Clinical research ed.), 350 PMID: http://www.ncbi.nlm.nih.gov/pubmed/25646809

Citation

February 19, 2015

+
8:39 AM | Metal sensitisation and chronic fatigue syndrome?
I have to admit that I pondered longer than usual over whether I should talk about the paper by Vera Stejskal [1] (open-access here) and the idea that: "Patients with CFS [chronic fatigue syndrome] and fibromyalgia are frequently sensitized to metals found in the environment or used in dentistry and surgery."It was't that I doubted that metals - certain types present in the wrong place or wrong concentration - can affect physical and psychological health and wellbeing as per the […]

Stejskal V (2014). Metals as a common trigger of inflammation resulting in non-specific symptoms: diagnosis and treatment., The Israel Medical Association journal : IMAJ, 16 (12) 753-8. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25630203

Citation

February 18, 2015

+
8:59 AM | Autism and the inter-pregnancy interval (again)
The paper from Maureen Durkin and colleagues [1] adds to something of a growing research evidence base suggesting that the temporal spacing between pregnancies / births - the inter-pregnancy interval (IPI) - may have something of an effect on the risk of receipt of a diagnosis of autism or autism spectrum disorder (ASD).We've been here before. In fact, a couple of times I've talked about the IPI in relation to autism risk (see here and see here) not including other, similar research findings in […]

Durkin MS, DuBois LA & Maenner MJ (2015). Inter-Pregnancy Intervals and the Risk of Autism Spectrum Disorder: Results of a Population-Based Study., Journal of autism and developmental disorders, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25636677

Citation

February 17, 2015

+
8:57 AM | Congenital rubella, autism and remote stroke
Case reports. I know they rank pretty low in the order of what counts as objective scientific evidence [1] despite their often interesting findings. That being said, when it comes to a diagnosis like autism, with all its associated heterogeneity and elevated risk of various comorbidity probably better encapsulated in a more 'plural autisms' understanding, case reports can offer something of an important view into the many and varied ways in which someone might arrive on the autism spectrum and […]

George J Hutton, J. (2014). Congenital Rubella with Autism and Evidence of a Remote Stroke, Journal of Vaccines & Vaccination, 05 (06) DOI: 10.4172/2157-7560.1000258

Citation

February 16, 2015

+
8:11 AM | Poo transplant and weight gain: a case study
The case report detailed by Neha Alang and Colleen Kelly [1] (open-access) reporting on "new-onset obesity after receiving stool from a healthy but overweight donor" has already garnered some significant press attention (see the BBC entry for example). Reporting on that seemingly most undesirable but in some cases life-saving of measures - the fecal microbiota transplant (FMT) - whereby some of those trillions of wee beasties which inhabit our deepest, darkest recesses are […]

Alang, N. & Kelly, C. (2015). Weight Gain After Fecal Microbiota Transplantation, Open Forum Infectious Diseases, 2 (1) DOI: 10.1093/ofid/ofv004

Citation

February 14, 2015

+
9:53 AM | Nutritional medicine as mainstream in psychiatry
Have you remembered? Flowers from the nearest petrol / gas station or something a little more amorous for February 14th?So as not to take up too much of your time today, I want to briefly draw your attention to the paper (personal view) from Jerome Sarris and colleagues [1] carrying the same title as that of this blog post: 'Nutritional medicine as mainstream in psychiatry' published in The Lancet Psychiatry.Aside from applauding the notion that nutrition is potentially of some importance to […]

Jerome Sarris, Alan C Logan, Tasnime N Akbaraly, G Paul Amminger, Vicent Balanzá-Martínez, Marlene P Freeman, Joseph Hibbeln, Yutaka Matsuoka, David Mischoulon, Tetsuya Mizoue & Akiko Nanri (2015). Nutritional medicine as mainstream in psychiatry, Lancet Psychiatry, Other:

Citation

February 13, 2015

+
9:46 AM | Autism, CNVs and sensitivity to maternal infection?
An intriguing quote to begin today's post: "Our findings support a gene-environment interaction model of autism impairment, in that individuals with ASD-associated CNVs are more susceptible to the effects of maternal infection and febrile episodes in pregnancy on behavioral outcomes and suggest that these effects are specific to ASD [autism spectrum disorder] rather than to global neurodevelopment."The findings come from the paper by Varvara Mazina and colleagues [1] who sought to […]

Mazina V, Gerdts J, Trinh S, Ankenman K, Ward T, Dennis MY, Girirajan S, Eichler EE & Bernier R (2015). Epigenetics of Autism-related Impairment: Copy Number Variation and Maternal Infection., Journal of developmental and behavioral pediatrics : JDBP, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25629966

Citation

February 12, 2015

+
9:58 AM | 15q11.2 microdeletion, developmental delay and congenital heart disease
"Our results support the hypothesis that 15q11.2 (BP1-BP2) microdeletion is associated with developmental delay, abnormal behaviour, generalized epilepsy and congenital heart disease."So it was written in the paper from Vanlerberghe and colleagues [1] following their analysis of 52 "unrelated patients" diagnosed with 15q11.2 microdeletion, a 'novel' microdeletion syndrome according to other research [2].Your REAL problem's the monkey.Autism spectrum disorder (ASD) is mentioned in the […]

Vanlerberghe C, Petit F, Malan V, Vincent-Delorme C, Bouquillon S, Boute O, Holder-Espinasse M, Delobel B, Duban B, Vallee L & Cuisset JM (2015). 15q11.2 Microdeletion (BP1-BP2) and Developmental delay, Behaviour issues, Epilepsy and Congenital heart disease: a series of 52 patients., European journal of medical genetics, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25596525

Citation

February 11, 2015

+
10:22 AM | Like buses. Vitamin D and autism again.
I don't know if everyone will have heard the term 'like buses' to infer that you seem to spend ages waiting for something (like a bus) and then two or more turn up at once. So it is with research, and the continuing interest that autism research seems to have with the sunshine vitamin/hormone that is vitamin D.Following on from my recent discussions on the paper by Fernell and colleagues [1] (see here) talking about early low vitamin D potentially being 'connected' to cases of autism or autism […]

Bener, A., Khattab, A. & Al-Dabbagh, M. (2014). Is high prevalence of Vitamin D deficiency evidence for autism disorder?: In a highly endogamous population, Journal of Pediatric Neurosciences, 9 (3) 227. DOI: 10.4103/1817-1745.147574

Citation

February 10, 2015

+
9:09 PM | New name: Systemic Exertion Intolerance Disease?
The name is: Systematic Exertion Intolerance Disease (SEID).A very quick post to direct you to the public release of the findings from the US Institute of Medicine (IoM) looking at the name and current criteria used to diagnose Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME) (see here). The proposed diagnostic criteria for CFS/ME, sorry SEID can be viewed here.Some of the background to these findings can be seen here and some of the media about the new IoM recommendations can […]

Morris G & Maes M (2013). Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions., Neuro endocrinology letters, 34 (3) 185-99. PMID: http://www.ncbi.nlm.nih.gov/pubmed/23685416

Citation
+
9:53 AM | Increased risk of chronic kidney disease in schizophrenia
"After adjusting for demographic characteristics, select comorbid medical disorders and NSAIDs [non-steroid anti-inflammatory drugs] usage, the current results reveal that patients with schizophrenia have an increased risk of nearly 40% (HR=1.36; 95% CI 1.13 to 1.63; p<0.001) of developing CKD [chronic kidney disease] within a 3-year follow-up period after their schizophrenia diagnosis."That was the rather surprising finding reported by Nian-Sheng Tzeng and […]

Tzeng, N., Hsu, Y., Ho, S., Kuo, Y., Lee, H., Yin, Y., Chen, H., Chen, W., Chu, W. & Huang, H. & (2015). Is schizophrenia associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study, BMJ Open, 5 (1) DOI: 10.1136/bmjopen-2014-006777

Citation

February 09, 2015

+
9:47 AM | What have we learned about autism?
Today's post is a bit of mash-up based on the review paper by Jason Chen and colleagues [1] and a news entry from Autism Speaks titled: '10 Years of Progress: What We've Learned About Autism' (see here). Cumulatively, these two commentaries try to paint a picture of where we are, knowledge-wise, when it comes to the label of autism or autism spectrum disorder (ASD) and highlight the many gaps that remain in what we 'think' we know about autism.The Chen paper approaches the 'emerging picture of […]

Chen JA, Peñagarikano O, Belgard TG, Swarup V & Geschwind DH (2015). The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology., Annual review of pathology, 10 111-144. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25621659

Citation

February 07, 2015

+
9:00 AM | Over a third of US children will have a behavioural / emotional disorder by 16 years of age
I had to do a second-take when it came to the clinical report from Carol Weitzman and colleagues [1] (open-access here) talking about promoting 'optimal development'  and "the need to increase behavioral screening" when it comes to the children and youth of the United States.The title of this post kinda said it all derived from the sentence: "Between 37% and 39% of children will have a behavioral or emotional disorder diagnosed by 16 years of age, regardless of geographic location in […]

Carol Weitzman, Lynn Wegner & et al (2015). Promoting Optimal Development: Screening for Behavioral and Emotional Problems, Pediatrics, Other:

Citation

February 06, 2015

+
10:00 AM | Depression and risk of coronary heart disease
"The results of our meta-analysis suggest that depression is independently associated with a significantly increased risk of CHD [coronary heart disease] and MI [myocardial infarction], which may have implications for CHD etiological research and psychological medicine."No owners means - no heartbreak!So said the conclusion of the paper by Yong Gan and colleagues [1] (open-access) and their synthesis of the peer-reviewed literature on the topic of heart health and depression. […]

February 05, 2015

+
9:38 AM | Tics, OCD and non-coeliac gluten sensitivity: a case report
A curious case report is documented in the paper by Luis Rodrigo and colleagues [1] (open-access) discussing the diagnosis of non-coeliac gluten sensitivity (NCGS) in a young lady "with a long history of 10 years of tics and obsessive compulsive disorder [OCD]." Further, quite a remarkable turn-around in her clinical symptoms was observed following institution of a gluten-free diet (GFD); as the authors note: "One week after the beginning of this diet, the tics diminished notably and […]

Huerta M, R. (2015). Tourette Syndrome and Non-Coeliac Gluten Sensitivity. Clinical Remission with a Gluten-Free Diet: A Description Case, Journal of Sleep Disorders & Therapy, 04 (01) DOI: 10.4172/2167-0277.1000183

Citation

February 04, 2015

+
9:40 AM | A rat model of early immune stimulation
It took me a few a reads of the paper by Anna Kubesova and colleagues [1] (open-access) to understand just how potentially important their findings might be to various conditions including schizophrenia and autism.Reporting results of a study where "early immune stimulation induced by postnatal systemic administration of LPS [lipopolysaccharide]" was performed in rats, researchers examined various potential effects on "the levels of monoamines (dopamine, serotonin) and their […]

Kubesova A, Tejkalova H, Syslova K, Kacer P, Vondrousova J, Tyls F, Fujakova M, Palenicek T & Horacek J (2015). Biochemical, Histopathological and Morphological Profiling of a Rat Model of Early Immune Stimulation: Relation to Psychopathology., PloS one, 10 (1) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25602957

Citation

February 03, 2015

+
10:04 AM | Are you sitting comfortably?
"It Doesn’t Matter How Much You Exercise If You Also Do This" was one of the headlines which followed the systematic review and meta-analysis completed by Aviroop Biswas and colleagues [1] concluding that: "Prolonged sedentary time was independently associated with deleterious health outcomes regardless of physical activity.""The benefits of exercise can be blunted if you also spend most of the rest of your day sitting" was a sentence included in the media take on the Biswas review, […]

Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS & Alter DA (2015). Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults: A Systematic Review and Meta-analysis., Annals of internal medicine, 162 (2) 123-132. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25599350

Citation

February 02, 2015

+
8:06 AM | Bisphenol A Exposure in Children With Autism
The paper by T. Peter Stein and colleagues [1] suggesting an "association" between BPA (Bisphenol-A) and autism spectrum disorder (ASD) was always bound to create some interest. Reporting results based on the analysis of urine samples from a group of children diagnosed with an autism spectrum disorder (ASD) (n=46) compared to controls (n=52), authors concluded that: "there is an association between BPA and ASD." Association... note that word.C'mon. Let's go see how much we're going for on […]

Stein, T., Schluter, M., Steer, R., Guo, L. & Ming, X. (2015). Bisphenol A Exposure in Children With Autism Spectrum Disorders, Autism Research, DOI: 10.1002/aur.1444

Citation

January 31, 2015

+
10:40 AM | Suramin and the Fragile X (Fmr1 knockout) mouse model (and autism)
Fancy some weekend reading? Well, you could do a lot worse than having a gander through the paper by Jane Naviaux and colleagues [1] (open-access) discussing the results of a whole host of analyses following the use of the antipurinergic agent suramin on a mouse model of Fragile X syndrome.Overprotective mother, forbidden road trip...Regular readers might remember some previous discussions about suramin - a pharmaceutic designed to treat African sleeping sickness - and autism which […]

Jane C Naviaux, Lin Wang, Kefeng Li, A Taylor Bright, William A Alaynick, Kenneth R Williams, Susan B Powell & Robert K Naviaux (2015). Antipurinergic therapy corrects the autism-like features in the fragile X (Fmr1 knockout) mouse model, Molecular Autism, Other:

Citation

January 30, 2015

+
10:02 AM | Diverse developmental trajectories in early years autism
"Findings confirm the heterogeneous nature of developmental trajectories in ASD [autism spectrum disorder]." That was the bottom line of the study by Peter Szatmari and colleagues [1] (open-access) tracking the developmental trajectory - autistic symptom severity and adaptive functioning - for a sample of "421 newly diagnosed preschool children with ASD 2 to 4 years old." Some accompanying media for the study can be found here.The Szatmari paper is open-access so it doesn't need any […]

Szatmari, P., Georgiades, S., Duku, E., Bennett, T., Bryson, S., Fombonne, E., Mirenda, P., Roberts, W., Smith, I., Vaillancourt, T. & Volden, J. (2015). Developmental Trajectories of Symptom Severity and Adaptive Functioning in an Inception Cohort of Preschool Children With Autism Spectrum Disorder, JAMA Psychiatry, DOI: 10.1001/jamapsychiatry.2014.2463

Citation

January 29, 2015

+
9:38 AM | Autism spectrum symptomatology in individuals with Down syndrome
I was not surprised to read the findings of the paper from Marie Moore Channell and colleagues [1] (open-access) who "identified patterns of ASD [autism spectrum disorder] symptomatology, measured by the SRS [Social Responsiveness Scale], in individuals with DS [Down syndrome] who do not have comorbid ASD."You're not going Turbo, are you?Harking back to the paper by Georgina Warner and colleagues [2] discussed not-so-long-ago on this blog (see here), the idea that […]

Marie Moore Channell, B Allyson Phillips, Susan J Loveall, Frances A Conners, Paige M Bussanich & Laura Grofer Klinger (2015). Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder, Journal of Neurodevelopmental Disorders, Other:

Citation

January 28, 2015

+
10:03 AM | Urinary histidine as a marker of 'dioxin-induced' neurodevelopmental issues?
The paper by Muneko Nishijo and colleagues [1] (open-access) caught my eye recently and their continuing investigations into the potential effects of perinatal dioxin exposure on offspring neurodevelopmental outcomes. For a bit of background on this initiative based in Vietnam, I would refer readers to a previous post on this blog (see here).Your weakness is copper? Y-you're kidding right?In case you can't be bothered to follow that previous link, the idea was that exposure to TCDD […]
1
27 Results