The Importance of Epigenetic Modification of RNA in miRNA Maturation and Breast Cancer

MicroRNAs (miRNAs) are single-stranded RNA molecules 18-24 bases in length that are important for the regulation of many biological processes by posttranscriptionally interfering with gene expression.   MiRNAs generally regulate gene expression by either facilitating mRNA degradation or repressing translation.  Generation of the mature and active form of miRNAs requires the cleavage of pre-miRNA molecules by ...