Aerobic exercise appears to have significant therapeutic benefits in the treatment of anxiety and depression. This effect has been demonstrated in animal models as well as in humans. However, there has been limited study of the potential brain mechanisms that produce an anti-anxiety or an anti-depressant effect.Brain serotonin neurotransmitter receptors have been implicated in anxiety and depressive disorders. Additionally, selective serotonin reuptake inhibitor drugs such as
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Greenwood BN, Strong PV, Loughridge AB, Day HE, Clark PJ, Mika A, Hellwinkel JE, Spence KG & Fleshner M (2012). 5-HT(2C) Receptors in the Basolateral Amygdala and Dorsal Striatum Are a Novel Target for the Anxiolytic and Antidepressant Effects of Exercise., PloS one, 7 (9) PMID: 23049953
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