The Bcl-2 family of proteins: A life or death situation

If you’ve taken a biochemistry class, you’ve probably heard the structure-function paradigm for proteins: amino acid sequence dictates how the protein will be folded, and the ordered 3D structure of the protein is necessary for function.(1) For example, proper formation … Continue reading →

Dunker, A.K., Lawson, J.D., Brown, C.J., Williams, R.M., Romero, P., Oh, J.S., Oldfield, C.J., Campen, A.M., Ratliff, C.M. & Hipps, K.W. (2001). Intrinsically disordered protein, Journal of Molecular Graphics and Modelling, 19 (1) 59. DOI: 10.1016/S1093-3263(00)00138-8

Rautureau, G.J.P., Day, C.L. & Hinds, M.G. (2010). Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis, International Journal of Molecular Sciences, 11 (4) 1824. DOI: 10.3390/ijms11041808

Rodi, D.J., Janes, R.W., Sanganee, H.J., Holton, R.A., Wallace, B.A. & Makowski, L. (1999). Screening of a library of phage-displayed peptides identifies human Bcl-2 as a taxol-binding protein, Journal of Molecular Biology, 285 (1) 203. DOI: 10.1006/jmbi.1998.2303

Dunker A.K., Lawson J.D., Brown C.J., Williams R.M., Romero P., Oh J.S., Oldfield C.J., Campen A.M., Ratliff C.M. & Hipps K.W. & (2001). Intrinsically disordered protein, Journal of Molecular Graphics and Modelling, 19 (1) 59. DOI: 10.1016/S1093-3263(00)00138-8

Rautureau G.J.P., Day C.L. & Hinds M.G. (2010). Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis, International Journal of Molecular Sciences, 11 (4) 1824. DOI: 10.3390/ijms11041808

Rodi D.J., Janes R.W., Sanganee H.J., Holton R.A., Wallace B.A. & Makowski L. (1999). Screening of a library of phage-displayed peptides identifies human Bcl-2 as a taxol-binding protein, Journal of Molecular Biology, 285 (1) 203. DOI: 10.1006/jmbi.1998.2303

The Bcl-2 family of proteins: A life or death situation

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