An autoantigen targeted during Lyme arthritis

Infection by the spirochete Borrelia burgdorferi, if left untreated, can lead to a form of Lyme disease called Lyme arthritis. About 10% of Lyme arthritis patients end up with a chronic form that doesn't go away with antibiotic treatment. Allen Steere's group has long suspected that the antibiotic-refractory form of Lyme arthritis involves an autoimmune process. This notion seems reasonable since those with antibiotic-refractory Lyme arthritis tend to have certain forms of the […]

Drouin, E.E., Seward, R.J., Strle, K., McHugh, G., Katchar, K., Londoño, D., Yao, C., Costello, C.E. & Steere, A.C. (2013). A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease., Arthritis & Rheumatism, 65 (1) 186-196. DOI: 10.1002/art.37732

Seward, R.J., Drouin, E.E., Steere, A.C. & Costello, C.E. (2010). Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis., Molecular & Cellular Proteomics, 10 (3) DOI: 10.1074/mcp.M110.002477

Steere, A.C., Drouin, E.E. & Glickstein, L.J. (2011). Relationship between immunity to Borrelia burgdorferi Outer-surface protein A (OspA) and Lyme arthritis., Clinical Infectious Diseases, 52 (Supplement 3) DOI: 10.1093/cid/ciq117

An autoantigen targeted during Lyme arthritis

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