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The epigenetics of Chronic Fatigue Syndrome?
"These data are consistent with evidence of multisystem dysregulation in CFS [Chronic Fatigue Syndrome] and implicate the involvement of DNA modifications in CFS pathology". So said the paper by Wilfred de Vega and colleagues [1] (open-access here) which, I think, represents a bit of a first for CFS with their examination of the possible role of epigenetic modifications in relation to the condition(s) [2].Ladies first @ Wikipedia I have to say that I was really quite excited […]

de Vega WC, Vernon SD & McGowan PO (2014). DNA Methylation Modifications Associated with Chronic Fatigue Syndrome., PloS one, 9 (8) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25111603

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Unpacking Recovery Part 4: Are We All on the Same Page?
Another issue in defining and understanding recovery is that patients and clinicians may have different opinions about what recovery looks like and how to get there. Certainly, there is a body of literature from the critical feminist tradition in particular that explores how at times, patients can “follow the rules” of treatment systems to achieve a semblance of “recovery,” from a weight restoration and nutrition stabilization perspective, but feels nothing like a full […]

Noordenbos, G. & Seubring, A. (2006). Criteria for Recovery from Eating Disorders According to Patients and Therapists, Eating Disorders, 14 (1) 41-54. DOI: 10.1080/10640260500296756

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Falsifiability and Gandy’s variant of the Church-Turing thesis
In 1936, two years after Karl Popper published the first German version of The Logic of Scientific Discovery and introduced falsifiability; Alonzo Church, Alan Turing, and Emil Post each published independent papers on the Entscheidungsproblem and introducing the lambda calculus, Turing machines, and Post-Turing machines as mathematical models of computation. The years after saw many […]

Gandy, R. (1980). Church's thesis and principles for mechanisms., Studies in Logic and the Foundations of Mathematics, (101) 123-148. DOI: 10.1016/S0049-237X(08)71257-6

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The hope behind climate change: adaptation strategies for coastal regions
Happy Labor Day!  In honor of a day traditionally taken off (except for retail employees, unfortunately) to enjoy grilling and relaxing outside, I thought I’d discuss something a bit more upbeat.  Climate change research can often be gloomy.  It is … Continue reading →

Brown, S., Nicholls, R., Hanson, S., Brundrit, G., Dearing, J., Dickson, M., Gallop, S., Gao, S., Haigh, I., Hinkel, J. & Jiménez, J. (2014). Shifting perspectives on coastal impacts and adaptation, Nature Climate Change, 4 (9) 752-755. DOI: 10.1038/nclimate2344

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Assemblages: 50 Years Later, We Know Nothing About Them
You would think we learn about every part of a cell in biology, but we really don’t. Case in point, about 50 years ago, electron microscopy revealed the presence of […]

Toretsky, J. & Wright, P. (2014). Assemblages: Functional units formed by cellular phase separation, The Journal of Cell Biology, 206 (5) 579-588. DOI: 10.1083/jcb.201404124

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Tracking the Daily Microbiome
Humans are essentially 90% bacteria. These bacteria pepper our skin and hang out in our digestive tracts, helping to break down complex carbohydrates and keeping bad bugs in check. We know how the human microbiome (our collection of bacteria) gets … Continue reading →

David LA, Materna AC, Friedman J, Campos-Baptista MI, Blackburn MC, Perrotta A, Erdman SE & Alm EJ (2014). Host lifestyle affects human microbiota on daily timescales., Genome biology, 15 (7) PMID: http://www.ncbi.nlm.nih.gov/pubmed/25146375

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New Clues Revealed about the Longevity of Naked Mole Rats
Naked Mole RatCredit: UT Health Science Center at San AntonioThe hairless, odd-looking creature in the photo is a naked mole rat (Heterocephalus glaber).Among many weird traits, the species also holds the record for longest living rodent. For comparison, the house mouse (Mus musculus) has a maximum lifespan of just 2-3 years, whereas naked mole rats have been recorded to live as much as 32 years!The exact mechanisms behind the species remarkable longevity have yet to be clearly unveiled, […]

Rodriguez KA, Osmulski PA, Pierce A, Weintraub ST, Gaczynska M & Buffenstein R (2014). A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition., Biochimica et biophysica acta, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25018089

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Students with more autistic traits make fewer altruistic choices
Most people with autism have difficulties socialising and connecting with others. It's generally agreed that part of this has to do with an impairment in taking other people's perspective. More specifically, an emerging consensus suggests that autism is associated with having normal feelings for other people, but an impaired understanding of them. Little explored before now is how this affects the behaviour of people with autism towards others who need help.Leila Jameel and her colleagues […]

Jameel L, Vyas K, Bellesi G, Roberts V & Channon S (2014). Going 'Above and Beyond': Are Those High in Autistic Traits Less Pro-social?, Journal of autism and developmental disorders, 44 (8) 1846-58. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24522968

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Lithium for mood disorder symptoms in autism?
Modern classroom? @ Wikipedia The paper published by Matthew Siegel and colleagues [1] talking about some preliminary observations on the use of lithium where symptoms of mood disorder might be present in cases of autism spectrum disorder (ASD) caught my eye recently. Concluding that: "lithium may be a medication of interest for those who exhibit two or more mood disorder symptoms, particularly mania or euphoria/elevated mood" the sentiments of more research-to-do in this area […]

Siegel M, Beresford CA, Bunker M, Verdi M, Vishnevetsky D, Karlsson C, Teer O, Stedman A & Smith KA (2014). Preliminary Investigation of Lithium for Mood Disorder Symptoms in Children and Adolescents with Autism Spectrum Disorder., Journal of child and adolescent psychopharmacology, PMID: http://www.ncbi.nlm.nih.gov/pubmed/25093602

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August lives up to its definition: respected and impressive
The things we noticed in and around canine science over the past two weeks, Storified in one neat location for your convenience:[View the story "Do You Believe in Dog? [16-31 August 2014]" on Storify] Further reading:Feuerbacher E.N. (2014). Shut up and pet me! Domestic dogs (Canis lupus familiaris) prefer petting to vocal praise in concurrent and single-alternative choice procedures, Behavioural Processes, DOI: http://dx.doi.org/10.1016/j.beproc.2014.08.019 Gygax L. (2014). The A to Z of […]

Gygax L. (2014). The A to Z of statistics for testing cognitive judgement bias, Animal Behaviour, 95 59-69. DOI: http://dx.doi.org/10.1016/j.anbehav.2014.06.013

Arnott E.R., Claire M. Wade & Paul D. McGreevy (2014). Environmental Factors Associated with Success Rates of Australian Stock Herding Dogs, PLoS ONE, 9 (8) e104457. DOI: http://dx.doi.org/10.1371/journal.pone.0104457

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